JOURNAL OF MATERIALS SCIENCE
·
2020
·Vol. 56
·期 3
·2725-2737
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IF 3.553
Chen Shaojun,Xie Jiapeng,Liu Jiaoshi,Huang Xiaoting,Wang Cai
Flexible, self-healing hydrogels with a variety of desirable properties are required for artificial skin applications. Here, we report a novel ionic conductive composite hydrogel consisting of polyacrylamide (PAM), a silk sericin (SS) network and NaCl for use on bionic skin.
The use of NaCl made the hydrogels good ionic conductors. Intrinsic interactions between the PAM and SS endowed the hydrogel with good mechanical properties, including a high tensile strength of 0.36 MPa and a compressive strength of 0.38 MPa. The ionic hydrogel showed a high transparency of 93%, a high adhesion strength of 52 kPa, and good conductivity. After being fractured, two pieces of the ionic hydrogel were re-bonded without external stimulation, which simulated the self-healing properties of skin after injury. The hydrogel displayed moisturizing and anti-mildew properties after being stored at room temperature for 2 months. These ionic hydrogels may find applications in artificial skin, human–machine interfaces and soft robotics.
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Scientific Reports
·
2020
·Vol. 10
·期 1
·1-11
·
IF 3.998
Liu Yi,Chen Yan,Zhang Junwei,Gao Junkai,Han Zhi
Copper microsphere hybrid mesoporous carbon (MPC-Cu) was synthesized by the pyrolysis of polydopamine microspheres doped with copper ions that were prepared using a novel, facile and simple one-step method of dopamine biomimetic polymerization and copper ion adsorption. The resulting MPC-Cu was then used as a supporter for polyethylene glycol (PEG) to synthesize shape-stabilized phase change materials (PEG/MPC-Cu) with enhanced thermal properties. PEG/MPC-Cu was studied by scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, thermogravimetric analysis, differential scanning calorimetry and thermal constant analysis. The results demonstrated that the thermal conductivity of PEG/MPC-Cu was 0.502 W/(m K), which increased by 100% compared to pure PEG [0.251 W/(m K)]. The melting enthalpy of PEG/MPC-Cu was 95.98 J/g, indicating that PEG/MPC-Cu is a promising candidate for future thermal energy storage applications. In addition, the characterization results suggested that PEG-MPC-Cu possessed high thermal stability. Therefore, the method developed in this paper for preparing shape-stabilized phase change materials with improved thermal properties has substantial engineering application prospects.
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Nano Research
·
2021
·Vol. 14
·期 11
·3988-3998
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IF 8.897
He Jiaqi,Chen Guoqin,Zhao Peng,Ou Caiwen
Bufalin is efficacious in treating various tumors, however, the clinical application of which is restricted by the myocardial toxicity. Developing a smart synergetic delivery system is widely considered as a promising therapeutic strategy. To address this issue, a black phosphorus hybrid polypeptides hydrogel was designed to highly load bufalin, and achieved near-infrared (NIR)-controllable drug release with synergistic photothermal-chemo therapeutic effect. Black phosphorus nanosheets (BPNSs) and bufalin were co-loaded in temperature-sensitive supramolecular hydrogel to receive smart hybridization (BP-bufalin@SH). With NIR irradiation (1 W·cm −2 ), BP-bufalin@SH exhibited a rapid and large temperature increase and released bufalin via light-controllable manner, with which the side effects of bufalin were greatly decreased. Combined with photothermal-chemo therapeutic effect, BP-bufalin@SH could collapse the mitochondrial transmembrane potential resulting in the irreversible apoptosis of tumor cells, and realize a highly efficient in vivo tumor elimination with good biosafety and biocompatibility. This work provides a new hydrogel platform for controlling bufalin release, and thus further promotes the practical application on antitumor therapy.
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Tissue Engineering and Regenerative Medicine
·
2021
·Vol. 18
·期 1
·113-125
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IF 4.169
Mou Donggang,Yu Qunying,Zhang Jimei,Zhou Jianping,Li Xinmin,Zhuang Weiyi,Yang Xuming
Background: Pain and cartilage destruction caused by osteoarthritis (OA) is a major challenge in clinical treatment. Traditional intra-articular injection of hyaluronic acid (HA) can relieve the disease, but limited by the difficulty of long-term maintenance of efficacy. Methods: In this study, an injectable and self-healing hydrogel was synthesized by in situ crosslinking of N -carboxyethyl chitosan ( N -chitosan), adipic acid dihydrazide (ADH), and hyaluronic acid–aldehyde (HA-ALD). Results: This supramolecular hydrogel sustains good biocompatibility for chondrocytes. Intra-articular injection of this novel hydrogel can significantly alleviate the local inflammation microenvironment in knee joints, through inhibiting the inflammatory cytokines (such as TNF-α, IL-1β, IL-6 and IL-17) in the synovial fluid and cartilage at 2- and even 12-weeks post-injection. Histological and behavioral test indicated that hydrogel injection protected cartilage destruction and relieved pain in OA rats, in comparison to HA injection. Conclusion: This kind of novel hydrogel, which is superior to the traditional HA injection, reveals a great potential for the treatment of OA.
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International Journal of Minerals Metallurgy and Materials
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2020
·Vol. 27
·期 12
·1703-1710
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IF 1.713
Zhou Jing,Nie Dan-dan,Jin Xian-bo,Xiao Wei
Pyrolysis of the Ta 2 O 5 /melamine mixture in molten chlorides is herein demonstrated as a facile and controllable method to nitridize and functionalize Ta 2 O 5 . The influence of the stoichiometry and composition of Ta 2 O 5 /melamine in molten salts on the nitridation process is rationalized to ensure the controllable preparation of Ta 3 N 5 and Ta 3 N 5 /TaON. The characterization results, including scanning electron microscopy, transmission electron microscopy, elemental mapping, X-ray photoelectron spectroscopy, and photoluminescence spectroscopy, all confirm the existence of the Ta 3 N 5 /TaON heterojunction, in which the TaON nanoparticles are closely anchored to the Ta 3 N 5 nanorods. Benefiting from its composition and structure, the Ta 3 N 5 /TaON composites show enhanced photocatalytic activity for the degradation of methylene blue. The present study highlights that the molten salt method using a solid nitrogen source can be a new technique for rationalizing the design of nitrides and oxynitrides.
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Nano Research
·
2021
·Vol. 14
·期 8
·2689-2696
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IF 8.897
Luo Feng-Qin,Chen Guojun,Xu Wei,Zhou Daojia,Li Jia-Xian,Huang Yong-Cong,Lin Run,Gu Zhen,Du Jin-Zhi
Glucose-responsive insulin delivery systems show great promise to improve therapeutic outcomes and quality of life for people with diabetes. Herein, a new microneedle-array patch containing pH-sensitive insulin-loaded nanoparticles (NPs) (SNP(I)) together with glucose oxidase (GOx)- and catalase (CAT)-loaded pH-insensitive NPs (iSNP(G+C)) is constructed for transcutaneous glucose-responsive insulin delivery. SNP(I) are prepared via double emulsion from a pH-sensitive amphiphilic block copolymer, and undergo rapid dissociation to promote insulin release at a mild acidic environment induced by GOx in iSNP(G+C) under hyperglycemic conditions. CAT in iSNP(G+C) can further consume excess H 2 O 2 generated during GOx oxidation, and thus reduce the risk of inflammation toward the normal skin. The in vivo study on type 1 diabetic mice demonstrates that the platform can effectively regulate blood glucose levels within normal ranges for a prolonged period.
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APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
·
2020
·Vol. 104
·期 24
·10503-10513
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IF 3.53
Hu Gaowei,Miao Yingjie,Luo Xi,Chu Wenhui,Fu Yongqian
Abstract Cell membranes are a great obstacle for entrance of gene therapeutic agents. Cell-penetrating peptides (CPPs) have been proven as a promising gene delivery tool. However, the early TAT peptide derived from the HIV transcription activator protein has been proven that the sequence contains Furin protease cleaved motifs which limited the TAT application in delivery of exogenous active molecules. In the present study, through the bioinformatics and experimental approach, we have identified a novel CPP derived from the N terminus of VP1 protein of chicken anemia virus (CAV), designated as CVP1-N2, which is rich in arginine residues and contains α-helical structure. Then, the ability of CVP1-N2 cell penetrating was detected using confocal imaging and flow cytometry. FITC-labeled CVP1-N2 peptide could rapidly internalize into different types of live cells with dose dependence and without cytotoxic effects by MTT assay. Surprisingly, CVP1-N2 with a pattern of nuclear sub-location has shown the higher uptake efficiency than TAT. At 10, 1, and 0.1 μM, the mean relative internalization of CVP1-N2 was respectively 1.08-, 12-, and 75-fold higher than that of CVP1, as well as 1.6-, 56-, and 75-fold higher than that of TAT. Moreover, using endocytic inhibitors along with low-temperature stress validated that the CVP1-N2 internalization route is direct translocation pathway. Finally, the capacity of CVP1-N2 for delivery of gene into cells was determined, where it was able to carry red fluorescent protein (RFP) and apoptin genes into cells respectively and induce the apoptosis. All these data indicate that CVP1-N2 could be used as a novel gene delivery vehicle for gene therapy in the future. Key points • 1CVP1-N2 was identified as a novel more efficient cell-penetrating peptide.
• 2. CVP1-N2 localized to the nucleus through the direct transduction pathway.
• 3. CVP1-N2 was able to deliver the apoptin gene into HCT116 cells and induce apoptosis.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2020
·Vol. 31
·期 24
·22375-22384
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IF 2.22
Wang Li,He Lin,Li Ji,Yu Yongsheng,Li Haibo
M-type strontium ferrite is a kind of magnetic functional material with wide application prospect. In this work, SrFe 12− x Al x O 19 (0 ≤ x ≤ 1) and Sr 1− y Ca y Fe 8 Al 4 O 19 (0 ≤ y ≤ 0.4) have been prepared by a hydrothermal method, and the effects of Al 3+ doping and Al 3+ and Ca 2+ co-doping on the magnetic properties have been investigated. X-ray diffraction analysis indicates all the samples are a hexagonal structure, and the shift of the diffraction peaks suggests that Al 3+ and Ca 2+ are successfully doped in SrFe 12 O 19 . Field emission scanning electron microscope images show the particles have the hexagonal shape with the size of 1.1–2.9 µm. Vibrating sample magnetometer reveals that the doping of Al 3+ and the co-doping Al 3+ and Ca 2+ can enhance magnetic properties of strontium ferrite. For example, the values of coercivity and the saturation magnetization of SrFe 8 Al 4 O 19 are 914.1 Oe and 44.0 emu/g, which are 3% and 117% enhancement compared with SrFe 12 O 19 , respectively. For Sr 1− y Ca y Fe 8 Al 4 O 19 , coercivity and saturation magnetization increase from 914.1 Oe and 41.8 emu/g to 1047.2 Oe and 50.2 emu/g when the Ca 2+ doping concentration increases from 0 to 0.4. Moreover, the effects of acid washing also on phase composition, morphology and magnetism are researched. The as-synthesized doping strontium ferrite will be useful for the applications in security switching and recording media.
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CATALYSIS LETTERS
·
2020
·Vol. 151
·期 6
·1766-1775
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IF 2.482
Zhou Yulan,Liao Wanfeng,Ni Xiuyuan
Abstract For the cationic photopolymerization of high value, we designed a new visible-light initiator complex consisting of the visible-light sensitive titanium dioxide (Py x% :TiO 2 , x = 3, 6, 9, 12), octanioc acid and iodonium salt (Iod). The ternary complex was proved to efficiently initiate the cationic ring-opening polymerization of the epoxide under the light irradiation at the wavelength of 520 nm. By using gas chromatography-mass spectra (GC-MS), electron spin resonance (ESR) and 1 H-nuclear magnetic resonance ( 1 H-NMR), the mechanism studies clearly presented that the Py x% :TiO 2 photocatalyzed the oxidation reaction of octanioc acid in the pathway of photo-Kolbe decarboxylation. Meanwhile, Iod was decomposed by the photocatalytic reduction reaction. The results of this visible-light photocatalytic cationic polymerization process were analyzed by using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy and gel permeation chromatography (GPC). The conversion of the epoxide can reach up to 93.8%. Graphic Abstract
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JOURNAL OF MATERIALS SCIENCE
·
2020
·Vol. 56
·期 4
·3111-3126
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IF 3.553
Yu Chuanming,Jiang Jin’e,Liu Yeyuan,Liu Ke,Situ Ziqing,Tian Lifen,Luo Wenjing,Hong Pengzhi,Li Yong
Oil spills cause serious environmental pollution and serious waste of resources, hydrophobic porous absorbent has been deemed as a simple, low-cost, efficient and environment-friendly in oil–water separation. In this paper, a facile emulsion template method was developed to fabricate an interconnected porous poly(DVB-MMA) sponge. A novel co-Pickering stabilization system of Span 80 and NiFe 2 O 4 nanoparticles was applied to fabricate ultra-concentrated internal phase W/O emulsions. After further polymerization, the resulting sponge showed excellent adsorption selectivity due to superhydrophobicity and superlipophilicity. Also, the characterization results exhibited that the composite had superior thermal stability, low density, high porosity and flexible three-dimensional porous structure. Besides, waste PS plastic was introduced to enhance the structural integrity of composite, and the addition of NiFe 2 O 4 provided the material with magnetic operability. High oil adsorption capacity (up to 44.3–101.0 g/g), high oil retention, fast adsorption rate and superior recyclability allowed the material to be used in the fields of oil–water separation and oil pollution treatment.
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JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
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2020
·Vol. 58
·期 10
·3780-3789
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IF 1.946
Chen Di,Shu Yang,Chen Jian,Cao Xianying
This work proposes a novel potential source of antiallergens based on bioactive peptides. Cashew-nut protein hydrolysate with antiallergic activity was prepared from cashew nuts through protease treatment. The change in the antiallergic activity of cashew-nut protein hydrolysate during in vitro simulated digestion was investigated. Cashew-nut protein hydrolysates were prepared through treatment using five different enzymes, namely, Alcalase, Protamex, Neutrase, papain, and bromelin. According to the results of molecular weight distribution, more small molecular weight peptides could be obtained by selecting Alcalase protease than other proteases, and the degree of hydrolysis, trichloroacetic acid-soluble peptide yield and hyaluronidase inhibitory rate of the hydrolysate were 17.0 ± 61.52%, 26.28 ± 0.13% and 62.06% ± 5.07%, which were significantly higher than those of other proteases. Therefore, Alcalase is the most suitable protease for the preparation of cashew-nut hydrolysates. Cashew-nut protein hydrolysates prepared with Alcalase under optimum conditions were fractionated through ultrafiltration. Fractions with low molecular weight exhibited the highest hyaluronidase inhibitory rate (90.57%) among all fractions. The inhibition of hyaluronidase activity during digestion showed that cashew-nut protein hydrolysate III (CPH III) has persistent antiallergic activity. Therefore, CPH III could serve as a potential source of functional peptides with health-promoting effects.
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MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 11
·1-9
·
IF 6.232
Wu Weihao,Fan Yaofang,Tan Bing,Zhao Huimin
With the merits of low cost, simple synthesis procedure, and high affinity for metal ions, deoxyribozyme (DNAzyme) have played important roles in metal ions detection. However, the intracellular applications of DNAzyme are limited because of enzymatic degradation and inefficient cellular uptake. To address these problems, GR-5 as model DNAzyme was encapsulated into zeolitic imidazolate frameworks-8 (ZIF-8) nanoparticles by biomimetic mineralization. The positively charged ZIF-8 with high DNAzyme loading capacity retained their ability to enter cells. Compared with free DNAzyme, the biomimetic mineralization synthesis method has greatly improved the stability of pristine DNAzyme. The as-synthesized DNAzyme@ZIF-8 composite exhibited good stability resisting DNase I, and was used as a sensitive fluorescent nanoprobe for Pb 2+ determination and successfully achieved selective and sensitive determination for Pb 2+ at λ ex / λ em = 494/522 nm in real samples. The linear range for the determination of Pb 2+ is 50 to 500 nM. Moreover, the highly active DNAzyme delivered by ZIF-8 allows noninvasive imaging of Pb 2+ measurement in living cells. This strategy will extend the suitability of functional nucleic acids for in vitro and in vivo bioanalysis and bioimaging.
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