FOOD CHEMISTRY
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2026
·
IF 10.4
Yinjiang Leng,Jing Zhang,He Li,Yi Ma,HuiBo Luo,Danqun Huo,Changjun Hou
A cross-reactive Au NPs/AuAg NCs colorimetric sensor array was developed. • Seven sulfur-containing analytes were discriminated, and GSH was quantified. • Blind-test accuracies reached 93.8% for Baijiu and 97.6% for distilled liquors. • Sensor responses were associated with sensory differences among Baijiu samples. Sulfur-containing compounds are important aroma contributors in Baijiu because of their low odor thresholds and strong sensory effects. A cross-reactive colorimetric sensor array based on positively charged Au nanoparticles and negatively charged AuAg nanoclusters was developed for sulfur-containing analyte discrimination and Baijiu classification. Analyte-induced perturbation of the nanoparticle–nanocluster assemblies generated differential optical fingerprints across four sensing elements. Combined with pattern-recognition analysis, the array discriminated seven sulfur-containing analytes at different concentrations and quantified glutathione over 0.1–50 mM. It also classified 16 commercial Baijiu samples and distinguished Baijiu from five other distilled liquors and 50% ethanol. Blind-sample prediction accuracies reached 93.8% for the 16 Baijiu categories and 97.6% for the 21 distilled-liquor categories. Correlation analysis showed associations between selected sensing channels and Baijiu sensory attributes. The proposed array provides a rapid optical fingerprinting approach for Baijiu differentiation and authenticity-related screening.
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DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 7
·495
·
IF 5.4
Shi Jian,Shan Xiaomu,Wang Hongren,Xu Yuanze,Zhang Zezheng,Fan Xiuwei,Du Xuejian,Jiang Shouzhen
A high-performance optical fiber surface plasmon resonance (SPR) biosensor for the determination of dopamine (DP) is reported based on gold nanocone arrays combined with gold nanoparticles (AuNPs). The sensor was fabricated via thermal nanoimprinting, gold sputtering, and single-stranded DNA-assisted AuNPs immobilization to form gap hotspots. Finite element simulation and experimental results verified strong electromagnetic field enhancement via extraordinary optical transmission and SPR-LSPR coupling. The sensor achieved a detection limit of 2.7 × 10 -14 M for DA, with sensitivity and FOM improved by 37.4% and 54.2% relative to conventional gold film structures. It showed excellent selectivity and stability in serum, cerebrospinal fluid (CSF), and whole blood. This robust, scalable design provides a promising label-free platform for ultrasensitive DA detection in clinical point-of-care applications. Graphical abstract
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2026
·
IF 4.8
Yuzhu Hao,Zicheng Zhao,Xiaohong Liu,Yutong Wang,Heping Bai,Ganggang Ai,Xiaofeng Liu,Ran Li
This study developed a novel SERS detection platform based on seed-mediated synthesis of core-shell structured Au@Ag NPs. Benefiting from the atomic synergistic effects between the gold core and silver shell, the substrate demonstrated exceptional stability, enabling simultaneous dual-target detection of Thiram and Paraquat. Experimental results revealed linear response ranges of 1.0 × 10 −6 –1.0 × 10 −4 M (LOD: 6.89 × 10 −8 M) at 1380 cm −1 for Thiram, and 1.0 × 10 −5 –1.0 × 10 −3 M (LOD: 9.75 × 10 −6 M) at 840 cm −1 for Paraquat. Spiked recovery rates in apple samples reached 95.6%–102% for Thiram and 95%–98.4% for Paraquat. Quantitative analysis of mixed systems using an MLP model achieved 91% accuracy, 89% recall, 89% F1-score, and 90% precision. This method provides a highly sensitive and reliable technical solution for simultaneous detection of multiple pesticide residues in complex food matrices, demonstrating significant potential for rapid food safety monitoring applications.
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PubMed
高影响因子
TALANTA
·
2026
·
IF 6.7
Ruyu Li,Tingting Zhang,Lijie Zhou,Jingjing Feng,Longgang Wang,Haiyan Xiao
Pd 3 Au-LCLP NPs-DOX with anti-protein adsorption properties was prepared. • Pd 3 Au-LCLP NPs-DOX exhibit good enzyme-like activity and photothermal performance. • More DOX was released under the irradiation of 808 nm laser. • Pd 3 Au-LCLP NPs-DOX shows significant anti-tumor effects by multi-therapy. Traditional cancer therapies are limited by severe side effects and therapeutic challenges, while noble metal nanozymes offer promising enzyme-like therapeutic potential but remain constrained by poor aqueous stability. In this work, palladium-gold bimetallic nanoparticles (Pd 3 Au-LCLP NPs) with peroxidase-like activity were constructed using Leonurus cardiaca L. polysaccharide as both a reducing agent and stabilizing template, and further loaded with doxorubicin (DOX) to form Pd 3 Au-LCLP NPs-DOX. The resulting nanoplatform exhibited excellent water dispersibility, structural stability, anti-protein adsorption capability, and enhanced photothermal conversion performance. Under 808 nm laser irradiation, Pd 3 Au-LCLP NPs-DOX achieved a cumulative DOX release of 81% at pH 5.5. In vitro , it showed significant cytotoxicity against A549 and HeLa cells. In vivo , the tumor inhibition rate reached 82.6%. Overall, this combined therapeutic strategy integrating chemodynamic therapy (CDT), photothermal therapy (PTT), and chemotherapy (CT) demonstrated strong synergistic anti-tumor efficacy. Download: Download high-res image (393KB) Download: Download full-size image
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高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Mingzhu Fu,Lizhen Long,Heming Wang,Meixian Li,Yujiao Qiu,Jiahao Dai,Juanjuan Meng,Jun Liu
Uniform hierarchical AuNFs are in-situ fabricated on SPCE via facile one-step electrodeposition. • AuNFs provide abundant accessible binding sites for antibody immobilization and efficient electron-transfer pathways. • The developed immunosensor achieves ultra-sensitive CEA detection with an ultra-low LOD. • The as-prepared immunosensor exhibits favorable reproducibility and satisfactory long-term storage stability. This study reports a highly sensitive electrochemical immunosensor based on branched hierarchical gold nanoflowers (AuNFs) for the selective detection of carcinoembryonic antigen (CEA). Uniform AuNFs were synthesized by optimized electrochemical deposition parameters on the screen-printed carbon electrode (SPCE). The distinct hierarchical branched structure of AuNFs endows the electrode interface with abundant uniformly distributed active sites and efficient electron-transport pathways. By integrating MUA self-assembly with EDC/NHS-mediated covalent antibody immobilization, a highly specific and stable electrochemical immunosensor was successfully developed for ultrasensitive CEA detection. The proposed immunosensor achieves a wide linear detection range from 0.1 to 100,000 pg·mL −1 and a low limit of detection (LOD) of 0.069 fg·mL −1 for CEA detection. Furthermore, the immunosensor exhibits excellent selectivity, reproducibility, and long-term storage stability, enabling reliable quantification of CEA in biological samples. This study demonstrates that the AuNFs-modified SPCEs immunosensor is a promising high-performance platform for point-of-care (POCT) tumor biomarker detection, with great application potential in early clinical cancer screening and postoperative dynamic monitoring. AuNFs modified screen-printed carbon electrodes (SPCEs) possesses excellent electrical conductivity and plasticity, which facilitates the construction of CEA-specific sensing interfaces and improve detection sensitivity. Download: Download high-res image (175KB) Download: Download full-size image
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高影响因子
Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 6
·124924
·
IF 7.5
Jing Yao,Liuqing Li,Tiefeng Xu,Wangyang Lu
As a renewable platform chemical, 2, 5-furandicarboxylic acid (FDCA) provides a sustainable alternative to petroleum-derived terephthalic acid with vital strategic importance. Achieving the efficient conversion of 5-hydroxymethylfurfural (HMF) to FDCA under environmentally friendly conditions is of great practical significance. Herein, an Au/Fe 3 O 4 /TiO 2 photocatalyst was prepared by first synthesising an Fe 3 O 4 /TiO 2 composite via a hydrothermal method, followed by amination and subsequent reduction of Au nanoparticles. Furthermore, multiple characterisations confirmed the successful loading of Fe 3 O 4 and Au nanoparticles, while abundant Fe signals were detected adjacent to the Au nanoparticles. Under simulated solar irradiation, an FDCA yield of 97% was achieved within 15 h, demonstrating the superior catalytic performance of the Au/Fe 3 O 4 /TiO 2 photocatalyst. Moreover, the photocatalytic activity remained at 85% after five consecutive cycles, indicating its excellent cycling stability and reusability. Simultaneously, superior photocatalytic activity and stability were attained owing to the strong synergistic effect among Au nanoparticles, Fe 3 O 4 and TiO 2 . In addition, the photocatalytic oxidation mechanism of HMF to FDCA over Au/Fe 3 O 4 /TiO 2 was elucidated, wherein h + , 1 O 2 and •O 2 - contributed to the production of FDCA. This study provides a promising strategy for the efficient photocatalytic conversion of HMF to FDCA under mild conditions.
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高影响因子
ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Zimiao Wen,Xinhua Lian,Zihan Zhang,Haiyan Zhao,Na Li,Min Cui,Cong Zhang
Insulin-like growth factor-1 (IGF-1) is a critical biomarker linked to various human diseases, necessitating sensitive and reliable detection methods. Herein, we report a novel sandwich-type ratiometric electrochemical immunosensor with signal on–off capability for the ultrasensitive measurement of IGF-1. The sensor was constructed using gold nanoparticle-engineered carbonized covalent organic frameworks (Au@C-COFs) as the sensing platform and thionine-enriched alkynyl COFs (Thi@aCOFs) as the signal amplification probe. Au@C-COFs exhibited excellent electrocatalytic activity toward hydroquinone (HQ) oxidation, providing a stable internal reference signal, while Thi@aCOFs generated a concentration-dependent reporter signal upon specific recognition of IGF-1 via the immobilized aptamer. The ratiometric strategy effectively eliminated external interferences, significantly enhancing accuracy and reliability. Under optimal conditions, the biosensor displayed a wide linear range from 10 fM to 1 nM, a low detection limit of 0.45 fM (S/N = 3), good specificity, stability, and satisfactory reproducibility. Furthermore, the sensor performed well for measuring IGF-1 in diluted human serum, achieving satisfactory recoveries. This work presents a robust and adaptable platform toward ratiometric electrochemical biosensing, holding great promise to achieve clinical diagnosis and management treatment of IGF-1-related disorders.
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高影响因子
OPTICAL MATERIALS
·
2026
·
IF 4.3
Yunqing Lu,Yu Feng,Mengmeng Li,Ji Xu,Jin Wang
The photocatalytic conversion of CO 2 into solar fuels presents a sustainable approach to alleviate climate change and address energy crisis. To address the limitations of conventional photocatalysts, such as their restricted visible-light response and rapid charge recombination, we have developed a ternary nanocomposite consisting of zeolitic imidazolate framework-8 (ZIF-8), plasmonic gold nanoparticles (Au NPs), and titanium dioxide (TiO 2 ). In this system, ZIF-8 provides high-density CO 2 adsorption sites, enhancing the local concentration of CO 2 and facilitating its subsequent reduction. The incorporation of Au NPs induces a strong localized surface plasmon resonance (LSPR) effect, significantly broadening the visible-light harvesting capability of the composite and promoting efficient charge transfer between TiO 2 and ZIF-8. TiO 2 serves as a stable photocatalytic platform, enabling effective charge separation and transfer. Comprehensive characterization verifies the uniform integration of the three components and the formation of close interfacial contacts. The ternary nanocomposite demonstrates significantly improved visible-light absorption, reduced charge recombination, and enhanced photogenerated carrier separation and transfer, as supported by UV-vis diffuse reflectance spectroscopy (DRS), photoluminescence (PL), electrochemical impedance spectroscopy (EIS), and photocurrent measurements. Under simulated sunlight, the ZIF-8/Au/TiO 2 photocatalyst achieves CO 2 -to-fuel conversion rates of 1.56 μmol g −1 h −1 for methane (CH 4 ) and 4.65 μmol g −1 h −1 for carbon monoxide (CO). This enhancement is attributed to the synergistic effects of plasmonic sensitization by Au nanoparticles and CO 2 adsorption enrichment by ZIF-8, which collectively enhance photon utilization, reactant concentration, and interfacial charge transfer dynamics.
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高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Yanxia Li,Fangqing Yu,Wen Li,Liping Liu
Laser-induced 3D porous graphene enables scalable, low-cost biosensing. • PB/PEDOT/Au composite synergistically enhances stability, antifouling, and electroactivity. • The immunosensor achieves ultrasensitive detection of H1N1 and a wide dynamic range. • Label-free and pretreatment-free detection is successfully demonstrated in complex biological matrices. As a major cause of seasonal influenza, H1N1 virus requires advanced monitoring. Custom-patterned conductive graphene microelectrodes are essential for building relevant sensing platforms. In this study, a label-free H1N1 electrochemical immunosensor was developed based on a sequentially engineered laser-induced graphene (LIG)/Prussian blue (PB)/poly3,4-ethylenedioxythiophene (PEDOT)/Au nanocomposite microelectrode. Unlike previous studies that focused on single-component modifications, our approach integrates multiple functional layers to synergistically enhance signal stability, sensitivity, and antifouling performance. The LIG microelectrode was fabricated using a low-cost intelligent semiconductor laser, which directly patterned a three-electrode system on a polyimide (PI) film. Subsequently, PB, PEDOT, and gold nanoparticles (Au NPs) were sequentially electrodeposited onto the LIG electrode. PB served as an ultrasensitive electrochemical signal reporter, while the encapsulating PEDOT polymer layer not only stabilized the electrical signal of PB in neutral environments but also significantly enhanced the electrode's antifouling properties. To construct the label-free immunosensor, Au NPs were introduced to improve conductivity and were functionalized via Au–S–COOH bonding for the immobilization of H1N1 antibodies. Under optimal conditions, the LIG/PB/PEDOT/Au composite electrode exhibited excellent electrochemical activity and conductivity. The fabricated immunosensor demonstrated ultrahigh sensitivity with a wide concentration range from 0.1 fg mL −1 to 100 ng mL −1 , and an extremely low detection limit of 0.063 fg mL −1 . The results confirmed that the immunosensor possesses excellent selectivity, precision, and stability, and is thus suitable for the analysis of complex biological samples without the need for labeled probes and sample pretreatment. Therefore, this environmentally friendly and label-free immunosensing platform represents a significant advancement in point-of-care biosensing and demonstrates strong potential for rapid on-site screening and prevention of infectious disease outbreaks. A label-free immunosensor based on laser-induced graphene microelectrode modified with PB/PEDOT/Au nanocomposite enables ultra-sensitive detection of H1N1 virus in complex biological samples without pretreatment. Download: Download high-res image (120KB) Download: Download full-size image
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高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2026
·
IF 3.1
Ali Ahmat,Guoping Zhang,Maimaiti Ayiguli,jing Li,Xuan Li
A ternary composite of thiolated poly(3,4-ethylenedioxythiophene), Au, Nitrogen-doped graphene was prepared via straightforward physical mixing. The optimal conditions for the uniform loading of Au nanoparticles on the composite materials were studied. The interaction between the polymer and Au nanoparticles as well as the influence of nitrogen-doped graphene on the electrocatalytic activity of the composite materials are discussed. The results show that the thiol groups on the polymer and the N atoms in the nitrogen-doped graphene have a strong adsorption effect on the Au nanoparticles, so that the Au nanoparticles are more uniformly loaded on the surface of polymer and nitrogen-doped graphene during the mixing process. In addition, the enhanced electron transfer rate, the high dispersibility of polymer and nitrogen-doped graphene, as well as the large specific surface area and catalytic activity of Au nanoparticles improve the electrocatalytic activity of the composite materials. Under the optimal conditions, the binary composite-modified electrodes exhibit superior electrocatalytic activity with the detection linear ranges of 0.5–65 μM, 0.02–60 μM, 0.06–55 μM and 0.1–70 μM for ascorbic acid, dopamine, uric acid, and nitrite ions, respectively. Graphical abstract The alternative text for this image may have been generated using AI.
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高影响因子
Surfaces and Interfaces
·
2026
·
IF 6
Tianran Yao,Lingfei Ji,Zhenyuan Lin,Weigao Sun,Ming Guan,Liang Qu,Bohao Zhou
Realizing Au-based SERS substrates via laser-driven confined interfacial coalescence. • Achieving high sensitivity (detectable concentration ≤ 10 −18 M) for the SERS test. • Revealing specific vibrational modes of aromatic ring functioning in SERS detection. In this study, a picosecond laser-driven interfacial coalescence method is developed for realizing highly sensitive and uniform Au-based surface-enhanced Raman scattering (SERS) substrates via enhancement of aromatic ring vibrational modes, achieving an ultralow detection limit of 10 −18 M toward aromatic-ring-containing dyes and an exceptional enhancement factor of 1.83×10 12 . The confined environment restricts liquid Au flow, generating interfacial vortices within ∼100 nm region and leading to the formation of high-density nanoparticles with excellent SERS performance. The enhancement mechanism is found to strongly correlate to the concentration, particularly at low concentration (<10 −8 M), the selective single-molecule-level enhancement of aromatic ring vibrational modes under sub-monolayer adsorption allows highly sensitive detection of five specific dyes and pigments with aromatic-ring (Rhodamine 6 G, Malachite Green, Alizarin Red, Carmine Red, and Indigo), confirming its broad applicability for trace molecular detection. The Au-based SERS substrate exhibits remarkable uniformity with a relative standard deviation of 5.74% and retains stable SERS activity for over 1 year under ambient conditions. This work establishes a scalable, cost-effective laser-based manufacturing paradigm for high-performance SERS sensors, offering exceptional sensitivity, reproducibility, and stability. The method enables ultralow-concentration detection of aromatic molecules via enhancement of aromatic ring vibrational modes, demonstrating versatility across cultural heritage preservation, environmental monitoring, and biomedical diagnostics. A laser-induced confined interfacial coalescence strategy is developed to fabricate high-density, uniform Au nanoparticles for SERS substrates, allowing precise control of nanoparticle size, shape, and distribution. This enables selective adsorption and ultrahigh sensitivity, providing a versatile and scalable platform capable of cultural heritage analysis while also applicable to environmental, food, and biomedical molecular detection. Download: Download high-res image (220KB) Download: Download full-size image
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Xing Wang,Jian Zhao,Xuening Duan,Yujie Ma,Yong Liu,Yu Xia,Yuhua Feng
To synthesize hybrid nanostructures, precise structural control holds promise to modulate their physicochemical properties. Interestingly, due to the close physico-chemical nature and Galvanic Replacement (GR) between Au ions and Ag, the fabrication of Ag-Au Janus-like structures by growing Au on Ag free of GR is challenging. In this work, in the growth of Au on AgNR seeds, through employing the Na₃Au(SO₃)₂ complex as precursor to inhibit GR and the MBIA ligand as surface energy tuning agent to induce anisotropic growth, the GR-free growth of Au-Island on AgNR was successfully achieved. More interestingly, GR-free site-specific growth of Au-Islands on the entire surface, both tips, and single tip of AgNRs was also realized by varying the concentration of MBIA or the amount of AA reductant, demonstrating the excellent feasibility in synthetic control. These AgNR–Au Janus-like structures exhibit tunable localized surface plasmon resonance (LSPR) across the UV–Vis-NIR range and strong surface-enhanced Raman scattering (SERS) signals, making them promising candidates for LSPR- and SERS-based applications. Our synergistic ligand-mediated structure control strategy can be extended to other bimetallic systems, thus enabling the construction of sophisticated heterostructures with enhanced or new properties for various applications.
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高影响因子
危险品化学品经营许可证（带存储）