ADVANCED FUNCTIONAL MATERIALS
·
2020
·Vol. 30
·期 45
·2004692
·
IF 16.836
Sheng Zhao,Yixuan Li,Quanyi Liu,Sirong Li,Yuan Cheng,Chaoqun Cheng,Ziying Sun,Yan Du,Christopher J. Butch,Hui Wei
Safe, effective, and convenient administration of therapeutic nanomaterials is one of the greatest difficulties in nanomedicine. To tackle this challenge, a system which couples multi-enzyme mimicking CeO 2 nanoparticles with clinically approved montmorillonite (MMT) for inflammatory bowel disease (IBD) therapy is reported. CeO 2 exhibits superoxide dismutase- and catalase-like activities, and hydroxyl radical scavenging activity, making it more efficient at scavenging reactive oxygen species (ROS) than non-catalytic antioxidants while being more stable than free enzymes. In addition, negatively-charged MMT can be orally administered and specifically adsorbed onto positively-charged inflamed colon tissue via electrostatic interactions for targeted delivery. When the two are assembled together by in situ growth of CeO 2 onto MMT, the optimized CeO 2 @MMT(1:9) is stable in the stomach for oral delivery, targets the inflamed colon through electrostatic interactions, and reduces inflammation through ROS scavenging, all without any significant systemic exposure as demonstrated by the relief of murine IBD in vivo.
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Zheng Lian,Youcai Lu,Shiyu Ma,Liqin Wang,Zhongjun Li,Qingchao Liu
In Li-CO 2 battery, redox mediators (RMs) are considered to have bright prospects due to their advantages of optimizing the mediated reaction pathway and reducing over-potential. However, some inherent defects caused by RMs, such as induced Li anode degradation and electron shuttle, limit its application in Li-CO 2 battery. In this work, ruthenium acetylacetonate (Ru(acac) 3 ) was innovatively applied as an efficient RM to boost the performance of Li-CO 2 battery, and the “shuttle effect” of Ru(acac) 3 to Li anode was also confirmed. To avoid the anode degradation caused by “shuttle effect” of RM, a novel Zn-MOF nanoplate modified glass fiber (M-GF) separator is skillfully prepared and used as a dual-function separator for Li-CO 2 battery. Experiments coupled with density functional theory simulations verifies that M-GF can protect Li anode by preventing Ru(acac) 3 from entering Li anode by physical and chemical interactions. Moreover, the highly ordered micropores in Zn-MOF also induce uniform deposition of Li + on the Li anode to delay the degradation process of anode, and thus prolonged the cycle life of the battery. Thanks to the bidirectional support of Ru(acac) 3 and M-GF strategy, the electrochemical performances of the Li-CO 2 battery, especially the round-trip efficiency and cycle life, has been greatly improved.
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BIOMATERIALS
·
2024
·
IF 12.8
Yucheng Ji,Yuwei Hu,Yubo Feng,Lei Liu,Zhanyi Chen,Hongxing Shen,Yingchao Han,He Xu,Lifeng Lao
Currently, mitochondrial dysfunction caused by oxidative stress is a growing concern in degenerative diseases, notably intervertebral disc degeneration (IVDD). Dysregulation of the balance of mitochondrial quality control (MQC) has been considered the key contributor, while it’s still challenging to effectively harmonize different MQC components in a simple and biologically safe way. Hydrogen gas (H 2 ) is a promising mitochondrial therapeutic molecule due to its bio-reductivity and diffusibility across cellular membranes, yet its relationship with MQC regulation remains unknown. Herein, we propose a mitochondrial ‘Birth-Death’ coordinator achieved by an intelligent hydrogen nanogenerator (Fe@HP-OD), which can sustainably release H 2 in response to the unique microenvironment in degenerated IVDs. Both in vitro and in vivo results prove alleviation of cellular oxidative stress and restoration of nucleus pulposus cells function, thereby facilitating successful IVD regeneration. Significantly, this study for the first time proposes the mitochondrial ‘Birth-Death’ coordination mechanism: 1) attenuation of overactivated mitochondrial ‘Death’ process (UPR mt and unselective mitophagy); and 2) activation of Adenosine 5‘-monophosphate-activated protein kinase (AMPK) signaling pathway for mitochondrial ‘Birth-Death’ balance (mitochondrial biogenesis and controlled mitophagy). These pioneering findings can fill in the gaps in molecular mechanisms for H 2 regulation on MQC homeostasis, and pave the way for future strategies towards restoring equilibrium of MQC system against degenerative diseases.
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高影响因子
Materials
·
2024
·Vol. 17
·期 22
·5628
·
IF 3.1
Xiaomin Zhang,Xiangrui Gao,Yue Yuan,Guangqin Yang,Yanchen Li
Fly ash (FA) is the main solid waste emitted from coal-fired power plants. Due to its high yield, low utilization rate, and occupation of a large amount of land, it exerts enormous pressure on the Earth’s environment. With the deepening of the concept of sustainable development, exploring the reuse of industrial waste such as FA has become a key strategy. If FA can be combined with commonly used jewelry in people’s lives, it will be of great significance to promote the high-net-worth utilization of FA. Therefore, this study synthesized a fly-ash-based composite material with color-changing function and combined it with necklaces as the main material. In the first stage, after blending fly ash and slag, an alkaline activator with a total mass of 10% was added. When the proportion of fly ash was 60%, the compressive strength of the prepared fly-ash-based composite material reached 10.1 MPa. This was attributed to the reaction between sodium silicate in the alkaline activator and free CaO, MgO, and other substances in the fly ash to form hydrated silicate colloids, which solidify the fly ash and transform it into a complex three-dimensional network skeleton. In the second stage, a UV resistant coating with thermochromic function was obtained by blending acrylic resin, TiO2, and a thermosensitive color-changing agent. It was applied to the surface of fly-ash-based composite materials, and the results showed that as the content of the color-changing agent increased, the number of pores on the surface of the coating gradually decreased. When the content of color-changing agent was 10%, the prepared 10%FAB not only had good surface color but also had good thermal stability, UV absorption ability, superhydrophobicity, and mechanical properties. Therefore, 10%FAB was selected as the basic material for jewelry design. In the third stage, the traditional Chinese technique of “gold inlaid with jade” was utilized to develop jewelry applications for the FA composites. As such, 10%FAB was processed into necklaces, which not only had modern design aesthetics but also had good color-changing effects above 30 °C. And after a long period of UV aging experiments, the necklace did not show any wrinkles, bubbles, or other phenomena. Due to the excitation of TiO2hole–electron pairs, the necklace’s UV absorption ability was further improved. This study demonstrates the potential application of industrial waste in decorative products, expands the high-end utilization of fly ash as a low-cost material, and provides new ideas for building a low-carbon lifestyle.
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Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Dong Dong,Shujun Zhang,Weiwei Huo,Ming Zhao,Jun Li,Guohua Dong,Yingnan Zhao,Min Zhu,Zhichun Shi
Antibiotic contamination remains a challenge for wastewater treatment . In this work, a hyper-cross-linked polymer (DHCP-TP 3 ) with a dual nitrogen-rich structure was synthesized by a one-step facile Friedel-Crafts reaction, and a Fe 3 O 4 @DHCP-TP 3 composite was prepared by postmodification with the introduction of magnetic iron oxide nanoparticles (Fe 3 O 4 NPs), which were applied to the adsorption of tetracycline (TC) from aqueous solution. The TC adsorption capacities of the DHCP-TP 3 and Fe 3 O 4 @DHCP-TP 3 composites reached 519.65 and 893.85 mg·g −1 , respectively, and the adsorption processes for both followed the pseudo-second-order kinetic model and the Freundlich isothermal model. Fe 3 O 4 @DHCP-TP 3 can achieve adsorption equilibrium for TC within 200 min, and also exhibits excellent regeneration and magnetic separation capabilities. Complexation, hydrogen bonding, cation exchange and π-π interactions were the main adsorption mechanisms. Moreover, Fe 3 O 4 @DHCP-TP 3 could also adsorb other pollutants, including sulfadiazine (SD), sulfamethoxazole (SMZ), methyl orange (MO), methylene blue (MB), 2,4-dichlorophenol (2,4-DCP), and iodine (I 2 ). The brief synthesis, high adsorption capacity and easy regeneration certified that HCPs were ideal adsorbents for removing pollutants from wastewater.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Wei-Hua Wang,Chu-Ran Li,Xu-Jie Qin,Xiao-Qin Yang,Si-Da Xie,Qian Jiang,Li-Hua Zou,Ying-Jun Zhang,Guo-Lei Zhu,Ping Zhao
Eleven alkaloids (1–11) including seven new ones, 1–7, were isolated from the solid fermentation of Aspergillus fumigatus VDL36, an endophytic fungus isolated from the leaves of Vaccinium dunalianum Wight (Ericaceae), a perennial evergreen shrub distributed across the Southwest regions of China, Myanmar, and Vietnam. Their structures were elucidated on the basis of extensive spectroscopic methods. The isolates were evaluated for in vitro antifungal activities against five phytopathogenic fungi (Fusarium oxysporum, Coriolus versicolor, Fusarium solani, Botrytis cinerea, Fusarium graminearum). As a result, the new compounds fumigaclavine I (1), 13-ethoxycyclotryprostatin A (5), 13-dehydroxycyclotryprostatin A (6), and 12β-hydroxy-13-oxofumitremorgin C (7) exhibited antifungal activities with MIC values of 7.8–62.5 μg/mL which were comparable to the two positive controls ketoconazole (MIC = 7.8–31.25 μg/mL) and carbendazim (MIC = 1.95–7.8 μg/mL). Furthermore, compounds 1 and 5 demonstrated potent protective and curative effects against the tomato gray mold in vivo. Preliminary structure–activity relationships of the tested indole diketopiperazine alkaloids indicate that the introduction of a substituent group at position C-13 enhances their biological activities.
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JOURNAL OF POLYMER SCIENCE
·
2025
·
IF 3.6
Xin Liu,Xiaojun Wang,Rongrong Chen,Qi Liu,Dalei Song,Gaohui Sun,Jing Yu,Jingyuan Liu,Jiahui Zhu,Shifeng Guo,Jun Wang
Biological fouling will cause severe damage to the functionality of marine underwater facilities, shorten their service life, impede their normal operation, and trigger a biological invasion event. The traditional marine antifouling coatings release heavy metal elements, which cause harm to the marine environment. To overcome this issue, a self-polishing antifouling resin based on vanillin methacrylate (VMA) was prepared via the free radical polymerization method. In seawater, the VMA-based coatings achieve self-polishing through the hydrolysis of the phenolic ester group. The hydrolysis mechanism of VMA was calculated using density functional theory by Cp2k software, and the results show that VMA achieves one-step hydrolysis by the S N 2 mechanism. It exhibited antibacterial and environmentally friendly antifouling properties by releasing vanillin, which is a natural antifouling active substance. The antibacterial, diatom adhesion inhibition, and the 9-month marine field test demonstrated the excellent antifouling performance of VMA-based coatings. It provides a novel concept for environmentally friendly self-polishing coatings and has a promising application prospect. Graphical
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NANOTECHNOLOGY
·
2024
·Vol. 35
·期 12
·125601
·
IF 2.9
Xia Pu,Wanling Cai,Huayao Chen,Fujie Yang,Xiaomei Mu
The key step in preparing mesoporous silica is to remove the organic template agent, and the most common method used to achieve this goal is high-temperature calcination. However, this method has many disadvantages, one of which is that it reduces the silanol density on the surface of mesoporous silica, which affects its subsequent modification. Ionic liquids (ILs) are often used as extractants. In this work, the 1-butyl-3-methylimidazolium chloride ([C4mim]Cl) IL is considered, and the effects of its concentration, reaction temperature, and reaction time as well as HCl concentration on the extraction rate and silanol density were investigated using an IL extraction template agent (cetyl trimethyl ammonium bromide (CTAB)). The results show that an IL concentration of 10%, a reaction temperature of 120 °C, a reaction time of 12 h, and an HCl concentration of 1% are the best reaction parameters; with these parameters, the extraction rate and the silanol density were found to be 93.19% and 2.23%, respectively. The silanol density of mesoporous silica treated by calcination is only 0.81%. A higher silanol density provides more reaction sites, so that the modified mesoporous silica treated with the IL can be loaded with more Zn ions.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2024
·
IF 8.1
Hua Ma,Xiuwen Wu,Xiuli Fu,Zhijian Peng
Developing stable, highly active, and economical non-precious metal catalysts for the oxygen evolution reaction (OER) has been highly demanded in the new energy field since it can meet the industrial demands of large-scale electrocatalytic water splitting . A novel FeP/Ni 2 P/Fe 0.64 Ni 0.36 /C (FeNiP–FeNi–C) nanofiber was prepared by electrospinning and high-temperature phosphating. Notably, the good dispersion of FeP, Ni 2 P, and FeNi alloy nanoparticles in the nanocarbon fiber greatly increased the number of electroactive sites, and the synergistic effect between the FeP/Ni 2 P heterogeneous interface and FeNi alloy significantly improved the inherent activity of each site. Moreover, the carbon nanofibers enhanced the long-term durability of the catalyst by preventing the corrosion of the FeP, Ni 2 P, and FeNi alloy particles. Therefore, the optimal FeNiP–FeNi–C catalyst revealed exceptionally high OER activity, with overpotentials of 364 mV and 236 mV at 50 mA cm −2 and 10 mA cm −2 respectively, and the slope of Tafel of 61.00 mV·dec −1 . This catalyst performs significantly better than commercial RuO 2 catalysts in alkaline electrolytes . The results of this study offer a novel perspective for the mass production of non-precious metal OER high-efficiency electrocatalysts .
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Advanced Materials Interfaces
·
2024
·Vol. 11
·期 24
·2400234
·
IF 4.3
Xue Shang,Panpan Chen,Wei Ling,Tian Hang
A novel synthesis strategy for hierarchical polypyrrole nanopillar/silver nanoparticle arrays is designed and its application as an antibacterial surface and nonenzymatic H 2 O 2 sensor is explored. The hierarchical structure is fabricated using a microporous membrane-templated method by multiple steps. Using a polypyrrole nanopillar array as the matrix, silver nanoparticles can be uniformly reduced and stably anchored onto the nanopillar array by a redox reaction in a AgNO 3 solution. The morphology, structural characteristics, conductivity, and reaction mechanisms of the composites are studied in detail. The incorporation of Ag nanoparticles not only significantly enhanced the antibacterial activity of the surface, but also contributed to the excellent ability to detect H 2 O 2 . This work provides a versatile approach to achieve the controlled fabrication of hierarchical metal-conducting polymer composite structures and demonstrates them as promising multifunctional interfaces with antibacterial and sensing activity.
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OPTICS EXPRESS
·
2024
·Vol. 32
·期 9
·15851-15861
·
IF 3.2
Xiujuan Zhong,Wang Zhan,Li Ma,Guolu Yin,Guolu Yin
Cadmium (Cd2+) ion is one of the most crucial industrial pollutants that cause serious harm to the human body. We proposed and experimentally demonstrated a highly sensitive Cd2+ sensor based on hydrogel coated excessively tilted fiber grating. The hydrogel with the functional monomer of the allyl thiourea can specifically bind to Cd2+, and hence forming a complex. The grating excites high order cladding modes, and ensures a sufficient interaction between the light and hydrogel binding to Cd2+, providing highly sensitive monitoring. The results show that the sensor can detect 0-160 pM Cd2+ in aqueous solution. The maximum sensitivity is 10600 nm/µM, and the minimum detection concentration is 20 pM (about 0.004 ppb), which is much less than that of the international standard (3 ppb). The proposed sensor exhibits high sensitivity, ultra-low detection limit, specificity, and a compact structure, offering potential as a tool for Cd2+ detection in aqueous solution.
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CHINESE JOURNAL OF CATALYSIS
·
2025
·
IF 17.7
Yao Yao,Juping Xu,Minhua Shao
Hydrogen evolution reaction (HER) is unavoidable in many electrochemical synthesis systems, such as CO 2 reduction, N 2 reduction, and H 2 O 2 synthesis. It makes those electrochemical reactions with multiple electron-proton transfers more complex when determining kinetics and mass transfer information. Understanding how HER competes with other electrochemical reduction reactions is crucial for both fundamental studies and system performance improvements. In this study, we employed the oxygen reduction reaction (ORR) as a model reaction to investigate HER competition on a polycrystalline-Au surface, using a rotating ring and disk electrode. It’s proved that water molecules serve as the proton source for ORR in alkaline, neutral, and even acidic electrolytes, and a 4-electron process can be achieved when the overpotential is sufficiently high. The competition from H + reduction becomes noticeable at the H + concentration higher than 2 mmol L –1 and intensifies as the H + concentration increases. Based on the electrochemical results, we obtained an equivalent circuit diagram for the ORR system with competition from the H + reduction reaction, showing that these reactions occur in parallel and compete with each other. Electrochemical impedance spectroscopy measurements further confirm this argument. Additionally, we discover that the contribution of H + mass transfer to the total H + reduction current is significant and comparable to the kinetic current. We believe this work will deepen our understanding of HER and its competition in electrochemical reduction systems.
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