AAPS PHARMSCITECH
·
2023
·Vol. 24
·期 8
·1-12
·
IF 3.3
Jiang Wenjing,Gao Xiangjun,Wang Qiuli,Chen Yang,Li Dan,Zhang Xiaoyan,Yang Xinggang
The existing exenatide microspheres have the problem of burst release in the early stage, and minimal release in the middle stage which makes it difficult to achieve effective blood drug concentration (platform period). In this study, the modified exenatide microspheres were constructed to address the aforementioned issues. Poly(D,L-lactic-co-glycolic acid) (PLGA) and triblock copolymer with sol-gel conversion characteristics (PLGA-PEG-PLGA gel) were introduced as carriers to prepare microspheres. The hot gel characteristics and hydrophilicity of PLGA-PEG-PLGA gel were utilized to decline the burst release and shorten the platform period. Simultaneously, zinc acetate and exenatide were combined to generate an insoluble complex to further reduce the burst release. Herein, we prepared three types of exenatide microspheres using the solvent evaporation method and investigated their characterization as well as in vitro and in vivo release. According to the experimental findings, the modified exenatide microspheres, i.e., PLGA-PEG-PLGA gel and PLGA co-loaded zinc-exenatide insoluble complex microspheres (Zn-EXT-Gel-MS), had smooth and rounded surfaces, with a particle size of 24.7 μm, and the encapsulation rate reached 89.43%. And it was released for 40 days in vitro , behaving better than the other two microspheres in terms of release behavior. When this product was administered subcutaneously to rats, it produced a comparatively constant plasma exenatide concentration that lasted for 24 days and superior bioavailability than the exenatide microspheres (EXT-MS). The creation of modified exenatide microspheres may serve as a heuristic method for other long-acting medications. Graphical Abstract Schematic diagram of the synthesis process and release curves of three types of exenatide microspheres in vitro and in vivo
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-9
·
IF 16.6
Li Meng,Zhao Nifang,Mao Anran,Wang Mengning,Shao Ziyu,Gao Weiwei,Bai Hao
Ice formation on solid surfaces is a ubiquitous process in our daily life, and ice orientation plays a critical role in anti-icing/deicing, organ cryo-preservation, and material fabrication. Although previous studies have shown that surface grooves can regulate the orientation of ice crystals, whether the parallel or perpendicular alignment to the grooves is still under debate. Here, we systematically investigate ice formation and its oriented growth on grooved surfaces through both in situ observation and theoretical simulation, and discover a remarkable size effect of the grooves. With the designability of surface groove patterns, the preferential growth of ice crystals is programmed for the fabrication of a crisscross-aligned graphene aerogel with large negative Poisson’s ratio. In addition, the size effect provides guidance for the design and fabrication of solid surfaces where the effective control of ice orientation is highly desired, such as efficient deicing, long time organ cryo-preservation, and ice-templated materials.
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Carbon Letters
·
2023
·
IF 4.5
Lu Tong,Zhang Qingxia,Yang Jingjing,Xin Yue,Zhang Zhilei,Hu Lingye,Hu Jing,Qin Qin,Yang Hao
The discharge of industrial oily wastewater and oil spill accidents has resulted in significant environmental pollution, creating an urgent need for the treatment of oily wastewater. Nanofiber membranes, known for their high stability, flux, and efficiency, are widely employed in oil–water separation. This study systematically compared the performance of polyacrylonitrile/graphene oxide (PAN/GO) composite nanofiber membranes prepared through immersion and electrospinning methods for oily wastewater treatment. Experimental findings demonstrated that immersion-prepared membranes achieved high flux (772.9 ± 2.9 L·m −2 ·h −1 , n-hexane/water mixture) and efficiency (98.8%) at a GO concentration of 1.0 g/mL. On the other hand, electrospinning-prepared membranes exhibited superior flux (1500.3 ± 4.4 L·m −2 ·h −1 , n-hexane/water mixture) and efficiency (99.6%) at a higher GO concentration (1.5 g/mL). This membrane displayed excellent stability, maintaining their exceptional performance even after ten cycles of separation. This study compared the advantages and disadvantages of the two methods for preparation of PAN/GO composite nanofiber membrane, offering valuable guidance for practical applications.
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JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 46
·17483-17499
·
IF 4.5
Tang Qin,Chen Hui,Shen Jun
The flower-like MoS 2 /cotton fiber-derived TiO 2 (MoS 2 /CF–TiO 2 ) composites were successfully prepared through the bio-template method and hydrothermal reaction. The influence of TiO 2 morphology and content on the electromagnetic wave (EMW) absorption performance of the composites was explored. The enhancement effect and mechanism of the heterostructure formed by MoS 2 and CF–TiO 2 on the EMW absorption performance were analyzed. The results showed that when CF–TiO 2 was added with a titanium-molybdenum atomic ratio of 2:1, the MoS 2 /CF–TiO 2 composites reached the minimum reflection loss (RL) of − 42.4 dB at 6.4 GHz when the thickness was 4.0 mm. The strong EMW absorption performance of MoS 2 /CF–TiO 2 composites could be attributed to the improvement of impedance matching. The good interface contact between the tubular CF–TiO 2 and flower-like MoS 2 not only increased the specific surface area of the material, but also greatly improved the conductivity of the material, enhancing the conduction loss and various polarization losses.
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Scientific Reports
·
2026
·
IF 4.9
Yan Mengqi,Li Chen,Li Cuixian,Zhuang Fan,Zhu Piao,Huang Beijian
To compare sonodynamic therapy (SDT) efficacy mediated by protoporphyrin IX-loaded liposomes (PLP) and heating effects across three non-focused ultrasound (US) platforms under approximately matched geometric-area-normalized intensity ( I MGA ). Three platforms were evaluated using a standardized direct-contact 96-well 4T1-cell model. Acoustic power was measured using a radiation force balance, with I MGA derived from measured power and visible transducer-face area. Cell viability was assessed by CCK-8, intracellular reactive oxygen species (ROS) generation by DCFH-DA-based imaging and flow cytometry, and the heating effect by infrared thermography supplemented with thermocouple measurements. Despite matched I MGA , platforms differed in cytotoxicity and heating. At low I MGA , US-alone cytotoxicity was limited, whereas PLP-dependent viability loss was observed for Platforms A and B. At high I MGA , Platforms A and B showed US-alone cytotoxicity and spatial heterogeneity, whereas Platform C retained PLP-dependent cytotoxicity. PLP + US enhanced intracellular ROS generation across all three platforms. Endpoint temperature was inversely associated with US-alone cell viability at high I MGA for Platforms A and B. At a fixed displayed intensity, measured time-averaged acoustic power scaled approximately with duty cycle. PLP-mediated SDT efficacy remained platform-dependent at approximately matched I MGA . Independent verification of acoustic output and temperature monitoring are essential for reproducible cross-platform interpretation of SDT studies.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-11
·
IF 16.6
Zhang Rong,Li Chuan,Cui Huilin,Wang Yanbo,Zhang Shaoce,Li Pei,Hou Yue,Guo Ying,Liang Guojin,Huang Zhaodong,Peng Chao,Zhi Chunyi
Most current research is devoted to electrochemical nitrate reduction reaction for ammonia synthesis under alkaline/neutral media while the investigation of nitrate reduction under acidic conditions is rarely reported. In this work, we demonstrate the potential of TiO 2 nanosheet with intrinsically poor hydrogen-evolution activity for selective and rapid nitrate reduction to ammonia under acidic conditions. Hybridized with iron phthalocyanine, the resulting catalyst displays remarkably improved efficiency toward ammonia formation owing to the enhanced nitrate adsorption, suppressed hydrogen evolution and lowered energy barrier for the rate-determining step. Then, an alkaline-acid hybrid Zn-nitrate battery was developed with high open-circuit voltage of 1.99 V and power density of 91.4 mW cm –2 . Further, the environmental sulfur recovery can be powered by above hybrid battery and the hydrazine-nitrate fuel cell can be developed for simultaneously hydrazine/nitrate conversion and electricity generation. This work demonstrates the attractive potential of acidic nitrate reduction for ammonia electrosynthesis and broadens the field of energy conversion.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-11
·
IF 16.6
Yan Yuandong,Wang Ruyi,Zheng Qian,Zhong Jiaying,Hao Weichang,Yan Shicheng,Zou Zhigang
A thorough comprehension of the mechanism behind organic electrooxidation is crucial for the development of efficient energy conversion technology. Here, we find that trivalent nickel is capable of oxidizing organics through a nucleophilic attack and electron transfer via a nonredox process. This nonredox trivalent nickel exhibits exceptional kinetic efficiency in oxidizing organics that possess the highest occupied molecular orbital energy levels ranging from −7.4 to −6 eV (vs. Vacuum level) and the dual local softness values of nucleophilic atoms in nucleophilic functional groups, such as hydroxyls (methanol, ethanol, benzyl alcohol), carbonyls (formamide, urea, formaldehyde, glucose, and N-acetyl glucosamine), and aminos (benzylamine), ranging from −0.65 to −0.15. The rapid electrooxidation kinetics can be attributed to the isoenergetic channels created by the nucleophilic attack and the nonredox electron transfer via the unoccupied e g orbitals of trivalent nickel (t 2g 6 e g 1 ). Our findings are valuable in identifying kinetically fast organic electrooxidation on nonredox catalysts for efficient energy conversions.
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IONICS
·
2023
·
IF 2.8
Wang Lu,Li Junru,Li Yonghua,Dong Xuelin,Shan Haoran,Chen Shiqi,Sun Peng,Zhang Fenghua,Li Wenjuan,Chu Xianxu,Li Fei,Zhou Yanli
The oxygen evolution reaction (OER) has an essential function in a multitude of renewable energy storage and conversion devices, and it is crucial to investigate efficient, stable, and cost-effective catalysts. Here, CoFeB nanosheets had been synthesized by a facile chemical reduction and in situ hydrolysis strategy. Nanosheet structure provided an abundance of active sites, which in turn facilitated mass transfer and electron transfer. Meanwhile, the formation of the highly oxidized state Co 3+δ is promoted by electron-deficient boron, which reduces the low onset potential, stimulates the activity of oxygen evolution, and enhances the kinetics of the OER. The overpotential was 390 mV and the Tafel slope was 66.35 mV dec −1 at a current density of 10 mA cm −2 in alkaline media. In addition, the electrocatalyst has exhibited long-term stability toward oxygen evolution and excellent catalytic activity. This research has further paved the way for the development of potentially novel and efficient OER electrocatalysts.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-9
·
IF 16.6
Ni Chujun,Chen Di,Wen Xin,Jin Binjie,He Yi,Xie Tao,Zhao Qian
Stimuli-responsive shape-changing hydrogels are attractive candidates for use as underwater soft robots. The bottleneck lies in the low actuation speed inherently limited by the water diffusion between hydrogels and their surrounding environment. In addition, accessing complex motions is restricted by the material fabrication methods. Here we report a hitherto unknown mechanism to achieve high-speed and programmable actuations for a disulfide crosslinked thermally responsive hydrogel. The dynamic photo-activated disulfide bond exchange allows photo-mechanical programming to introduce spatio-selective network anisotropy. This gives rise to an actuation behavior dominated by thermally driven conformation change of the locally oriented polymer chains instead of the common mass-diffusion-based mechanism. With the incorporation of photothermal fillers, light-powered oscillation at frequencies as high as 1.7 Hz is realized. This, coupled with the versatility of the programming, allows access to robots with diverse high-speed motions including continuous swimming, step-wise walking, and rotating.
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MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 9
·1-10
·
IF 5.705
Zhou Xiu-Jie,Zhang Li-Shun,Song Wen-Fang,Huang Yan-Ping,Liu Zhao-Sheng
An inorganic-organic hybrid monolith incorporated with stellated mesoporous silica nanoparticles (SMSNs) was prepared. Using binary solvents, deep eutectic solvents and room temperature ionic liquids, an SMSN-incorporated poly(butyl methacrylate- co -ethylene glycol dimethacrylate) monolith demonstrated uniform structure with good column permeability. A systematic investigation of preparation parameter was performed, including SMSN content, crosslinking monomer content, and the component of binary solvent. The optimized monoliths were characterized by field emission scanning electron microscopy, transmission electron microscopy, area scanning energy dispersive spectrometry, and nitrogen adsorption. Column performance was tested by separating four groups of analytes (alkylbenzenes, anilines, naphthalenes and phenols) by capillary electrochromatography (CEC). Baseline separation of all analytes was obtained with column efficiencies of up to 266,000 plates m −1 . The performance of the resulting monolith was further investigated in detail by separating mixtures of polycyclic aromatic hydrocarbons (PAHs), nonsteroidal antiinflammatory drugs (NSAIDs), and hydroxybenzoic acid isomers. Compared with the corresponding SMSN-free monolith, the CEC performance was improved by about six times. Successful extraction of PAHs and quinolones (QNs) were also performed using this capillary. Improved extraction efficiency (20.2%) for complex samples, lake water, was also found when the material was applied to solid phase microextraction of fluoranthene.
A poly(butyl methacrylate-co-ethylene glycol dimethacrylate) monolith incorporated with stellated mesoporous silica nanoparticles was prepared. It demonstrated column efficiency up to 266,000 plates m −1 in capillary electrochromatography and ability as solid phase microextraction for organic small molecules with good column permeability.
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-15
·
IF 17.694
Xia Neng,Jin Dongdong,Pan Chengfeng,Zhang Jiachen,Yang Zhengxin,Su Lin,Zhao Jinsheng,Wang Liu,Zhang Li
The geometric reconfigurations in three-dimensional morphable structures have a wide range of applications in flexible electronic devices and smart systems with unusual mechanical, acoustic, and thermal properties. However, achieving the highly controllable anisotropic transformation and dynamic regulation of architected materials crossing different scales remains challenging. Herein, we develop a magnetic regulation approach that provides an enabling technology to achieve the controllable transformation of morphable structures and unveil their dynamic modulation mechanism as well as potential applications. With buckling instability encoded heterogeneous magnetization profiles inside soft architected materials, spatially and temporally programmed magnetic inputs drive the formation of a variety of anisotropic morphological transformations and dynamic geometric reconfiguration. The introduction of magnetic stimulation could help to predetermine the buckling states of soft architected materials, and enable the formation of definite and controllable buckling states without prolonged magnetic stimulation input. The dynamic modulations can be exploited to build systems with switchable fluidic properties and are demonstrated to achieve capabilities of fluidic manipulation, selective particle trapping, sensitivity-enhanced biomedical analysis, and soft robotics. The work provides new insights to harness the programmable and dynamic morphological transformation of soft architected materials and promises benefits in microfluidics, programmable metamaterials, and biomedical applications.
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Journal of Coatings Technology and Research
·
2023
·
IF 2.3
Lai Yuwen,He Jin,Li Yanchun,Zhou Shilin,Yan Wentao,Zhou Yong,Gao Congjie
Metal–organic frameworks (MOFs) are widely employed in designing nanocomposite membranes owing to their excellent performance and diversity. However, their inherent hydrophobicity limits their application in nanocomposite membranes. In order to improve the hydrophilicity of zeolitic imidazolate framework-8 (ZIF-8), tannic acid (TA) was utilized to etch-modify it, resulting in a TA-ZIF-8 nanostructure with a hydrophilic shell. TA-ZIF-8 was subsequently introduced into the aqueous phase and used to prepare a nanocomposite matrix reverse osmosis membrane through interfacial polymerization (IP). The prepared nanocomposite reverse osmosis membrane had a surface with good hydrophilicity and a pure water flux increased to 55.28 L m −2 h −1 (approximately 1.74 times). Additionally, the introduction of TA-ZIF-8 significantly enhanced the electronegativity of the membrane surface, and the nanoparticles were compatible with the polyamide layer, leading to a salt rejection rate of up to 99.5% for a NaCl solution with a concentration of 32000 ppm. These results indicate great potential for applying hydrophilically modified ZIF-8 to reverse osmosis membranes.
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