Science China-Chemistry
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2025
·
IF 9.7
Xu Xihan,Li Juan-Juan,Li Jiamin,Zhang Hui-Yan,Qi Yilin,Shi Bing-Sen,Li Tianqi,Su Shan-Shan,Zhao Weitao,Chen Chang,Gong Zhongying,Liu Huiyu,Wang Ke-Rang,Guo Dong-Sheng,Xue Xue
The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window, resulting in high rates of disability and mortality. Combination therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke treatment. Here we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke, which utilizes calixarene as a building block to effectively load the neuroprotective drug simvastatin. The calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1) on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic conditions. Additionally, the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses, achieving a multistage therapeutic approach that transitions from targeting to release and finally to treatment. This approach combines anti-inflammation and neuroprotection, providing a multi-level treatment strategy. This system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO), demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO induction. This work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.
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JOURNAL OF MATERIALS SCIENCE
·
2025
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IF 3.9
Liu Tingrui,Zhang Jiahui,Zhong Zixi,Huang Xiaofeng,Yu Jian,Wang Yuan,Yuan Shaojun
Nanocomposites consisting of conducting polymers and metal oxide are promising material in electrochemical energy storage. The design of nanostructure is regarded as an efficient strategy to improve electron and ion transfer. However, the construction of nanocomposites usually needs multistep reaction. Herein, a poly(3,4-ethylenedioxythiophene)-encapsulated iron oxide/carbon nanotube nanocomposite (Fe 2 O 3 /CNTs@PEDOT) is demonstrated as an efficient anode for aqueous supercapacitors. The Fe 2 O 3 /CNTs nanocomposite is firstly constructed by a rapid combustion strategy, which provided electrode a good hydrophilic ability. The PEDOT is further in situ constructed on the surface of Fe 2 O 3 /CNTs by an electrochemical polymerization process for enhancing the cycling stability. The Fe 2 O 3 /CNTs@PEDOT electrode delivers an enhanced ions transfer and stability during the charge/discharge process. In 1 M Na 2 SO 4 , such Fe 2 O 3 /CNTs@PEDOT-180 s electrode delivers a specific capacitance of 1014 mF cm −2 at 2 mA cm −2 and retains 89.7% of initial capacitance at 20 mA cm −2 after 3000 cycles, which is superior than that of the Fe 2 O 3 /CNTs electrode (79.2%). The asymmetric aqueous supercapacitor consisted of Fe 2 O 3 /CNTs@PEDOT and MnO 2 /CC electrodes with an operating potential of 2.0 V reaches a high areal energy density of 0.207 mWh cm −2 at a power density of 2.0 mW cm −2 . Graphical abstract
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International Journal of Environmental Research
·
2024
·Vol. 18
·期 6
·1-16
·
IF 2.6
Gao Yu-qiong,Ma Jia-xin,Rao Yan-yan,Chen Ju-xiang,Gao Nai-yun
Bezafibrate (BZF), an extensively used lipid-regulating agent, has been frequently detected in aqueous environments. In this work, we systematically investigated the Fe(II)/sulfite process for degrading BZF and its impact on disinfection byproducts (DBPs) during postchlorination. Degradation conditions were optimized by adjusting the pH, sulfite concentration, Fe(II), and BZF concentration. Under the conditions of pH = 4, [BZF] 0 = 5 μM, [Fe(II)] 0 = 25 μM, and [sulfite] 0 = 250 μM, the BZF removal efficiency reaches 97.9% in 15 min. Sulfate radicals (SO 4 ●– ) and singlet oxygen ( 1 O 2 ) are recognized as the main reactive agents, with Fe(IV) also contributing to the removal of BZF. Common anions (Cl − and HCO 3 − ) and humic acid generally impede the degradation process, except that trace amounts of Cl − can slightly accelerate BZF degradation. A total of ten products are recognized by ultra high performance liquid chromatography and quadrupole time-of-flight mass spectrometry, and four major degradation pathways are proposed: hydroxylation, cleavage of amino bonds, removal of fibrate chains, and dechlorination. Meanwhile, the toxicity assessment shows that the majority of products exhibit lower biological toxicity and less bioaccumulation potential than BZF itself. The Fe(II)/sulfite pretreatment alters the DBP formation potential, especially when Br − is present. The formation of trichloromethane (TCM) is diminished following pretreatment with the Fe(II)/sulfite process, whereas a noticeable increase in the formation of dichloroacetonitrile (DCAN) is found. Moreover, Fe(II)/sulfite pretreatment enhances the formation of brominated DBPs. Therefore, special consideration should be given to DBP formation when a Fe(II)/sulfite system is employed as a pretreatment for the removal of BZF in water. Graphical abstract
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 11
·1-15
·
IF 5.3
Zhang Shiyu,Chen Xin,Hu Shuai,Cai Ke,Peng Chenxi,Luo Lixia,Gu Yingying,Mei Yong
An electrochemical biosensor was created to identify the liver cancer marker alpha-fetoprotein (AFP) by employing nanocomposite materials. A combination of reduced graphene oxide (rGO) and molybdenum disulfide (MoS 2 ) was selected as the substrate material for the sensor to prepare the PtNPs/MoS 2 @rGO electrochemical immunosensor. Among them, rGO has strong conductivity and MoS 2 provides a large surface area for the anchoring of PtNPs for better attachment to the hybridized nanomaterials. Meanwhile, PtNPs exhibit consistent biocompatibility and excellent electrocatalytic activity. PtNPs also attach to hybrid nanomaterials and bind the antibody via the Pt–S bond, thereby furnishing the antibody with multiple binding sites for enhanced antibody adhesion. The immunosensor achieved ultra-sensitive AFP detection by exploiting the specific antigen–antibody binding. The structure and morphology of the PtNPs/MoS 2 @rGO composites were investigated by transmission electron microscopy (TEM), energy dispersive X-ray (EDS) spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and Raman spectroscopy, and the sensor was electrochemically characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Under optimized conditions, using differential pulse voltammetry the biosensor detected AFP in serum within a linear range of 1 ~ 10 5 pg/mL, with a correlation coefficient ( r 2 ) of 0.9989, and a detection limit of 0.12 pg/mL ( S / N = 3). The method offers a new approach for the ultrasensitive detection of serum AFP and is extremely selective, accurate, and precise with a relative standard deviation (RSD) of less than 6%. It has been successfully applied to the analysis of real human blood samples. Graphical
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Advanced Composites and Hybrid Materials
·
2024
·Vol. 7
·期 4
·1-12
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IF 23.2
Lu Yukun,Zhang Yaojie,Zhang Jiale,Li Zhaoyang,Hu Feiyang,Pan Duo,Melhi Saad,Shi Xuetao,Amin Mohammed A.,El-Bahy Zeinhom M.,Shao Qian
Tin (Sn) micro-nanoparticles with special pine tree dendritic morphology were synthesized by using tin foil as the anode and titanium as the cathode through simple anodization method. Surprisingly, it is found that the morphology of Sn particles is closely related to factors such as the type of electrolyte, the concentration of the electrolyte, and the different applied voltages, and briefly discussed the influence of various factors on the growth of Sn particles. In addition, Sn particles are calcined under different temperature conditions to obtain Sn/SnO 2 hybrid materials with different tin dioxide (SnO 2 ) contents. The changes in morphology and the phase of SnO 2 crystal lattices were characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD), respectively, which proved the successful synthesis of Sn/SnO 2 mixed materials. Finally, the Sn/SnO 2 hybrid material with metal-doped modified semiconductor properties was used to photocatalytic degradation of simulated organic pollutants rhodamine B (RhB). It was found that the photocatalytic degradation efficiency of the Sn/SnO 2 hybrid material under simulated sunlight conditions is near 90% in 5 h. Therefore, this work provides a convenient and effective environmental protection approach for the treatment of architecture and industrial dyes. Graphical Abstract Tin (Sn) micro-nanoparticles with special pine tree dendritic morphology are synthesized through simple anodization method, and the final product Sn/SnO 2 particles after different heat treatments show superior photocatalytic degradation of RhB under simulated solar light.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-13
·
IF 14.7
Wu Yuhan,Zhao Yuying,Yuan Qixin,Sun Hao,Wang Ao,Sun Kang,Waterhouse Geoffrey I. N.,Wang Ziyun,Wu Jingjie,Jiang Jianchun,Fan Mengmeng
Carbon nanomaterials show outstanding promise as electrocatalysts for hydrogen peroxide (H 2 O 2 ) synthesis via the two-electron oxygen reduction reaction. However, carbon-based electrocatalysts that are capable of generating H 2 O 2 at industrial-level current densities (>300 mA cm −2 ) with high selectivity and long-term stability remain to be discovered. Herein, few-layer boron nanosheets are in-situ introduced into a porous carbon matrix, creating a metal-free electrocatalyst (B n -C) with H 2 O 2 production rates of industrial relevance in neutral or alkaline media. B n -C maintained > 95% Faradaic efficiency during a 140-hour test at 300 mA cm −2 and 0.1 V vs. RHE, and delivered a mass activity of 25.1 mol g catalyst −1 h −1 in 1.0 M Na 2 SO 4 using a flow cell. Theoretical simulations and experimental studies demonstrate that the superior catalytic performance originates from B atoms with adsorbed O atoms in the boron nanosheets. B n -C outperforms all metal-based and metal-free carbon catalysts reported to date for H 2 O 2 synthesis at industrial-level current densities.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
Feng Kaizheng,Wang Zhenzhen,Wang Shi,Wang Guancheng,Dong Haijiao,He Hongliang,Wu Haoan,Ma Ming,Gao Xingfa,Zhang Yu
Although Prussian blue nanozymes (PBNZ) are widely applied in various fields, their catalytic mechanisms remain elusive. Here, we investigate the long-term catalytic performance of PBNZ as peroxidase (POD) and catalase (CAT) mimetics to elucidate their lifespan and underlying mechanisms. Unlike our previously reported Fe 3 O 4 nanozymes, which exhibit depletable POD-like activity, the POD and CAT-like activities of PBNZ not only persist but slightly enhance over prolonged catalysis. We demonstrate that the irreversible oxidation of PBNZ significantly promotes catalysis, leading to self-increasing catalytic activities. The catalytic process of the pre-oxidized PBNZ can be initiated through either the conduction band pathway or the valence band pathway. In summary, we reveal that PBNZ follows a dual-path electron transfer mechanism during the POD and CAT-like catalysis, offering the advantage of a long service life.
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JOURNAL OF NANOPARTICLE RESEARCH
·
2024
·Vol. 26
·期 4
·1-10
·
IF 2.1
Van Thuy Vu,Trang Vu Thao,Chun Sangeun,Thu Tran Viet
As a promising electrode material for electrochemical energy storage, iron hexacyanoferrate (FeHCF) possesses diverse structures and properties that strongly relate to synthetic conditions. In this work, we synthesized FeHCFs by co-precipitation route and studied the influence of two surfactants (sodium citrate and potassium bitartrate) on the material characteristics and K + storage properties of the resulting FeHCFs. Electrochemical measurements revealed that the FeHCF synthesized in the absence of surfactants exhibited superior performance to those synthesized in the presence of either surfactant due to reduced electrical resistivity and improved diffusion kinetics. The assembled all-solid-state symmetric device delivered an areal capacitance of 3.24 mF cm −2 , a wide potential window (1.4 V), an energy density of 3.17 μWh cm −2 , and a power density of 315.7 μW cm −2 at a current density of 0.5 mA cm −1 , indicating its potential application for energy storage.
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JOURNAL OF PLANT GROWTH REGULATION
·
2024
·
IF 3.9
Luo Liping,Zhang Gaowei,Liang Wenjing,Wu Dong,Sun Qifang,Hao Yingbin
Broccoli microgreens represent a novel type of vegetable characterized by high levels of bioactive compounds. Here, we investigated the effects of light-emitting diode (LED) light quality on the development and nutritional uptake of broccoli microgreens. The plants were exposed to five distinct light treatments: white, single red, and red: blue at 5:1, 5:3, and 5:5 ratios. The soluble sugars, nutrients, and secondary metabolites of broccoli sprout extracts were examined using high-performance liquid chromatography and ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry under various light-quality conditions. In addition, the expression levels of genes encoding important enzymes in the glucosinolates (GLs) biosynthesis pathway were examined using quantitative real-time polymerase chain reaction. Overall, the findings demonstrated that mixed red-blue light, especially the 5:1 red: blue ratio, was beneficial for broccoli microgreens in terms of their hypocotyl length, fresh weight, edible rate, soluble proteins, vitamin C, total phenolics, total flavonoids, and GLs. Our findings provide a foundation and reference point for selecting the most appropriate LED light ratio in microgreens production.
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Nature Sustainability
·
2024
·
IF 25.7
Liang Qirui,Huang Yanan,Guo Yaxin,Zhang Xin,Hu Xiaomeng,Zeng Hui,Liang Kang,Zhao Dongyuan,Jiang Lei,Kong Biao
Hydrogen, a clean energy carrier, has emerged as a promising solution to decarbonize the power sector and move towards a more sustainable future. However, the heavy dependence of its production on fossil fuels highlights the pressing need to prioritize the acquisition of green hydrogen from renewable sources, ideally without any additional energy input. Here we utilize the osmotic energy between seawater and freshwater to generate hydrogen directly. With a tandem of high-performance ion exchange membrane and electrocatalytic electrode, our design serves to harvest osmotic energy and drive hydrogen production. Notably, the integrated device demonstrates a consistent alkaline hydrogen evolution rate exceeding 300 l m −2 h −1 for more than 12 days under the artificial salinity gradient. Our study presents a viable pathway for hydrogen production through renewable sources.
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VETERINARY RESEARCH
·
2024
·Vol. 55
·期 1
·1-9
·
IF 3.7
Yang Jia,Li Li,Xu Fuqiang,Jia Fan
Feline herpesvirus type 1 (FHV-1), a member of the Herpesviridae family, is one of the most important pathogens that causes upper respiratory tract disease in felines. Following infection, FHV-1 can spread retrogradely to the trigeminal ganglia, establishing a life-long latency. Although vaccines are available for routine feline vaccination, FHV-1 is still an agent that poses a serious threat to feline health. There are currently no specific drugs for the treatment of FHV-1. To facilitate the screening of antiviral drugs, we constructed a reporter FHV-1 virus, which expresses a secreted Gaussia luciferase (GLuc) and a bright green fluorescent protein, mNeonGreen. The reporter virus shows slower growth than does the wild-type FHV-1. The expression of the two reporter genes, Gluc and mNeonGreen, was consistent with viral propagation and remained stable during continuous passage in CRFK cells, even after twenty rounds. In addition, the known inhibitor ganciclovir was used to confirm the characteristics of the reporter virus for drug screening. We found that the reporter FHV-1 is suitable for antiviral screening assays. Overall, our work provides a useful tool for screening drugs to combat FHV-1.
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 9
·1-15
·
IF 5.3
Guo Jieli,Li Jin,Xing Xiujing,Xiong Wei,Li Hao
As an ideal transition metal oxide, Co 3 O 4 is a P-type semiconductor with excellent electrical conductivity, non-toxicity and low cost. This work reports the successful construction of Co 3 O 4 materials derived from metal-organic frameworks (MOFs) using a surfactant micelle template-solvothermal method. The modified electrodes are investigated for their ability to electrochemically detect Pb 2+ and Cu 2+ in aqueous environments. By adjusting the mass ratios of alkaline modifiers, the morphological microstructures of Co 3 O 4 -X exhibit a transition from distinctive microspheres composed of fiber stacks to rods. The results indicate that Co 3 O 4 -1(NH 4 F/CO(NH 2 ) 2 = 1:0) has a distinctive microsphere structure composed of stacked fibers, unlike the other two materials. Co 3 O 4 -1/GCE is used as the active material of the modified electrode, it shows the largest peak response currents to Pb 2+ and Cu 2+ , and efficiently detects Pb 2+ and Cu 2+ in the aqueous environment individually and simultaneously. The linear response range of Co 3 O 4 -1/GCE for the simultaneous detection of Pb 2+ and Cu 2+ is 0.5–1.5 μM, with the limits of detection (LOD, S/N = 3) are 9.77 nM and 14.97 nM, respectively. The material exhibits a favorable electrochemical response, via a distinctive Co 3 O 4 -1 microsphere structure composed of stacked fibers. This structure enhances the number of active adsorption sites on the material, thereby facilitating the adsorption of heavy metal ions (HMIs). The presence of oxygen vacancies (O V ) can also facilitate the adsorption of ions. The Co 3 O 4 -1/GCE electrode also exhibits excellent anti-interference ability, stability, and repeatability. This is of great practical significance for detecting Pb 2+ and Cu 2+ in real water samples and provides a new approach for developing high-performance metal oxide electrochemical sensors derived from MOFs. Graphical abstract
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