Nanoscale Research Letters
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2021
·Vol. 16
·期 1
·1-11
·
IF 4.703
Li Zihaoran,Wu Xinghan,Wang Wenyu,Gai Chengcheng,Zhang Weifen,Li Wentong,Ding Dejun
Suppression of tumor development by inducing ferroptosis may provide a potential remedy for triple-negative breast cancer, which is sensitive to intracellular oxidative imbalance. Recently, artemisinin (ART) and its derivatives have been investigated as potential anticancer agents for the treatment of highly aggressive cancers via the induction of ferroptosis by iron-mediated cleavage of the endoperoxide bridge. Owing to its poor water solubility and limited intracellular iron content, it is challenging for further application in antitumor therapy. Herein, we developed ferrous-supply nano-carrier for ART based on tannic acid (TA) and ferrous ion (Fe(II)) coated on the zeolitic imidazolate framework-8 (ZIF) with ART encapsulated (TA-Fe/ART@ZIF) via coordination-driven self-assembly. Drug release experiments showed that ART was not nearly released in pH 7.4, while 59% ART was released in pH 5.0 after 10 h, demonstrating the excellent pH-triggered release. Meanwhile, a high level of intracellular ROS and MDA, accompanied with decreasing GSH and GPX4, displayed a newly developed nano-drug system displayed markedly enhanced ferroptosis. Compared with monotherapy, in vitro and vivo tumor inhibition experiments demonstrated higher efficiency of tumor suppression of TA-Fe/ART@ZIF. This work provides a novel approach to enhance the potency of ferroptotic nano-medicine and new directions for TBNC therapy.
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BMC MICROBIOLOGY
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2021
·Vol. 21
·期 1
·1-10
·
IF 3.605
Xu Meng,Lu Feifeng,Lyu Chenang,Wu Qingping,Zhang Jumei,Tian Peng,Xue Liang,Xu Ting,Wang Dapeng
Background Human noroviruses (HuNoVs) are a major cause of nonbacterial gastroenteritis in all age groups worldwide. HuNoVs can be detected in vitro using molecular assays such as RT-PCR and RT-qPCR. However, these molecular-based techniques require special equipment, unique reagents, experienced personnel, and extended time to obtain results. Besides, the diversity of viral genotypes is high. Therefore, methods that are rapid, broad-range and effective in the detection of HuNoVs are desiderated for screening the feces or vomit of infected people during outbreaks. Results In this study, a colloidal-gold-based immunochromatographic assay (ICA) was developed for effective detection of HuNoVs in clinical samples. Monoclonal antibodies (MAbs) against the shell (S) domain in the major capsid protein of HuNoVs were used in the ICA. The limitations of detection for HuNoVs in clinical samples were 1.2 × 10 6 genomic copies per gram of stool sample (gc/g) and 4.4 × 10 5 gc/g for genogroup I and II (GI and GII) HuNoVs, respectively. A total of 122 clinical samples were tested for HuNoVs by ICA and compared against RT-qPCR. The relative sensitivity, specificity and agreement of ICA was 84.2% (95% CI: 83.6–84.8%), 100.0% (95% CI: 98.5–100.0%) and 87.7% (95% CI: 85.6–89.8%), respectively. No cross-reaction with other common enteric viruses or bacteria was observed. The ICA detected a broad range of genotypes, including GI.1, GI.3, GI.4, GI.6, GI.14, GII.2, GII.3, GII.4, GII.6, GII.13, and GII.17 HuNoVs. Conclusions This study demonstrates that ICA targeting the S domain of VP1 is a promising candidate for effectively identifying the different genotypes of HuNoVs in clinical samples with high sensitivity and specificity.
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CATALYSIS LETTERS
·
2021
·Vol. 151
·期 9
·2560-2569
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IF 3.186
Han Jishu,Wang Ying,Liu Ying,Bai Jiayu,Zhao Ruiyang,Wang Lei
In this paper, novel CdSe/NH 2 -MIL-101(Cr) nanocomposites for photocatalytic hydrogen production were synthesized. When the prepared NH 2 -MIL-101(Cr) MOFs were modified with CdSe QDs, the photocatalytic hydrogen production amount was significantly increased and reached to 17,664 μmol g −1 in 7 h. The formation of CdSe/NH 2 -MIL-101(Cr) nanocomposites enhanced the light absorption intensity, broadened the visible light absorption range, promoted the transfer of photogenerated electrons and inhibited the recombination of photogenerated electron–hole pairs, then effectively improved the photocatalytic hydrogen production performance. In addition, the CdSe/NH 2 -MIL-101(Cr) nanocomposites exhibited high cycle stability, which was beneficial to the practical application in photocatalytic hydrogen production. Graphic Abstract
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Advanced Composites and Hybrid Materials
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2020
·Vol. 3
·期 4
·473-484
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IF 0
Wang Yaqing,Xie Wenhao,Liu Hu,Gu Hongbo
Three-dimensional (3D) porous network materials with large pore volume, high specific surface area, and controllable porosity have potential application in wastewater treatment. This work aims to develop a novel hyperelastic and ultra-light magnetic reduced graphene oxide (rGO-Fe 3 O 4 ) 3D framework with a density of 4.52 mg cm −3 through a covalent bond of aminated nanomagnetite (Fe 3 O 4 -NH 2 ) onto graphene oxide (GO) and subsequent reduction. This 3D framework exhibited high adsorption capacities to ethyl acetate (215.8 ± 11.8 g g −1 ), cyclohexane (239.7 ± 9.9 g g −1 ), acetone (149.1 ± 6.5 g g −1 ), dichloromethane (308.0 ± 16.4 g g −1 ), and sesame oil (204.7 ± 10.2 g g −1 ), which were much higher than those of pure rGO aerogel (45.6 ± 2.3 g g −1 to ethyl acetate). Meanwhile, the 3D framework demonstrated superelastic mechanical properties with a 100% recoverability during the cyclic compression loading tests under an optimal fabrication condition of 1 mg mL −1 GO concentration and 3:1 mass ratio of GO to Fe 3 O 4 -NH 2 nanoparticles. Most importantly, this rGO-Fe 3 O 4 3D framework could achieve an effective oil/water separation within only 25 s and maintained an outstanding adsorption capability to ethyl acetate after 10 cycles of the adsorption/desorption process without any obvious change, depicting an excellent recyclability and reusability. This work aims to provide a promising material for environmental control and oil/organic solvent adsorption. Graphical abstract Hyperelastic and ultra-light magnetic reduced graphene oxide 3D frameworks demonstrate a superb oil and organic solvent adsorption capacity.
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JOURNAL OF NANOPARTICLE RESEARCH
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2020
·Vol. 22
·期 9
·1-14
·
IF 2.132
Li Ling,Jiang Xiangqian,Ban Chuncheng,Xie Dequan,Chen Weiping,Song Keguan,Liu Xiaowei
Thermoelectric (TE) material nanocomposite film is widely used in the design of many kinds of wearable flexible device and portable sensors. Herein, BNNT/Bi 2 Te 3 and BCNNT/Bi 2 Te 3 TE nanocomposite films were successfully fabricated by a cost-effective hot pressing and millipore membrane filter (HPMMF) method. Their thermoelectric performance was systematically investigated at room temperature, the highest power factor of the TE nanocomposite film was 1843.2 nW/mK 2 when the film contained 0.006 wt.% BCNNT. The Seebeck coefficient of the thermoelectric nanocomposite film will reach up 205 μV/K. The power factor of BCNNT/Bi 2 Te 3 TE nanocomposite film is 17.2 times higher than that of BNNT/Bi 2 Te 3 nanocomposite film and 14 times higher than that of Bi 2 Te 3 film. It is promising to be used in many situations such as flexible wearable device and solar cell thermoelectric power generation. Graphical abstract
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POLYMER JOURNAL
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2020
·Vol. 52
·期 12
·1395-1400
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IF 2.826
Wu Jianbing,Guo Wenjun,Zhang Lixiang,Wang Yongfeng,Liu Leigen,Wang Wei,Sun Yinyin,Tao Jin,Wang Xiaoqin
The present study described a new method with one step to fabricate silk fibroin nano- and microspheres, with the size of spheres and crystalline structure being controllable during processing. Polyethylene glycol, a type of synthetic polymer that is widely used in the pharmaceutical industry as a formulation excipient, was utilized to induce silk fibroin to self-assemble into nano- and microspheres. The addition of a certain amount of salt in the blending solution with subsequent titration into ethanol could improve the size dispersion, yield, and crystalline β-sheet structure (silk II) compared to those prepared without salt addition during preparation. Silk microspheres prepared in the presence of salts were less porous and more homogeneous in size than those prepared in the absence of salts.
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JOURNAL OF FLUORESCENCE
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2020
·Vol. 30
·期 6
·1463-1468
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IF 2.093
Xue Gao,Zhiying Ma,Xiuying Liu,Lijun Tang,Jianrong Li
Graphene quantum dots (GQDs), which have high photostability, anti-photobleaching and scintillation, good biocompatibility and low toxicity, are important member of the fluorescent material family, and have attracted extensive research interest. In this paper, a fluorescence resonance energy transfer (FRET) biosensor based on protoporphyrin IX (PpIX) and GQDs was developed for melamine detection. PpIX was bound to the surface of GQDs to produce self-assembled nanosensors, and a FRET process occurred between GQDs and PpIX. However, due to the combination of melamine and PpIX, the FRET process was shut down in the presence of melamine. The FRET system could quickly and accurately detect melamine with a detection range of 1.0 × 10 −8 to 2.0 × 10 −6 mol/L based on the fluorescence intensity ratio of PpIX and GQDs, and the detection limit was 3.6 × 10 −9 mol/L. This method obtained satisfactory results when it was employed to the determination of melamine in milk samples.
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Journal of Natural Medicines
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2020
·Vol. 75
·期 1
·129-141
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IF 2.055
An Meng-Fei,Wang Ming-Yue,Shen Chang,Sun Ze-Rui,Zhao Yun-Li,Wang Xuan-Jun,Sheng Jun
Abstract Isoorientin (ISO), a natural flavonoid compound, has been identified in several plants and its biological activity is determined and the study on lowering uric acid has not been reported. In view of the current status of treatment of hyperuricemia, we evaluated the hypouricemic effects of ISO in vivo and in vitro, and explored the underlying mechanisms. Yeast extract-induced hyperuricemia animal model as well as hypoxanthine and xanthine oxidase (XOD) co-induced high uric acid L-O2 cell model and enzymatic experiments in vitro were selected. The XOD activity and uric acid (UA) level were inhibited after the treatment of ISO in vitro and in vivo. Furthermore, serum creatinine (CRE) and blood urea nitrogen (BUN) levels were also significantly reduced and liver damage was recovered in pathological histology after the ISO administration in hyperuricemia animal model. The results of mechanism illustrated that protein expressions such as XOD, toll-like receptor 4 (TLR4), cathepsin B (CTSB), NLRP3, and its downstream caspase-1 as well as interleukin-18 (IL-18) were markedly downregulated by ISO intervention in vitro and in vivo. Our results suggest that ISO exerts a urate-lowering effect through inhibiting XOD activity and regulating TLR4-NLRP3 inflammasome signal pathway, thus representing a promising candidate therapeutic agent for hyperuricemia. Graphic abstract Both animal models and in vitro experiments suggested that ISO may effectively lower uric acid produce. The mechanism might be the inhibition of XOD activity and NLRP3 inflammasome of upregulation.
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JOURNAL OF MATERIALS SCIENCE
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2020
·Vol. 56
·期 6
·4254-4265
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IF 3.553
Zhang Wenqiang,Zhu Xiaotong,Liang Liang,Yin Peng,Xie Peitao,Dastan Davoud,Sun Kai,Fan Runhua,Shi Zhicheng
With the rapid development of miniaturization and high integration of electronic devices, increasing attention has been paid to the exploration of dielectric composites with further improved dielectric permittivities. Herein, a unique design of high dielectric permittivity composites consisting of three-dimensional porous W-WO 3 /BaTiO 3 foams hosted in epoxy matrix is proposed. It is demonstrated that the introduction of W-WO 3 /BaTiO 3 foams into the epoxy matrix results in substantially improved dielectric permittivities in comparison with the epoxy matrix. Meanwhile, low loss which is comparable to that of the epoxy matrix is well maintained. Interestingly, obviously enhanced dielectric permittivities and greatly depressed loss are concurrently achieved via increasing the oxidation temperature. In particular, the composite with 53.1 wt% W-WO 3 /BaTiO 3 foam oxidized at 1300 °C exhibits a high dielectric permittivity of ~ 536 and a low loss tangent of ~ 0.05@10 kHz which are about 149 and 1.5 times those of the epoxy matrix, respectively. It is believed that the strong interfacial polarization and the numerous equivalent micro-capacitors result in the significantly improved dielectric permittivities. The finite element simulation results reveal that the formation of the WO 3 shell on the surface of W can effectively weaken the leakage current density, yielding the sharply depressed loss. This work provides a new strategy to design polymer composites with simultaneous high dielectric permittivity and low loss, and the strategy could also be applicable to the exploration of other high-performance dielectric composites.
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JOURNAL OF NANOBIOTECHNOLOGY
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2020
·Vol. 18
·期 1
·1-14
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IF 6.518
Su Chenyu,Liu Shanshan,Cao Shenghan,Yin Shuyan,Zhou Chenggang,Gao Shangkun,Jia Chunyan,Ji Yingchao,Liu Yanxue
Background Trunk-boring pests (TBPs) are an important type of forest pest, TBPs not only feed on the branches and trunks of trees, but also spread quarantine diseases in forests. However, because the larvae of TBPs live inside the trunk and are well concealed, prevention and control are difficult. The lack of effective control methods leads to the death of many trees in forests. In this study, a novel nanopesticide featuring high bioactivity and slow-release properties was developed to control TBPs. Thiacloprid (THI), which is commonly used to control Coleoptera species, was used as a model pesticide.Results The oleophobic properties of bovine serum albumin (BSA) were exploited to encapsulate the hydrophobic pesticide THI by self-assembly, and the size of the obtained nanoparticles, THI@BSA·NPs, was approximately 23 nm. The loading efficiency reached 70.4%, and THI@BSA·NPs could be released continuously for over 15 days, with the cumulative release reaching 93.5%. The fluorescein isothiocyanate (FITC)-labeled nanoparticles were evenly distributed in the digestive tract and body surface of a typical TBPs, M. alternatus, and the stomach and contact toxicities increased by 33.7% and 25.9%, respectively, compared with those of free THI. Furthermore, the results showed that the transport efficiency of THI@BSA·NPs was highest at a concentration of 50 μg/mL, and the THI@BSA·NPs content in the trunk, from to lower to higher layers, was 8.8, 8.2, 7.6, and 5.8 μg/g. At the same time, THI@BSA·NPs also exhibited high transport efficiency in dead trees.Conclusion The transport efficiency and toxicity of the active ingredients are the key factors for the control of TBPs. This work provided idea for the application of biological delivery system encapsulated hydrophobic pesticides. The novel self-assembled THI@BSA·NPs have promising potential for sustainable control of TBPs.
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JOURNAL OF MATERIALS SCIENCE
·
2020
·Vol. 56
·期 7
·4782-4796
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IF 3.553
Li Lu,Yang Chao,Li Yong,Nie Yulun,Tian Xike
Abstract Sulfur quantum dots are promising alternatives for traditional heavy metal-containing quantum dots due to their benign chemical properties and low cytotoxicity. Herein, cysteine-decorated sulfur dots were prepared from facile modification of pristine sulfur dots and can be acted as a chemosensor for the fluorometric and colorimetric dual-channel detection of cobalt (Co 2+ ) with high sensitivity and selectivity. Visual colors of the as-prepared chemosensor in the presence of Co 2+ changed from blue to colorless under UV light and also can transform from colorless to yellow under sunlight based on the photoinduced electron transfer effect. The detection limit of cysteine-decorated sulfur dots toward Co 2+ was determined as low as 0.16 μM with a wide detection range, which is lower than the permitted guideline level by Department of Environmental Protection for drinking water (1.7 μM). Furthermore, portable paper sensor-based cysteine-decorated sulfur dots were fabricated for Co 2+ detection and showed superior detection ability. Aided by a common smartphone as detector, the rapid, on-site and accurate quantification of Co 2+ in real water samples can be accomplished. Our research has provided a novel chemosensor based on sulfur dots for dual-channel detection of Co 2+ , which would expand applications of sulfur dots in environmental monitoring, diseases diagnosis, cell imaging, light-emitting diodes, etc. Graphical Abstract Cysteine-decorated sulfur dots were acted as a chemosensor for fluorometric and colorimetric dual channel detection of Co2+ based on the photoinduced electron transfer effect.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2020
·Vol. 326
·期 2
·1323-1331
·
IF 1.137
Wu Hao,Kubota Masahiko,Osawa Naoki,Kim Seong-Yun
Adsorption and separation performances of a microporous silica-based (DAMIA-EH + TOA)/SiO 2 -P adsorbent towards Pd(II) were systematically investigated under the effect of contact time, temperature, concentration of nitric acid, chromatography etc. in a simulated high-level liquid waste containing 14 kinds of representative co-existing metal ions. Successful recovery of around 97.95% Pd(II) was achieved under the elution with 0.01 M Tu (pH = 2) solution in column experiment.
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