INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Mingxia Wang,Tariq Muhammad,Huiling Gao,Jianzhang Liu,Hao Liang
Persistent bacterial infection caused by biofilms is one of the most serious problems that threatened human health. The development of antibacterial agents remains a challenge to penetrate biofilm and effectively treat the underlying bacterial infection. In the current study, chitosan-based nanogels were developed for encapsulating the Tanshinone IIA (TA) to enhance the antibacterial and anti-biofilm efficacy against Streptococcus mutans ( S. mutans ). The as-prepared nanogels (TA@CS) displayed excellent encapsulation efficiency (91.41 ± 0.11 %), uniform particle sizes (393.97 ± 13.92 nm), and enhanced positive potential (42.27 ± 1.25 mV). After being coated with CS, the stability of TA under light and other harsh environments was greatly improved. In addition, TA@CS displayed pH responsiveness, allowing it to selectively release more TA in acidic conditions. Furthermore, the positively charged TA@CS were equipped to target negatively charged biofilm surfaces and efficiently penetrate through biofilm barriers, making it promising for remarkable anti-biofilm activity. More importantly, when TA was encapsulated into CS nanogels, the antibacterial activity of TA was enhanced at least 4-fold. Meanwhile, TA@CS inhibited 72 % of biofilm formation at 500 μg/mL. The results demonstrated that the nanogels constituted CS and TA had antibacterial/anti-biofilm properties with synergistic enhanced effects, which will benefit pharmaceutical, food, and other fields.
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FOOD RESEARCH INTERNATIONAL
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2023
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IF 8.1
Chen Cheng,Zongcai Tu,Hui Wang
The aim of this study was to investigate the phase behavior and structural properties of fish gelatin complex coacervation with carboxylated chitosan as a function of pH by varying the amount of carboxylated chitosan added (0–0.25%, w/v) while keeping the fish gelatin concentration constant at 0.667% (w/v). Zeta potential indicated that electrostatic interaction drove the complex coalescence of fish gelatin and carboxylated chitosan to form soluble or insoluble complexes. The turbidity of the fish gelatin-carboxylated chitosan complex system was greatest at a carboxylated chitosan concentration of 0.2%. UV and fluorescence spectroscopy indicated that the carboxylated chitosan changed the tertiary conformation of fish gelatin. Circular dichroism showed that complexation of fish gelatin with carboxylated chitosan resulted in a shift from the α-helix to the β-sheet structure of fish gelatin. In particular, at pH 5, the fish gelatin complexed with carboxylated chitosan had a disordered structure. X-ray diffraction and scanning electron microscopy of the composite coacervates both investigated that electrostatic interaction between the two replaced molecular interaction within the carboxylated chitosan to form a new lamellar porous structure. These findings may in future enable the use of fish gelatin-carboxylated chitosan complex systems in the design of new food matrices.
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EUROPEAN POLYMER JOURNAL
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2023
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IF 6
Peiyun Cheng,Na Liang,Wei Zhao,Xianfeng Gong,Weijia Wang,Shaoping Sun
In this study, an amphiphilic polymer mPEG-CS-Bio-Hz-Q with capabilities of near-infrared (NIR) fluorescence imaging, active tumor targeting, minimized protein adsorption and pH-responsive drug release was designed and synthesized. The polymer was served as a micellar carrier for paclitaxel (PTX) delivery. The mean size of PTX-loaded mPEG-CS-Bio-Hz-Q micelles was 123.5 nm. In vitro drug release study indicated the pH-triggered PTX release behavior of the micelles. Cellular uptake study demonstrated that the micelles could be effectively internalized by MCF-7 cells and exhibit bright fluorescence. In vivo investigation illustrated the high antitumor activity and excellent safety of the micelles. The mPEG-CS-Bio-Hz-Q micellar system would be promising candidate for bioimaging and cancer therapy.
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Chemosensors
·
2023
·Vol. 11
·期 4
·243
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IF 4.2
Sha Li,Wenyan Yao,Licheng Xie,Yan Jiang
Chiral enantiomer recognition has important research significance in the field of analytical chemistry research. At present, most prepared chiral sensors are used for recognizing amino acids, while they are rarely used in the identification of drug intermediates. This work found that combining CS and reduced graphene oxide can enhance conductivity, increasing the recognition effect by connecting CS with BSA. Based on the above preparation, a new type of chiral sensor (3D–rGO–CS–BSA) was synthesized for the identification of drug intermediates, including the 1–Boc–3–hydroxypyrrolidine enantiomer. An obvious difference was achieved (IR/IS= 2.82) in the oxidation peak currents between the two enantiomers. The detection limits of the R–enantiomer and S–enantiomer were 4.85 nM and 11.76 nM, respectively. The proposed electrochemical sensing platform also has better potential for detecting the percentage content of mixed chiral enantiomer drugs.Keywords:three–dimensional reduced graphene oxide;chitosan;bovine serum albumin;electrochemical chiral recognition
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EUROPEAN POLYMER JOURNAL
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2023
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IF 6
Mengting Du,Ying Yi,Yihua Yin,Zhi Cai,Weiquan Cai,Junli Li,Guanghua He,Jingli Zhang
Faced with increasingly serious drug resistance and environmental pollution, there is an urgent necessity to develop green and efficient pesticides with new mechanisms of action. A novel antibacterial nano-system for plant protection based on photodynamic action was prepared by grafting hematoporphyrin (HP) onto modified chitosan through ester bonding. The self-quenching effect caused by aggregation of grafted HP could effectively inhibit its photodegradation, thus enhancing its photostability. The breakage of ester bonds induced by enzyme stimulation at the sites of bacterial infection could trigger HP release exerting an efficient photodynamic effect. The antibacterial experiments showed that the nanoparticles (NPs) have good photodynamic antibacterial activity, and the inhibition rate was as high as 96 % after 60 min of light exposure. Adhesion and safety studies have shown that the NPs are well retained on plant foliage without causing damage to the crop. Thus, NPs have great potential in sustainable plant disease management.
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NEW JOURNAL OF CHEMISTRY
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2023
·Vol. 47
·期 16
·7910-7921
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IF 3.3
Ruiyao Huang,Qi Zhu,Weixin Wang,Yuhan Hu
With the increased use of antibiotic medications, more and more ciprofloxacin (CIP) is contaminated into the environment, which could endanger both humans and ecosystems. In this work, chitosan modified Fe pretreated biochar (CS-FBC), which was produced utilizing a straightforward and reduced synthesis process, was tested for its effectiveness in the removal of CIP from an aqueous solution. CS-FBC was analyzed using XPS, XRD, BET, SEM, FTIR, and a zetasizer. In addition, we investigated how ciprofloxacin removal was influenced by a number of variables, including initial concentration, time, pH, and temperature. The findings of the experiment showed that the adsorption impact was very rapid and could reach 80% over the first 60 minutes of the overall adsorbent. The kinetic model of CS-FBC adsorbed CIP in solution was discovered to be comparable to the pseudo-second-order kinetic model, suggesting that it may be connected to chemical adsorption. By matching the adsorption properties, a maximum peak value of 76.72 mg g−1 at 35 °C was found, and the fitting was found to match better with the Langmuir isotherm model. Investigations into the adsorption thermodynamics revealed that the process was temperature dependent and instantaneous. By raising the amount of NaCl, the adsorptive power might be reduced to an extent. However, the adsorption action was seldom affected by amounts of less than 0.01 M NaCl. Furthermore, in addition to hydrogen bonding and hydrophobic interaction, the adsorption process for CS-FBC on CIP also involves electrostatic interaction and π–π electron-donor–acceptor (EDA) interaction. The adsorption rate could still be maintained at 61.25% after 7 experiments. The removal effect of CS-FBC on CIP can prove that CS-FBC is a green, economical, and sustainable adsorbent with a low preparation cost.
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CELLULOSE
·
2023
·Vol. 30
·期 6
·3837-3852
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IF 5.7
Zhang Lihua,Feng Song,Huang Furong,Li Bo,Li Yunqi,Sheng Hailiang,Hu Lijie,Liang Songmiao,Xie Haibo
Well-dispersed gold nanoparticles (Au NPs) anchored by polymeric three-dimensional hydrogels for catalysis have received great attention, especially in aqueous-phase catalysis. In this study, thiol-functionalized chitosan poly(protic ionic liquids) hydrogel (TCPPILH) is delicately designed and prepared as a selective support material to anchor Au NPs by taking advantages of Au-thiol chemistry and facile preparation of protic ionic liquids (PILs). The TCPPILH was successfully synthesized by a protonation reaction of chitosan with 3-mercaptopropionic acid (MPA) and mercaptosuccinic acid (MSA) in water, and followed by shaping in ethanol coagulation bath via solution-gelation transition, and the properties can be facilely adjusted by changing the feed ratio of MPA and MSA. It is found that the TCPPILH can act as a selective support for adsorption of Au 3+ ions, and a maximal anchoring capacity for Au NPs could reach up to 151.5 mg/g. The as-prepared TCPPILH @ Au NPs catalysts were systematically characterized by FTIR, XPS, SEM, TEM, XRD and ICP-OES analysis, and the findings demonstrated that the TCPPILH could effectively inhibit the agglomeration of Au NPs (ca. 4.20 nm in diameter). As a proof of concept, hydrogenation of water pollutes, such as 4-nitrophenol and azo dyes with NaBH 4 as reductant was selected as model applications, and the results indicated that TCPPILH @ Au NPs catalysts exhibited high catalytic activity and satisfactory reusability. Graphical abstract
Thiol-functionalized chitosan poly(protic ionic liquids) hydrogel (TCPPILH) was delicately designed and prepared as a selective support material to adsorb Au 3+ and anchoring Au NPs by taking advantages of Au-thiol chemistry and facile preparation of protic ionic liquids (PILs). This TCPPILH@Au NPs catalysts exhibited desired catalytic activity for the hydrogenation of 4-nitrophenol and azo dyes in water.
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INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES
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2023
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IF 3.4
Yurui Wang,Jing Zhao,Xiaoran Wang,Rong Zhang,Fei Liang
It is very crucial to develop ideal tissue adhesive materials with high toughness, super tissue adhesion, biodegradability and biocompatibility for the treatment of accidental trauma and surgery. Inspired by mussels, a novel injectable bioadhesive chitosan-based hydrogel was developed by dual-ionic crosslinking in this paper, which was composed of catechol-modified chitosan (Cat-CS), thermosensitive polymer (PNAM) and NaHCO 3 . The gelation time of Cat–CS–PNAM/NaHCO 3 hydrogel is 50 s at 37 °C, showing good sol-gel transition under different temperatures. The prepared hydrogels have the ability to adhere to a variety of materials surface, wherein the adhesion strength to metal surface is 126.20 ± 15.17 kPa. They also possess compact microstructure and excellent dry/wet adhesion to tissues due to the interaction between catechol/amino groups and tissues, combined with physical crosslinking . In addition, the hydrogels can be completely degraded after 14 days in vitro and show good cytocompatibility. This newly designed mussel-inspired chitosan hydrogels have the characteristics of injectability , fast gelation, bioadhesion and biocompatibility, with great potential for application in biomedical fields .
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JOURNAL OF FOOD SCIENCE
·
2023
·Vol. 88
·期 7
·3075-3089
·
IF 3.9
Yuhua Xia,Xu Tang,Xudong Wu,Yizhen Li,Changan Xu,Shaohua Chen,Peng Wu
Bioactive packaging can improve the shelf-life of food products and enhance consumer health. It can also alleviate environmental stress on the planet by reducing food waste. Here, the electrospinning of tea tree oil-loaded 2-hydroxypropyltrimethyl ammonium chloride chitosan nanofibers was investigated. The fabricated nanofiber films were characterized by scanning electron microscopy, thermal gravimetric analysis, Fourier transform infrared spectroscopy, and contact angle meter analysis. The prepared nanofibers have a well-defined diameter of about 200 nm and a smooth shape. They have good antibacterial properties against Staphylococcus aureus and Escherichia coli in vitro. Tea tree oil-loaded chitosan-based nanofibers were found to be effective in delaying spoilage and extending the shelf life of salmon by sensory evaluation, texture analysis, color, total viable counts, thiobarbituric acid, and total volatile basic nitrogen during storage in the freshness experiments, thus indicating their health benefits in bioactive packaging.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Abid Naeem,Yu Chengqun,Hetonghui,Zang Zhenzhong,Zhu Weifeng,Guan Yongmei
Gallic acid is an important phenolic compound with extensive applications in the food and pharmaceutical industries due to its health-promoting properties. However, due to its poor solubility and bioavailability, it is rapidly excreted from the body. Therefore, β-cyclodextrin/chitosan-based (polyvinyl alcohol- co -acrylic acid) interpenetrating controlled release hydrogels were developed to improve its dissolution and bioavailability. pH, polymer ratios, dynamic and equilibrium swelling, porosity, sol-gel, FTIR, XRD, TGA , DSC , SEM and structural parameters like an average molecular weight between crosslinks, solvent interaction parameters, and diffusion coefficient affecting release behavior were investigated. The highest swelling and release were observed at pH 7.4. Furthermore, hydrogels showed good antioxidant and antibacterial properties . Hydrogels improved the bioavailability of gallic acid in a pharmacokinetics study in rabbits. In vitro biodegradation showed that hydrogels were more stable in blank PBS than lysozyme and collagenase . Hydrogels were safe for rabbits (3500 mg/kg) without causing hematological or histopathological changes. The hydrogels showed good biocompatibility, and no adverse reactions were observed. Moreover, the developed hydrogels can be used to improve the bioavailability of various other drugs.
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Frontiers in Bioengineering and Biotechnology
·
2023
·
IF 5.7
Pang Yuxuan,Guan Lin,Zhu Yanlin,Niu Ruijuan,Zhu Song,Lin Quan
An open critical-size bone defect is a major medical problem because of the difficulty in self-healing, leading to an increased risk of bacterial infection owing to wound exposure, resulting in treatment failure. Herein, a composite hydrogel was synthesized by chitosan, gallic acid, and hyaluronic acid, termed “CGH.” Hydroxyapatite was modified with polydopamine (PDA@HAP) and introduced to CGH to obtain a mussel-inspired mineralized hydrogel (CGH/PDA@HAP). The CGH/PDA@HAP hydrogel exhibited excellent mechanical performances, including self-healing and injectable properties. Owing to its three-dimensional porous structure and polydopamine modifications, the cellular affinity of the hydrogel was enhanced. When adding PDA@HAP into CGH, Ca2+ and PO43- could release and then promoted differentiation of BMSCs into osteoblasts. Without any osteogenic agent or stem cells, the area of new bone at the site of defect was enhanced and the newly formed bone had a dense trabecular structure after implanting of the CGH/PDA@HAP hydrogel for 4 and 8 weeks. Moreover, the growth of Staphylococcus aureus and Escherichia coli was effectively inhibited through the grafting of gallic acid onto chitosan. Above, this study provides a reasonable alternative strategy to manage open bone defects.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Manyue Zhang,Wenxin Xu,Xiaodan Li,Guixia Ling,Peng Zhang
With the increasing prevalence of drug-resistant bacterial infections and frequent occurrences of slow wound healing, the development of novel antibacterial wound dressings has become a serious challenge. Hydrogel dressings have attracted extensive attention on wound healing due to their unique three-dimensional network structures and properties. However, it is a challenge to develop natural long-acting antibacterial hydrogels with multiple functions such as excellent cell affinity, wet adhesion and mechanical properties. Inspired by the wound healing mechanism and adhesion characteristics of tunicates , a series of biomimetic antibacterial hydrogels were prepared by utilizing pyrogallol-modified chitosan (GACS) and polyvinyl alcohol (PVA) as matrix, zinc ions (Zn 2+ ) as crosslinking and antibacterial agents, and ethyl N -lauroyl l -arginate hydrochloride (LAE) as the antibacterial active ingredient. The morphology, swelling, water retention, degradability, wet adhesion, biocompatibility, mechanical and rheological properties of PVA/GACS/Zn 2+ /LAE hydrogels were evaluated. And the adhesion ability conferred by the pyrogallol structures enabled the hydrogel with enhanced antibacterial effect and hemostatic ability. Moreover, the in vivo experiments on rat models with full-thickness infected wounds confirmed that PVA/GACS/Zn 2+ /LAE hydrogels could efficiently kill bacteria, significantly improve the wound microenvironment, greatly promote fibroblast proliferation and collagen deposition and ultimately accelerate wound healing. In a word, this study provided a feasible and simple way for the development of biomimetic antibacterial hydrogel dressings applied in infected wounds, which could not only seal wounds with various shapes and provide a moist and antibacterial environment for wounds, but also have certain mechanical strength, excellent wound adhesion, good biocompatibility and hemostatic performance.
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