COLLOID AND POLYMER SCIENCE
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2025
·
IF 2.3
Zhang Fei,Xie Mingzhu,Zhao Jing
With the rapid development of nanotechnology, nanocarriers play an important role in achieving precise drug delivery and controlled release. Among them, nanoscale metal organic frameworks (NMOFs) have shown great potential due to ultra-high specific surface area, controllable size, tunable structure and open metal sites. The aim of this study is to enhance the multifunctionality of UiO-66-NH 2 NMOFs, such as physiological stability, biocompatibility, pH responsiveness, and targeting, by post-synthetic modification with hyaluronic acid-dopamine (HA-DA) functional material. The structure, size, and morphology were characterized by IR, XRD, DLS, and SEM, and the stability, drug-loading capacity, controlled release, and biocompatibility under different conditions were evaluated. The results showed that the particle size distribution and surface properties were improved after modification. This modification not only enhanced the stability in physiological environment, but also accelerated drug release in the acidic environment and improved drug bioavailability, which was of great significance for targeting acidic microenvironments. Cytotoxicity experiments further showed that the introduction of HA-DA effectively reduced the cytotoxicity and provided more suitable environment for cell growth. This study can achieve responsive release, alleviate inflammatory response, and promote tissue repair, especially for sports injuries, which provides a new approach for developing efficient and safe drug delivery systems. Graphical abstract Based on the structural properties of NMOF, a UiO-66-NH 2 NMOF drug delivery system was constructed by the post-synthetic modification of hyaluronic acid-dopamine (HA-DA). This kind of drug delivery system exhibits excellent stability and biocompatibility, and achieves responsive release, which may alleviate inflammatory response and promote tissue repair. This study provides a new approach for developing efficient and safe drug delivery systems.
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Advanced Composites and Hybrid Materials
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2024
·Vol. 7
·期 2
·1-15
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IF 23.2
Li Hefeng,Liu Cong,Zhu Jiabao,Huan Xianhua,Qi Pengfei,Xu Ke,Geng Hongbo,Guo Xiaodong,Wu Haoming,Zu Lei,Ge Lei,Jia Xiaolong,Yang Xiaoping,Wang Hao
The application of carbon fiber–reinforced polymer (CFRP) composites in high-temperature environments was hindered by the bottleneck of poor interfacial performance between carbon fiber and epoxy resin at elevated temperatures. In this work, a sophisticated “brick-and-mortar” interphase, inspired by the structure of nacre, was produced through an industrialized roll-to-roll process. The resulting interphase comprised both inorganic and organic components, namely graphene oxide (GO) and amino-functionalized polyetherimide (APEI), respectively. At 180 ℃, the APEI-GO@carbon fiber (CF)/epoxy (EP) composite showed significant improvements in both interfacial shear strength (IFSS) and transverse fiber bundle tensile (TFBT) strength, with increases of 91.2% and 144.4%, respectively, compared to desized CF/EP composites. These enhancements were attributed to synergistic reinforcement facilitated by strengthened interaction and interphase. Furthermore, the “brick-and-mortar” interphase demonstrated a strong moisture barrier effect, enabling the composite to retain good ILSS (92.8%) after 70 days of hydrothermal aging. The proposed bio-inspired strategy for constructing “brick-and-mortar” interphase with excellent thermostability shed fresh insights into the industrialized design and fabrication of CFRP composite with outstanding high-temperature durability. Graphical Abstract
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Journal of Bionic Engineering
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2024
·
IF 4.9
Zhang Jiaxin,Liu He,Wang Jincheng,Shang Jing,Xu Mingwei,Zhu Xiujie,Xu Chao,Bai Haotian,Zhao Xin
3D-printed Porous Titanium Alloy Implants (pTi), owing to their biologically inertness and relatively smooth surface morphology, adversely affect the biological functions of surrounding cells. To address the challenges, constructing a bioinspired interface that mimics the hierarchical structure of bone tissue can enhance the cellular functions of cells. In this context, Hollow Mesoporous Silica Nanoparticles (HMSNs), renowned for their unique physicochemical properties and superior biocompatibility, offer a promising direction for this research. In this research, the initially synthesized HMSNs were used to construct a “hollow-mesoporous-macroporous” hierarchical bioinspired coating on the pTi surface through the Layer-by-Layer technique. Simultaneously, diverse morphologies of coatings were established by adjusting the deposition strategy of PDDA/HMSNs on the pTi surface (pTi-HMSN-2, pTi-HMSN-4, pTi-HMSN-6). A range of techniques were employed to investigate the physicochemical properties and regulation of cellular biological functions of the diverse HMSN coating strategies. Notably, the pTi-HMSN-4 and pTi-HMSN-6 groups exhibited the uniform coatings, leading to a substantial enhancement in surface roughness and hydrophilicity. Meantime, the coating constructed strategy of pTi-HMSN-4 possessed commendable stability. Based on the aforementioned findings, both pTi-HMSN-4 and pTi-HMSN-6 facilitated the adhesion, spreading, and pseudopodia extension of BMSCs, which led to a notable upsurge in the expression levels of vinculin protein in BMSCs. Comprehensive analysis indicates that the coating, when PDDA/HMSNs are deposited four times, possesses favorable overall performance. The research will provide a solid theoretical basis for the translation of HMSN bioinspired coatings for orthopedic implants.
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JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
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2024
·Vol. 39
·期 2
·298-308
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IF 1.3
Tan Junjun,Wu Mingchen,Li Yuzhe,Peng Jiamei,Xiong Yan
Hydroxyapatite (HA) nanoparticles impart outstanding mechanical properties to organic-inorganic nanocomposites in bone. Inspired by the composite structure of HA nanoparticles and collagen in bone, a high performance HA/gelatin nanocomposite was first developed. The nanocomposites have much better mechanical properties (elongation at break 29.9%, tensile strength 90.7 MPa, Young’s modulus 5.24 GPa) than pure gelatin films (elongation at break 9.3%, tensile strength 90.8 MPa, Young’s modulus 2.5 GPa). In addition, the composite films keep a high transmittance in visible wavelength range from 0% to 60% of the HA solid content. These differences in properties are attributed to the homogeneous distribution of HA nanoparticles in the gelatin polymer matrix and the strong interaction between the particle surfaces and the gelatin molecules. This protocol should be promising for HA-based nanocomposites with enhanced mechanical properties for biomedical applications.
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Biomass Conversion and Biorefinery
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2024
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IF 3.5
Jiang Ruiting,Yang Guang
The cost-effectiveness and renewability of biomass-derived carbon spheres have important advantages for wide application, yet efficient synthesis methods and green activation studies are still challenging. Here, hemicellulose from corncobs was extracted, and then N 2 plasma technology was used to modify the carbon spheres produced from hemicellulose in a single process. The effect of hydrothermal reaction parameters on the yield of carbon spheres was investigated, and the optimal preparation conditions were determined with solid–liquid ratio of 1:10 (g/mL), reaction time of 12 h, and pH of 1.5. The modified carbon spheres featured 3.02% nitrogen content and mesoporous structure. As an anode material for a lithium-ion battery, the modified sample has a specific capacity of 232.1 mAh g −1 after 50 cycles at 0.1 A g −1 . In this study, biomass-derived carbon spheres containing multifunctional groups were prepared under green and mild conditions, and this innovative process provides an effective basis for the sustainable utilization of biomass.
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Science China-Chemistry
·
2025
·
IF 9.7
Shi Quan,Xu Yun-Hao,Chen Ming-Hui,Zhao Peng,Deng Wen-Bo,Xiong Ji,Guo Kai,Feng Ya-Qing,Zhang Bao
Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application prospects. However, due to the unpredictable formation of the nodes, it is still challenging to design novel RE-MOFs. A novel versatile strategy was developed employing a RE-acetate complex (RE 2 (CH 3 COO) 6 ·4H 2 O) as a precursor to construct RE-MOFs. 2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H 2 DBP and tetracarboxylic porphyrin ligands H 2 TCPP, respectively. Ten RE-MOFs were further synthesized to verify the universality of the methodology. Highly crystalline RE-MOFs could also be prepared at room temperature via the developed strategy, which could significantly promote large-scale preparation and practical application of RE-MOFs. As proof of the concept, the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO 2 with epoxides. Among the RE-DBP(Co) MOFs, Tb-DBP(Co) exhibited the best photocatalytic performance, which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer process. This work not only provides a novel versatile strategy to design and develop RE-MOFs, but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.
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BMC PLANT BIOLOGY
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2024
·
IF 4.3
Minmin Chen,Xiaoqun Wang,Xiawen Zhou,Baiyu Huang,Yujie Zhao,Haiying Liu,Qiuling He
Tetrastigma hemsleyanum , a traditional Chinese medicinal plant with anti-inflammatory, anti-cancer, and anti-tumor properties, faces increasing abiotic stress due to climate change, agricultural chemicals, and industrialization. This study investigated how three abiotic stress factors influence antioxidant enzyme activity, MDA levels, DPPH free radical scavenging capacity, chlorophyll, carotenoids, active compounds, and gene expression in different T. hemsleyanum strains. The comprehensive evaluation indicates that the ZJWZ strain holds potential as a preferred parental material for future resistance breeding. Furthermore, PAL gene expression was strongly positively correlated with flavonoid and phenol contents, highlighting its role in the stress response through the phenylpropanoid-flavonoid pathway. This study contributes to the standardization of the production and breeding of superior strains of T. hemsleyanum . It also lays the foundation for investigating how plants react to environmental stressors.
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Journal of Analysis and Testing
·
2024
·Vol. 8
·期 1
·1-8
·
IF 5.5
Tu Mengling,Zhang Wei,Zhu Yunxiao,Ma Wen,Li Xiao,Zhou Shukun,Li Hongmei,Li Xianjiang
Thiacloprid is the first-generation neonicotinoid insecticide, which is widely used in modern agriculture. Reference materials are essential for sound measurement and traceability of results in chemical analysis. Pure thiacloprid was comprehensively assessed by two orthonormal methods: mass balance (MB) and quantitative nuclear magnetic resonance spectroscopy (qNMR). From MB, its mass fraction value was 998.4 mg/g with the subtraction of structurally related impurities (99.87%), inorganic impurities (0.006 mg/g), water (0.33 mg/g), and volatile organic solvent (0 mg/g). To guarantee sufficient separation of structurally related purity, peak purity of thiacloprid was evaluated by five points of UV spectra. From the qNMR of hydrogen, its mass fraction value was 995.7 mg/g which was traced to the internal standard (methyl sulfone). Finally, the certified value was assigned to 997 mg/g, together with an expanded uncertainty of 3 mg/g ( k = 2). This high-purity thiacloprid can be applied to routine monitoring in agriculture and the food fields.
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JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
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2024
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IF 2.2
Yang Wenqiang,Han Shanyu,Yin Yakun,Wang Zelong,Shi Wen,An Juan,Wang Hongdan,Xia Wentang
The production of ultralight copper powder (UCP) remains challenging due to the requisite ultralow apparent density coupled with a well-developed dendritic morphology, which greatly constrain the modulation and optimization of process parameters. In this study, we conducted a comprehensive investigation to gain deeper insights into the impact of these parameters on the performance of deposited UCPs. Our findings revealed the limitations of relying solely on conventional electrolytic parameters for tailored UCP production. To overcome this challenge, the introduction of hydrochloric acid into the electrolyte system was proposed. Upon which, remarkable improvements in UCP production were observed, including optimized dendritic morphology, enhanced current efficiency and reduced power consumption. By adjusting the amount of chloride addition, UCPs with tunable particle sizes and apparent densities were obtained. Under the benchmark factory process condition, the chloride-treated UCP exhibited an ultralow apparent density (0.47 g cm −3 ) and particle size (19.96 μm), considerably surpassing the corresponding figures for industrial copper powder (1.79 g cm −3 and 64.10 μm) and even the optimum values achieved by GGP Metalpowder AG for their UCP products (0.55 g cm −3 and < 63 μm), with 22.5% of the particles exhibiting simultaneously ultralight and ultrafine properties.
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Cell Death & Disease
·
2024
·Vol. 15
·期 7
·1-18
·
IF 8.1
Wang Sikai,Cheng Hongxia,Li Miaomiao,Gao Dongmei,Wu Haoran,Zhang Shanshan,Huang Yilan,Guo Kun
An increasing evidence supports that cell competition, a vital selection and quality control mechanism in multicellular organisms, is involved in tumorigenesis and development; however, the mechanistic contributions to the association between cell competition and tumor drug resistance remain ill-defined. In our study, based on a contructed lenvitinib-resistant hepatocellular carcinoma (HCC) cells display obvious competitive growth dominance over sensitive cells through reprogramming energy metabolism. Mechanistically, the hyperactivation of BCL2 interacting protein3 (BNIP3) -mediated mitophagy in lenvatinib-resistant HCC cells promotes glycolytic flux via shifting energy production from mitochondrial oxidative phosphorylation to glycolysis, by regulating AMP-activated protein kinase (AMPK) -enolase 2 (ENO2) signaling, which perpetually maintaining lenvatinib-resistant HCC cells’ competitive advantage over sensitive HCC cells. Of note, BNIP3 inhibition significantly sensitized the anti-tumor efficacy of lenvatinib in HCC. Our findings emphasize a vital role for BNIP3-AMPK-ENO2 signaling in maintaining the competitive outcome of lenvitinib-resistant HCC cells via regulating energy metabolism reprogramming; meanwhile, this work recognizes BNIP3 as a promising target to overcome HCC drug resistance.
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BMC Pharmacology & Toxicology
·
2024
·Vol. 25
·期 1
·1-12
·
IF 2.8
Tian Chunyan,Liu Qi,Zhang Xiaoyu,Li Zhuying
Background Calycosin, a flavonoid compound extracted from Astragalus membranaceus , has shown anti-asthma benefits in house dust mite-induced asthma. Recent studies have suggested that innate-type cells, including group 2 innate lymphoid cells (ILC2s) and macrophages, serve as incentives for type 2 immunity and targets for drug development in asthma. This work focuses on the effects of calycosin on the dysregulated ILC2s and macrophages in allergic asthma. Methods In vivo, the asthmatic mouse model was established with ovalbumin (OVA) sensitization and challenge, and calycosin was intraperitoneally administered at doses of 20 and 40 mg/kg. In vivo, mouse primary ILC2s were stimulated with interleukin (IL)-33 and mouse RAW264.7 macrophages were stimulated with IL-4 and IL-13 to establish the cell models. Cells were treated with calycosin at doses of 5 and 10 µM. Results In vivo, we observed significantly reduced numbers of eosinophils, neutrophils, monocyte macrophages and lymphocytes in the bronchoalveolar lavage fluid (BALF) of OVA-exposed mice with 40 mg/kg calycosin. Histopathological assessment showed that calycosin inhibited the airway inflammation and remodeling caused by OVA. Calycosin markedly decreased the up-regulated IL-4, IL-5, IL-13, IL-33, and suppression tumorigenicity 2 (ST2) induced by OVA in BALF and/or lung tissues of asthmatic mice. Calycosin repressed the augment of arginase 1 (ARG1), IL-10, chitinase-like 3 (YM1) and mannose receptor C-type 1 (MRC1) levels in the lung tissues of asthmatic mice. In vivo, calycosin inhibited the IL-33-induced activation as well as the increase of IL-4, IL-5, IL-13 and ST2 in ILC2s. Calycosin also repressed the increase of ARG1, IL-10, YM1 and MRC1 induced by IL-4 and IL-13 in RAW264.7 macrophages. In addition, we found that these changes were more significant in 40 mg/kg calycosin treatment than 20 mg/kg calycosin. Conclusions Collectively, this study showed that calycosin might attenuate OVA-induced airway inflammation and remodeling in asthmatic mice via preventing ILC2 activation and macrophage M2 polarization. Our study might contribute to further study of asthmatic therapy.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-12
·
IF 14.7
Wan Chuchu,He Si,Cheng Quanyong,Du Kehan,Song Yuhang,Yu Xiang,Jiang Hao,Huang Caili,Xu Jiangping,Ma Cong,Zhu Jintao
Large-amount encapsulation and subsequent expressing are common characteristics for many biomedical applications, such as cosmetic creams and medical ointments. Emulsion gels can accomplish that, but often undergo exclusive, complex, multiple synthesis steps, showing extremely laborious and non-universal. The method here is simple via precisely interfacial engineering in homogenizing a nanoparticle aqueous dispersion and a polymer oil solution, gaining interfacial 45° three-phase-contact-angle for the nanoparticle that can bridge across oil emulsions’ interfaces and ultimately form interconnected macroscopic networks. Their bridged skeletons and rheology are tunable over a vast range and deterministic on the basis of components’ inputs. Furthermore, emulsion gels with high encapsulation and storage ability encapsulating active sunscreen ingredients, as a proof-of-concept, outperform commercial products. The ease (only seconds by strongly mixing two solutions) and the versatile chemical selection of our synthetic emulsion gels suggest an exciting general, scalable strategy for the next-generation cosmetic, ointment or otherwise food gel systems.
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