JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·
IF 6.7
Qiongya Lu,Jingcheng Hu,Xing Ni,Xue Zhang,Jiaojiao Xia,Yani Zhao,Rubing Huang,Bin Zou
In this study, we successfully synthesized two immobilized enzyme carrier: hollow mesoporous carbon spheres (HMCS) and mesoporous carbon spheres (MCS). The carriers were thoroughly characterized by using a range of techniques, including scanning electron microscopy, water contact angle measurement, and BET surface area analysis. HMCS exhibited a unique hollow structure, moderate hydrophobicity, and a larger specific surface area. The high-performance immobilized lipase, CRL@HMCS was prepared by using HMCS as the carrier. The basic enzymatic properties and reaction kinetic parameters of CRL@HMCS were studied. CRL@HMCS exhibited significantly higher catalytic efficiency, with a Vmax approximately 2.7-fold greater than that of the free CRL. Excellent operational stability was showed by retaining 64.14% of its relative activity after being reused 7 times and 84.05% after 22 days of storage. Under optimal conditions (45 °C, 200 rpm, 5 h), CRL@HMCS achieved a 70.4% yield in geranyl acetate synthesis, significantly higher than the free enzyme (48.65%).
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Lu Han,Qingqing Pan,Mengting Chen,Xi Fan,Bin He,Yuji Pu
The development of oral drug delivery systems with colon-targeted release and high biocompatibility is of critical importance for the treatment of ulcerative colitis (UC), considering the chronic nature of the disease and the genetic susceptibility of patients. Herein, we report a composite delivery system (UA@PB/Gel) based on Generally Recognized As Safe (GRAS) materials, poly(vinyl alcohol) (PVA) and inulin, designed for colon-specific delivery of ursolic acid (UA). In this system, butyrate-conjugated PVA nanoparticles efficiently encapsulate UA and respond to colonic esterase, enabling the localized release of both UA and butyrate. Embedding these nanoparticles within an inulin hydrogel further enhances colonic retention and provides a sustained release. The composite system demonstrates efficient colon-targeting delivery, prolonged retention, and potent anti-inflammatory effects in vitro and in vivo. In a dextran sulfate sodium-induced colitis mouse model, UA@PB/Gel effectively alleviates colonic inflammation, restores epithelial barrier integrity, reduces proinflammatory cytokine expression, and modulates gut short-chain fatty acid levels, with minimal systemic toxicity. These results highlight the potential of the GRAS materials-based nanoparticle–hydrogel composite as a safe and effective therapeutic platform for UC.
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ACS Omega
·
2026
·
IF 5.2
Ling Chen,Li Huang,Xingbo Yan,Panpan Zhang,Enben Su,Yu Zhang
Although a variety of novel strategies have been used to select antibody-producing cells efficiently either from natural B cell collections or from plasma cell collections postimmunization, the production of monoclonal antibodies against weak antigens with high affinity and special epitopes for diagnostic or therapeutic applications remains fraught with challenges and uncertainty. In this report, we proposed an effective method for generating monoclonal antibodies from rabbits by using histone deacetylase inhibitor (HDACi) to improve antibody gene diversity, particularly the diversity of the complementarity-determining regions (CDRs) which determines the specificity of the antibody. HDACi was encapsulated in nanoliposomes to form an immunomodulator, which was administered to neonatal rabbits during the ontogeny of the immune systems. It was observed that the number of antigen-specific plasma cells in these treated rabbits was increased, and more importantly, the antibody gene diversity, especially the CDRs, was proven to have increased after 3 times of antigen immunization compared with the untreated group, probably due to the promoted efficiency of gene conversion. The results indicated that the histone modification mediated by HDACi treatment has an effect of promoting diversification of the antibody genes in treated animals. The nanoliposomes as a carrier of HDACi helped to increase the utilization rate of the loaded drugs, reduce the total dosage of administrations, and extend the time interval between administrations, making the drug feasible for newborn animals. This new method enables animals to generate antibodies against different epitopes of weakly immunogenic antigens, such as peptide antigens, and makes it possible to select antibodies with better performance for subsequent application in diagnostic reagents.
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ACS Applied Bio Materials
·
2026
·
IF 5.6
Jiajia Ren,Jie Liu,Yingying Wei,Jinglei Du,Lin Chen,Yongzhen Yang,Xuguang Liu,Shiping Yu,Yong Chen
Early diagnosis and precise treatment of liver cancer represent critical directions in medical research. Theranostic strategies integrating bioimaging and drug delivery have demonstrated significant potential, offering advantages such as high precision, enhanced imaging clarity, and improved therapeutic efficacy. Room temperature phosphorescence carbon dots@silica composites (RTP CDs@SiO2) stand out in bioimaging for their excellent properties such as long phosphorescence lifetime and low toxicity. However, their irregular morphology and large particle size restrict applications in drug delivery. In this study, RTP CDs@SiO2 composites were synthesized in an an aqueous solution via three approaches with different alkaline additives: no alkaline additive, ammonia solution, and arginine. Through the synergistic effect of the guanidine group, amino group, and carboxyl group in arginine molecules, nanoparticles with an average particle size of 14.2 nm, a phosphorescence lifetime of 1398.91 ms, and a visible afterglow duration of 12 s were prepared. The resultant composites possessed favorable biocompatibility with low toxicity, as well as outstanding phosphorescence imaging performance both in vitro and in vivo. The RTP CDs drug delivery system (CDs@SiO2-HA-DOX) was further constructed by loading the targeting molecule hyaluronic acid (HA) and the chemotherapy drug doxorubicin (DOX) via electrostatic adsorption and covalent coupling using CDs@SiO2 as a carrier. Results demonstrated that this system achieved a maximum drug loading capacity of 49.39% and exhibited pH-dependent DOX release under weakly acidic conditions. In vitro antitumor experiments revealed that CDs@SiO2-HA-DOX reduced the viability of HepG2 cells to 22.95%. In vivo studies using tumor-bearing mouse models confirmed a tumor inhibition rate of 75.48%, demonstrating significant antitumor efficacy. This work represents the first successful application of RTP CD composites in drug delivery. The developed system shows great promise as a theranostic candidate for liver cancer by integrating drug delivery and RTP imaging, highlighting its significant potential for cancer therapy applications.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Biyun Peng,Jian Wang,Weihao Dai,Yifei Zhang,Honghong Gong,Bintao Wu,Yunchuan Xie,Sen Liang,Mingxu Xia
In-situ electric-field-directed 3D printing co-engineers molecular alignment, deep traps and interfacial barriers. • Achieves 30.5 J cm −3 energy density, >84.5% efficiency and 750 MV m −1 breakdown strength. • Novel multiscale charge-blocking mechanism couples H-bond deep traps with band bending to suppress injection. • Establishes a scalable design paradigm to break the polarization-breakdown-efficiency trade-off in polymer dielectrics. The inherent conflict between polarization and breakdown strength limits the development of high-energy-density polymer dielectrics with both high efficiency and reliability. Here, we report an electric-field-directed 3D printing strategy that creates in-situ phase-regulated interfaces in an all-organic composite of partially hydrogenated poly(vinylidene fluoride- co -chlorotrifluoroethylene) (PVCT) and hydrogenated poly(methyl methacrylate) (PMAA). By coupling in-situ electric poling with hydrogen-bond-assisted assembly, we construct a seamless integration of a surface charge-blocking layer, a bulk deep-trap network, and a highly oriented polar crystalline matrix. This multi-scale engineered dielectric overcomes the traditional polarization-insulation trade-off. It delivers an exceptional discharged energy density of 30.5 J cm −3 , an efficiency exceeding 84.5%, and a remarkable breakdown strength of 750 MV m −1 . The printed capacitor also demonstrates superior thermal stability and outstanding cycling endurance, retaining over 98.7% of its initial efficiency after 10,000 cycles. This work establishes a scalable manufacturing paradigm for designing high-performance polymer dielectrics, opening new avenues for next-generation energy storage and power electronics. In-situ phase-regulated interfaces via electric 3D printing overcome the polarization-insulation trade-off for ultrahigh energy density, efficiency, and stability in polymer dielectrics. Download: Download high-res image (178KB) Download: Download full-size image
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·Vol. 65
·期 35
·18572-18586
·
IF 3.9
Dai Yasen,Zhu Congfei,Wang Bingru,Gao Minjie,Ren Shuhang,Hou Yucui,Wu Weize
To
overcome the high energy consumption associated with
conventional
CO 2 capture and conversion processes, this study develops
an integrated strategy combining CO 2 capture and in situ hydrogenation to methanol using
a novel basic deep eutectic solvent (DES). The DES, composed of N,N,N ′ ,N ′ -tetraethylethylenediamine
(TEEDA) as a hydrogen bond acceptor and ethylene glycol (EG) as a
hydrogen bond donor (optimal molar ratio 1:20), serves as both a capture
medium and a reaction promoter. When coupled with a commercial Cu/ZnO/Al 2 O 3 catalyst, the system achieved efficient CO 2 capture (1.14 mmol·g –1 ) and direct in situ conversion. Under optimized conditions
(240 ° C, 8 MPa H 2 , 12 h), a methanol selectivity of
92.9% with a yield of 72.5% was attained; even at 180 ° C, a selectivity
of 96.0% with a yield of 57.5% was obtained. Control experiments confirmed
that the polar EG solvent enhances CO 2 conversion through
solvation effects, while the DES itself possesses no intrinsic catalytic
activity. Mechanistic studies indicate that CO 2 is captured
via the formation of alkyl carbonate ions, and subsequent hydrogenation
proceeds through a formate pathway. Density functional theory (DFT)
calculations further demonstrate that the polar DES environment reduces
the activation energy barrier for the rate-limiting H 2 heterolysis
step. The DES showed good recyclability over four cycles, and catalyst
deactivation was primarily attributed to sintering-induced loss of
Cu surface area. This work presents a viable DES-based integrated
process for CO 2 capture and valorization, highlighting
the solvent’s dual function and providing insights into the
design of efficient integrated capture–conversion systems.
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ACS Chemical Neuroscience
·
2025
·
IF 3.9
Lingbo Zhao,Chunyan Hou,Yu Gao,Hong Jin,Chun-Feng Liu,Shuwei Li,Junfeng Ma,Shuang Yang
Parkinson’s disease (PD) is a progressive neurodegenerative disorder lacking definitive diagnostic tests. To identify new diagnostic biomarkers, we employed glycoproteomics-mass spectrometry (MS) to investigate dynamic changes in protein N-glycosylation across the serum, urine, and saliva of PD patients. Our comparative analysis of differentially expressed glycoproteins (DEGs) between PD patients and healthy controls (HCs) revealed distinct patterns. Specifically, ATPase phospholipid transporter 11B (ATP11B) was significantly upregulated in the serum of PD patients, while urine and saliva showed an opposite trend. Other key findings included elevated myeloperoxidase (MPO) in urine and clusterin (CLU) in serum. Zinc-α-2-glycoprotein (AZGP1), detected in all three biofluids, displayed increased sialylation and core fucosylation in serum but decreased levels in the saliva and urine of PD patients, along with a distinct bifucosylation pattern in saliva. These glycoprotein expression changes were further validated using enzyme-linked immunoassay (ELISA). Pathway analysis indicated that these DEGs are primarily involved in inflammatory response, complement activation, and synaptic plasticity, suggesting that glycosylation dysregulation may contribute to PD progression by modulating neuroinflammation and protein homeostasis. This study represents the first comprehensive analysis of multibiofluid N-glycosylation in PD. The findings offer potential biomarkers and provide insights into the molecular mechanisms of the disease, which could ultimately inform early diagnosis and the development of targeted therapies.
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Molecular Catalysis
·
2026
·
IF 4.3
Yanping Zhang,Yi Zeng,Qingyin Wang,Gongying Wang,Wei Bai,Weixin Qian
Intrinsic acidity vs. accessibility in biomass dehydration is investigated. • TOF diverges from macroscopic yield in sorbitol dehydration. • The para-isomer gives the highest yield (∼74%) despite its lower site-normalized TOF. • Highly accessible acid-site density and balanced adsorption behavior contribute to the para-isomer's performance. This study investigates how intrinsic acid-site activity and spatial accessibility jointly regulate biomass dehydration. Using position-isomeric sulfonated carbon catalysts, namely 2-, 3-, and 4-CBC-PhSO₃H, we demonstrate a divergence between microscopic site activity and macroscopic catalytic performance in sorbitol dehydration. Kinetic analysis shows that the ortho-isomer exhibits the highest site-normalized turnover frequency (TOF), whereas the para-isomer achieves the highest overall isosorbide yield of approximately 74%. This difference arises from a synergistic balance between intrinsic reactivity and accessible acid-site density: the lower steric hindrance of the para-configuration favors a higher density of effective acid sites, which compensates for its lower single-site TOF. Theoretical calculations further suggest that substitution position affects proton dissociation, charge distribution, and adsorption behavior. In particular, the para-isomer maintains favorable interactions with organic reactants/intermediates while showing relatively weak water binding, which may help reduce competitive water adsorption during dehydration. These findings highlight that the catalytic performance of carbon-based solid acids is governed by the combined effects of intrinsic acidity, spatial accessibility, acid-site density, and interfacial adsorption behavior, guiding the rational design of robust solid acid catalysts for biomass conversion. Download: Download high-res image (210KB) Download: Download full-size image
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JOURNAL OF NUCLEAR MATERIALS
·
2026
·
IF 3.3
Qiang Xian,Weijie Fan,Yulin Gu,Zishan Zhang,Jiaqi Liu,Hui Xian,Li Chen,Hui Dan,Yi Ding
New SnS@SBA-15 was developed for the efficient adsorption and storage of iodine. • The iodine adsorption capacity was up to 2062 mg/g. • The iodine adsorption mechanism was chemical adsorption (SnS + I 2 → SnI 4 + S). • The retention rate of adsorption product SnI 4 was up to 76.5% after storage for 90 d. • Stable iodine storage was due to the in-situ reconstructed hydrophobic environment. Tin-based materials are expected to be excellent iodine adsorbent, but the stability of the adsorption product (SnI 4 ) poses challenge. Herein, a novel strategy based on the in-situ reconstruction of hydrophobic environment was presented for efficient iodine adsorption and storage. Stannous sulfide@mesoporous silica (SnS@SBA-15) was developed and employed for the adsorption of I 2 gas. The optimal material, SnS@SBA-15–50wt%, exhibited an excellent iodine uptake of 2062 mg/g. The adsorption was attributed to a chemical reaction (SnS + 2I 2 = SnI 4 + S). Notably, the retention rate of SnI 4 was as high as 76.5% after storage in air for 90 days due to the in-situ reconstructed hydrophobic environment. The obtained SnS@SBA-15 exhibited efficient iodine adsorption and excellent storage ability. This work presents a novel strategy to design iodine adsorbents, aimed at addressing the storage challenges of iodine adsorption products susceptible to hydrolysis. Download: Download high-res image (214KB) Download: Download full-size image
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Carbon Letters
·
2025
·
IF 5.8
Wang Shihui,Lei Yuyao,He Chao,Miao Junhe,Liu Yang,Xie Quanhua,Hassan Karimi-Maleh,Zhong Nianbing
In the pursuit of achieving in-situ real-time detection of methanol production rate during the photocatalytic reduction of CO 2 , we developed a methanol sensor using a copolymer-coated fiber Bragg gratings. The theoretical model of methanol measurement by sensor was established. The effect of methanol-selective sensitive material and its thickness on the performance of the sensor were investigated. Humidity and temperature interference to sensor measurements was compensated. Furthermore, TiO 2 photocatalyst was prepared and the photocatalytic reactor was constructed. The methanol production rate in the photocatalytic CO 2 reduction process was monitored by the prepared sensor in-situ. The results highlight that the fiber Bragg grating methanol sensor with 600 nm-thick poly(N-isopropylacrylamide)/polymethyl-methacrylate coating showed a high sensitivity, lower limit of detection, fast response and recovery speed, and high selectivity. The methanol generation rate of TiO 2 photocatalytic reduction of CO 2 measured by gas chromatograph and prepared fiber Bragg grating methanol sensor was 1.42 and 1.53 μmol/g-cat·h, respectively, the error of the two detection methods was 7.86%. This highlights the efficacy of the developed fiber Bragg grating methanol sensor for real-time in-situ detection of the methanol production rate during the photocatalytic reduction of CO 2 .
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MOLECULAR PHARMACEUTICS
·
2023
·
IF 4.9
Fulong Man,Yinqian Yang,Haisheng He,Jianping Qi,Wei Wu,Yi Lu
In vitro dissolution that predicts the in vivo performance of solid preparations is extremely important in formulation optimization. Fraction absorbed (Fa) has been used to screen in vitro dissolution protocols based on the idea of in vitro–in vivo correlation (IVIVC) but failed to increase the success rate due to the inaccuracy of the Fa. The essence of IVIVC is the correlation between in vitro dissolution and in vivo dissolution. We tried to establish in vitro dissolution protocol via similarity with in vivo dissolution using aripiprazole (APZ) as a model drug. Hybrid APZ crystals (APZ-HCs) were prepared by physically embedding aggregation-caused quenching (ACQ) fluorophores inside the lattice to measure the in vivo dissolution. The process did not change the physicochemical properties and crystallinity of APZ. The fluorophore illuminated APZ crystals but was quenched upon dissolution of APZ-HCs in aqueous media, enabling monitoring intact APZ-HCs in real-time. The good correlation between fluorescent quenching and dissolution of APZ-HCs justified reliable quantification of intact APZ crystals. The residual percentage of fluorescence intensity in rats treated by APZ-HCs was recorded with time, which was converted to in vivo dissolution by the difference from 100%. The in vivo dissolution was validated with the Fa. The in vitro dissolution profile of APZ was set up via a similarity factor larger than 50 in comparison with the in vivo dissolution. The study provides a novel idea and method to establish in vitro dissolution protocol.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 17
·51061-51074
·
IF 5.8
Zheng Siheng,Sheng Feng,Gu Cheng,Li Yanying,Fang Zhou,Luo Jun
Triazines are frequently detected in nature water and agricultural soils worldwide. They are considered harmful to plants, animals, and the human health. In this study, diffusive gradients in thin films (DGT) method was developed for the assessment of several triazines. DGT device was used for the in situ measurement of atrazine in a pesticide factory and obtained reliable data. The atrazine concentrations measured by DGT, and solvent extraction method was in a constant ratio. The DIFS model was coupled with DGT technique to study the desorption kinetics of atrazine in four kinds of different soils. The yellow–brown soil was more inclined to adsorb atrazine than other three soils. 2_D DIFS model was used to obtain the partition coefficient for labile atrazine ( K dl ), the values of the response time ( T c ), and desorption/adsorption rates ( k 1 and k −1 ). The yellow–brown soil has a larger labile pool size, and a faster resupply speed of atrazine. The 1_D DIFS model was used to simulate the profiles of atrazine concentrations in soil solution and solid phase. The results show that the desorption of atrazine in soil was limited by kinetic limitation at short time, and was limited by the solid phase reservoir at long time.
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