ACS Biomaterials Science & Engineering
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2022
·
IF 5.395
Xujie Zhou,Qing Zhou,Qiang Chen,Yahao Ma,Zhenfang Wang,Lei Luo,Qiang Ding,Hang Li,Shunqing Tang
Local causes of slow wound healing include infection and wound hemorrhage. Using sodium bicarbonate as a neutralizer, a variety of carboxymethyl chitosan–tannic acid (CMC-TA) composite hydrogels solidify through hydrogen bonding in this study. The best-performing hydrogel was synthesized by altering the concentration of TA and exhibited remarkable mechanical properties and biocompatibility. Following in vitro characterization tests, the CMC-TA hydrogel exhibited remarkable antibacterial and antioxidant properties, as well as quick hemostasis capabilities. In the in vivo wound healing study, the results showed that the CMC-TA hydrogel could relieve inflammation and promote the recovery of skin incision, re-epithelialization, and collagen deposition. Overall, this multifunctional hydrogel could be an ideal wound dressing for the clinical therapy of full-thickness wounds.
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CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Yucheng Song,Hui Li,Tianhang Shan,Peipei Yang,Songwei Li,Zhong Liu,Chuntai Liu,Changyu Shen
In this study, a composite hydrogel with a low swelling ratio, excellent mechanical properties, and good U (VI) adsorption capacity was developed by incorporating a metal-organic framework (MOF) with a poly (acrylamide- co -acrylic acid)/chitosan (P(AM-co-AA)/CS) composite. The CS chain, which contains NH 2 , reduces the swelling ratio of the hydrogel to 4.17 after 5 h of immersion in water. The coordinate bond between the MOF and carboxyl group on the surface of P(AM-co-AA)/CS improves the mechanical properties and stability of P(AM-co-AA)/CS. The U(VI) adsorption capacity of P(AM-co-AA)/CS/MOF-808 is 159.56 mg g −1 at C 0 = 99.47 mg L −1 and pH = 8.0. The adsorption process is well fitted by the Langmuir isotherm and pseudo-second-order model. The P(AM-co-AA)/CS/MOF-808 also exhibits good repeatability and stability after five adsorption–desorption cycles. The uranium adsorption capacity of the developed adsorbent after one month in natural seawater is 6.2 mg g −1 , and the rate of uranium adsorption on the hydrogel is 0.21 mg g −1 day −1 .
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CONSTRUCTION AND BUILDING MATERIALS
·
2022
·
IF 7.693
Junxian Huang,Yu Liu,Yaseen Muhammad,Jia Qing Li,Yuting Ye,Jing Li,Zhuang Li,Ruinan Pei
Composite material using glutaraldehyde (GA) cross-linked chitosan (CTS) and graphene oxide (GO-CTS-GA) was designed applying electrostatic interaction strategy under strong alkali environment. GO-CTS-GA was in turn applied to prepare styrene butadiene styrene (SBS) GO-CTS-GA/SBS composite modified asphalt (MA)_binder. The effect of GO-CTS-GA on the physical properties of SBS modified asphalt binder was investigated and its mechanism of action was analyzed. Scanning electron microscopy (SEM), transmission electron microscopy (TEM) and atomic force microscopy tests confirmed the retainment of GO flakes microscopic dimensions while compensating for the chemical structural defects and mechanical property damage of GO. The results of dynamic shear rheometer and multi-stress creep recovery tests indicated that the GO-CTS-GA/SBS-MA binder exhibited better viscosity performance and elasticity performance, rutting resistance and high temperature thermal stability. At 64 °C, the loss modulus of 0.10 % GO-CTS-GA/SBS-MA was 29.5 % and 25.2 % higher than that of SBS-MA and GO/SBS-MA, respectively. SEM and TEM analyses of the four components of asphalt binder before and after modification revealed that the change of asphaltene microscopic morphology seriously affects the stability of asphalt colloidal system. Fourier transform infra-red analysis of the MA binder revealed that the change of saturation fraction and colloidal polarity by GO-CTS-GA is responsible for the dispersion and cross-linking of SBS chain segments in the asphalt binder phase. This study provides important reference information for nanomaterials to change the macroscopic mechanical properties by modulating the microstructure, physical and chemical properties of asphalt binder at the micro and nano-scale.
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RARE METALS
·
2022
·Vol. 42
·期 2
·430-437
·
IF 6.318
Xu Hao-Hang,Yue Liang,Tang Yang,Liu Fan,Zhu Hong-Jiu,Bao Shu-Juan
Quasi-solid electrolytes promote the development of safe and flexible energy storage devices. In this work, a chitosan and citric acid crosslinked membrane is prepared by a freeze–thaw cross-linking method, in which the chemical crosslinking of chitosan and citric acid increase the viscoelastic behavior of the polymer membrane, and the freeze–thaw assist freeze drying process to create abundant interconnected open-pores and three-dimensional (3D) network. Due to the good viscoelasticity, excellent electrolyte loading capacity (596%) and high ion conductivity (7.7 × 10 –3 S·cm −1 ), as quasi-solid electrolyte, our proposed chitosan and citric acid crosslinked membrane helps Zn|CCFT-ZnSO 4 |AC hybrid supercapacitor to delivers wide operating voltage, high specific capacity of 100.5 F·g −1 and stable cycle life (93% after 1000 cycles), which suggests that our proposed freeze–thaw assisted freeze drying method has great potential in designing quasi-solid state electrolyte for energy storage device. Graphical abstract
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2023
·Vol. 24
·期 3
·2447
·
IF 5.6
Shunxian Ji,Yushuang Zhao,Xinrang Zhai,Lu Wang,Huali Luo,Zhiyong Xu,Wei Dong,Bingbing Wu,Wei Wei
The skin is the largest organ of the human body. Skin injuries, especially full-thickness injuries, are a major treatment challenge in clinical practice. Therefore, wound dressing materials with therapeutic effects have great practical significance in healthcare. This study used photocrosslinkable gelatin methacryloyl (GelMA) and sulfhydrylated chitosan (CS-SH) to design a double-crosslinked hydrogel for wound dressing. When crosslinked together, the resulting hydrogels showed a highly porous inner structure, and enhanced mechanical properties and moisture retention capacity. The compression modulus of the GelMA/CS-SH hydrogel (GCH) reached up to about 40 kPa and was much higher than that of pure GelMA hydrogel, and the compression modulus was increased with the amount of CS-SH. In vitro study showed no cytotoxicity of obtained hydrogels. Interestingly, a higher concentration of CS-SH slightly promoted the proliferation of cells. Moreover, the double-crosslinked hydrogel exhibited antibacterial properties because of the presence of chitosan. In vivo study based on rats showed that full-thickness skin defects healed on the 15th day. Histological results indicate that the hydrogel accelerated the repair of hair follicles and encouraged the orderly growth of collagen fibers in the wound. Furthermore, better blood vessel formation and a higher expression of VEGFR were observed in the hydrogel group when compared with the untreated control group. Based on our findings, GCH could be a promising candidate for full-thickness wound dressing.Keywords:sulfhydrylated chitosan;hydrogel;wound healing
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Baokang Wang,Jupen Liu,Ping Zhang,Hongqiu Wei,You Yu
Natural and biocompatible chitosan has demonstrated wide applications. However, rapidly fabricating high-performance chitosan hydrogels in one-step controllable processes is still a challenge for some advanced applications. Here, we report a trifunctional microgel-mediated photochemical (TMMP) strategy to achieve the fabrication of printable tough chitosan-based hydrogels (PTCHs) in seconds. Such microgels help the slow release of persulfate anions and their uniform dispersion in an aqueous solution of cationic chitosan. The released persulfates are available for preparing multiple networks of phenolic coupling of modified chitosan and radical polymerization of Pluronic F127 via orthogonal tris(bipyridine)ruthenium(II)-based photochemistry, respectively. Trifunctional microgels have reversible Ca2+-crosslinked networks that further improve the hydrogels’ mechanical properties and toughness. The maximum stress and toughness increase by >20 folds compared to the chitosan and F127 hydrogels with single network structures. Moreover, these microgels enable the precursor to have a good shearing-thinning property and benefit the controllable preparation of PTCHs in a short time, as low as ∼4 s under visible light irradiation. It, therefore, is compatible with standard printing techniques to make complex structures. Strain sensors based on structured PTCHs have stable mechanical and responsive properties in the water, which are applied for real-time underwater communications (<0.4 s). It is anticipated that this one-step TMMP strategy opens new horizons for designing advanced chitosan hydrogels.
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BIOMACROMOLECULES
·
2022
·
IF 6.978
Baoer Fan,Naifu Cui,Zhewei Xu,Kun Chen,Panchao Yin,Kan Yue,Wen Tang
Hospital-acquired infections are a serious threat to the recovery of patients. To prevent such infections, an antibacterial coating is an effective method to eliminate bacterial colonization on healthcare-related surfaces. Herein, we report an antibacterial hydrogel composed of silver-containing polyoxometalate (AgP5W30 POM) and carboxymethyl chitosan (CMC). The silver ion is encapsulated inside the POM cage and demonstrates long-lasting bacteriostasis after repeated exposure to both Gram-positive and Gram-negative bacteria. The chemical structure of chitosan derivatives, as well as the concentration and pH, is studied to tune the mechanical properties of the hydrogel. The hydrogel undergoes a gel–sol transition above the critical temperature and possesses self-healing ability. This hydrogel can be readily coated on the surface of versatile bulk materials, which is especially convenient for porous objects and resists the growth of Staphylococcus aureus, Escherichia coli, and methicillin-resistant S. aureus (MRSA). In summary, we envision that the AgP5W30-CMC hydrogel has great potential to serve as an antibacterial coating to decrease the prevalence of hospital-acquired infections.
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Reaction Kinetics Mechanisms and Catalysis
·
2022
·Vol. 135
·期 1
·425-439
·
IF 1.843
Bai Maojuan,Niu Deli,Xia Liquan,Yin Yajie,Wan Jun
In this study, chitosan biochar was prepared by one-step pyrolysis of chitosan and used to activate persulfate to remove phenol with high salinity wastewater. Chitosan biochar was characterized by scanning electron microscope, energy-dispersive spectroscopy, X-ray photoelectron spectroscopy and FTIR spectrum. The effect of chitosan biochar dosage, persulfate dosage, and pH on the phenol removal was explored and optimized. Meanwhile 98% phenol removal rate and 80% phenol mineralization rate were achieved under the optimum conditions. Phenol was successfully oxidized and degraded into water, carbon dioxide and other small molecular organics. The system was different from the general persulfate advanced oxidation system, sulfate radical played a minor role, singlet oxygen played a major role. The leading role of non-radical 1 O 2 in degradation was determined by radical quenching experiments and ESR experiments. By simulating high salt wastewater and studying the effect of common anions and cations on the system, system's stability was also investigated.
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CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Jinfa Qin,Jinping Zhao,Yang Wu,Long Li,Dan Li,Hongbing Deng,Jinping Liu,Li Zhang
The morbidity of a diverse array of esophageal diseases has been increasing in recent years, and postoperative bacterial infection is a common potential risk. Current research on artificial esophageal stents is lacking and less than satisfactory. Artificial materials with excellent mechanical, antimicrobial, and cytocompatible properties at the same time still have great potential. In this study, chitosan (CS) and collagen (COL) were deposited on nylon 6 (N6)/silk fibroin (SF) composite nanofibers using layer-by-layer self-assembly (LBL). The obtained nanofibrous mats were characterized, and the results indicated that the surface morphology and hydrophilicity of the composite nanofibrous mats were obviously improved by the deposition of CS and COL. The mechanical properties of the composite nanofibrous mats were also improved after LBL modification. In addition, the LBL-structured nanofibrous mats possessed excellent antibacterial activity , reaching more than 90% inhibition of gram-positive and negative bacteria. The results of cell experiments indicated that the nanofibrous mats modified by CS and COL had excellent biocompatibility for promoting human esophageal epithelial cell adhesion and proliferation. In vivo animal experiments showed that the LBL-structured nanofibrous mats were beneficial to the healing of esophageal defects compared with the control group. In summary, LBL-structured nanofibrous mats are very promising materials for esophageal replacement to reduce the incidence of postoperative complications.
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CHEMICAL ENGINEERING RESEARCH & DESIGN
·
2022
·
IF 4.119
Haohe Huang,Qifeng Yang,Lanyu Zhang,Chongxing Huang,Yong Liang
A simple polyacrylamide modification method was developed to improve the adsorption capacity and anti-interference of kaolin, which enhanced the adsorption performance of sodium alginate/carboxymethyl chitosan composite hydrogel. Fourier transform infrared spectroscopy, Scanning electron microscopy and energy dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy were used to determine the composition and adsorption mechanism of the adsorbent. In addition, the adsorption effect of the adsorbent on Cu 2+ was measured. The results showed that the adsorption rate conformed to the pseudo-second-order kinetic model and the Langmuir isotherm model, and the maximum adsorption capacity of the adsorbent was 5.5157 mg/g. In addition, adding modified kaolin reduced the interference of certain coexisting ions and the influence of pH. After five reuse cycles, its adsorption capacity was more than 82%. Therefore, this study provides a theoretical basis for improving the adsorbent of biomass-based materials.
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Foods
·
2022
·Vol. 11
·期 3
·450
·
IF 5.561
Jiaxin Lu,Xiaojing Li,Chao Qiu,David Julian McClements,Aiquan Jiao,Jinpeng Wang,Zhengyu Jin
This study aimed to fabricate food-grade Pickering emulsions stabilized by chitosan-phytic acid-β-cyclodextrin (CS-PA-CD) nanoparticles. The CS-PA-CD nanoparticles were characterized with FITR, XRD, and TGA to prove its successfully crosslinking, then characterized by DLS system and scanning electron microscopy showing the smallest average particle size was 434.2 ± 2.5 nm and it increased with the ratio of PA-CD to CS increasing. Pickering emulsions stabilized by CS-PA-CD nanoparticles was prepared and it showed the best stability at around pH 6. The particle concentration higher than 1.0% (w/v) and the oil fraction above 0.5% (v/v) could reach the emulsion stability. In addition, the Pickering emulsions were stable at various temperature (30–70 °C) and influenced by the certain change of ionic strength (0–500 mM). These CS-PA-CD Pickering emulsions showed great application in the formation of functional foods and pharmaceutical industries.Keywords:chitosan/cyclodextrin;nanoparticles;Pickering emulsions;rheological properties;stability;phytic acid
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Jianbo Zhao,Haixin Jiang,Qiuyu Huang,Jingting Xu,Mengxia Duan,Shan Yu,Zijian Zhi,Jie Pang,Chunhua Wu
Advanced carboxymethyl chitosan (CMCS) based functional films were fabricated by involving some amounts of gliadin/phlorotannin nanoparticles (GPNPs) using a solution casting method. GPNPs were synthesized by an antisolvent precipitation approach, and they presented a spherical morphology with a mean diameter of 145.30 ± 2.06 nm. The effect of GPNPs concentration on the structural, physical, antioxidant and antimicrobial properties of CMCS-GPNPs (C-G) functional films was evaluated. It was found that the added GPNPs were homogeneously distributed over the whole CMCS matrix, allowing to reduce the free volume of the nanocomposite matrix and subsequently improve the physical properties of the final film (evidenced by mechanical and water barrier properties). FT-IR spectra indicated the intermolecular interactions, such as hydrogen bonds and electrostatic interaction, within the matrix of the nanocomposite films were increased. Impressively, the anti-ultraviolet properties, antioxidant activity and antimicrobial behaviors of the as-formed C-G functional films were greatly enhanced compared to the pure CMCS film. All these results suggested that our as-prepared C-G nanocomposite films could be a promising food packaging material.
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