JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2012
·Vol. 23
·期 12
·2098-2103
·
IF 1.076
Zhou Dongxiang,Hao Liangbin,Gong Shuping,Fu Qiuyun,Xue Fei,Jian Gang
This paper presents the structural, ferroelectric, ferromagnetic, resonance and magnetoelectric (ME) properties of multilayered ME composites fabricated using tape casting method. The compositions corresponding to CoFe 2 O 4 (CFO) with particle size of ~150 nm and BaTiO 3 (BTO) with particle size of ~100 nm were chosen as ferromagnetic and ferroelectric phases, respectively. Delamination was found at the interface between CFO and BTO layers, which was related to the residual stress due to the difference in thermal expansion coefficient between the two layers. The largest direct magnetoelectric and converse magnetoelectric coefficients of the multilayered ME composite were, respectively, 36 μV/cm Oe at a bias magnetic field of 2,800 Oe and 1.16 × 10 −3 G/V at a frequency of 30 kHz. In addition, the corresponding interfacial coupling coefficient was calculated to be 3.2 × 10 −5 . For the multilayered ME composite, a resonance frequency of 4.96 MHz and a bandwidth of 40 kHz were obtained using capacitance-frequency spectrum method.
✓ 已验证
产品关联
DOI
高影响因子
CATALYSIS LETTERS
·
2012
·Vol. 143
·期 2
·200-205
·
IF 2.242
Zeng Yan,Wang Yanhua,Xu Yicheng,Song Ying,Jiang Jingyang,Jin Zilin
Abstract A thermoregulated ionic liquid and organic biphasic system composed of ionic liquid [CH 3 (OCH 2 CH 2 ) 16 N + Et 3 ][CH 3 SO 3
− ] (IL PEG750 ) with IL PEG750 -stabilized Pd nanoparticles and organic solvents, which allows for not only a highly efficient homogeneous catalytic reaction, but also an easy biphasic separation and reuse of catalyst attributed to the thermoregulated phase-transition property of the system, was employed for Heck reaction. The IL PEG750 -stabilized Pd nanoparticle catalyst exhibited high efficiency, more importantly, after reaction the Pd nanoparticle catalyst could be separated from products by simple phase separation and recycled for six times without evident loss of activity. Graphical Abstract A thermoregulated ionic liquid and organic biphasic system containing [CH 3 (OCH 2 CH 2 ) 16 N + Et 3 ][CH 3 SO
- 3
] (IL PEG750 )-stabilized Pd nanoparticles was applied to Heck reaction for the first time. The Pd nanoparticle catalyst exhibited high efficiency and good recyclability.
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-13
·
IF 14.7
Wu Shuyi,Luo Shulu,Cen Zongheng,Li Qianqian,Li Luwei,Li Weiran,Huang Zhike,He Wenyi,Liang Guobin,Wu Dingcai,Zhou Minghong,Li Yan
The sophisticated hierarchical structure that precisely combines contradictory mechanical and biological characteristics is ideal for biomaterials, but it is challenging to achieve. Herein, we engineer a spatiotemporally hierarchical guided bone regeneration (GBR) membrane by rational bilayer integration of densely porous N-halamine functionalized bacterial cellulose nanonetwork facing the gingiva and loosely porous chitosan-hydroxyapatite composite micronetwork facing the alveolar bone. Our GBR membrane asymmetrically combine stiffness and flexibility, ingrowth barrier and ingrowth guiding, as well as anti-bacteria and cell-activation. The dense layer has a mechanically matched space maintenance capacity toward gingiva, continuously blocks fibroblasts, and prevents bacterial invasion with multiple mechanisms including release-killing, contact-killing, anti-adhesion, and nanopore-blocking; the loose layer is ultra-soft to conformally cover bone surfaces and defect cavity edges, enables ingrowth of osteogenesis-associated cells, and creates a favorable osteogenic microenvironment. As a result, our all-in-one porous membrane possesses full protective abilities in GBR.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2024
·
IF 3.8
Zhang Pingping,Wang Huimin,Liang Man,Wang Zhifang,Liu Chunlong,Han Yanlin
Accurate measurement of serum glycocholic acid (GCA) is crucial for evaluating the activity of chronic hepatitis. Moreover, GCA is a novel identified biomarker for hepatocellular carcinoma. Although some laboratories have used the liquid chromatography-tandem mass spectrometry (LC–MS/MS) method to measure GCA in recent years, the problem of potential interference of GCA analogues has not been solved well yet. Neither reference measurement procedures nor reference materials for GCA have been listed in the Joint Committee for Traceability in Laboratory Medicine (JCTLM) database. For standardization of GCA, it is urgent to establish a candidate measurement procedure for GCA. In this study, a candidate reference measurement procedure for the quantification of GCA in human serum based on isotope dilution liquid chromatography-tandem mass spectrometry (ID-LC–MS/MS) by a two-step sample pretreatment of protein precipitation and MAX solid-phase extraction was developed and validated. GCA can be completely separated from its structural analogues with gradient elution in 9 min compared with short time gradients published in previous literature by Huang’s group. Method validation indicated perfect quantitation precision with intra-day and inter-day values that were ≤1.30% and ≤1.80%, respectively. The method showed excellent linearity with high regression coefficients ( R 2 > 0.999) over a range of 0.92 ng/g–38.38 μg/g and perfect recoveries at three spiked levels (99.87–100.43%). No interference, matrix effect, and carryover were observed. Moreover, the cRMP was successfully applied to measure GCA in serum samples and compared with two immunoassays in a clinical laboratory. As a candidate reference method, this method can promote a GCA standardization program. Graphical Abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-12
·
IF 14.7
Pan Hui,Wang Lei,Shi Yu,Sheng Chuanchao,Yang Sixie,He Ping,Zhou Haoshen
Applying high stack pressure (often up to tens of megapascals) to solid-state Li-ion batteries is primarily done to address the issues of internal voids formation and subsequent Li-ion transport blockage within the solid electrode due to volume changes. Whereas, redundant pressurizing devices lower the energy density of batteries and raise the cost. Herein, a mechanical optimization strategy involving elastic electrolyte is proposed for SSBs operating without external pressurizing, but relying solely on the built-in pressure of cells. We combine soft-rigid dual monomer copolymer with deep eutectic mixture to design an elastic solid electrolyte, which exhibits not only high stretchability and deformation recovery capability but also high room-temperature Li-ion conductivity of 2×10 −3 S cm −1 and nonflammability. The micron-sized Si anode without additional stack pressure, paired with the elastic electrolyte, exhibits exceptional stability for 300 cycles with 90.8% capacity retention. Furthermore, the solid Li/elastic electrolyte/LiFePO 4 battery delivers 143.3 mAh g −1 after 400 cycles. Finally, the micron-sized Si/elastic electrolyte/LiFePO 4 full cell operates stably for 100 cycles in the absence of any additional pressure, maintaining a capacity retention rate of 98.3%. This significantly advances the practical applications of solid-state batteries.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
·
2025
·
IF 4.9
Jin Shuang,Yang Jiaxin,Pu Changtao,Yang Lan,Zhou Yuhui
Multifunctional and lightweight polymer foams exhibit a promising prospect, both nucleating and foaming agent play a crucial role among it. Moreover, nucleating agent with cavity structure showed a great influence on the cell morphology of foaming materials. In this work, nucleating agent hemicucurbit[6]uril@reduced graphene oxide (HQ[6]@RGO) was prepared through structurally variable reduced graphene oxide (RGO) complexing with hemicucurbit[6]uril (HQ[6]). Foaming agent 1, 2-cyclohexanediamine-CO 2 (TRK-CO 2 ) was obtained through curing CO 2 by using 1, 2-cyclohexanediamine (TRK) under normal temperature and pressure, and CO 2 can be reversibly released under heating. Finally, polyethylene (PE) foams were prepared with complex nucleating-foaming agent (HQ[6]@RGO: TRK-CO 2 ) through mold foaming process. The results showed that the specially designed HQ[6]@RGO: TRK-CO 2 based on the classical nucleation theory can effectively improve the foaming behavior of PE. The optimal cell morphology was obtained with 3 wt% HQ[6]@3 h-RGO: TRK-CO 2 , the minimum cell diameter was 84 μm and the maximum cell density was 15.6 × 10 4 cells/cm 3 . The crystallization performance and the viscoelasticity of PE foams were improved. With the assistance of excellent cell morphology, the impact strength was nearly doubled, the thermal conductivity was as low as 0.05 W/m·k and the highest acoustic absorption coefficient reached 0.886 for PE/HQ[6]@3 h-RGO: TRK-CO 2 with 3 wt% addition, compared with pure PE. Graphical
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-13
·
IF 14.7
Wang Zihao,Zhang Qian,Jiang Yayun,Zhou Jun,Tian Ye
Morphogens play a critical role in coordinating stress adaptation and aging across tissues, yet their involvement in neuronal mitochondrial stress responses and systemic effects remains unclear. In this study, we reveal that the transforming growth factor beta (TGF-β) DAF-7 is pivotal in mediating the intestinal mitochondrial unfolded protein response (UPR mt ) in Caenorhabditis elegans under neuronal mitochondrial stress. Two ASI sensory neurons produce DAF-7, which targets DAF-1/TGF-β receptors on RIM interneurons to orchestrate a systemic UPR mt response. Remarkably, inducing mitochondrial stress specifically in ASI neurons activates intestinal UPR mt , extends lifespan, enhances pathogen resistance, and reduces both brood size and body fat levels. Furthermore, dopamine positively regulates this UPR mt activation, while GABA acts as a systemic suppressor. This study uncovers the intricate mechanisms of systemic mitochondrial stress regulation, emphasizing the vital role of TGF-β in metabolic adaptations that are crucial for organismal fitness and aging during neuronal mitochondrial stress.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BMC INFECTIOUS DISEASES
·
2025
·Vol. 25
·期 1
·1-9
·
IF 3
Ma Ying-Chao,Yang Xiu-Ling,Gu Jian-Jun
ObjectiveTo evaluate the effects of different SARS-CoV-2 inactivation methods on the blood concentration of colistin sulfate.Methods A colistin sulfate reference substance, a quality control plasma sample, and a clinically measured sample were transferred and heated in a 56 °C water batch for 30 min or irradiated under an ultraviolet (UV) lamp for 60 min to examine the stability of the reference solution and quality control plasma sample. Statistical analysis was conducted for the concentration of the clinically measured sample before and after inactivation with the intraclass correlation coefficient (ICC) method, the Passing–Bablok regression, and the Bland–Altman analysis.Results The reference substance of colistin sulfate was unstable under UV inactivation. Under moist heat inactivation, the reference substance and quality control plasma sample of colistin sulfate were stable. The ICC of the concentration results of 27 clinical blood samples with and without moist heat inactivation was 0.995 (P < 0.001). The Passing–Bablok regression equation was Y = 0.01347 + 0.9861X (R2 = 0.994, n = 27). Finally, 96.30% (26/27) of test data was within the 95% limit of agreement. The results obtained with the three statistical analysis methods all showed a high correlation and agreement between the plasma concentration results of samples not inactivated and inactivated with moist heat inactivation.Conclusion The clinical plasma concentration test samples for colistin sulfate can be processed with the moist heat virus inactivation method to reduce the risk of virus infection of medical staff.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULAR AND CELLULAR BIOCHEMISTRY
·
2011
·Vol. 363
·期 1
·309-313
·
IF 2.168
Zhao Hui,Li Ling,Fan Hua-Jun,Wang Fei,Jiang Li-Ming,He Pin-Gang,Fang Yu-Zhi
Communication between cells by release of specific chemical messengers via exocytosis plays crucial roles in biological process. Catecholamines, like dopamine, epinephrine, and norepinephrine, which are types of neurotransmitters released from cells, can be oxidized and detected by the microelectrodes, and amperometric detection of exocytosis is an effective method for studying the communication between cells. The experimental results depend on many factors, among which the property of the microelectrode, cell states, and their positions to each other are particularly important. A type of indium tin oxide (ITO) micro-pore electrodes, which is characterized by its stability, has been developed with photolithography. SH-SY5Y cells can adhere and spread on ITO micro-pore electrodes. Therefore, it is possible to investigate the correlation between cell morphology and exocytosis. The results show that cells with clear process have higher release frequency of norepinephrine compared with cells in spherical shape. Combined with fluorescence observation, this technique provides a simple and convenient methodology for cell study.
✓ 已验证
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2011
·Vol. 173
·期 1
·241-247
·
IF 2.578
Fan Yang,Liu Jin-Hang,Lu Hai-Ting,Zhang Qin
We describe a glassy carbon electrode (GCE) modified with a film composed of Nafion and TiO 2 -graphene (TiO 2 -GR) nanocomposite, and its voltammetric response to the amino acids L-tryptophane (Trp) and L-tyrosine (Tyr). The incorporation of TiO 2 nanoparticles with graphene significantly improves the electrocatalytic activity and voltammetric response compared to electrodes modified with Nafion/graphene only. The Nafion/TiO 2 -GR modified electrode was used to determine Trp and Tyr with detection limits of 0.7 and 2.3 μM, and a sensitivity of 75.9 and 22.8 μA mM −1 for Trp and Tyr, respectively.
The electrochemical sensor based on Nafion/TiO 2 -GR composite film modified GCE was presented. The integration of TiO 2 nanoparticles with graphene provides an efficient microenvironment to promote the electrochemical reaction of amino acids Trp and Tyr. The fabricated electrochemical sensor exhibits favorable analytical performance for Trp and Tyr, with high sensitivity, low detection limit and good reproducibility.
✓ 已验证
产品关联
DOI
高影响因子
Science China-Chemistry
·
2010
·Vol. 53
·期 11
·2265-2271
·
IF 0
Dong HaiQing,Zhao ZhiLei,Wen HuiYun,Li YongYong yongyong_li@tongji.edu.cn,Guo FangFang,Shen AiJun,Pilger Frank,Lin Chao,Shi DongLu
A novel methoxy-poly(ethylene glycol) modified nano-graphene oxide (NGO-mPEG) was designed and synthesized as a photosensitizer (PS) carrier for photodynamic therapy of cancer. NGO with a size below 200 nm was prepared using a modified Hummers’ method. NGO was observed by AFM to exhibit a structure with single-layer graphene oxide sheets down to a few nanometers in height. Hydrophilic mPEG conjugation of NGO (NGO-mPEG) was found to enhance solubility in cell culture media. No apparent cytotoxicity of the NGO-mPEG was observed towards MCF-7 carcinoma cell line. Zinc phthalocyanine (ZnPc), a photosensitizer for photodynamic therapy, was loaded in the NGO-PEG through π-π stacking and hydrophobic interactions, with the drug loading efficiency up to 14 wt%. Hydrophobic ZnPc was internalized in MCF-7 cells, exhibiting a pronounced phototoxicity in the cells under Xe light irradiation. The results indicate a great potential of NGO-mPEG for photodynamic therapy of cancer.
✓ 已验证
产品关联
DOI
JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-18
·
IF 10.6
Gao Weihang,Li Jiao Jiao,Shi Jingyu,Lan Hongbing,Guo Yuanyuan,Fu Dehao
Osteoporosis is a highly prevalent metabolic disease characterized by low systemic bone mass and deterioration of bone microarchitecture, resulting in reduced bone strength and increased fracture risk. Current treatment options for osteoporosis are limited by factors such as efficacy, cost, availability, side effects, and acceptability to patients. Gold nanoparticles show promise as an emerging osteoporosis therapy due to their osteogenic effects and ability to allow therapeutic delivery but have inherent constraints, such as low specificity and the potential for heavy metal accumulation in the body. This study reports the synthesis of ultrasmall gold particles almost reaching the Ångstrom (Ång) dimension. The antioxidant alpha-lipoic acid (LA) is used as a dispersant and stabilizer to coat Ångstrom-scale gold particles (AuÅPs). Alendronate (AL), an amino-bisphosphonate commonly used in drug therapy for osteoporosis, is conjugated through LA to the surface of AuÅPs, allowing targeted delivery to bone and enhancing antiresorptive therapeutic effects. In this study, alendronate-loaded Ångstrom-scale gold particles (AuÅPs-AL) were used for the first time to promote osteogenesis and alleviate bone loss through regulation of the WNT signaling pathway, as shown through in vitro tests. The in vivo therapeutic effects of AuÅPs-AL were demonstrated in an established osteoporosis mouse model. The results of Micro-computed Tomography, histology, and tartrate-resistant acid phosphatase staining indicated that AuÅPs-AL significantly improved bone density and prevented bone loss, with no evidence of nanoparticle-associated toxicity. These findings suggest the possible future application of AuÅPs-AL in osteoporosis therapy and point to the potential of developing new approaches for treating metabolic bone diseases using Ångstrom-scale gold particles.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）