ACS Applied Electronic Materials
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2020
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IF 0
Zhi Wang,Yulan Han,Jing Liang,Haoliang Huang,Chuansheng Hu,Ping Liu,Junxiang Xiang,Zeming Qi,Yalin Lu,Kaihui Liu,Jun Jiang,Bin Xiang
Hydrogenation plays a critical role in tuning the material structural phase that fundamentally determines their electronic, optical, magnetic, and catalytic properties. However, prevailing hydrogenating techniques rely on noble-metal catalysis, high-temperature/pressure conditions, and high-energy proton implantation. Here, we report an optically controlled hydrogenation strategy of atomic-layered material α-MoCl3 via laser illumination treatment in a moist atmosphere environment. With the assistant of laser, hydrogens are generated from the reaction between water molecules and highly electronegative element chlorine, intercalate into α-MoCl3, and ultimately produce a more conductive phase with a maximum hydrogen-doping density of 0.04 wt %. Without laser, hydrogens are reversibly released and the structure restores to pristine α-MoCl3. Density-functional theory studies reveal the facile mechanism of α-MoCl3 hydrogenation including the dependence on the laser wavelength and power, the concomitant electronic phase transition, and improved material stability. Our results provide a plausible way for hydrogenating low-dimensional materials through precise control of laser treatment, which can find its multifunctional applications in hygrometer, photodetector, and photocontrollable smart devices.
研究领域:
材料科学
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纳米技术
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光电子学
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物理化学
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凝聚态物理
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DOI
Journal of Materials Chemistry B
·
2026
·
IF 5.7
Lingling Wei,Haoyu Jin,Zhongke Ji,Haoyang Tian,Jiayang Han,Yanyan Liu,Wanjia Li,Di Liu,Hui Song
Oral squamous cell carcinoma (OSCC) remains a challenging malignancy with high recurrence and metastasis rates, often limited by insufficient immunogenicity and a suppressive tumor microenvironment. Immunogenic cell death (ICD) offers a promising approach to convert cell death into antitumor immunity, yet its efficacy depends on precise modulation of autophagy and endoplasmic reticulum stress (ERS). Here, we report that combining the BET inhibitor JQ1 with the autophagy inhibitor chloroquine (CQ) synergistically amplifies ERS, leading to enhanced ICD in OSCC models. This combination promotes robust damage-associated molecular pattern (DAMP) release, dendritic cell activation, and antigen-specific CD8⁺ T-cell responses. To enable localized and efficient delivery, we engineered self-assembled JQ1/CQ nanoparticles stabilized through π–π stacking and integrated them into dissolvable cryomicroneedles. This minimally invasive platform ensures sustained drug release, improves tumor accumulation, and minimizes systemic exposure. Our study not only elucidates a druggable autophagy–ERS–ICD axis but also provides a versatile transdermal delivery strategy with potential applicability to a range of solid tumors.
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PubMed
高影响因子
MOLECULAR DIVERSITY
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2026
·
IF 3.8
Xia Hailun,Wu Jun,Fu Haoxin,Wang Peiqi,Li Ruibin,Cao Lu,Liu Ya-nan,Shi Lu,Xu Ren-ai
Escitalopram, a selective serotonin reuptake inhibitor (SSRI), treats depression and related anxiety symptoms by enhancing the physiological effects of serotonin (5-HT). This study explored the potential drug-drug interactions (DDIs) of combining escitalopram with flavonoid compounds (kaempferol and quercetin). The inhibitory effects of flavonoids on escitalopram metabolism were studied using human liver microsomes (HLM), rat liver microsomes (RLM) and Sprague–Dawley rats. The concentration of escitalopram and its metabolites were detected by ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). Our findings revealed that the half-maximal inhibitory concentration (IC 50 ) of kaempferol against escitalopram in HLM and RLM were 14.34 and 8.69 μM, respectively, and both were mixed inhibitory mechanisms, consisting of competitive and non-competitive inhibition in HLM and non-competitive and un-competitive inhibition in RLM, respectively. Moreover, the IC 50 of quercetin against escitalopram in HLM and RLM were 11.25 and 8.14 μM, respectively, and the inhibitory mechanisms were both mixed inhibitory mechanisms consisting of non-competitive and un-competitive inhibition. The in vivo results showed that quercetin significantly increased the AUC (0-t) , AUC (0-∞) and C max of escitalopram by 0.91-, 0.90- and 1.83-fold, respectively, while kaempferol and quercetin significantly reduced the CL z/F by 41.3% and 44.7%, respectively. In addition, kaempferol reduced the C max of N-desmethyl escitalopram by 62.1%. Therefore, the inhibitory effects of kaempferol and quercetin on the metabolism of escitalopram carries the risk of causing DDI and requires caution in combination.
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TRANSPORTATION RESEARCH RECORD
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2019
·
IF 0.748
Yan Xia,Jie Yang,Zhiyuan Liu,Jing Dong
This paper investigates the economic viability of plug-in hybrid electric vehicles (PHEV) in Shanghai, China based on a real-world in-use PHEV dataset. To quantify PHEV drivers’ gross profit compared with internal combustion engine vehicle (ICEV) owners, a total cost of ownership (TCO) model is adopted taking account of vehicle retail price, tax credits, subsidies, insurance, maintenance, energy prices, and resale value. The impact of the determinants for gross profit are examined in relation to vehicle distance traveled (VDT) electrically, gasoline price, electricity price, and car-buying cost. It is found that: (1) only 10% of the deployment of PHEVs (i.e., BYD Qin) is economically viable if the benefit from a free license plate is exempt; (2) the 100-kilometer gross profit of PHEVs increases linearly with the electric driving distance, while the saving of energy cost per kilometer decreases with the total VDT; (3) PHEVs’ profit could be significantly improved by reducing the car-buying cost—a decrease of 10% in car-buying cost makes 80% of the PHEV deployment feasible; and (4) if switching the daytime charges to off-peak hours, 50% of the PHEV deployment will become feasible.
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高影响因子
ELECTROCHIMICA ACTA
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2026
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IF 5.8
Wenna Zhang,Zeguang Fang,Tong Yang,Zhiwen Han,Minglei Cao,Chuankun Zhang,Jian Li,Xiaobin Liao,Yan Zhao
● Non-flammability fluorinated electrolytes boost antioxidant activity and LMBs safety. ● Fluorinated electrolytes weaken the coordination between Li + and dipole. ● Advanced solvation structures promote ideal interfacial chemistry. ● The electrolyte is compatible with both Li metal anode and high-voltage cathode. Lithium metal batteries (LMBs) operated with high-voltage Ni-rich cathodes suffer from interphase fragility, electrolyte depletion, and safety concerns, which are tightly coupled to Li⁺ solvation chemistry. Here, guided by DFT screening and molecular dynamics analysis, we develop a nonflammable all-fluorinated electrolyte by co-solubilizing fluoroethylene carbonate (FEC) and bis(2,2,2-trifluoroethyl) carbonate (TFEC) at a 1:1 vol ratio. The relevant electrocatalyst weakens Li⁺-dipole interactions, reduces the solvent coordination number, and increases PF₆⁻ participation in the first solvation shell, thereby enabling anion-involved interfacial reactions. As a result, the relevant electrocatalyst with a tailored solvation configuration contributes to highly reversible Li plating/stripping with an average Coulombic efficiency of 98.4% over 300 cycles in Li||Cu cells and stable Li||Li cycling for over 900 h at 1 mA cm⁻ 2 . More importantly, Li||NCM811 full cells exhibit markedly improved high-voltage durability, retaining 60% of the initial capacity after 300 cycles at 4.3 V and 58% after 300 cycles at 4.6 V, with discharge capacities of 170.1 and 148.4 mAh g⁻¹ at 4 and 5 C, respectively. This work establishes a solvation structure-driven design principle for safe, high-voltage LMBs. The addition of TFEC solvent effectively adjusts the solvation configuration of the electrolyte and enhances the safety of Li metal batteries, further improving their high-voltage performance. Download: Download high-res image (232KB) Download: Download full-size image
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高影响因子
Nature Communications
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2026
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IF 18.1
Xuelian Wang,Hanyu Ma,Yongqiang Li,Liangfeng Chen,Caichao Ye,Yuhao Zhao,Hang Wang,Wanting Fu,Chen Yu,Fei Wang,Siwei Yang,Yuli Kang,Guqiao Ding,Zhen Li
Integrating the diagnostic and therapeutic functions of drugs poses challenges due to specific structural design requirements. However, the trial-and-error dilemma in performance-driven structural evolution of nanomaterials is unsatisfactory. Here, we propose a strategy using graphene quantum dots with sp 2 – sp 3 hybridized carbon frameworks for visualized, intelligent targeted clearance of metabolically reprogrammed senescent cells. We establish a structure-activity relationship between the complex nanostructures and photochemical reactivity. We show that property descriptor-based machine learning promotes the evolution of carbon nanostructures, endowing them with exceptionally high photodynamic efficiency. These machine-learning results also guide the design of carbon-based photo/electrocatalytic structures. By examining the interfacial transport properties of in situ carbon nanostructures in excited states, we identify changes in fluorescence and photodynamic activity of C 3 N quantum dots within metabolically reprogrammed cellular microenvironments. This allows fluorescence detection technology for senescent cells based on C 3 N quantum dots and an intelligent targeted clearance treatment plan. Designing complex carbon frameworks for specific applications often relies on trial-and-error. Here, authors integrate machine learning and interfacial mechanisms to evolve graphene quantum dot carbon frameworks, enabling selective detection and clearance of metabolically reprogrammed senescent cells.
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PubMed
高影响因子
Nutrients
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2026
·Vol. 18
·期 12
·2021
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IF 5.8
Xiaojing Liu,Fei Pan,Yandan Wang,Wei Wei,Jun Jin,Xingguo Wang,Zhe Cui
Background/Objectives: Controlled comparisons of extracellular β-hydroxybutyrate (β-HB) responses induced by individual dietary fatty acids (FAs) remain limited. This study established a preliminary hepatocyte-derived in vitro assay for comparing FA-associated β-HB responses and used exploratory descriptor-based modeling for hypothesis-generating FA ranking. Methods: Dose- and time-dependent extracellular β-HB accumulation induced by nineteen dietary FAs was quantified in HepG2 and AML12 cells under nutrient-deprived assay conditions. For exploratory descriptor-based modeling, the 19-FA HepG2 dataset was split into 15 training compounds and four held-out compounds. Model stability was further assessed using repeated random splits, LOOCV, permutation testing, MCFA sensitivity analyses, and simple structural baseline models. Four additional structurally related FAs were tested only for preliminary experimental ranking assessment, not as an independent external test set. Results: C8:0 and C10:0 consistently induced the highest extracellular β-HB accumulation, whereas most long-chain saturated FAs and very-long-chain monounsaturated FAs showed lower responses. The single four-compound held-out subset yielded an apparent R2of 0.875, but repeated random-split assessment showed substantial split-dependent variability, and simple baseline models performed similarly to GradientBoosting. Conclusions: This study provides a preliminary in vitro dataset for comparing extracellular β-HB responses to selected dietary FAs under defined nutrient-deprived hepatocyte assay conditions. The descriptor-based analysis should be interpreted only as a small-sample, exploratory, hypothesis-generating structure–response framework.
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PubMed
高影响因子
Medicine in Novel Technology and Devices
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2026
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IF 4.5
Yuqi Li,Jiawei Wang,Dongyan Li,Min Zhang,Lizhen Wang,Yubo Fan
Poly(glycerol dodecanoate) (PGD) is a biodegradable shape-memory elastomer that can be rendered magnetically responsive by incorporating Fe 3 O 4 . However, the effects of Fe 3 O 4 loading on degradation and biosafety remain unclear, which limits the in vivo translation of PGD/Fe 3 O 4 composites. This study aimed to clarify the relationship between Fe 3 O 4 content, degradation behavior, and gastrointestinal biosafety, thereby informing the design of PGD/Fe 3 O 4 devices. Five formulations containing 0, 5, 10, 20, or 40 wt% Fe 3 O 4 were prepared and designated as ION-0, ION-5, ION-10, ION-20, and ION-40. The composites were evaluated by FTIR, SEM/EDS, lipase-mediated degradation under dynamic and static conditions, Caco-2 assays, and 70-day oral exposure in mice. FTIR confirmed Fe 3 O 4 incorporation without altering the principal polyester backbone. Under both degradation conditions, the degradation percentage and medium acidification decreased with increasing Fe 3 O 4 content. Conditioned degradation media from ION-0, ION-5, ION-10, and ION-20 preserved Caco-2 viability and proliferation and maintained ZO-1 and Occludin expression, whereas ION-40 reduced junctional marker expression despite limited overt cytotoxicity. After daily gavage for 70 days, no obvious pathological lesions were observed in the heart, liver, spleen, lung, or kidney in any group, except for the intestine, where evident ileal injury and decreased ileal ZO-1 and Occludin expression were observed in the ION-40 group, whereas the other groups remained well tolerated. Overall, increasing Fe 3 O 4 loading improved structural persistence during degradation but narrowed the biosafety window. Within the present formulation set, composites containing up to 20 wt% Fe 3 O 4 provided the most favorable balance between degradation behavior and intestinal biosafety, supporting their further development for biomedical devices.
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高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
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2026
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IF 3.2
Jing Song,Xueqi Cao,Zixuan Zhang,Jingui Li,Pengyu Zhang,Yufeng Zhao,Conghui Cao,Li Wang,Peijie Ma,Jiawen Xiao,Linlin Liu,Huanzhen Zhang,Yadi Zhai,Lihua Wang
Water vapor plays a pivotal role in both the crystallization of CsPbBr-based perovskites and the operational stability of devices incorporating these materials. However, previous studies on this topic have been limited to indirect ex situ observation. Here, we utilize in situ environmental scanning electron microscopy (ESEM) to directly monitor the dynamic growth of CsPbBr-based perovskite at a water vapor pressure of 609 Pa (equivalent to 75% relative humidity at 4 °C) under a controlled gas atmosphere. Our real-time in situ observation captures the concomitant and direct crystallization of CsPb 2 Br 5 and CsPbBr 3 , challenging the conventional phase-transition-mediated formation pathway. Furthermore, we demonstrate that the dual emission in the mixture of CsPbBr 3 and CsPb 2 Br 5 originates from distinct emissive centers, in contrast to the self-absorption and re-emission mechanism in rod-like CsPbBr 3 . These findings offer direct evidence of water-vapor-mediated crystallization and their impact on material performance, thereby paving the way for both the design of environmentally stable perovskite-based devices and future ESEM investigations into complex multiphase processes.
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高影响因子
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
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2026
·
IF 4.3
Jingjing Li,Xiaoxia Feng,Ranran Si,Yuanyuan Liu,Zhifang Huo,Huanqing Song,Chuan Zhou
Bronchopulmonary dysplasia (BPD), characterized by inflammation, is a severe pulmonary condition of preterm infants. This study aimed to investigate the role of secreted frizzled related protein 2 (SFRP2) in BPD and to elucidated its underlying mechanisms, focusing on inflammation, apoptosis, and the Nrf2/HO-1 signaling pathway. In vivo neonatal mouse models and in vitro murine lung epithelial-12 (MLE-12) models were established by hyperoxia induction. Administration of recombinant SFRP2 (rSFRP2) aggravated hyperoxia-induced lung injury, reduced alveolation, and increased inflammatory cytokines (TNF-α, IL-1β, and IL-6) in both lung tissues and cells (all P < 0.05). This demonstrated that SFRP2 aggravated hyperoxia-induced inflammation. These results were also evidenced by elevated numbers of inflammatory cells in the BALF and increasing counts of MAC-3 positive cells in the lung tissues of rSFRP2-treated BPD mice (all P < 0.05). rSFRP2 treatment promoted hyperoxia-induced apoptosis of lung tissue in mice and MLE-12 cells, reflected in increased count of TUNEL-positive cells. The Nrf2/HO-1 pathway was inhibited in the lung tissues of mice and MLE-12 cells after hyperoxia induction, and rSFRP2 therapy further suppressed its activity. Rescue experiments demonstrated that the activation of Nrf2 expression mitigated rSFRP2-induced inflammation and apoptosis in MLE-12 cells. Mechanically, SFRP2 promoted competitive binding of BACH1 to the ARE sequence of HO-1, impaired Nrf2 binding, and suppressed antioxidant signaling. We concluded that SFRP2 might exacerbate lung inflammation and apoptosis by inhibiting the Nrf2/HO-1 pathway, thus promoting the progression of BPD.
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PubMed
高影响因子
TALANTA
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2026
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IF 6.7
Ziyi Chen,Yaqian Feng,Shu Chen,Wenfu Liu,Peisheng Zhang,Rongjin Zeng,Yuanqiang Hao
This study presents a polarity-switchable photoelectrochemical (PEC) method for determining hydrogen sulfide (H 2 S) in fruit matrices by electrochemically programming BiOI into a BiOI/Bi 2 S 3 heterojunction on FTO. BiOI nanosheets were first deposited potentiostatically and then partially sulfidized in Na 2 S under a mild cathodic bias, forming a tightly coupled BiOI/Bi 2 S 3 heterostructure with an in-situ generated surface Bi 2 S 3 layer. The heterojunction broadens visible-light absorption and strengthens interfacial charge separation, leading to a cathodic-to-anodic photocurrent inversion that greatly improves signal discrimination at 0 V bias. Under optimized conditions, the device shows a linear range of 0.05–30 μM with a 5.42 nM LOD, high selectivity, and stable on/off cycling. Applied to real samples, H 2 S levels of 2.13, 1.54, and 1.32 μM were obtained for apple, pear, and kiwifruit, with 93.8%‒107.4% recoveries by standard additions. This simple, low-bias PEC platform couples in-situ structural conversion with polarity switching for rapid quality monitoring and early spoilage assessment.
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PubMed
高影响因子
BIOLOGICAL TRACE ELEMENT RESEARCH
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2026
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IF 4.3
Zhang Zhenyang,Chen Weijun,Shen Jiaqi,Dong Haowei,Zhang Chunnuan,Gao Xiaochan,Ren Hongtao,Huang Yong,Gao Shiyang
Waterborne cadmium (Cd) remains a significant threat to the intestinal health and growth of largemouth bass ( Micropterus salmoides ), necessitating the search for effective dietary mitigants. In this 56-day trial, the protective efficacy of paeonol (PAE) was evaluated across five experimental groups: a negative control, a Cd-stressed group (Cd, 2.75 mg/L waterborne exposure), and three treatment groups concurrently exposed to 2.75 mg/L Cd and supplemented with dietary PAE at 100, 200, and 400 mg/kg, respectively. The results showed that Cd exposure induced intestinal oxidative stress, impaired structural integrity, downregulated antimicrobial peptide expression, compromised immune function, and disrupted intestinal microbial homeostasis ( P < 0.05). PAE supplementation significantly decreased malondialdehyde (MDA) content, and the PAE200-Cd exhibited increased activities of total superoxide dismutase (T-SOD) and catalase (CAT), as well as elevated expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and cytochrome P450 1A1 (CYP1A1) ( P < 0.05). Intestinal villus structure was restored, the number of goblet cells increased, and the expression of tight junction proteins (Occludin, ZO-1, Claudin-1) genes was significantly upregulated ( P < 0.05). Meanwhile, the expression of β-defensin, Lysozyme, and Mucin 2 was significantly upregulated ( P < 0.05). The PAE100-Cd showed increased expression of immunoglobulins (e.g., IgM and IgT), while the PAE200-Cd inhibited the expression of pro-inflammatory factors ( P < 0.05). Cd-induced negative changes in intestinal microbial diversity and stability were restored by PAE, and the PAE200-Cd exhibited decreased abundances of Proteobacteria and Pseudomonas , and increased abundance of Firmicutes ( P < 0.05). Under the present experimental conditions, the appropriate dietary PAE level based on oxidative stress and intestinal physical barrier was preliminarily estimated to be 115.51–229.55 mg/kg. Collectively, PAE can alleviate Cd-induced intestinal injury by improving antioxidant capacity and enhancing intestinal barrier function, and represents a promising functional candidate for heavy metal mitigation. Graphical The alternative text for this image may have been generated using AI.
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