JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2024
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IF 5.7
Wanxian Wang,Yanfang Liu,Dian Liu,Han Zhou,Yan Li,Wenjie Yuan,Suowen Xu,Jixia Wang,Xinmiao Liang,Jianping Weng
Pueraria lobata (Willd.) Ohwi, known as kudzu and used as a “longevity powder” in China, is an edible plant which is rich in flavonoids and believed to be useful for regulating blood sugar and treating diabetes, although the modes of action are unknown. Here, a total of 53 flavonoids including 6 novel compounds were isolated from kudzu using multidimensional preparative liquid chromatography. The flavonoid components were found to lower blood sugar levels, promote urine sugar levels in mice, and reduce the urine volume. Molecular docking and in vitro assays suggested that the antidiabetic effect of kudzu was attributed to at least three targets: sodium-dependent glucose transporter 2 (SGLT2), protein tyrosine phosphatase-1B (PTP1B), and alpha-glucosidase (AG). This study suggests a possible mechanism for the antidiabetic effect that may involve the synergistic action of multiple active compounds from kudzu.
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Small Methods
·
2024
·
IF 10.7
Yijia Kang,Zhilan Qian,Haishuang Yu,Jian Lu,Qing Zhao,Xue Qiao,Min Ye,Xiangshan Zhou,Menghao Cai
Previous data established 4′-deoxyflavone glycosides (4′-DFGs) as important pharmaceutical components in the roots of rare medical plants like Scutellaria baicalensis Georgi. Extracting these compounds from plants involves land occupation and is environmentally unfriendly. Therefore, a modular (“plug-and-play”) yeast-consortium platform is developed to synthesize diverse 4′-DFGs de novo. By codon-optimizing glycosyltransferase genes from different organisms for Pichia pastoris , six site-specific glycosylation chassis are generated to be capable of biosynthesizing 18 different 4′-DFGs. Cellular factories showed increased 4′-DFG production (up to 18.6-fold) due to strengthened synthesis of UDP-sugar precursors and blocked hydrolysis of endogenous glycosides. Co-culturing upstream flavone-synthesis-module cells with downstream glycoside-transformation-module cells alleviated the toxicity of 4′-deoxyflavones and enabled high-level de novo synthesis of 4′-DFGs. Baicalin is produced at the highest level (1290.0 mg L −1 ) in a bioreactor by controlling the consortium through carbon-source shifting. These results provide a valuable reference for biosynthesizing plant-derived 4′-DFGs and other glycosides with potential therapeutic applications.
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ACS Sensors
·
2025
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IF 9.1
Xinyuan Ye,Leqi Li,Zonglei Wang,Yuli Wang,Jiawei Yang,Meiqiong Zheng,Mingzhe Wang,Zichong Ji,Shihong Lin,Yujie Zhang,Jian Luo,Junhong Yi,Pengcheng Zhou,Xuanwen Cao,Xuezhong He,Yan Wang
Long-term, high-fidelity electrophysiological monitoring requires epidermal electrodes that simultaneously offer conformability, breathability, and mechanical durability─attributes rarely achieved in current designs─through a scalable, simple, and low-cost fabrication strategy. We report a 5.2-μm-thick, transparent, air- and vapor-permeable “tattoo” electrode that adheres to the human skin through water-activated hydrogen bonding provided by a NaCl/glycerol/water hydrating solution, echoing the mechanism of temporary tattoos. The fabrication process is easy, efficient, and scalable. The device consists of a poly(vinyl alcohol) matrix reinforced by an electrospun polyurethane nanomesh, yielding an interfacial area adhesion energy of 2060.8 μJ cm–2, and a low skin contact impedance of 21.0 kΩ at 100 Hz. Unlike conventional hydrogel or dry electrodes, our design needs no external adhesive layer, resists dehydration, and withstands everyday mechanical stress while remaining comfortable to wear. It exhibits an air permeance of 0.94 cm3 cm–2 s–1 cmHg–1, a water-vapor transmission rate of 1856.5 ± 36.9 g m–2 day–1, and survives 1000 cycles of 100% uniaxial strain. The electrode also retains >81.4 ± 1.7% of its initial water content after 7 days of storage and maintains its stretchability, adhesion, skin contact impedance, and conductivity even after 60 days. These properties enable reliable, minimized motion artifact acquisition of biosignals during vigorous activities and extended daily use. Finally, we demonstrate wireless surface electromyogram that tracks muscle-recruitment dynamics during strength-training and rehabilitation exercises, including push-ups and climbing, underscoring the potential of the tattoo electrode for real-world wearable health monitoring.
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JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
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2025
·Vol. 40
·期 4
·905-913
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IF 1.1
Pang Zengyuan,Gao Pengxiang,Meng Haonan,Cheng Zhenyu,Li Shen,Zhu Yanan
One-dimensional titanium dioxide (TiO 2 ) whiskers with controllable aspect ratios were synthesized by molten salt method adopting anatase TiO 2 nanoparticles as precursor, sodium chloride (NaCl) and dibasic sodium phosphate (Na 2 HPO 4 ) as medium. The particle size of TiO 2 nanoparticles and ratio of precursor and medium that can help to generate high aspect ratio TiO 2 whiskers were studied and selected. Light-colored antimony-doped tin oxide @ titanium dioxide (ATO@TiO 2 ) conductive whiskers were prepared by coating ATO on TiO 2 whiskers through coprecipitation then. Finally, the ATO@TiO 2 light-colored conductive whiskers were dispersed in polyacrylonitrile (PAN) to fabricate light-colored conductive fibers. The experimental results show that the ATO@TiO 2 whiskers exhibits ideal whiteness and conductivity with 65.5 Wb and 106 Ω·cm, respectively, and the resistivity of conductive fibers was 6.07×10 6 Ω·cm with 15wt% whisker content.
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CELL
·
2025
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IF 42.5
Yong Ding,Xi Luo,Jiasheng Guo,Baiying Xing,Haoyu Lin,Haohan Ma,Yicun Wang,Meng Li,Chuan Ye,Sen Yan,Kangjie Lin,Jinxin Zhang,Yingying Zhuo,Qixing Nie,Donghui Yang,Zhipeng Zhang,Yanli Pang,Kai Wang,Ming Ma,Luhua Lai,Changtao Jiang
The modifications of bile acids (BAs) are fundamental to their role in host physiology and pathology. Identifying their synthetases is crucial for uncovering the diversity of BAs and developing targeted interventions, yet it remains a significant challenge. To address this hurdle, we developed an artificial intelligence (AI)-assisted workflow, bile acid enzyme announcer unit tool (BEAUT), which predicted over 600,000 candidate BA metabolic enzymes that we compiled into the human generalized microbial BA metabolic enzyme (HGBME) database ( https://beaut.bjmu.edu.cn ). We identified a series of uncharacterized BA enzymes, including monoacid acylated BA hydrolase (MABH) and 3-acetoDCA synthetase (ADS). Notably, ADS can produce an unreported skeleton BA, 3-acetoDCA, with a carbon-carbon bond extension. After determining its bacterial source and catalytic mechanism, we found that 3-acetoDCA is widely distributed among populations and regulates the microbial interactions in the gut. In conclusion, our work offers alternative insights into the relationship between microbial BAs and the host from an enzymatic perspective.
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DIGESTIVE DISEASES AND SCIENCES
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2025
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IF 2.5
Liu Huifang,Zhou Weifeng,Li Chuanhong,Shen Hao,Zhang Nuobei
Background Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with poor prognosis due to late diagnoses and limited therapeutic targets. The AT-hook containing transcription factor 1 (AHCTF1) is linked to various cancers, yet its role in HCC is unclear. Aims This study aimed to investigate AHCTF1's role in HCC progression. Methods Bioinformatics analysis was performed using The Cancer Genome Atlas (TCGA) database to evaluate AHCTF1 expression in HCC and normal tissues. Differentially expressed genes (DEGs) associated with AHCTF1 were identified and analyzed for enrichment in key signaling pathways. The function of AHCTF1 in HCC was assessed in vitro by overexpressing AHCTF1 in Huh7 cells and knocking it down in HepG2 cells. The effect of AHCTF1 on tumor growth and metastasis in vivo was validated through xenograft tumor models and lung metastasis models. Results AHCTF1 was significantly upregulated in HCC tissues and correlated with poor prognosis. Bioinformatics analysis demonstrated that DEGs associated with AHCTF1 were enriched in the PI3K-Akt and Hedgehog signaling pathways, cell adhesion, and glycolysis. Overexpression of AHCTF1 enhanced HCC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) process, while knockdown of AHCTF1 suppressed these malignant phenotypes. These findings have been validated through xenograft and lung metastasis models, and AHCTF1 promotes tumor growth and metastasis. Conclusion This study identifies AHCTF1 as a potential oncogenic factor, with high expression levels in HCC and a positive correlation with poor prognosis. AHCTF1 promotes tumor progression by enhancing the proliferation, migration, invasion, and EMT process of HCC cells.
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CHEMICAL PHYSICS LETTERS
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2025
·
IF 3.1
Jiaying Yang,Yiman Qian,Jingqi Yan,Jiayin Li,Pengfei Liu
Advanced oxidation processes (AOPs) surpass photocatalytic methods in energy efficiency, enabling organic dye degradation under mild conditions without light activation. In this study, we crafted a highly effective Zr(WO 4 ) 2 catalyst for AOPs, rigorously characterized through SEM, TEM, TG-DTA, N 2 -sorption, XRD, and XPS analyses. The system demonstrated exceptional catalytic performance, achieving 95.62 % phenol removal (2 mg/L) within 60 min using only 0.1 g/L Zr(WO 4 ) 2 and 1 mM PMS, with singlet oxygen ( 1 O 2 ) identified as the dominant reactive species. Crucially, the synergistic redox interplay between Zr 4+ and WO 4 2− surface species emerged as the critical driver for efficient PMS activation. Beyond its catalytic prowess, the Zr(WO 4 ) 2 system exhibited remarkable reusability and versatility across multiple applications, while generating treated water with minimal toxicity, positioning it as an environmentally promising solution.
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Inorganic Chemistry Frontiers
·
2024
·
IF 6.1
Lizhong He,Tingting Dong,Xiaoyang Hu,Zibao Gan
Precisely tailoring the structure of bimetal nanoclusters (NCs) at the atomic level has been proven to be an effective way to tune their physicochemical properties; however, achieving this remains challenging. Herein, the regulation from the reported Ag26Pt(2-EBT)18(PPh3)6 (Ag26Pt) to Ag16Pt(2-EBT)6(dppm)4Cl2 (Ag16Pt; 2-EBTH = 2-ethylbenzenethiol; dppm = bis-(diphenylphosphino)methane) NC was instantaneously (within one minute) realized through an asymmetrical pseudo-ligand exchange strategy. Single crystal X-ray crystallography (SCXC) combined with X-ray photoelectron spectroscopy (XPS) and thermogravimetric analysis (TGA) confirmed its composition and structure. The target Ag16Pt NC consists of a Pt@Ag12 icosahedral core capped by a ligand shell of a pair of dimetric -SR-Ag-SR-Ag-SR- staple motifs, four dppm ligands, and two chlorine atoms. Their geometrical, electronic and crystallographical structures were comparatively investigated before and after regulation, which also provides some clues for understanding the blueshift of the emission center (Ag26Pt: 845 nm vs. Ag16Pt: 675 nm). This work provides important insights into the regulation of structures and photoluminescence of bimetal NCs protected by co-ligands.
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CHINESE JOURNAL OF CATALYSIS
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2025
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IF 17.7
Yao Yao,Juping Xu,Minhua Shao
Hydrogen evolution reaction (HER) is unavoidable in many electrochemical synthesis systems, such as CO 2 reduction, N 2 reduction, and H 2 O 2 synthesis. It makes those electrochemical reactions with multiple electron-proton transfers more complex when determining kinetics and mass transfer information. Understanding how HER competes with other electrochemical reduction reactions is crucial for both fundamental studies and system performance improvements. In this study, we employed the oxygen reduction reaction (ORR) as a model reaction to investigate HER competition on a polycrystalline-Au surface, using a rotating ring and disk electrode. It’s proved that water molecules serve as the proton source for ORR in alkaline, neutral, and even acidic electrolytes, and a 4-electron process can be achieved when the overpotential is sufficiently high. The competition from H + reduction becomes noticeable at the H + concentration higher than 2 mmol L –1 and intensifies as the H + concentration increases. Based on the electrochemical results, we obtained an equivalent circuit diagram for the ORR system with competition from the H + reduction reaction, showing that these reactions occur in parallel and compete with each other. Electrochemical impedance spectroscopy measurements further confirm this argument. Additionally, we discover that the contribution of H + mass transfer to the total H + reduction current is significant and comparable to the kinetic current. We believe this work will deepen our understanding of HER and its competition in electrochemical reduction systems.
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Journal of Materials Chemistry C
·
2025
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IF 5.1
Weijun Deng,Mengke Wang,Jing Hu,Huitao Wen
Discriminative and sensitive detection of low-concentration odorous gases is of great significance for health diagnostics, product quality control and robotics. However, achieving a biomimetic olfactory system in those applications with hydrogel remains a challenge. Here, by learning the mechanism of human olfactory epithelium, we design a flexible and ion-conductive hydrogel based on cellulose as an artificial nose. The hydrogel is soft, flexible, adhesive, self-healing and conductive, enabling the integration to various devices. The artificial nose exhibits high selectivity to H2S over other gas molecules such as NH3, NO2, CO2, CH3CH2OH, CH2O, etc. It has high linear sensitivity (0.34 ppm-1) with a fast response (143 s). More importantly, the sensoring range of this artificial nose moves into human olfactory threshold of H2S. The sensor is operated under low voltage (1 V) and mild temperature (0-25 °C) with sensoring stability for at least 2 weeks. Furthermore, this artificial nose are demonstrated as promising in applications of noninvasive halitosis diagnosis and meat spoilage identification. Our work may inspire odorant sensor development with artificial olfactory system for robotics and other specific applications.
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MICROCHEMICAL JOURNAL
·
2025
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IF 5.1
Haoxiang Wang,Yuyang He,Ruoyu Wang,Mengqi Lu,Yuting Luo,Yiwei Sun,Dongpo Xu
An electrochemical sensor with a dual recognition strategy was designed using molecularly imprinted polymers (MIPs) and boric acid for the highly sensitive detection of rutin. The synthesized metal-organic framework (MOFs) is combined with phenylboronic acid, which increases the recognition area of phenylboronic acid and its recognition ability towards adjacent diol compounds. Meanwhile, the molecularly imprinted polymer (MIP) provides specific recognition for rutin. The dual recognition strategy is widely adopted in sensors, enhancing the specificity of the imprinted cavity and effectively addressing the influence of interfering substances in complex matrices. After optimizing the experimental parameters, the detection range of this sensor is from 1 nM to 200 nM, and the limit of detection is 0.43 nM, indicating that this sensor has high potential for practical applications.
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Acta Pharmaceutica Sinica B
·
2025
·
IF 14.6
Mengwan Jiang,Mingyue Chen,Wen Zou,Yingxin Xie,Jinjin Shi,Junjie Liu,Aibing Chen,Xiu Zhao
Studies have shown that radiotherapy (RT) has powerful immune-stimulating effects. However, RT-mediated distal tumor regression is rare in clinical practice. Here, with an animal experimental model, we found that RT shaped an immunosuppressive landscape characterized by a high-influx of myeloid-derived suppressor cells (MDSCs), and the induction of immunologically silent tumor apoptosis, hindering the efficacy of radioimmunotherapy. To address this issue, we developed a spatiotemporally controlled nanomedicine for remodeling the immunosuppressive tumor microenvironment (TME) post-RT. Decitabine (DAC)-loaded ferritin (Ft) were crosslinked via an azobenzene linker, and meanwhile encapsulated with all-trans-retinoic acid (ATRA) to construct a Ft@DAC@ATRA nanoassembly (denoted as FD@ATRA), which dissociated into monodispersive Ft@DAC units in hypoxia TME. The released ATRA could eliminate immunosuppressive MDSCs, and meanwhile Ft@DAC selectively induced immunogenic pyroptosis of the tumor by targeting the transferrin receptor 1 overexpressed on the tumor to effectively activate CD8 + T cells. FD@ATRA treatment reshaped the tumor immune landscape post-RT with an increase of 16.8% in tumor-infiltrating IFN- γ + CD8 + T cells. Moreover, FD@ATRA-enhanced RT remained effective in large, treatment-resistant tumors, and the inhibition rate of FD@ATRA-enhanced RT on distant tumors improved by 47% compared to the RT group alone, providing an effective therapeutic approach to improve the clinical outcomes of radioimmunotherapy.
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