PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
·
2018
·Vol. 35
·期 5
·1700379
·
IF 4.384
Xiaotong Li,Junshu Zhang,Shufang Kou,Xianfeng Yang,Xia Guo,Jian Yang
Pt/Co and Au are organized into well-defined nanostructures by a simple and mild method, such as dumbbell-like nanorods and core–shell nanorods. The resultant dumbbell-like nanorods show a superior performance in the electrooxidation of formic acid, as compared with core–shell nanorods, Pt-tipped gold nanorods, and commercial Pt/C. This result can be attributed to electronic effect between Au and Pt, heteroatom effect of Co, irregular surface at the tips, and the interface effect.
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高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2018
·Vol. 165
·期 5
·A856
·
IF 3.662
Chenlong Wang,Xugang Zhang,Jinshuang Wang,Yongjun Ma,Shixian Lv,Junyu Xiang,Mingna Chu,Ting Sun,Chuanli Qin
From the practical application of supercapacitors, the development of carbon materials with high volumetric performance is highly desired. We report the synthesis of B/N/O co-doped carbon by a facile one-step carbonization method of polyvinylpyrrolidone/melamine formaldehyde resin with boric acid/urea treatment and a subsequent washing process. It is shown that a boric acid/urea treatment is an effective approach to incorporating B into N/O enriched carbon and effectively restraining the generation of inert B-O and B-N species. Moreover, a boric acid/urea treatment and washing process can increase specific surface area, optimize pore structure, and retain many active heteroatoms without lowering density, contributing to good conductivity, fast charge transfer and electrolyte ion diffusion, and high volumetric performance. The fabricated B/N/O co-doped carbon shows high active heteroatoms of 8.69 at.% (N-5, N-6, B-C and O-I), moderate surface area, and pore volume (778.02 m2 g−1 and 0.341 cm3 g−1), high density (1.3 g cm−3), high specific volumetric, and gravimetric capacitances (309 F cm−3 and 238 F g−1 at 0.5 A g−1) and superior cycling stability. The assembled symmetric supercapacitor delivers relatively high volumetric energy density (11.5 Wh L−1 at 622 W L−1) in 6 M KOH electrolyte. The B/N/O co-doped carbon has great potential for applications in supercapacitors.
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BIOMATERIALS
·
2015
·
IF 8.557
Song Shen,Chun-Yang Sun,Xiao-Jiao Du,Hong-Jun Li,Yang Liu,Jin-Xing Xia,Yan-Hua Zhu,Jun Wang
As part of HCC tumor cellularity , cancer stem cells (CSCs) are considered a major obstacle to eradicate hepatocellular carcinoma (HCC), which is the third most common cause of cancer-related death worldwide, and the accumulation of chemotherapeutic drug-resistant CSCs invariably accounts for poor prognosis and HCC relapse. In the present study, we explored the efficacy of co-delivery of platinum drug and siRNA targeting Notch1 to treat CSCs-harboring HCC. To overcome the challenging obstacles of platinum drug and siRNA in the systemic administration, we developed a micellar nanoparticle (MNP) to deliver platinum(IV) prodrug and si Notch1 , hereafter referred to as Pt(IV) MNP/si Notch1 . We demonstrated that Pt(IV) MNP/si Notch1 was able to efficiently deliver two drugs into both non-CSCs and CSCs of SMMC7721, a HCC cell line. We further found that siRNA-mediated inhibition of Notch1 suppression can increase the sensitivity of HCC cells to platinum drugs and decrease the percentage of HCC CSCs, and consequently resulting in enhanced proliferation inhibition and apoptosis induction in HCC cells in vitro . Moreover, our results indicated that the combined drug delivery system can remarkably augment drug enrichment in tumor tissues, substantially suppressing the tumor growth while avoiding the accumulation of CSCs in a synergistic manner in the SMMC7721 xenograft model.
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高影响因子
Catalysts
·
2015
·Vol. 5
·期 2
·606-633
·
IF 2
Hongmei Qin,Xiaoshuang Qian,Tao Meng,Yi Lin,Zhen Ma
Conventional supported Pt catalysts have often been prepared by loading Pt onto commercial supports, such as SiO2, TiO2, Al2O3, and carbon. These catalysts usually have simple metal-support (i.e., Pt-SiO2) interfaces. To tune the catalytic performance of supported Pt catalysts, it is desirable to modify the metal-support interfaces by incorporating an oxide additive into the catalyst formula. Here we prepared three series of metal oxide-modified Pt catalysts (i.e., Pt/MOx/SiO2, Pt/MOx/TiO2, and Pt/MOx/Al2O3, where M = Al, Fe, Co, Cu, Zn, Ba, La) for CO oxidation. Among them, Pt/CoOx/SiO2, Pt/CoOx/TiO2, and Pt/CoOx/Al2O3showed the highest catalytic activities. Relevant samples were characterized by N2adsorption-desorption, X-ray diffraction (XRD), transmission electron microscopy (TEM), H2temperature-programmed reduction (H2-TPR), X-ray photoelectron spectroscopy (XPS), CO temperature-programmed desorption (CO-TPD), O2temperature-programmed desorption (O2-TPD), and CO2temperature-programmed desorption (CO2-TPD).Keywords:Pt catalysts;cobalt oxide;CO oxidation
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Scientific Reports
·
2014
·Vol. 4
·期 1
·1-10
·
IF 5.078
Luo Guo-Feng,Chen Wei-Hai,Liu Yun,Lei Qi,Zhuo Ren-Xi,Zhang Xian-Zheng
A multifunctional enveloped nanodevice based on mesoporous silica nanoparticle (MSN) was delicately designed for subcellular co-delivery of drug and therapeutic peptide to tumor cells. Mesoporous silica MCM-41 nanoparticles were used as the core for loading antineoplastic drug topotecan (TPT). The surface of nanoparticles was decorated with mitochondria-targeted therapeutic agent (Tpep) containing triphenylphosphonium (TPP) and antibiotic peptide (KLAKLAK) 2 via disulfide linkage, followed by coating with a charge reversal polyanion poly(ethylene glycol)-blocked-2,3-dimethylmaleic anhydride-modified poly(L-lysine) (PEG-PLL(DMA)) via electrostatic interaction. It was found that the outer shielding layer could be removed at acidic tumor microenvironment due to the degradation of DMA blocks and the cellular uptake was significantly enhanced by the formation of cationic nanoparticles. After endocytosis, due to the cleavage of disulfide bonds in the presence of intracellular glutathione (GSH), pharmacological agents (Tpep and TPT) could be released from the nanoparticles and subsequently induce specific damage of tumor cell mitochondria and nucleus respectively with remarkable synergistic antitumor effect.
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SOLAR ENERGY
·
2015
·
IF 3.469
Haoran Yan,Jianxin Wang,Bo Feng,Ke Duan,Jie Weng
In the present work, a novel multistage structure dye-sensitized solar cell (DSSC), which consists of Ag nanowires (AgNWs), TiO 2 nanoparticles and graphene wrapped TiO 2 mesoporous microspheres (GTMs), was fabricated by using simple spin coating steps. The aim of this study was to modify the bandgap of GTMs by using graphene so as to promote the light absorption of GTMs in the visible light region and in turn to improve the power conversion efficiency (PCE) of DSSCs. Additionally, graphene and AgNWs can enhance the electron transfer in the DSSC to further improve the PCE of DSSCs. The effect of AgNWs and GTMs light scatting layer on the photovoltaic performance of DSSCs was investigated. The results showed that a PCE of 7.42% was achieved for the DSSC co-modified by GTMs and AgNWs, which was about twice as much as that for the DSSCs only with a TiO 2 nanoparticle layer (with a PCE of 3.53%). This present study might open a new avenue for the improvement of the PCE of DSSCs.
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RSC Advances
·
2015
·Vol. 5
·期 104
·85640-85645
·
IF 3.84
Benxia Li,Xiankun Shao,Yonggan Hao,Yan Zhao
Transition metal oxides with hollow or mesoporous microstructures represent a unique class of heterogeneous catalysts or catalyst supports with many fascinating features such as the large surface areas, tunable pore sizes and volumes, multitude of compositions, and ease of functionalization. In this work, we demonstrated a general ultrasonic-spray-assisted synthesis of various transition metal oxide hollow/mesoporous microspheres, using only low-cost commercial metal chlorides as precursors and water as solvent. As typical examples, five mono-component metal oxides (CeO2, α-Fe2O3, Co3O4, SnO2 and TiO2) hollow or mesoporous microspheres were prepared and their formation mechanisms were discussed. The catalytic carbon monoxide (CO) oxidation indicated that these metal oxide products exhibited improved catalytic activities than some of those reported previously, due to their tiny crystalline grains, large pore volume and specific surface area. The universality of this synthetic method was also demonstrated in producing multi-component and multi-functional metal oxides with hollow/mesoporous structures. This work therefore provides an industrial level producing method for the scalable preparation of various metal oxide hollow/mesoporous microspheres which are expected to be used as high-performance catalysts or catalyst supports in more chemical reactions.
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Materials Science & Engineering C-Materials for Biological Applications
·
2014
·
IF 2.736
Juan Huang,Yanan Xue,Ning Cai,Han Zhang,Kaikai Wen,Xiaogang Luo,Sihui Long,Faquan Yu
To reduce leakage on the drug-delivery pathway to minimize side effect of reduction or pH sensitive drug delivery systems, we designed a glutathione (GSH)/pH co-triggered magnetic nanogel drug delivery system for doxorubicin (DOX) based on the GSH concentration and pH difference between intracellular and extracellular environments. The introduction of superparamagnetic iron oxide nanoparticles (SPION) was intended for magnetic targeting. The magnetic DOX-loaded nanogel was then prepared by the oxidation of thiolated alginate with thiolated SPION in the presence of DOX. The nanogel size can be readily regulated in a range of 120–320 nm upon preparation conditions, with a negative surface charge of around − 40 mV. Saturation magnetization was estimated at 27.4 emu/g Fe by VSM. In vitro release was conducted in simulated cancerous environment conditions such as a high GSH concentration and mild acidity. As a result, the nanogel expressed, upon dual stimuli of pH 5/10 mM GSH, significantly higher accumulative release than upon single stimulus of pH 5 without GSH or pH 7.4/10 mM GSH. In vitro cytotoxicity against HeLa cells clearly illustrated that the nanogel could effectively inhibit cell growth, and the IC 50 was figured out to be 2.3 μg/mL of the nanogel, while the nanogel exclusive of DOX was nontoxic. Confocal laser scanning microscopy observation, combined with the result of Prussian blue staining, indicated that DOX was efficiently internalized into HeLa cells through endocytosis, released into the cytoplasm, and then principally entered the nuclei. The quantitative examination of the iron content revealed an exponential increase in the cellular uptake and an exponential decrease in the uptake efficiency with the fed nanogel. This drug-loaded nanogel could be a promising drug carrier for effective tumor-targeted chemotherapy.
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APPLIED SURFACE SCIENCE
·
2015
·
IF 2.711
Xi Zhang,Peng-Fei Ren,Hao-Cheng Yang,Ling-Shu Wan,Zhi-Kang Xu
We report a novel approach toward the surface modification of commercial polymer membranes via co-deposition of tannic acid (TA) and diethlyenetriamine (DETA). Particle-free, superhydrophilic, and almost colorless coatings are fabricated on the surfaces of polypropylene, poly(vinylidene fluoride), and poly(tetrafluoroethlene) microfiltration membranes. Cross-linking between TA and DETA plays a crucial role during the co-deposition process, as well as the adhesion of TA on the hydrophobic membrane surfaces. Both the surface wettability and water permeation flux are dramatically improved for the studied membranes after the co-deposition. The results indicate that co-deposition of TA and DETA is great potential for the surface modification of hydrophobic membranes.
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高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2015
·Vol. 33
·期 4
·587-596
·
IF 1.835
Song Zhi-ming,Shi Bo,Ding Jian-xun,Zhuang Xiu-li,Zhang Xiao-nan,Fu Chang-feng,Chen Xue-si
An electrospun poly(lactide- co -glycolide) (PLGA) membrane was prepared and used to perform the anti-adhesion of Achilles tendon. Throughout the experiments, the membrane showed an appropriate degradation rate, and the pH values of degradation media were maintained at around 7.4. Simultaneously, the excellent biocompatibility of the membrane in vitro and in vivo was confirmed by live/dead and histopathological analyses. Meanwhile, the membrane can reduce tendon adhesion significantly and promote functional recovery effectively. The encouraging results were further demonstrated by hematoxylin and eosin (H&E), and Masson’s trichrome stainings, and type I collagen immunohistochemical analysis. It was concluded that the model treated with the electrospun PLGA membrane was significantly better with respect to the adhesion prevention and tissue repair than that without treatment. Considering the results of degradation and adhesion prevention efficacy, the electrospun PLGA membrane would be a great candidate for the prevention of postoperative tendon adhesion.
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Nanoscale
·
2015
·Vol. 7
·期 28
·11956-11961
·
IF 7.394
Wenxiu Yang,Xiaoyu Yue,Xiangjian Liu,Junfeng Zhai,Jianbo Jia
A highly efficient N, S co-doped porous carbon ORR catalyst was simply designed in our report from ordered mesoporous carbon (OMC) and trace ionic liquids (ILs). The microstructure OMC was chosen as the template for improving the specific area, confining the ILs in the mesopores, and promoting the formation of the planar N and S doping. The resulting IL/OMC (IOMC) nanostructure exhibits comparable ORR activity and better stability than the commercial Pt/C catalyst in 0.10 M KOH solution, which makes it one of the best-performing metal-free carbon ORR catalysts. We deduced that the excellent ORR activity is attributed to the synergistic effect of N, S, and the ordered mesoporous structure. Interestingly, the ORR activity can be further boosted in both basic and acidic solutions after Fe doping into the IOMC nanostructures which clearly emphasizes that transition metal Fe is important for the construction of ORR active functional sites especially in acidic solution.
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高影响因子
ANALYST
·
2015
·Vol. 140
·期 8
·2656-2663
·
IF 4.107
Na Yang,Hongjie Song,Xiangyu Wan,Xiaoqing Fan,Yingying Su,Yi Lv
A metal (Co)–Organic Framework (Co-MOF) was first found to catalyze the chemiluminescence (CL) of luminol. On the basis of X-ray photoelectron spectroscopy, powder X-ray diffraction, CL spectral, UV-visible absorption spectral, and electron spin resonance (ESR) spectral studies, as well as the research of the influence of various free radical scavengers, a possible CL mechanism was proposed. The enhanced CL might be attributed to the formation of a peroxide analogous complex between the oxygen-related radicals and the active metal site of the Co-MOF material. The established Co-MOF–luminol CL system was successfully applied to determine L-cysteine (CySH), based on the selective and sensitive enhancing effect of CySH on this CL system. Under the optimized conditions, CySH was selectively detected in the range 0.1–10 μM with a detection limit of 18 nM. This novel CL system obviously gives impetus to the new research field of metal–organic frameworks (MOFs) in chemiluminescence.
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