SENSORS AND ACTUATORS B-CHEMICAL
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2023
·
IF 8.4
Jingbo He,Dianwei Zhang,Huilin Liu,Baoguo Sun
In this paper, a turn-on fluorescence sensor (COF TPDD @ILMIPs) was prepared for the detection and removal of the α–dicarbonyl compound 3-deoxyglucosone (3-DG) in milk. The sensor uses ultra-high quantum yield green fluorescent covalent organic frameworks (COFs) as the fluorescence center, and introduces ionic liquids to improve its fluorescence performance and mass transfer rate, and the selectivity and anti-interference ability of the sensor were improved by molecular imprinted technique. In addition, the sensor was combined with a smartphone sensing platform to achieve real-time quantitative detection of 3-DG in the field. The quantitative detection of 3-DG in a good linear range (0.5–100 μg/L) was observed, and the low limit of detection was 0.31 μg/L. The spiked recoveries of 3-DG in milk samples ranged from 81.96–117.39 %, which provided an effective strategy for the accurate and rapid detection of hazardous substances in milk.
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ACS Applied Materials & Interfaces
·
2021
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IF 9.229
Fu Yang,Liuzhu Zhou,Xuexue Dong,Wanyu Zhang,Shuying Gao,Xuyu Wang,Lulu Li,Chao Yu,Qian Wang,Aihua Yuan,Jin Chen
Visible-light-driven environmental contaminants control using 2D photocatalytic nanomaterials with an unconfined reaction–diffusion path is advantageous for public health. Here, cost-effective siliceous composite microsheets (FeSiO-MS) combined with two distinct refined α-Fe2O3 nanospecies as photofunctional catalysts were constructed via a one-pot synthesis approach. Through precise control of Fe2+ precursor addition, specially configured α-Fe2O3 nanofibers combined with FeOx cluster-functionalized siliceous microsheets of ∼15 nm gradually evolved from the iron oxide-bearing molecular sieve, endowing a superior light-response characteristic of the formed nanocomposite. The catalytic experiment along with the ESR study demonstrated that the produced FeSiO-MS showed reinforced photo-Fenton reactivity, which was effective for rapid phenol degradation under visible light radiation. Moreover, the phenol removal process was found to be regulated by the specially configured types and concentrations of iron oxides. Notably, the obtained composites exhibited a considerable visible-light-induced bactericidal effect against E. coli. The constructed FeSiO-MS nanocomposites as integrated and eco-friendly photocatalysts exhibit enormous potentials for environmental and hygienic application.
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ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Zhenfu Wang,Yang Liu,Xiaoyan Dong,Yan Sun
Chemoenzymatic catalysis combining the traits of chemical and enzymatic catalysis provides tremendous possibilities for the design of biosynthetic pathways utilizing inorganic catalysts and enzymes. However, the efficiency of chemoenzymatic catalysis is usually governed by the synergy and compatibility of the two catalysts. Here, we report for the first time the catalase-like activity of cobalt phosphate nanocrystals (CoPs). By a one-pot biomimetic mineralization with CoPs and l-amino acid oxidase (LAAO) under a mild condition, we have fabricated a hybrid nanobiocatalyst, LAAO@CoPs, for the chemoenzymatic synthesis of α-keto acid. The as-fabricated nanobiocatalyst with directly contacted catalytic sites of the enzyme and nanozyme maximizes the substrate channeling effects for in situ chemical decomposition of the oxidative intermediate, H2O2, during the enzymatic oxidation of l-tryptophan (l-Trp), thus minimizing the H2O2 accumulation and byproduct generation. Benefiting from the superiority of LAAO@CoPs, complete conversion (100.0%) of l-Trp to indole pyruvic acid is achieved, over two times higher than the yield of the free LAAO system (47.6%). Meanwhile, LAAO@CoPs show high stabilities against heat and proteolytic treatments. This work offers a new design approach for constructing a high-performance nanobiocatalyst for cascade reactions, especially for those systems with toxic or reactive intermediates.
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ACS Applied Nano Materials
·
2020
·
IF 0
Zhihao Zhang,Zhongying Ma,Yuhua Wang
At present, most flame retardants, especially halogenated compounds, are banned because of concern for environmental and health issues. In prospect of developing more ecofriendly and effective flame retardants, an alternative solution to develop novel biobased and inorganic flame retardants is addressed. Herein, a nano flame retardant consisting of a lamellar α-zirconium phosphate (α-ZrP) nanosheet modified with chitosan (CH), phytic acid (PA), and a metal ion (Cu2+) with a core–multishell structure is fabricated in water solution via a green and facile self-assembly method and applied to enhance the fire retardant effect of poly(vinyl alcohol) (PVA). Thermogravimetric analysis (TGA) demonstrated that after the addition of α-ZrP@CH@PA@Cu, PVA composites maintained their well-performed ability of char formation. The limit oxygen index (LOI) of pure PVA increased from 18.4 to 29.8% for PVA/α-ZrP@CH@PA@Cu and it reached UL-94 V-1 grade. In the microscale combustion calorimeter test (MCC), the peak heat release rate (pHRR) and the total heat release (THR) of PVA/α-ZrP@CH@PA@Cu sharply decreased by 82.3 and 62.2% compared with pristine PVA. The results implied that α-ZrP@CH@PA@Cu could endow PVA with superior fire retardant properties. Moreover, the research manifested the synergy between α-ZrP and CH@PA@Cu and a double barrier flame retardant mechanism in a condensed phase. In the α-ZrP@CH@PA@Cu flame retardant system, the inorganic α-ZrP nanosheet acted as an insulating core, and the CH@PA@Cu constituted an intumescent shell, where the outer CH@PA@Cu intumescent shell formed an expanded char layer serving as the first barrier to hinder heat and oxygen transfer, and then the inner α-ZrP core layer, as the second barrier, would prevent the further exchange of flammable gases and energy between the polymer and fire during combustion. As a result, this ecofriendly nano flame retardant with the core–multishell structure has a potential application value.
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JOURNAL OF CATALYSIS
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2020
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IF 7.888
Minchen Du,Yanyan Gong,Chao Bu,Jia Hu,Yongxing Zhang,Cheng Chen,Somboon Chaemchuen,Ye Yuan,Francis Verpoort
Oxazolidinones and α-hydroxyl ketones are two series of fine chemicals that have been generally utilized in biological, pharmaceutical, and synthetic chemistry. Herein, a AgNO 3 /ionic liquid (IL) catalytic system was developed for the simultaneous synthesis of these compounds through the atom-economical three-component reactions of propargyl alcohols, 2-aminoethanols, and CO 2 . Notably, this system behaved excellent catalytic activity with the lowermost metal loading of 0.25 mol%. Meanwhile, it is the first reported metal-catalyzed system that could efficiently work under atmospheric CO 2 pressure and be recycled at least five times. Evaluation of the green metrics proved the AgNO 3 /IL-catalyzed processes to be relatively more sustainable and greener than the other Ag-catalyzed examples. Further mechanistic investigations revealed the derivative active species of N-heterocyclic carbene (NHC) silver complexes and CO 2 adducts generated during the process. Subsequently, their reactivity in this reaction was assessed for the first time, which was finally identified as beneficial for the catalytic activity.
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MICROCHIMICA ACTA
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2020
·Vol. 187
·期 12
·1-10
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IF 6.232
Zhong Yingying,Li Qing-lan,Lu Minglei,Wang Tiantian,Yang Huiyi,He Qiyi,Cui Xiping,Li Xiangguang,Zhao Suqing
A highly sensitive colorimetric sensing strategy based on enzyme@metal-organic framework (GAA@Cu-MOF) and IrO 2 /MnO 2 nanocomposite was exploited innovatively for screening of α-glucosidase (GAA) inhibitors. IrO 2 /MnO 2 nanocomposite exhibits excellent oxidase-mimicking activity which can directly catalyze the oxidation of 3,3 , 5,5 , -tetramethylbenzidine (TMB) into a blue product with an absorption maximum at 652 nm. And GAA@Cu-MOF can decompose L-ascorbic acid-2-O-α-D-glucopyranosyl (AAG) to ascorbic acid (AA). The produced AA can destroy the IrO 2 /MnO 2 nanocomposite and reduce its oxidase-like activity. However, the generation of AA is restricted when GAA inhibitors are added to the system, which allows the oxidase-like activity of the IrO 2 /MnO 2 nanocomposite to be maintained. In view of this, a method for screening of GAA inhibitors was developed. In addition to enhancing the stability of GAA, the method can also effectively avoid the potential interference of H 2 O 2 in the screening process of GAA inhibitors, which helps to improve the sensitivity of the method. Therefore, highly sensitive determination for acarbose and ascorbic acid are achieved with detection limits of 6.27 nM and 1.23 μM, respectively. The proposed method was successfully applied to screen potential GAA inhibitors from oleanolic acid derivatives.
Graphical abstract
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BIOORGANIC CHEMISTRY
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2020
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IF 4.831
Mengting Wang,Jianchu Chen,Xingqian Ye,Donghong Liu
Chinese bayberry leaves proanthocyanidins (BLPs) belongs to the prodelphinidin category with potent EGCG unit, whose inhibition effect on α-amylase and their interaction were investigated by in vitro digestion and enzyme kinetic analysis, multi fluorescence spectroscopies (fluorescence quenching, synchronous fluorescence, and three-dimensional fluorescence), circular dichroism spectra, Fourier transform infrared spectroscopy and in silico modelling. The results revealed that BLPs was a mixed inhibitor to α-amylase with the IC 50 value of 3.075 ± 0.073 μg/mL. BLPs could lead to a static fluorescence quenching of α-amylase, mainly by means of interacting with amino acids (mainly Try and Tyr residues) in one site on α-amylase molecule under the action of hydrogen bonding and/or Van der Waals force. This interaction further induced the change of secondary conformational structure, functional group structure and hydrophobicity of α-amylase, thus resulting in lowering activity. Molecular docking simulated that this binding occurred in a cavity on the surface of the α-amylase molecule, and BLPs trimer showed a relatively high binding energy. The present study provided a new insight of BLPs as an α-amylase inhibitor, which could be considered in anti-diabetic therapy.
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ACS Sustainable Chemistry & Engineering
·
2020
·
IF 7.632
Di Li,Yanyan Gong,Minchen Du,Chao Bu,Cheng Chen,Somboon Chaemcheun,Jia Hu,Yongxing Zhang,Ye Yuan,Francis Verpoort
α-Hydroxy ketones are a series of biologically active fragments in nature as well as important synthons for organic chemistry. Herein, an AgOAc/1-ethyl-3-methylimidazolium acetate ionic liquid system was developed for the CO2-promoted hydration of propargylic alcohols and H2O to produce α-hydroxy ketones. Diverse desired products could be obtained in satisfactory yields under 1 bar of CO2 pressure with the catalysis of only a trace amount of silver (0.005–0.25 mol %), which is the lowest level ever reported for the metal-catalyzed systems. In particular, this system had robust recyclability, and it could be reused effectively at least 5 times. Furthermore, an unprecedented turnover number (TON) of 9200 was achieved, which is considered to be the highest TON ever reached for this hydration.
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FOOD CHEMISTRY
·
2021
·
IF 7.514
Limin Wang,Yunsen Zhang,I. Agbaka Johnpaul,Kai Hong,Yumei Song,Xiao Yang,Chenyan Lv,Changwei Ma
Hops are abundant in natural bioactive compounds. In this work, nine prenylated bitter compounds from hop were evaluated for their inhibitory activity against α-glucosidase. As a result, four flavonoids and one phloroglucinol (lupulone, LP) outperformed acarbose in inhibiting α-glucosidase. Isoxanthohumol (IX) and LP with two types of structures were selected for inhibition mechanism studies by spectroscopic methods and molecular dynamics simulation (MD). Results showed that IX acted as noncompetitive inhibitor and bound to α-glucosidase in allosteric sites via hydrogen bonds, hydrophobic, van der Waals (vdW), and electrostatic force, whereas LP was uncompetitive inhibitor and bound to catalytic sites via hydrophobic and vdW interactions. Notably, the conformation around binding site of α-glucosidase formed stable α-helix and tightened after binding IX and LP, respectively, which helped to elucidate noncompetitive and uncompetitive inhibitory mechanisms. This work demonstrated that two types of prenylated bitter compounds are discrepant in their mechanisms of interaction with α-glucosidase.
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DRUG DELIVERY
·
2021
·
IF 6.419
Jianbo Li,Tiange Feng,Weijing Yang,Yaru Xu,Shuaishuai Wang,Huijie Cai,Zhilei Liu,Hong Qiang,Jinjie Zhang
Although Fraxinellone (Frax) isolated from Dictamnus albus L. possessed excellent anti-hepatic fibrosis activity, oral administration of Frax suffered from the inefficient therapeutic outcome in vivo due to negligible oral absorption. At present, the oral formulation of Frax is rarely exploited. For rational formulation design, we evaluated preabsorption risks of Frax and found that Frax was rather stable while poorly dissolved in the gastrointestinal tract (78.88 μg/mL), which predominantly limited its oral absorption. Further solubility test revealed the outstanding capacity of cyclodextrin derivatives (CDs) to solubilize Frax (6.8–12.8 mg/mL). This led us to study the inclusion complexes of Frax with a series of CDs and holistically explore their drug delivery performance. Characterization techniques involving 1H-NMR, FT-IR, DSC, PXRD, and molecular docking confirmed the most stable binding interactions when Frax complexed with 6-O-α-D-maltosyl-β-cyclodextrin (G2-β-CD-Frax). Notably, G2-β-CD-Frax exhibited the highest solubilizing capacity, fast dissolution rate, and superior Caco-2 cell internalization with no obvious toxicity. Pharmacokinetic studies demonstrated markedly higher oral bioavailability of G2-β-CD-Frax (5.8-fold that of free drug) than other Frax-CDs. Further, long-term administration of G2-β-CD-Frax (5 mg/kg) efficiently inhibited CCl4-induced hepatic fibrosis in the mouse without inducing any toxicity. Our results will inspire the continued advancement of optimal oral Frax formulations for anti-fibrotic therapy.
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TALANTA
·
2019
·
IF 4.916
Yongmei Wang,Zongshan Zhao,Jianyuan Qin,Huan Liu,Aifeng Liu,Mengmeng Xu
A simple, green and nondestructive method based on terahertz fingerprint peaks has been developed for rapid in situ analysis of l -histidine and α-lactose in dietary supplements. Fingerprint absorption peaks of l -histidine and α-lactose located at 0.77 and 0.53 THz could be directly used for identification and quantitation of these analytes in commercial dietary supplements. Compared with the partial least squares regression model (PLSR), the linear least squares regression (LLSR) method based on peak areas presented better performance, with the linear correlation coefficients of 0.9899 and 0.9910 for l -histidine and α-lactose, respectively. Furthermore, analysis time per sample can be shortened to less than 1 min due to the narrower spectral acquisition region. The accuracies were 94.8–110% and 98.9–110%, comparable to those of ion chromatography for l -histidine and high-performance liquid chromatography for α-lactose. The results presented great potential of the developed method for rapid in situ analysis of nutrients in dietary supplements.
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JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2019
·
IF 2.983
Runjing Zhang,Tao Huang,Qiuyu Zhang,Yufeng Yao,Changhui Liu,Chaozhan Lin,Chenchen Zhu
Intrahepatic cholestasis is a clinical syndrome of liver damage with systemic circulation and intrahepatic accumulation of excessive toxic bile acids without effective therapeutic methods so far. Xiaoyan Lidan Formula (XYLDF), a traditional Chinese prescription, has long been clinically applied for hepatobiliary disorders due to cholestasis. But its mechanism remains unknown. In this study, a non-targeted metabolomics approach based on UHPLC-Q-TOF-MS/MS combined with a bile acids (BAs) - targeted metabolomics approach based on UHPLC-MS/MS were performed to elucidate the functional mechanisms of XYLDF on α-naphthylisothiocyanate(ANIT)-induced intrahepatic cholestasis rats. The results showed that a total of 39 endogenous metabolites with significant difference (VIP > 1.00, P < 0.05) were identified as biomarkers of ANIT-induced intrahepatic cholestasis in rats. After treatment by XYLDF, 22 biomarkers were reversed to the control-like levels, which involved in primary BA biosynthesis, bile acid metabolism and excretion, steroids metabolism, retinol metabolism, starch and sucrose metabolism, inter conversions between pentose and glucoronate as well as arachidonic acid metabolism. Meanwhile, the results of contents variation of BAs in liver and serum showed that both hydrophilic and hydrophobic BAs were markedly increased in the model rats, while XYLDF treatment could restore the increase induced by ANIT, which suggested that one of the mechanisms of XYLDF on cholestasis referred to regulation of metabolic homeostasis of cholic acid.
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