JOURNAL OF NANOBIOTECHNOLOGY
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2024
·Vol. 22
·期 1
·1-21
·
IF 10.6
Zhou Hao,Wang Wei,Cai Zedong,Jia Zhou-Yan,Li Yu-Yao,He Wei,Li Chen,Zhang Bang-Le
Chemotherapy and immunotherapy have shown no significant outcome for unresectable pancreatic ductal adenocarcinoma (PDAC). Multi-drug combination therapy has become a consensus in clinical trials to explore how to arouse anti-tumor immunity and meanwhile overcome the poorly tumoricidal effect and the stroma barrier that greatly hinders drug penetration. To address this challenge, a comprehensive strategy is proposed to fully utilize both the ferroptotic vulnerability of PDAC to potently irritate anti-tumor immunity and the desmoplasia-associated focal adhesion kinase (FAK) to wholly improve the immunosuppressive microenvironment via sustained release of drugs in an injectable hydrogel for increasing drug penetration in tumor location and averting systematic toxicity. The injectable hydrogel ED-M@CS/MC is hybridized with micelles loaded with erastin that exclusively induces ferroptosis and a FAK inhibitor defactinib for inhibiting stroma formation, and achieves sustained release of the drugs for up to 12 days. With only a single intratumoral injection, the combination treatment with erastin and defactinib produces further anti-tumor performance both in xenograft and Kras G12D -engineered primary PDAC mice and synergistically promotes the infiltration of CD8 + cytotoxic T cells and the reduction of type II macrophages. The findings may provide a novel promising strategy for the clinical treatment of PDAC.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2024
·Vol. 35
·期 34
·1-13
·
IF 2.8
Xu Jialing,Jing Haofeng,Hou Xiong,Feng Hengheng,Yu Hongtao
For capacitor applications, Ba(Sm 1- x - y La x Bi y ) 2 Ti 4 O 12 dielectric ceramics with La/Bi co-substitution for Sm were prepared using the conventional solid-state method. Part of Sm 3+ was found to be replaced by La 3+ and Bi 3+ in ceramics that exhibit an orthorhombic tungsten bronze structure. As the concentration of Bi 3+ increased, a second phase of Bi 4 Ti 3 O 12 was observed. The co-substitutions could reduce the sintering temperature and effectively increase the dielectric constant from 80 to 140. The dielectric loss increased slightly with increasing La 3+ and Bi 3+ , but it still remained below 0.1% at 1 kHz. After sintering, a specific composition was achieved with x = 0.1 and y = 0.4. It has a high dielectric constant of 132, an ultra-low dielectric loss of approximately 0.06%, and excellent frequency stability. Additionally, it exhibits a capacitance-temperature change of ± 1% at 1 kHz over a temperature range of − 55 to 125 °C.
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Food and Bioprocess Technology
·
2024
·
IF 5.3
Fu Jin-Xian,Jiao Jiao,Gai Qing-Yan,He Xiao-Jia,Fu Yu-Jie,Feng Xue,Gao Jie
Baicalein and wogonin, two health-promoting flavonoid aglycones in Scutellaria baicalensis Georgi roots, have better bioactivity and bioavailability than their glycoside precursors (baicalin and wogonoside). The search for novel microorganisms for the fermentation of S. baicalensis roots to improve the yields of baicalein and wogonin is of great interest in the food and nutraceutical industries. In this study, a novel endophytic fungus ( Penicillium rubens ) capable of producing cellulase (0.82 ± 0.12 U/mL) and β-glucosidase (4.55 ± 0.97 U/mL) was used to ferment S. baicalensis roots to obtain high yields of baicalein and wogonin. Semi-solid-state fermentation with homogeneous fungal cultures was found to be the appropriate strategy. Under the optimal fermentation parameters (temperature 30 °C, inoculation dose of fungal cultures 4 mL/g, and time 60 h), the yields of baicalein and wogonin (46.95 ± 4.98 mg/g DW and 31.41 ± 9.36 mg/g DW) from S. baicalensis roots were tremendously increased by 16.13-fold and 15.47-fold over control, respectively. Results of industrial enzyme bioprocessing and scanning electron microscope indicated that the remarkable increase in aglycone product yields could be due to the synergistic effects of cellulase and β-glucosidase produced by P. rubens on cell wall hydrolysis and glycoside deglycosylation. In addition, extracts of S. baicalensis roots fermented by P. rubens showed a significant increase in antioxidant and antimicrobial activities. Overall, the semi-solid-state fermentation of S. baicalensis roots using the novel P. rubens was an effective strategy that could yield high quantities of baicalein and wogonin, which had promising potential in the food and nutraceutical industries. Graphical Abstract
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-16
·
IF 15.7
Zheng Hongyue,Zhang Ke,Piao Jigang,Mu Chaofeng,Xie Xiaowei,Cheng Mengying,Yue Tianxiang,Sun Jiang,Li Bin,Wei Yinghui,Zheng Hangsheng,Jiang Lai,Habiballah Douae Nihed,Li Fanzhu
Late-stage and advanced colorectal cancer (CRC) often prove to be resistant to current treatment regimens, due to the evolving tumor microenvironment. Chemotherapy-dominated multi-modal therapeutic strategies based on the specific CRC microenvironment open a new horizon for eradicating colorectal tumors. Here, in situ valence-transited arsenic nanosheets are developed as a multi-modal therapeutic platform by responding to the H 2 S-enriched CRC microenvironment. Carrier-free pegylated nanosheets of pentavalent arsenic (As V ), aminooxyacetic acid (AOAA), and copper ion (Cu 2+ ) are innovatively self-assembled via coordination with high loading content and good stability. As V in pegylated arsenic nanosheets (CAA-PEG NSs) is rapidly released and reduced to trivalent arsenic (As III ) to exert its chemotherapy in the local tumor. Furthermore, the immunosuppressive microenvironment is thoroughly remodeled via H 2 S depletion of As V to As III conversion and impairment of H 2 S production by AOAA. Additionally, the in situ produced ultrasmall CuS nanoparticles exhibit photothermal activity against CRC under the guidance of photoacoustic imaging. This multi-modal therapeutic strategy, dominated by chemotherapy, completely inhibits CRC progression and prevents its relapse.
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CELLULOSE
·
2024
·
IF 4.9
Zhang Qing,Dai Ziliang,Zhang Lili,Wang Zhiguo
Complex interactions between cellulose molecules and small molecules of deep eutectic solvents (DESs) can lead to dramatic changes in the structure of the hydrogen bond network in cellulose. However, the molecular and ionic evolution mechanism of DESs on cellulose nanofibrillation is still unclear. In this study, the mechanism and the critical role of ions in DESs on cellulose nanofibrillation were investigated. The results showed that cellulose nanofibers (CNFs) with a diameter of less than 200 nm could be prepared directly using DES consisting of lactic acid (LA) and chloride, e.g., LA/ammonium chloride (NH 4 Cl) or LA/dodecyltrimethylammonium chloride (DTAC). Using LA/Zinc chloride (ZnCl 2 ), CNFs with a diameter of less than 100 nm can be prepared. The Kamlet-Abboud-Taft parameters (KAT value) showed that DESs containing LA had higher hydrogen bond acidity ( α ) than other systems (such as ethylene glycol and urea) without LA, which provided more active protons to improve the proton mobility in the cellulose nanofibrillation. Also, DESs composed of LA and Cl − had high hydrogen bond alkalinity ( β ), which led to great changes in the original hydrogen bond network of cellulose and the formation of a new hydrogen bond structure, thereby easing the dissolution of the cellulose. Thus, the cellulose hydroxy groups could be esterified by the LA under high-temperature moistening conditions, and the CNFs prepared by the DES system containing LA and Cl − had the highest degree of substitution (DS) (up to 0.73 in LA/ZnCl 2 system) after high-temperature moistening.
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2024
·Vol. 42
·期 10
·1495-1504
·
IF 4.1
Wu Shi-Long,Yang Huan-Huan,Chen Quan
In this study, we synthesized a series of ABA-type vitrimers by crosslinking the short A moieties of precursors with a bifunctional crosslinker and evaporating the small molecular byproduct. The vitrimer samples thus prepared exhibit linear viscoelasticity dependent on the length of A moiety as well as the content of the crosslinks. When the average number of A monomers per end moiety m =1.1, the crosslinker can only extend the chain but not crosslink the chain. When m becomes 2.8 or higher, introducing a crosslinker first leads to the gelation, whereas excess in crosslinker molecules leads opening of the crosslinking sites and accordingly reentry into the sol regime. Surprisingly, a further increase in the length of the A moieties increases the relaxation time much weaker than the exponential increase seen for the physically crosslinked ABA-type ionomers. We attribute this difference to the distinct relaxation mechanisms: the relaxation of the vitrimer samples is based on relatively independent exchange reactions, which contrasts with the ABA-type ionomers that relax through the collective hopping of connected ionic groups from one ion aggregate to another.
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Scientific Reports
·
2025
·Vol. 15
·期 1
·1-12
·
IF 3.9
Tang Zhouzhou,Li Zhihao,Wu Guofeng,Li Jianjun,Tan Jianye,Zhu Lixin
Osteosarcoma (OS) is the most common primary malignant bone tumor. Recent evidence suggests that the novel long noncoding RNA DHRS4 antisense RNA 1 (DHRS4-AS1) serves an important role in cancer progression and metastasis. However, its function and molecular mechanism in OS remain largely unknown. In the present study, DHRS4-AS1 expression was detected in OS cells by quantitative PCR. Gain- and loss-of-function experiments were conducted to study the effects of DHRS4-AS1 on the proliferation and apoptosis of OS cells. The potential mechanism of DHRS4-AS1 was examined through bioinformatics analysis and rescue experiments. DHRS4-AS1 was downregulated in OS cell lines. DHRS4-AS1 depletion promoted proliferation and inhibited apoptosis in OS cells, whereas DHRS4-AS1 overexpression had the opposite effects. Further research suggested that DHRS4-AS1 inhibited OS progression by regulating the microRNA-362-5p/aminopeptidase puromycin sensitive axis. The present findings suggested that DHRS4-AS1 may serve as a potential therapeutic target for OS.
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AAPS PHARMSCITECH
·
2024
·Vol. 25
·期 8
·1-12
·
IF 3.4
Li Bo,Zhao Qianhui,Yang Hanyu,Wang Xueyuying,Zhang Zhijun,Gong Yanling,Wan Xu
Osteosarcoma (OS) is one of the most common primary bone sarcoma with high malignant degree and poor prognosis, for which there is an urgent need to develop novel therapeutic approaches. Recent research has revealed that mifamurtide significantly improved the outcome of OS patients when combined with adjuvant chemotherapy drugs including cisplatin (DDP). The present study aimed to construct a drug delivery system co-loading DDP and mifamurtide. Long-circulating targeted liposomes co-loading DDP and mifamurtide were constructed with Soy lecithin (SPC), cholesterol (Chol) and 1,2-distearoylglycero-3-phosphoethanolamine-n-[poly(ethyleneglycol)] (DSPE-PEG), modified with MMP14 targeting peptide BCY-B in the surface of liposomes. In addition to characterization, the cellular uptake, endocytosis pathway and inhibition on cell viability, migration, invasion and cell apoptosis of MG-63 cells were explored. The constructed liposomal delivery possessed the basic characteristics of liposomes and showed high affinity to MG-63 cells, resulting in high uptake efficiency in MG-63 cells. The endocytosis might be involved in multiple pathways including caveolae-mediated endocytosis, clathrin-mediated endocytosis and macropinocytosis, dependently on energy. The constructed long-circulating targeted liposomes co-loading DDP and mifamurtide significantly inhibited the cell viability, migration, invasion and cell apoptosis of MG-63 cells, improving the antitumor effect of DDP and mifamurtide in vitro . The constructed liposomal delivery system is suitable for co-loading DDP and mifamurtide to achieve active tumor targeting, supplying a new strategy for the treatment of OS. Graphical Abstract
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Reaction Kinetics Mechanisms and Catalysis
·
2024
·
IF 1.7
Lu Tengfei,Wang Yongjie,Zhang Yi
In this study, Methane dehydrogenation aromatization (MDA) over the 1Zn3Pt/Al 2 O 3 -6Mo/HZSM-5 physically mixed catalyst overcame the thermodynamic limitations through an efficient two-step cascade reaction at 550 °C and atmospheric pressure. Meanwhile, MDA reaction realized long-term stability during 30 h with methane conversion of 2.6% and as high as 98% selectivity of aromatics. A series of characterizations of this bifunctional physically mixed catalyst proved that the bifunctional physically mixed catalyst inhibits the coke deposition induced by over-aromatization and deep dehydrogenation, and the added Zn promoter promotes hydrogen spillover on Pt metal and inhibits further the sintering of Pt particles, contributing to the stable cascade conversion of methane to aromatics at low temperatures.
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IONICS
·
2025
·
IF 2.6
Yang Yue,Zhang Zheng,Ma Tianhui,Jia Shaoting,Huang Chao
To achieve high density and high Li-ion conductivity in the garnet LLZO (Li 7 La 3 Zr 2 O 12 ), an effective strategy is to dope it with high-valence elements to stabilize the cubic phase and to lower the sintering temperature. As well known, flash sintering (FS) is characterized by short sintering times and low furnace temperature. Herein, the doping modification of Ta-LLZO by flash sintering at 700 °C for the higher conductivity of LLZO was investigated in the present study. The results indicate that the addition of an appropriate amount of Ta 5+ can enhance the ionic conductivity. The relative density of the sintered cubic Li 6.4 La 3 Zr 1.4 Ta 0.6 O 12 is 94.72%, with a corresponding total ion conductivity of 9.8 × 10 –4 S cm −1 , demonstrating good electrical performance. A solid-state lithium metal battery with Li 6.4 La 3 Zr 1.4 Ta 0.6 O 12 electrolyte was assembled, and its electrical performance was tested at 50 °C. The results showed that an initial discharge specific capacity of 126.5 mAh g −1 at a 0.1C rate could be reached.
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Nano Research
·
2024
·
IF 9.5
Yu Cheng-Xin,Meng Yu-Feng,Yang Bo,Pang Jun,Meng Xiang-Sen,Zhao Zi-Ye,Wang Qing-Yue,Mao Li-Bo,Wu Zhi-Kun,Yu Shu-Hong
Biological structural materials, despite consisting of limited kinds of compounds, display multifunctionalities due to their complex hierarchical architectures. While some biomimetic strategies have been applied in artificial materials to enhance their mechanical stability, the simultaneous optimization of other functions along with the mechanical properties via biomimetic designs has not been thoroughly investigated. Herein, iron oxide/carbon nanotube (CNT)-based artificial nacre with both improved mechanical and electromagnetic interference (EMI) shielding performance is fabricated via the mineralization of Fe 3 O 4 onto a CNT-incorporated matrix. The micro- and nano-structures of the artificial nacre are similar to those of natural nacre, which in turn improves its mechanical properties. The alternating electromagnetic wave-reflective CNT layers and the wave-absorptive iron oxide layers can improve the multiple reflections of the waves on the surfaces of the reflection layers, which then allows sufficient interactions between the waves and the absorption layers. Consequently, compared with the reflection-dependent EMI-shielding of the non-structured material, the artificial nacre exhibits strong absorption-dependent shielding behavior even with a very low content of wave-absorptive phase. Owing to the high mechanical stability, the shielding effectiveness of the artificial nacre that deeply cut by a blade is still maintained at approximately 70%–96% depending on the incident wave frequency. The present work provides a new way for designing structural materials with concurrently enhanced mechanical and functional properties, and a path to combine structural design and intrinsic properties of specific materials via a biomimetic strategy.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-18
·
IF 10.6
Chen Yukun,Chen Yuanyuan,Wang Zhenzhi,Yang Lian,Zhang Yu,Zhang Zhanxia,Jia Lijun
Reversing the hypoxic microenvironment of tumors is an important method to enhance the synergistic effect of tumor treatment. In this work, we developed the nanoparticles called Ce6@HGMOF, which consists of a photosensitizer (Ce6), glucose oxidase (GOX), chemotherapy drugs (HCPT) and an iron-based metal-organic framework (MOF). Ce6@HGMOF can consume glucose in tumor cells through “starvation therapy”, cut off their nutrition source, and produce gluconic acid and hydrogen peroxide (H 2 O 2 ). Utilizing this feature, Ce6@HGMOF can produce oxygen through catalase-like catalytic activity, thereby reversing the hypoxic microenvironment of tumors. This strategy of changing the hypoxic environment can help to slow down the growth of tumor blood vessels and improve the drug-resistant microenvironment to some extent. Meanwhile, increasing the supply of oxygen can enhance the effect of photodynamic therapy (PDT) and enhance the oxidative stress damage caused by reactive oxygen species (ROS) in tumor cells. On the other hand, cancer cells usually produce higher levels of glutathione (GSH) to adapt to high oxidative stress and protect themselves. The Ce6@HGMOF we designed can also consume GSH and induce ferroptosis of tumor cells through Fenton reaction with H 2 O 2 , while enhancing the effect of PDT. This innovative synergistic strategy, the combination of PDT/ferroptosis /starvation therapy, can complement each other and enhance each other. It has great potential as a powerful new anti-tumor paradigm in the future.
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