International Journal of Nanomedicine
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2026
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IF 8.7
Zidong Wu,Kai Ma,Zixuan Wu,Xiaoyu Guo,Yuning Qu,Zheyue Zhu,Weidong Zhu,Chengxin Li,Yi Liu,Rui Ma,Pei Yang
Background Polyetheretherketone (PEEK) is a promising orthopedic implant material due to its bone-matched elastic modulus and radiolucency. However, its clinical application is limited by biological inertness and lack of antibacterial activity, which predispose to implant-associated infection (IAI) and poor osseointegration. This study developed a multifunctional coating on sulfonated PEEK (SPEEK) via polydopamine (PDA)-mediated co-delivery of simvastatin-loaded ZIF-8 nanoparticles (SIM@ZIF-8) and moxifloxacin (MOX) to address these limitations.Methods A time-programmed release coating was fabricated on SPEEK by embedding SIM@ZIF-8 within a PDA layer and surface-loading MOX onto the surface. The coating’s physicochemical properties, drug release profiles, biocompatibility, antibacterial activity, and osteogenic capacity were evaluated in vitro. Antibacterial efficacy and osseointegration were further assessed in vivo using rat subcutaneous infection and rabbit femoral defect models.Results Release profiles revealed that MOX exhibited burst release within 24 h, whereas SIM quickly reached therapeutic concentrations during the initial phase and was slowly released over five weeks, while Zn2+ from ZIF-8 was released synchronously with SIM. In vitro antimicrobial assays showed that the synergistic release of MOX and SIM exhibited potent antibacterial activity against Staphylococcus aureus and Escherichia coli, providing sustained inhibition of Staphylococcus aureus biofilms. The coating also promoted MC3T3-E1 cell adhesion, spreading, and osteogenic differentiation, as indicated by upregulated osteogenic markers (Runx2, OCN, OPN, COL1A1), enhanced matrix mineralization, and increased BMP-2 expression. In rat models, bacterial colonization on the coated surface and residual bacteria in tissues were significantly reduced. In rabbit femoral defects, sustained co-release of SIM and Zn2+ accelerated new bone formation and improved osseointegration, confirmed by micro-CT, double fluorescence labeling, and histological analysis.Conclusion This study presents a novel bioactive PEEK implant coating integrating antibacterial and osteogenic functions through a MOX/SIM@ZIF-8/PDA system. The strategy effectively combats IAI and enhances osseointegration, offering potential for clinical orthopedic applications.
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PubMed
高影响因子
Materials Today Communications
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2026
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IF 4.9
Wenhui Pei,Xiaofei Li,Haojun Chen,Xiangrong Guo,Jinhui Pang,Yingjie Du,Yuanyuan Xie,Peng Wang,Caoxing Huang
The intertwined pathology of bacterial infection and dysregulated inflammation represents a major barrier to the healing of full-thickness skin wounds. Nanocarriers such as zeolitic imidazolate framework-8 (ZIF-8) provide efficient platforms for localized and pH-dependent drug delivery. In this study, a ZIF-8 nanoparticle system co-embedded with vancomycin (Van) and iron oxide nanoparticles (IONPs), termed Van-IONPs@ZIF-8, was engineered to combine antibacterial and inflammation-modulating functions. In vitro experiments demonstrated growth-inhibitory activity against Staphylococcus aureus ( S. aureus ) and modulation of inflammatory cytokine expression in LPS-stimulated RAW 264.7 macrophages, with TNF-α mRNA expression decreased by 67% and IL-10 mRNA expression increased by 244%. The nanocomposite was incorporated into a triple-crosslinked hydrogel matrix, and the resulting Van-IONPs@ZIF-8-Gel exhibited sustained and pH-dependent Van release under the tested conditions. In a rat full-thickness S. aureus -infected wound model, Van-IONPs@ZIF-8-Gel treatment was associated with improved wound closure, lower recoverable bacterial colony counts, attenuated inflammatory markers, and increased collagen-positive area. These findings provide proof-of-concept evidence supporting Van-IONPs@ZIF-8-Gel as an integrated antibacterial and inflammation-modulating platform for infected-wound management. Download: Download high-res image (248KB) Download: Download full-size image An engineered ZIF-8 composite hydrogel co-delivering vancomycin and iron oxide nanoparticles provides combined antibacterial and inflammation-modulating functions.
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FOOD RESEARCH INTERNATIONAL
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2026
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IF 8.8
Bin Liu,Miaohuan Xiong,Wanlin Sun,Huipeng Wu,Jialu Li,Yuqi Wang,Qing Wang,Jian He,Xuelan Chen
Ochratoxin A (OTA) is a widespread mycotoxin contaminating cereals, grape products, coffee, and spices, threatening global food safety and human health. Efficient detoxification strategies are therefore urgently needed. Herein, an OTA-degrading bacterium, Terribacillus saccharophilus JX-8, was isolated from Chinese sauerkraut juice, which completely degraded 12.4 μM OTA within 12 h via amide bond hydrolysis to yield non-toxic ochratoxin α (OTα). A novel OTA amidohydrolase OtaH was identified, sharing only 33%–42% sequence identity with previously characterized homologs. OtaH exhibited high catalytic efficiency ( k cat / K m = 4028.57 mM −1 min −1 ) and remarkable thermostability, retaining >50% activity after incubation at 65 °C for 1 h. Moreover, 5 μg/mL OtaH achieved 64.9% and 94.6% degradation of OTA in grape juice and wheat flour, respectively, within 2 h at 25 °C, reducing residual OTA to 1.76 μg/L and 0.54 μg/kg. Notably, enzymatic treatment did not significantly alter pH, soluble solids content, titratable acidity, polyphenol content, or nutritional composition. This study provides a promising enzymatic strategy for OTA detoxification in food processing.
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高影响因子
Applied Materials Today
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2026
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IF 7
Xiaowan Zhao,Qikai Qiao,Yuanqing Li,Aiqin Zhang,Hong Guo,Jing Guo,Haixia Zhang,Jianjun Lu
To address the issue of secondary contamination caused by the lack of antibacterial properties in polypropylene (PP) meltblown nonwoven fabrics while preserving its core filtration performance, this work employed an immersion-ultrasonic method to construct Ag@T-ZIF-8 antibacterial materials with a core-shell structure. Subsequently, PP/Ag@T-ZIF-8-G composite meltblown fibers was prepared via covalent modification and meltblown spinning technology. The systematic characterization of Ag@T-ZIF-8 was conducted in terms of its chemical structure, microstructure, and photocatalytic antibacterial performance. The effects of Ag@T-ZIF-8 on the antibacterial, filtration and comfort properties of the composite melt-blown nonwoven fabrics were investigated, and the enhancement mechanisms of antibacterial and filtration were revealed. The results indicate that Ag@T-ZIF-8 exhibits a uniform core-shell structure with a particle size of 40∼50 nm and a specific surface area of 531.83 m²/g. At an antibacterial concentration of 200 mg/L, it achieves a 99.99% antibacterial rate against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) within 8 min in the dark or 4 min under illumination. Compared with PP meltblown nonwoven fabrics, it demonstrates 73.31% in filtration efficiency for particles with a pressure drop of only 37.3 Pa. When Ag@T-ZIF-8 loading reaches 1 wt%, the composite meltblown fabrics completely eliminates E. coli and S. aureus after 160 min of illumination or 240 min in the dark. This outstanding comprehensive filtration performance stems from a synergistic filtration mechanism combining mechanical filtration, ionic adsorption, and dual-mode antibacterial action under light or dark condition. Integrating superior filtration capabilities, broad-spectrum antibacterial properties, and wear comfort, PP/Ag@T-ZIF-8-G meltblown nonwoven fabrics deliver a highly efficient integrated antibacterial-filtration solution for the medical protective field.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Hao Zhan,Wenlong Chen,Xingyu Pei,Hao Wang,Bing Zhao,Xiefei Wang,Qingqing Liang,Yukang Xu,Weiwei Zhu
Highly diffuse cationic dyes and copper ions are normal pollutants in dye wastewater and pose a potential ecological risk, threatening human health. However, current MOF-based fibrous composites usually scarify their stability of active sites for photocatalytic reaction, which inevitably causes nondurable removal of these diffuse particles. Here, an in situ growth strategy was proposed to fabricate robust core-shell heterostructure of ZnO@ZIF-8 nanorods which were anchored within polytetrafluoroethylene (PTFE) micro-scale fibers by the solution-blowing spinning (SBS) technique to achieve ZnO@ZIF-8/PTFE hierarchical fibrous networks (ZZP-HFN). It presents superior degradation of cationic dyes (over 97%) and durable decompose stability of more than 20 cycles, and prominent adsorption capacity for copper ions (86.53 mg/g). Moreover, contrast to the existing MOF-based fibrous membranes, ZZP-HFN exhibits the self-cleaning performance on account of its stable composite structure between ZnO@ZIF-8 nanorods and PTFE fiber. The cationic dyes removal of ZZP-HFN from wastewater is attributed to the synergistic effect of adsorption and photocatalytic ability. This work provides an insight to design advanced MOF-based composites with durable photocatalytic performance for dye wastewater purification.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.6
Yuze Jiao,Zeyuan Li,Haoyu Zheng,Huiqi Jiangjia,Hui Yang,Qilong Zhang
The thermally conductive functional material ZIF-8/BN was co-loaded onto the fiber via electrostatic self-assembly. • The effects of stabilization heat treatment on the morphology and properties of the reinforcement were investigated. • The roles of uniform ZIF-8 and ZIF-8/BN nanoparticles loaded at the resin-reinforcement interface were analyzed. • Composites obtained solely via reinforcement functionalization showed excellent thermal expansion and thermal conductivity. Polytetrafluoroethylene (PTFE) is widely used in high-frequency substrate materials due to its favorable dielectric constant and excellent thermal stability. However, its high coefficient of thermal expansion (CTE) and low thermal conductivity cause some processing challenges. Herein, we report a modified reinforcement, designated ZIF-8/BN@GF (ZB@G), which was fabricated by electrostatically assembling thermally conductive BN (boron nitride) with the metal-organic framework (MOF), followed by in-situ growth onto glass fibers (GF) through an impregnation process. Thermal stabilization was found to markedly enhance the structural compactness and moisture resistance of the fibers during processing. The rough surface morphology of the MOF facilitates mechanical interlocking and resin infiltration into its porous structure, thereby strengthening the interfacial bonding between the reinforcement and the resin matrix and consequently improving the dimensional stability of the composites. Moreover, the uniform distribution of flat BN nanosheets along the fiber surface serves to regulate interfacial interactions, establish oriented thermal conduction pathways, and simultaneously tailor the thermal expansion behavior. As a result, the resulting PTFE composites exhibit a suitable in-plane CTE parallel to the reinforcement of 16.97 ppm/°C and a maximum thermal conductivity of 1.481 W·m −1 ·K −1 . In addition, they retain excellent dielectric properties, achieving a low dielectric constant of 2.39 and a low dielectric loss of 0.00145 at 10 GHz. This work demonstrates that a straightforward in-situ loading of nano-functional materials onto reinforcements can concurrently deliver substantial improvements in thermal conductivity and mechanical performance, providing a promising strategy for the selection of reinforcements in next-generation high-frequency substrate materials. Download: Download high-res image (155KB) Download: Download full-size image
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ENVIRONMENTAL RESEARCH
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2026
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IF 8.2
Yisong Zhu,Ying Zhou,Zhikai Zhu,Guangfeng Zhang,Wei He,Yumei Chen,Pengchao Li,Weichong Long,Shuohai Fang,Hui Luo,Changzhong Liao
Efficient capture of radioactive iodine isotopes from nuclear waste is crucial for environmental protection and human health. In this study, a high-entropy strategy was introduced into the zeolitic imidazolate framework-8 (ZIF-8) system to overcome the inherent limitations of conventional monometallic ZIF-8 and to elucidate entropy-regulated iodine capture behavior. Using a solvothermal method assisted by triethylamine (TEA), a series of ZIF-8 derivatives with entropy levels ranging from low to high were successfully synthesized to explore the relationship between entropy level and iodine adsorption performance. Furthermore, given that Cd incorporation has been reported to enhance the structural flexibility of ZIF-8, the influence of different Zn/Cd ratios was investigated. Characterization results showed that although TEA enhanced the doping efficiency of poorly coordinating metal ions, it simultaneously reduced crystallinity and BET surface area, leading to pore blockage and a substantial decline in iodine adsorption performance. Iodine adsorption did not show a positive correlation with increasing compositional complexity. The synergistic effects of multimetal nodes did not improve the iodine uptake capacity of ZIF-8, and the high-entropy ZnCdCoMgNi-ZIF-8 exhibited the lowest iodine uptake capacity (1.10 g⋅g −1 ). In contrast, Cd doping increased the iodine uptake capacity to 2.80 g g −1 in phase-pure Cd-ZIF-8, corresponding to a 2.2-fold enhancement over conventional ZIF-8. Moreover, a structural phase transition was induced during iodine adsorption in Cd-rich systems. This work provides important insights into the design of high-performance iodine capture materials and highlights the potential of cadmium-modified ZIF-8 derivatives as promising adsorbents.
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JOURNAL OF HAZARDOUS MATERIALS
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2026
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IF 10.6
Hanlin Li,Shuangqin Tian,Xin Wang,Yujing Long,Tianhong Ye,Lihong Tang
When used individually, ZIF-8 suffers from hydrolysis in aqueous media, while CAU-17 is limited by its low specific surface area (64.71 m²/g). Therefore, we employed an in situ self-assembly strategy to construct a MOF-on-MOF heterostructure (CAU-17@ZIF-8) for the synergistic removal of Cd(II) and methylene blue (MB). The composite achieved maximum adsorption capacities of 607.65 mg/g for Cd(II) and 1025.38 mg/g for MB, with a 99% removal efficiency for low-concentration pollutants in real wastewater. Even after five cycles, 75% efficiency was maintained. Mechanistic studies combining batch experiments, characterization, and DFT calculations revealed that the heterojunction interface promotes substantial charge transfer from CAU-17 to ZIF-8, significantly enhancing electrostatic attraction toward cations. Simultaneously, new mesopores formed at the interface increase the specific surface area (239.62 m 2 /g) and provide rapid mass-transfer channels. MB adsorption is governed by electrostatic attraction, hydrogen bonding, and π-π interactions, while Cd(II) adsorption relies on ion exchange, coordination, and electrostatic attraction. This work demonstrates that constructing MOF-on-MOF heterojunctions is a promising strategy to overcome the intrinsic limitations of single MOFs in water remediation, thereby greatly enhancing the adsorption capacity toward methylene blue (MB) and Cd(II).
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POLYMER COMPOSITES
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2025
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IF 4.7
Yiwen Chen,Yinlong Li,Xulin Yang,Fei Zhu,Hongshan Jia,Hongyi Zhang,Yingqing Zhan
The two-dimensional MXene holds tremendous potential for enhancing the corrosion resistance of waterborne epoxy (WEP) coating. However, its long-term application is limited by the poor dispersion and high conductivity of MXene. Herein, a pH-responsive composite filler of polydopamine modified MXene/zeolitic imidazolate framework-8 (ZIF-8) loaded with benzotriazole (BTA) was constructed by anchoring ZIF-8 loaded with BTA onto the MXene carrier via electrostatic interaction (MMB), which was applied as an effective shielding layer for waterborne epoxy coatings. The rational design offered the synergy of corrosion inhibition and the labyrinth effect, which remarkably improved the active-passive anticorrosion performance of WEP composite coatings. The electrochemical test revealed that the low-frequency impedance (|Z| 0.01Hz ) of the MMB/WEP composite coating reached 1.83 × 10 9 Ω·cm 2 after long-term immersion in electrolyte solution (3.5 wt% NaCl, 55 days). Benefiting from the good dispersion state and the interface compatibility of functionalized MXene via polydopamine and BTA loaded ZIF-8, the mechanical strength of the MMB/WEP composite coating was also effectively enhanced. In addition, the anticorrosion mechanism of the composite coating was proposed. This study proposes an alternative strategy for MXene functionalization and shows the promising application of MXene/WEP composite coating in the area of metal protection.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Xiao Zhang,Qi Yu,Jingmiao Zhou,Bin Luo,Jie Li,Rong Gao,Mengdan Li,Bo Cui,Jing Chen
Oil spills and oily wastewater pose severe threats to marine ecosystems and public health, necessitating the development of materials capable of high-performance and durable separation. Herein, a dopamine-based three-in-one strategy was employed to form a zeolitic imidazolate framework-8 (ZIF-8)/reduced graphene oxide (RGO) nanocoating in situ on the surface of polyurethane (ZRP) foam, thereby synthesizing a composite foam with a layered structure. The ZRP foam exhibits excellent hydrophobic/oleophilic properties, with an adsorption capacity for organic solvents as high as 98.76 g/g. Under gravity, the foam achieves an oil-water separation efficiency of 99.2% while effectively repelling water. For surfactant-stabilized water-in-oil emulsions, the compressed ZRP foam shows a separation efficiency of 99.8% and a flux of 664 L·m −2 ·h −1 . The material retains over 97% of its initial absorption capacity after 100 adsorption-desorption cycles and maintains structural and functional stability under harsh chemical (pH 5–14), thermal (−30 °C to 100 °C), and mechanical (compression, torsion, abrasion) conditions. Furthermore, the ZRP foam demonstrates remarkable photothermal conversion capability, which significantly reduces the viscosity of heavy oils under illumination and thereby enhances separation efficiency, including solar-assisted recovery of crude oil. This study offers a robust and sustainable strategy for oil-water separation and environmental remediation in oilfields.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Li Ming,Ning Li,Hongyan Zhang,Xiaobo Zou,Can Zhang
A “all-in-one” nanolabel APZ was constructed. • High Nbs coupling, dual spectral overlap, visible absorption, pH-triggered catalysis. • The three orthogonal signals enhance reliability and enable flexible applicability. • ZIF-8 “enrichment–confinement–pH-triggered collapse” synergy boosts catalysis. • Stabilize Au Pt heterostructure via ZIF-8–enabled physical isolation and protection. Conventional lateral flow immunoassay (LFIA) suffers from limited sensitivity due to single-signal readout, low antibody conjugation efficiency, and steric hindrance associated with bulky conventional antibodies. Herein, we developed a multimodal LFIA employing Au@Pt@ZIF-8 (APZ) as a multifunctional nanolabel, prepared by encapsulating flower-like Au@Pt nanoparticles (Au@Pt NPs) within a ZIF-8 framework. Benefiting from its high specific surface area and mesoporous structure, APZ significantly enhanced the coupling efficiency and stability of anti-3-phenoxybenzoic acid nanobodies (3-PBA Nbs), achieving a coupling efficiency of 94.75% under identical conditions, compared with 69.61% for Au@Pt NPs. APZ further exhibits a broad absorption spectrum, fluorescence quenching due to dual spectral overlap, and high catalytic activity arising from the intrinsic peroxidase-mimicking activity of Au@Pt, synergistically enhanced by ZIF-8 enrichment/confinement and pH-triggered framework collapse. These features enabled the integration of three orthogonal readout modes, namely aggregation-induced coloration, catalysis-induced chromogenesis, and fluorescence quenching, into a single test strip. The resulting multimodal APZ-LFIA attains limits of detection (LOD) for 3-PBA of 0.004 ng/mL, 0.001 ng/mL, and 0.0003 ng/mL, respectively. By integrating multiple complementary signals, this strategy offers a flexible and reliable platform for trace 3-PBA analysis and shows great promise for on-site food safety monitoring. Download: Download high-res image (87KB) Download: Download full-size image
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高影响因子
JOURNAL OF MOLECULAR STRUCTURE
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2026
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IF 4.9
Di-Ming Chen,Yu-Ting Shi,Xue-Jing Zhang,Shao-Ming Fang
A robust Al-MOF built from octanuclear [Al 8 (μ 2 -OH) 8 (COO) 12 ] clusters with oxygen-rich 1D channels has been prepared. • It exhibits a high C₂H₆ uptake of 147.6 cm 3 /g and an IAST selectivity of 1.69 for equimolar C 2 H 6 /C 2 H 4 at 298 K and 1 bar. • The separation potential (ΔQ = 1.42 mmol/g) outperforms many reported Al-MOFs, reflecting a balanced capacity–selectivity trade-off. • Combined GCMC, DFT, and MD simulations reveal that multiple C–H···O contacts and greater charge transfer govern the ethane preference. The separation of ethane (C 2 H 6 ) from ethylene (C 2 H 4 ) represents a critically important yet highly challenging process in the petrochemical industry, as these two hydrocarbons possess nearly identical molecular sizes and boiling points. In this work, we report the C 2 H 6 adsorption and separation performance of a three-dimensional aluminum-based metal–organic framework (Al-MOF) constructed from octanuclear aluminum clusters and a tricarboxylate linker, featuring one-dimensional channels decorated with abundant strongly electronegative oxygen atoms originating from coordinated formate groups and μ 3 -OH moieties. The presence of these electron-rich oxygen sites creates a polar pore environment that establishes multiple C–H···O short interactions with C 2 H 6 molecules, thereby imparting a distinct recognition preference toward the paraffin over the olefin. Upon activation, the material exhibits a C 2 H 6 adsorption capacity of 147.6 cm 3 /g at 298 K and 1 bar. The ideal adsorbed solution theory (IAST) selectivity for an C 2 H 6 /C 2 H 4 (10/90) mixture reaches 1.69 at 298 K and 1 bar. Furthermore, the separation potential (Δ Q ), which integrates both adsorption capacity and selectivity, is determined to be 1.42 mmol/g, indicating a well-balanced performance profile. The different adsorption performance of 1a toward C 2 H 6 /C 2 H 4 was thoroughly studied via a combination of GCMC, DFT and MD calculations, which demonstrates that deliberate introduction of electron-rich oxygen functionalities into the pore walls of Al-MOFs represents an effective strategy for enhancing ethane-selective adsorption, positioning the present material as a competitive candidate for energy-efficient ethylene purification. Graphical -Synopsis A robust Al-MOF with octanuclear clusters and oxygen-rich pore walls was synthesized for C 2 H 6 /C 2 H 4 separation. It exhibits preferential C₂H₆ adsorption (147.6 cm 3 /g at 298 K, 1 bar), an IAST selectivity of 1.69 for equimolar mixtures, and a separation potential of 1.42 mmol/g. Combined GCMC, DFT, and MD simulations reveal that stronger C–H···O hydrogen bonding and greater charge difference lead to a more favorable host–guest interaction energy (–1.34 vs. –1.27 eV) for ethane. This work demonstrates that engineering electronegative oxygen sites in Al-MOFs is an effective strategy for energy-efficient ethylene purification. Graphical -Pictogram Download: Download high-res image (322KB) Download: Download full-size image
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危险品化学品经营许可证（带存储）