Gels
·
2026
·Vol. 12
·期 4
·333
·
IF 6.4
Panpan Feng,Jianguo Lin,Yan Ran,Yingying Zhang,Jiaxin Xu,Yuxin Cheng,Yuanyuan Liu
To address inherent limitations of chitosan-based edible films, including inadequate mechanical strength and poor moisture resistance, cellulose nanofibers (CNF) were employed as a synergistic film-forming component to partially substitute chitosan in the fabrication of ternary composite films (denoted as CSTF-CNFs). This approach was based on a previously developed chitosan matrix modified with tannin-Fe 3+ nanoparticles (TF). It was hypothesized that CNF could function as a reinforcing scaffold to improve the dispersion of TF within the film matrix and, through hydrogen bonding and physical entanglement, form an interpenetrating fiber network with chitosan, thereby enhancing the structural and barrier properties of the films. The present study systematically evaluated the influence of varying CNF substitution ratios (0–30%) on the physicochemical characteristics of the resulting composite films and their performance in tomato preservation. The results demonstrated that an appropriate CNF incorporation facilitated the formation of a dense, cross-linked network with chitosan and TF via hydrogen bond interactions, significantly improving both mechanical strength and water resistance. Among all formulations, the CSTF-CNF20 film exhibited optimal comprehensive performance, achieving the highest tensile strength of 27.60 MPa. Moreover, its swelling ratio markedly decreased from 675.5% (CSTF-CNF0) to 120.9%, while the water contact angle increased to 113.7°, and the DPPH radical scavenging activity remained above 85%. Tomato preservation assays revealed that, in comparison with the untreated control and polyethylene film-wrapped groups, the application of CSTF-CNF20 coating effectively mitigated the decline in weight loss and firmness, preserved surface color integrity, and resulted in the highest L* value alongside the lowest soluble solids content. These findings suggest that the synergistic integration of CNF with nano-scale metal–phenolic networks offers a viable strategy for developing high-performance chitosan-based edible films. The CSTF-CNF20 composite film holds significant promise for application in the postharvest preservation of fruits and vegetables.
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DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
·
2026
·
IF 2.4
Jie Wang,Xiang-Ming Chang,Chen-Yang Zhang,Rui-Geng Niu,Xiao-Tong Cao,Jiang-Feng Lan
Molting is a critical physiological process for growth and development in arthropods. After molting, Procambarus clarkii (red swamp crayfish) exhibits a distinctive behavior of ingesting its exuviae. However, the functional significance of this behavior during the molting process remains unclear. Histological analysis revealed distinct intestinal remodeling during molting, characterized by the sequential detachment of the peritrophic membrane (PM) and the sloughing of the degenerating intestine (DI) into the lumen. To simulate the physiological effects of exuviae ingestion, chitosan, a key bioactive derivative of the exoskeleton, was administered via oral gavage. Transcriptomic analysis was performed to identify key events in the intestine and hemocytes following chitosan supplementation. The results showed that chitosan supplementation upregulates the expression of genes associated with immune responses and enzyme inhibitors in the intestine. Meanwhile, transcriptomic analysis of hemocytes reveals the enrichment of pathways involved in cell motility and exoskeleton hardening-related processes. This process is potentially linked to the enhanced expression of immune-related genes and shapes the microbial community during molting, thereby providing a novel foundation for investigating disease management strategies in crayfish during the molting cycle.
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iScience
·
2026
·
IF 4.5
Na Wang,Huirui Zhu,Dongkun Li,Xuena Wang,Ziyan Zhang,Bao Chai,Meining Li,Tao Gong
Hard-healing or non-healing diabetic wounds feature complex pathogenesis, posing significant challenges to clinical treatment. Platelet-rich plasma (PRP) is rich in various growth factors and possesses significant therapeutic potential, while its clinical application is largely limited by the rapid release of these bioactive factors. In this study, a multifunctional hydrogel dressing (GACP@PRP) based on PRP was fabricated for the promotion of type 2 diabetes wound healing via the physical cross-linking of graphene oxide-silver nanoparticles (GO-Ag NPs),chitosan (CS), and poly(N-isopropylacrylamide) (PNIPAM). The wound dressing possesses injectability, self-healing, favorable porosity, water absorption, moisture retention, adhesiveness, antibacterial and hemostatic functionalities. Moreover, the GACP@PRP hydrogel protects PRP to sustain growth factors release, promote cell proliferation and migration, which significantly accelerated wound healing rate in SD rats full-thickness skin defect model. Together with its great biocompatibility and biosafety, GACP@PRP meets the multiple functional requirements of diabetic wound dressing and is promising for clinical diabetic wounds management.
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JOURNAL OF THE TEXTILE INSTITUTE
·
2023
·
IF 1.7
Heng Dai,Xia Zhou,Zhiqi Gu,Haili Zhou,Yan Zhang,Ping Wang,Yuanyuan Li
Although several strain sensors based on carbon nanotubes have been reported, it is still a great challenge to fabricate strain sensors possessed with large workable strain range, high sensitivity and stability. Herein, we developed a highly elastic strain and high sensitivity sensor based on stretchable spandex yarns manufactured by an easy layer-by-layer assembly method. Effects of multi-walled carboxylic carbon nanotubes and chitosan on sensor’s properties were investigated. The prepared sensor exhibited fascinating comprehensive sensing performance, including large workable strain range (∼115%), superior sensitivity (gauge factor up to 159 at 0–40% strain and 8175 over 100% strain), In addition, it still exhibited good work stably after 3500 cycles at strain of 50%. The sensor can detect both large and small scale human motions, including joint movement, phonation, swallowing, and drinking.
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CARBOHYDRATE POLYMERS
·
2026
·
IF 12.5
Kaixuan Chen,Min Lin,Danni Zhou,Kailei Xu,Jin Mei,Chunyu Chang,Mengxiang Zhu,Chenhui Zhou
Spinal cord injury (SCI) causes severe neurological deficits and remains difficult to treat with current strategies such as surgical decompression or corticosteroids, which offer limited benefits. Hydrogels represent a promising alternative because they provide structural support and serve as therapeutic carriers. Quaternized chitosan (QCS), a derivative of chitosan, shows improved solubility and anti-inflammatory properties but lacks crosslinking ability and degrades rapidly, restricting its application in SCI. To overcome these limitations, we introduced methacrylate groups into QCS (QCS-MA), enabling photo-crosslinking, faster gelation, and enhanced mechanical stability while preserving bioactivity. QCS-MA was blended with type I collagen to form an interpenetrating hydrogel (QCS-MA/COL) through hydrogen bonding, then loaded with progranulin (PGRN), a multifunctional growth factor known to promote neuronal survival and modulate immune responses. The resulting PGRN@QCS-MA/COL hydrogel displayed favorable mechanical properties, injectability, and biocompatibility, while inducing macrophage polarization toward a reparative M2 phenotype. In a mouse SCI model, it significantly improved motor recovery, reduced lesion cavity formation, attenuated chronic inflammation, and enhanced axonal and neural regeneration. These findings highlight the potential of QCS-MA as a tunable immunomodulatory delivery platform, synergizing with PGRN and collagen to provide a biomimetic strategy for neural repair.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2019
·Vol. 136
·期 43
·48050
·
IF 2.188
Zhijian Zhang,Xin Ge,Ruiguang Xing,Bangwen Zhang
Effects of different silane coupling agents on clay surface modification were studied. Herein, functionalized superfine kaolin was compounded with starch–chitosan (SCS) to prepare starch–chitosan-functionalized superfine kaolin composite. The characterization results showed that kaolin (K) was successfully modified; the composite formed a dense intercalated structure. The glass-transition temperature ( T g ) was measured by differential scanning calorimetry and dynamic mechanical analysis. It decreased by 60 °C which attested the crystallinity of SCS. The results of thermogravimetric analysis showed that the fastest weight-loss temperature ( T max ) was elevated by over 50 °C for composites. Mechanical properties of the composites were explored by electronic universal testing machine. Tensile strength and elongation of composites were improved by 4.7 and 10.9 times. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 48050.
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CHEMICAL ENGINEERING JOURNAL
·
2012
·
IF 3.461
Kungang Chai,Hongbing Ji
Removal of benzoic acid from industrial wastewater is important for the water treatment, and adsorption is an efficient treatment process. Chitosan and β-cyclodextrin (β-CD) are well investigated as feedstock for preparing polysaccharide-based toxic compounds removing adsorbents. In this study, chitosan grafted β-CD (CGC) was synthesized using glutaraldehyde as cross-linker in acidic aqueous solution. The successful grafting of β-CD onto chitosan was confirmed by FTIR and XRD. Compared with β-CD-epichlorohydrin copolymer (CDP) and cross-linked chitosan resin (CCR), CGC showed an excellent ability to adsorb benzoic acid. The CGC adsorption kinetics toward benzoic acid at 298.15 K, and isotherms at varying temperatures were studied systematically. Kinetics of the adsorption process agreed well with the pseudo-second-order kinetic model, and the experimental data of equilibrium isotherms fitted well with Langmuir model ( R 2 > 0.99). Furthermore, thermodynamic parameters revealed the spontaneity and exothermic nature of the adsorption process. The adsorption–desorption of benzoic acid by CGC and other two commercial adsorbents were evaluated and compared in five cycles, demonstrating high regeneration efficiency of CGC. The reversibility of benzoic acid adsorption by CGC was further proved by column recycle test. Finally, the adsorption mechanism was proposed according to the inclusion behavior of β-CD toward benzoic acid as well as the electrostatic interaction between chitosan units and benzoic acid.
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CARBOHYDRATE RESEARCH
·
2026
·
IF 3.4
Wenting Shi,Rui Li,Yan Fang,Zhangqi Huang,Lin Yue,Imran Mahmood Khan,Zhouping Wang
Chitosan oligosaccharide (COS) derivatives present significant potential as antimicrobial agents. Our previously developed geraniol (Ger) grafted Chitosan oligosaccharide (COS-Ger) has demonstrated commendable solubility and antibacterial activity. To further improve its effectiveness, exploring methods for bacterial targeting could be a beneficial approach. Therefore, we herein report a novel dual-functional derivative, phenylboronic acid (PBA) and Ger co-modified COS, by strategically integrating PBA into the COS-Ger framework. The molecular structure of the derivative has been validated through several characterization techniques. Biological evaluations demonstrated that PBA incorporation synergistically enhanced the compound's bacterial targeting, resulting in markedly improved antibacterial performance. PBA incorporation synergistically enhanced the compound's bacterial targeting. Specifically, at a low concentration of 0.2 mg/mL, the inhibition rate of PBA–COS–Ger against Staphylococcus aureus ( S. aureus ) reached 73.10%, significantly outperforming that of COS-Ger (30.61%). Moreover, it achieved nearly 100% inhibition against both S. aureus and Escherichia coli ( E. coli ) at 1.0 mg/mL. These results clearly indicate that the grafting of PBA greatly enhanced the antibacterial ability of COS-Ger. The practical potential of this derivative was preliminarily verified through a preservation experiment on cherry tomatoes. This approach establishes a conceptual platform for the rational design of highly efficient, bio-based antimicrobial agents.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 3
·142
·
IF 5.4
Liu Guangmei,Liu Zeqi,Yang Yu,Hu Yanling,Liu Qingye,Zhou Jingli
Chitosan with different molecular weights (i.e., CS 200 and CS 2 ) as the ligand was employed to stabilize copper nanoclusters (CuNCs), developing a fluorescence “turn-on” probe to recognize fluoroquinolones. Chitosan chains not only can prevent the CuNCs from oxidation and overgrowth, but also provide the regulable luminescence and aggregation-induced emission (AIE) behaviors. The experimental results revealed that the CS 200 @CuNCs probe displayed better sensitivity, selectivity and anti-interference towards ciprofloxacin and several other specific fluoroquinolones than CS 2 @CuNCs. When recognizing the analytes, a more obvious AIE phenomenon occurred in CS 200 @CuNCs. The ciprofloxacin concentration for linear response was 1.0 ~ 180 µM, with a detection limit of 0.067 µM. Moreover, the CS 200 @CuNCs probe could be practically used to determine the ciprofloxacin residue from real samples with good recoveries, implying the perspective in various scenarios. These advantages are attributed to the flexile chain conformation for chitosan in CS 200 @CuNCs, which can generate the reasonable spatial-constraint. This structural feature significantly promotes the recognition and capture of target molecules. This work paves a distinctive way for designing novel biosensors by regulation of the ligand chain length, demonstrating high potential for rapid antibiotic screening.
Section
Graphical
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RSC Advances
·
2016
·Vol. 6
·期 115
·113940-113950
·
IF 3.289
Xi Wen,Chun-Tao Shao,Wei Chen,Yong Lei,Qin-Fei Ke,Ya-Ping Guo
Pb(II) ions are highly harmful to the environment and human health because of their bioaccumulation, non-degradability and toxicity. Herein, we fabricated mesoporous carbonated hydroxyapatite (HAP)/chitosan (CS) porous materials (MHCMs) by using calcium carbonate/CS porous materials (CCPMs) as precursors. After soaking in phosphate buffer solution (PBS), the CaCO3 particles in the CCPMs were converted to carbonated HAP plates with a preferred c-plane orientation via a dissolution–precipitation reaction. The MHCMs possessed interconnected macropores with pore sizes of 50–150 μm and mesopores with pore sizes of 3.97 nm, which caused them to have a great BET surface area of 111.3 m2 g−1 and a pore volume of 0.199 cm3 g−1. The sorption performance of the MHCMs for Pb(II) ions was evaluated by the flow of 400 mg L−1 lead solutions through the adsorbents, and HAP/CS porous materials (HCPMs) served as control samples. After adsorbing Pb(II) ions, the HAP particles in both the MHCMs and HCPMs were transferred into lead hydroxyapatite (PbHAP) rods. At the adsorption equilibrium, the adsorption amounts of the MHCMs and HCPMs arrived at 559.6 and 264.4 mg g−1, respectively. The MHCMs had better adsorption properties than the HCPMs because of their large surface area, hierarchically porous structures, low Ca/P ratio, good degradability and plate-like carbonated HAP with a preferred c-plane orientation. The adsorption of Pb(II) ions on MHCMs exhibited higher compliance with the pseudo-second-order kinetic model than the pseudo-first-order kinetic model, suggesting that the adsorption process was mainly controlled by chemical adsorption for Pb(II) ions. Therefore, the MHCMs have great potential for the removal of Pb(II) ions from aqueous solutions even under flow conditions.
研究领域:
环境科学
·
材料科学
·
水处理
·
吸附技术
·
无机化学
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2015
·Vol. 22
·期 13
·9668-9675
·
IF 2.828
Yin Zheng,Cao Jingjing,Li Zhen,Qiu Dong
Dithiocarbamate chitosan (DTC-CTS) was used as a new amendment for remediation of cadmium (Cd)-contaminated soils to reduce the Cd bioavailability. Arabidopsis thaliana was chosen as a model plant to evaluate its efficiency. It was found that DTC-CTS could effectively improve the growth of A. thaliana . The amount of Cd up-taken by A. thaliana could be decreased by as much as 50 % compared with that grown in untreated Cd-contaminated soil samples. The chlorophyll content and the aerial biomass of Arabidopsis also increased substantially and eventually returned to a level comparable to plants grown in non-contaminated soils, with the addition of DTC-CTS. These findings suggested that DTC-CTS amendment could be effective in immobilizing Cd and mitigating its accumulation in plants grown in Cd-contaminated soils, with potential application as an in situ remediation of Cd-polluted soils.
研究领域:
环境科学
·
土壤学
·
植物生理学
·
修复技术
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Jianmin Zou,Genna Ba,Yan Zhang,Jian He,Chong Chen,Kai Zhou,Wenhua Jin,Hejing Tang,Senyang Hu,Zihao Wang,Wei Xiong,Liyi Chen,Huichang Zhong,Dian Wang,Wei Tan,Hongsheng Du,Pengjie Wang,Baocai Xu,Yinhua Zhu
A zein-chitosan composite microcapsule was developed for rumen-protected DHA delivery. • Microcapsules exhibited high encapsulation efficiency (>90%) and strong structural stability. • In vitro digestion showed 85.76% ruminal passage and > 75% intestinal release. • Compared with algal oil, the DHA conversion rate of milk reached 21.82% after adding microcapsules. Docosahexaenoic acid (DHA) is a long-chain omega-3 polyunsaturated fatty acid with significant nutritional value. Natural DHA-enriched milk is an excellent source, but DHA is lost in the rumen, limiting its enrichment in milk. Herein, a novel zein-chitosan (CS) composite microcapsule system was developed to bypass ruminal degradation and enable controlled post-ruminal DHA release. Zein-CS microcapsules and two zein-only formulations, namely freeze-dried zein microcapsules (Zein-FD) and spray-dried zein microcapsules (Zein-SD), were physically and chemically characterized. Addition of chitosan increased particle size, surface positive charge, and polydispersity index of nanoemulsions. For dried microcapsules, chitosan increased encapsulation efficiency and decreased surface oil. Fourier transform infrared spectroscopy and X-ray diffraction confirmed strong hydrogen bonding, electrostatic, and hydrophobic interactions among zein, chitosan, and DHA. In vitro simulated rumen digestion assays revealed that zein-CS microcapsules achieved a ruminal DHA passage rate of 85.75%, markedly outperforming Zein-FD (34.07–63.70%) and Zein-SD (45.60–58.05%), because chitosan suppressed burst release and premature lipid exposure in the rumen. Total DHA release during simulated stomach and intestinal digestion reached ≥75% for zein-CS capsules. Only Zein-CS preserved alpha-diversity and community structure of rumen microbiota comparable to untreated controls; conversely, oil, Zein-FD, and Zein-SD treatments reduced microbial richness and diversity, and stimulated Lachnospiraceae . Animals fed Zein-CS produced milk containing 10.40 mg/100 mL DHA, higher than goats fed algae oil (3.57 mg/100 mL), with a DHA transfer efficiency of 21.82%. Therefore, Zein-CS microencapsulation effectively shields DHA from ruminal biohydrogenation, preserves rumen microbial homeostasis, enables targeted gastrointestinal release, and enhances milk DHA enrichment.
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