NEUROGASTROENTEROLOGY AND MOTILITY
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2019
·Vol. 31
·期 6
·e13555
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IF 3.803
Mengjuan Lin,Lei Chen,Yong Xiao,Baoping Yu
Background Irritable bowel syndrome (IBS) is a common disease with intestinal dysmotility, whose mechanism remains elusive. The endocannabinoid system is emerging as an important modulator of gastrointestinal (GI) motility in multiple diseases, but its involvement in IBS is unknown. We aimed to determine whether cannabinoid 2 (CB2) receptor modulates intestinal motility associated with stress-induced IBS. Methods A rat IBS model was established by chronic water avoidance stress (WAS). Colonic pathological alterations were detected histologically and intestinal motility was assessed by intestinal transit time (ITT) and fecal water content (FWC). Visceral sensitivity was determined by visceromotor response (VMR) to colorectal distension (CRD). Real-time PCR, western blot, and immunostaining were performed to identify colonic CB2 receptor expression. Colonic muscle strip contractility was studied by isometric transducers and nitric oxide (NO) was detected by the Griess test. The effects of AM1241, a selective agonist of CB2 receptors, on colonic motility were examined. Key Results After 10 days of WAS exposure, ITT was decreased and FWC elevated while VMR magnitude in response to CRD was significantly enhanced. Colon CB2 protein and mRNA levels increased and density of CB2-positive macrophages in the mucosa and enteric neurons in the myenteric plexus was higher than in controls. Pharmacological enhancement of CB2 activity by AM1241 relieved colonic hypermotility in WAS rats in a concentration-dependent manner via inhibition of p38 phosphorylation and elevation of NO production. Conclusion CB2 receptor may exert an important inhibitory effect in stress-induced colonic hypermotility by modulating NO synthesis through p38 mitogen-activated protein kinase signaling. AM1241 could be used as a potential drug to treat disorders with colonic hypermotility.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2019
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IF 4.175
Wenxiu He,Hengrui Qiu,Jing Meng,Bin Liu,Jinlong Cui,Yongqiang Zhang
A nanoscale petal-like α-Ni(OH) 2 /reduced graphene oxide (α-Ni(OH) 2 /RGO) composite was synthesized with the one-step microwave method. α-Ni(OH) 2 particles with sizes of approximately 200 nm are uniformly distributed on the reduced graphene oxide sheet in the sample. When used as an electrode for alkaline rechargeable batteries, the discharge capacity of the α-Ni(OH) 2 /RGO composite reaches 333.5 mAh/g at 0.2C and 247.1 mAh/g at 10 C, respectively, with an excellent rate capability. After 2000 cycles, the capacity of the electrode is insignificantly attenuated, indicating a high capacity retention and cycling stability. The outstanding electrochemical properties are attributed to the nanoscale petal-like structure α-Ni(OH) 2 anchoring on the RGO sheets, which facilitates ion diffusion and increases the active surface, which is effectively reacting with the electrolyte. The nanoscale petal-like electrode material fabricated in this study provides clues to address the problem of energy applications of high-performance alkaline rechargeable batteries.
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Analytical Methods
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2019
·Vol. 11
·期 11
·1516-1521
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IF 2.378
Fujuan Luan,Zuhong Yu,Ling Yin,Xia Leng,Yuxue Shi,Jie Wang,Haibin Shi,Weichang Chen
Matrix metalloproteinase-2 (MMP-2) plays an important role in tumorigenesis and metastasis of gastric cancer. Therefore, specific and sensitive detection of MMP-2 is of great significance for clinical diagnosis and therapeutic evaluation of gastric cancer. Herein, we developed a new approach for accurate detection of MMP-2 activity both in gastric cancer cells and clinical tissues using a fluorescent probe Dab-PLGVRGY-FITC. The capability of the probe for detecting MMP-2 was systematically evaluated in gastric cancer MGC-803 cells and clinical gastric cancer tissues. Around 40-fold fluorescence enhancement at a wavelength of 520 nm was determined for the assays of the probe with recombinant MMP-2. The detection limit of MMP-2 was as low as 42 ng mL−1. Strong fluorescence signals were detected in MGC-803 cells and mouse gastric cancer tissues. Fluorescence signal enhancements of 11 clinical gastric cancer tissue lysates were 5.8 ∼ 9 times (7.53 ± 0.77 on average) higher than those from gastritis patients. This probe could be potentially used for early diagnosis of gastric cancer in clinics.
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JOURNAL OF MOLECULAR LIQUIDS
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2019
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IF 4.561
Yi Li,Songwei Zhang,Qi Ding,Baofeng Qin,Litian Hu
Ionic liquids (ILs) are extensively used in many fields owing to their attractive characteristics. Good structure designability provides ILs an opportunity to integrate multiple functions into their structures, which could promote their industrial applications as versatile materials. In this study, three 4, 6-dimethyl-2-mercaptopyrimidine (DMMP) based phosphonium ILs were firstly synthesized. The corrosion inhibition behaviors of these ILs for mild steel in 0.5 M H 2 SO 4 aqueous solutions were investigated by electrochemical tests. Results indicated that all of the three ILs exhibited surprising inhibition efficiencies as high as 99%, even at an ultralow concentration of 0.1 mM. The ILs' adsorption behavior on surface obeys Langmuir isotherm, indicating that the ILs inhibit corrosion of mild steel by monolayer adsorption on the mild steel surface. Moreover, due to the superior adsorption capacity on steel surface, DMMP based ILs are expected have great application potentials as high-performance lubricating materials. As expected, DMMP based ILs showed excellent lubrication performances both at 30 °C and 100 °C as compared to PAO and 1-butyl-3-methylimidazolium tetrafluoroborate (LB104). Surface analyses indicated that tribofilms consist of ILs adsorption layer and tribochemical products, such as FeS, Fe 2 O 3 and organic compounds containing C O bonds, are responsible for the predominant lubrication performances. Therefore, versatile ILs designed in this paper have gathered two significant abilities for industrial applications, which are high corrosion inhibiting properties and excellent lubrication performances. This work is believed to be instructive for designing multifunctional ILs and promoting the ILs' application in industry in the future.
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MATERIALS TECHNOLOGY
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2019
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IF 1.82
Xinyu Jiang,Wenbo Cheng,Huijie Hu,Yiming Hu,Yunpeng Cao,Shengnan Yan,Ruixin Di,Xiaoze Wang,Li Hou
As an excellent electrode material for supercapacitors, it should have high capacitance like transition metal oxides and good stability like carbon materials. In this work, we reported a novel composite electrode material, Co-Ni(OH)2/carbon sphere, obtained by a solvothermal method. At first, the activated carbon spheres with an uniform size of about 4µm were synthesized, and then the sheet-like Co-Ni(OH)2 adsorbed on the cracks and outer surface of the carbon spheres to form the Co-Ni(OH)2/carbon sphere composite. The influence of mass ratio of Co-Ni(OH)2 to carbon spheres on capacitance performance was investigated. Benefitting from the unique composite structure, the synthesized Co-Ni(OH)2/carbon sphere presents a high specific capacitance up to 959.7 F/g in 6 M KOH at current density of 1 A/g. Meanwhile, the capacitance retention maintains its 75% after 3000 cycles, which is about 2.8 times higher than that of the pure Co-Ni(OH)2, indicating a good stability.
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CARBOHYDRATE POLYMERS
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2019
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IF 6.044
Jing Zhang,Lingdong Chen,Biao Shen,Liqun Chen,Jie Feng
Hydrogels with good mechanical properties are promising for various applications. In this work, a simple yet effective method for preparing a novel double-network hydrogel was reported. First, nonfouling polymer, poly( N- (2-hydroxyethyl)acrylamide) (PHEAA), was crosslinked through covalent bonds. Antibacterial polysaccharide, chitosan (CS), was then crosslinked by chelation between the N- glucosamine units on the CS and citrate or sulfate ions. The poly( N- (2-hydroxyethyl)acrylamide)/chitosan double-network hydrogels (PHEAA/CS DN hydrogels) exhibited high tensile strength (3.8 MPa), strong elastic modulus (0.6 MPa). And the dynamic ionic crosslinking in CS network provided the DN gels with fast self-recovery ability as well as excellent fatigue resistance. Furthermore, the mechanical properties of the DN gels were enhanced after stretching and relaxing because of the molecular orientation and reconstruction of chitosan network. More importantly, the hydrogels have excellent antifouling and antibacterial properties, which is called “repelling and killing”, making them competitive candidates for applications in the biomedical field.
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BIOMATERIALS
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2019
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IF 10.273
Haoyi Niu,Yifan Ma,Guangyu Wu,Bing Duan,Ying Wang,Yuan Yuan,Changsheng Liu
Synchronization of material resorption and new bone formation is vital to achieve harmonious bone regeneration in the treatment of large bone defects. To exposit the resorption/osteogenesis properties in the guided bone repairing, rhBMP-2-loaded trimodal macro/micro/nano-porous bioactive glass scaffolds (TMS-rhBMP-2) were set as substrate model. We penetratingly investigated the particular function of hierarchical structure and incorporated rhBMP-2 in the resorption/osteogenesis, and dissected the cellular interplay throughout the regenerative procedure. The results suggested that rhBMP-2 significantly facilitated osteoclastogenesis-mediated scaffold degradation and strikingly up-regulated mesenchymal stem cells (MSCs)-involved osteogenesis in vitro. Further gene microarray and related proteins expression indicated that in the presence of rhBMP-2, MSCs rather than differentiated MSCs could exert synergistic effects on osteoclastogenesis , osteoclasts maturation and resorptive function; meanwhile, rhBMP-2-induced MSCs osteogenesis was also strengthened by the osteoclasts. In vivo micro-CT, X-ray, kinetic and histological analyses qualitatively and quantitively demonstrated the optimized coupling of bioresorption/osteogenesis and the most rapid regeneration in TMS-rhBMP-2. Consequently, with rhBMP-2 acted as ignitor and MSCs/osteoclasts interaction as booster, a harmonious bone regeneration was obtained. Besides, long-term magnetic resonance imaging (MRI) in virtue of Gd 3+ suggested that the degradation products mainly distributed in liver and spleen, verifying the accumulation/discharge profiles and safety application of TMS-rhBMP-2 system in vivo. This study will not merely provide guidance for the design of clinical bone repairing materials, but shed substantial light on the multicell-mediated tissue regeneration .
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Nano Energy
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2019
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IF 15.548
Sheng Huang,Chao Meng,Min Xiao,Shan Ren,Shuanjin Wang,Dongmei Han,Luyi Sun,Yuezhong Meng
Pseudocapacitive Na + storage based on the fast absorption/desorption kinetics is a new alternative to realize the high rate capability, which rely on increasing the surface area and creating surface vacancies. This means low Na + capacity because of low dielectric constant for the reported pseudocapacitive Na + storage materials. According to the capacitance formula, we find increasing the dielectric constant is a new path to improve the Na + capacity. This dielectricity (other than surface engineering) based pseudocapacitance can be called more real pseudocapacitance. The superparaelectric 2-dimensional (2D) Sn 2 P 2 S 6 has much higher dielectric constant than the bulk counterpart. The identical polaron direction triggered superparaelectricity and high dielectric constant of 2D Sn 2 P 2 S 6 are well verified. And 2D assembly between the 2D Sn 2 P 2 S 6 and graphene construct the compact network for conductivity of electron and Na + . As results, the 2D Sn 2 P 2 S 6 battery based on more real pseudocapacitance delivers alloy-like capacity and long cycle stability.
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Molecular Medicine Reports
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2019
·Vol. 19
·期 6
·5417-5423
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IF 1.851
Zhimin Wang,Fang Li,Yuan Quan,Junye Shen
Hepatocellular carcinoma (HCC) has become a global public health problem. Therefore, the development of novel and effective therapeutic agents for the treatment of HCC is considered an emergency. Avicularin, a bio‑active flavonoid from plants, has been reported to exhibit diverse pharmacological properties. The aim of the present study was to investigate the role of avicularin in HCC and the underlying mechanism of action. Huh7 cells were treated with avicularin in a concentration‑dependent manner, and the cell proliferation was examined using a 3‑(4, 5‑dimethylthiazol‑2‑yl)‑2, 5‑diphenyltetrazolium bromide assay kit. The cell migration and invasion abilities were detected using wounding‑healing assays and Transwell assays. Flow cytometric analysis was performed to investigate the cell cycle distribution and cell apoptosis. The activity of nuclear factor (NF)‑κB (p65), cyclooxygenase‑2 (COX‑2) and peroxisome proliferator‑activated receptor γ (PPAR‑γ) were measured by reverse transcription‑quantitative polymerase chain reaction and western blot analyses, respectively. The results indicated that avicularin treatment markedly decreased cell proliferation concentration‑dependently in HCC, and inhibited cell migration and invasion in Huh7 cells. It was also found that the treatment of avicularin markedly inhibited the G0/G1‑phase cells and decreased the accumulation of S‑phase cells in the cell cycle and induced cell apoptosis. In addition, it was confirmed that the anticancer efficacy of avicularin in HCC was dependent on the regulation of NF‑κB (p65), COX‑2 and PPAR‑γ activities. In conclusion, the findings suggested that avicularin serves an antineoplastic role in HCC and may provide a potential therapeutic strategy for the treatment of HCC.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2019
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IF 5.107
Changlin Yu,Hongbo He,Wanqin Zhou,Zhen Liu,Longfu Wei
An interesting rugby-ball-like Zn 3 (PO 4 ) 2 @C 3 N 4 photocatalyst with well- controlled structures as high-efficient visible-light photocatalysts was synthesized via two steps of solvothermal-grinding calcination method. The composition, structure, morphology, and optical absorption properties of as-synthesized Zn 3 (PO 4 ) 2 @C 3 N 4 samples were intensively characterized by XRD, N 2 physical adsorption, SEM, TEM, FT-IR, UV–vis DRS, XPS, PL and photoelectrochemical measurements, respectively. The formation of C 3 N 4 shell obviously increased the surface area and induced the rich pore structures. The intimate interface between Zn 3 (PO 4 ) 2 and C 3 N 4 phase obviously enhanced the transport rate of photogenerated carriers and restrained the recombination of photogenerated electrons and holes. The optimal Zn 3 (PO 4 ) 2 @C 3 N 4 (35 wt%) exhibited the highest adsorption and photocatalytic activity in the degradation of methylene blue (MB), which was 150 and 7.5 times as high as C 3 N 4 , respectively. Moreover, the robust Zn 3 (PO 4 ) 2 @C 3 N 4 nanoheterojunctions fabricated by this grinding-calcination route have high stability in recycling reactions.
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Micro & Nano Letters
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2019
·Vol. 14
·期 7
·749-752
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IF 0.975
Li Hong Qian,Xiao Cai Liang,Hua lan Zhou
The Ni(OH) 2 /NiOOH nanoparticles (NPs) electrodeposited on a glassy carbon electrode (GCE) in Ni(NO 3 ) 2 and NH 3 ·H 2 O aqueous solution for the electrode materials. Then the nickel hydroxide/oxyhydroxide acetate was formed in acetate solution. The effects of deposition conditions such as the concentration of Ni(NO 3 ) 2 solution, the number of sedimentary cycles, the concentration of acetate in the soaking liquid and the soaking time are discussed in detail. The electrochemical properties of the material have been investigated by cyclic voltammetry, Tafel curve, EIS and amperometric i–t curve techniques. The result displays excellent electrocatalytic activity towards the electrocatalytic oxidation of urea in alkaline solution. Furthermore, the modified electrode for oxidation reaction has the advantages of simple preparation, good electrochemical properties and stabilisation.
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APPLIED CLAY SCIENCE
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2019
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IF 3.89
Shangying Li,Hongping He,Qi Tao,Yunfei Xi,Aiqing Chen,Shichao Ji,Chaoqun Zhang,Yiping Yang,Jianxi Zhu
In this study, beidellite , paragonite and other 2:1 type layered aluminosilicates with high layer charges (2:1 type LA-HLC) were synthesized under hydrothermal conditions by using boehmite as a precursor. The concentrations of dissolved Al from boehmite precursor had important effects on the mineral components of the hydrothermal products and the layer charge density of the resultant minerals. A combination of 2:1 type LA-HLC, paragonite, and minor beidellite formed at a relatively high concentration of dissolved Al, while beidellite with a small amount of 2:1 type LA-HLC was produced at a low concentration of dissolved Al. The resultant 2:1 type LA-HLC exhibited poor swelling ability when treated with ethylene glycol. A solid-state transformation mechanism was proposed for the transformation based on the HRTEM images and EDS analyses, which showed that lattice fringes representing (001) faces of 2:1 type layered aluminosilicates (2:1 type LA) were parallel to the (020) direction of boehmite. The successful transformation of boehmite into 2:1 type LA provides insights to well understand the formation of 2:1 type LA in geological processes and offer a facile preparation approach for the synthesis of 2:1 type LA with different layer charges.
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