INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Qiang-Qiang Ma,Peng Zhou,Yizhen Liu,Zuowei Xie
Transition metal catalyzed selective cage B–H functionalization of carboranes has made significant progress in recent years, giving rise to the efficient synthesis of a large variety of cage B-functionalized carboranes including alkenylation, arylation, alkynylation, borylation, hydroxylation, acyloxylation, amination, and halogenation. However, the mechanisms of these catalytic B–X coupling reactions are not well understood. Herein, we describe the isolation and characterization of the catalytically relevant o-carborane based palladium(II) metallacycle, disclosing the details of Pd-catalyzed B–H functionalization of o-carboranes. As a result, highly selective catalytic B(3,6)-dihalogenation, -dimethylation, and -diarylation of o-carboranes have been achieved.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-22
·
IF 12.6
Liu Yanhong,Gong Liming,Feng Jing,Xiao Congcong,Liu Chenfei,Chen Bohan,Chen Liqing,Jin Mingji,Guan Youyan,Gao Zhonggao,Huang Wei
Immune checkpoint inhibition (ICI) has become the mainstay of immunotherapy for the treatment of renal cell carcinoma (RCC). However, only a small portion of patients exhibit a positive response to PD-1/PD-L1 blockade therapy and the key reason is that RCC belongs to a vascular-rich tumor for promoting immunosuppression. Specifically, the dysfunctional tumor vasculature hinders effector T cell infiltration and induces immunosuppressive tumor microenvironment via the release of cytokine, which attenuates the therapeutic efficacy of ICI. Therefore, regulating abnormal tumor vasculature may be a promising strategy to overcome the immunosuppressive microenvironment and enhance ICI therapy. Here, we propose an NGR peptide-modified actively targeted liposome (Axi/siRNA PD−L1 @NGR-Lipo) to encapsulate the anti-angiogenic agents Axitinib and PD-L1 siRNA to promote tumor vasculature normalization and relieve immune evasion for enhanced anti-tumor immunotherapy. With NGR-mediated tumor homing and active targeting, Axi/siRNA PD−L1 @NGR-Lipo could act on tumor vascular endothelial cells to inhibit neo-angiogenesis, increase pericyte coverage and vascular perfusion, and normalize the structure and function of tumor blood vessels. Meanwhile, it also enhanced immune effector T cells and NK cells infiltration and reduced the proportion of immunosuppressive T cells including MDSC cells and Tregs, thus improving the tumor immunosuppressive microenvironment. Moreover, Axi/siRNA PD−L1 @NGR-Lipo reduced the expression of PD-L1 protein in tumor cells, restored the recognition and killing ability of cytotoxic T cells, and relieved immune evasion. As expected, Axi/siRNA PD−L1 @NGR-Lipo displayed superior anti-tumor and anti-metastatic efficacy in mice bearing RCC. Overall, this study demonstrated the important potential of regulating abnormal tumor vasculature to reshape the immunosuppressive microenvironment and boost ICI therapy, which represents a promising avenue for the synergistic anti-tumor with cancer immunotherapy. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 77
·63044-63049
·
IF 3.84
Hualei Hu,Jinghui Lyu,Jie Cen,Qunfeng Zhang,Qingtao Wang,Wenwen Han,Jiayao Rui,Xiaonian Li
The effect of MgO and Pd modification on the catalytic performance of hierarchical porous ZSM-5 for benzene alkylation with methanol was investigated. The results indicated that the introduction of MgO could reduce the Brönsted acid sites which suppressed the side reaction of methanol to olefins and in turn effectively promoted the alkylation of benzene. However, the single modification of MgO could not completely suppress the formation of ethylbenzene and coke. Doping a small amount of Pd had a positive effect on inhibiting the generation of ethylbenzene and coke, which could be attributed to the hydrogenation of ethylene into ethane on Pd. The dual modified catalyst (MgO and Pd) exhibited high benzene conversion (56%) and xylene selectivity (39.1%), and the lowest ethylbenzene selectivity (0.13%) and coke content (0.4 wt%).
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS A-GENERAL
·
2016
·
IF 4.012
Jing-Jing Lv,Zheng-Jun Wang,Jiu-Ju Feng,Renhua Qiu,Ai-Jun Wang,Xinhua Xu
The construction and design of nanomaterials are important for improving their performance. Here we present a simple one-pot wet-chemical method for the preparation of alloyed Pd-Cu nanowires using octylphenoxypolyethoxyethanol (NP-40) as structure-directing and stabilizing agents. The obtained nanocrystals display outstanding catalytic activity for ligand-free Suzuki cross coupling reaction under mild conditions, and can be easily recovered and reused for at least 5 consecutive cycles without showing significant loss of catalytic activity.
✓ 已验证
产品关联
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2017
·
IF 5.951
Pengtao Qiu,Jinglei Bi,Xiaojing Zhang,Shengchun Yang
We present a novel synthetic strategy for the shape-controlled synthesis of Pt-based alloy nanoparticles (NPs) in inorganic molten salt without using any organic surfactants or capping agents. Graphene oxide (GO) was chosen as the stabilizer in the inorganic molten salt synthetic strategy, due to the existence of various oxygen-containing functional groups on its surface, which adsorb, anchor, and stabilize the metal ions or NPs. After GO was added in molten salt, the PtPd nanosheets were formed on its surface in H2 atmosphere. In addition, when KI was chosen as the shape-inducing agent to selectively adsorb on and fully protect the (100) facets of alloys, PtPd nanocubes with core–shell structure, PtCu nanohemicubes, and PtPdCu nanocubes were prepared successfully on the surface of GO in molten salt. Introduction of GO as the stabilizer in molten salt proves a new approach in synthesis of Pt-based nanocrystals with controlled morphologies.
✓ 已验证
产品关联
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2017
·
IF 4.798
Zhi Liang Zhao,Qi Wang,Lian Ying Zhang,Hong Ming An,Zhou Li,Chang Ming Li
Development of an inexpensive high performance catalyst with low Pt loading remains a great challenge. Herein galvanic exchange-formed ultra-low Pt loaded porous Ag-Pd binary alloy nanotubes (Pt/Ag-Pd) was prepared as a catalyst toward oxygen reduction reaction (ORR). With highly dispersed active but ultra-low Pt atoms (Pt: about 5.8 wt%) on the porous binary alloy surface, the Pt/Ag-Pd catalyst increases mass activity toward ORR by 1.82 times than commercial Pt/C while possessing excellent operation stability. The performance enhancement is mainly attributed to the unique porous Pt shell/Ag-Pd core tubular structure for increased active sites and facilitated interfacial electron transfer rate by a unique Ag-Pd jointly modified electronic structure. This catalyst holds great promise for practical applications in low temperature fuel cells.
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2014
·Vol. 21
·期 7
·5201-5210
·
IF 2.757
Chen Xi,Yao Xiaoyan,Yu Chunna,Su Xiaomei,Shen Chaofeng,Chen Chen,Huang Ronglang,Xu Xinhua
Soil pollution by polychlorinated biphenyls (PCBs) arising from the crude disposal and recycling of electronic and electrical waste (e-waste) is a serious issue, and effective remediation technologies are urgently needed. Nanoscale zerovalent iron (nZVI) and bimetallic systems have been shown to promote successfully the destruction of halogenated organic compounds. In the present study, nZVI and Pd/Fe bimetallic nanoparticles synthesized by chemical deposition were used to remove 2,2′,4,4′,5,5′-hexachlorobiphenyl from deionized water, and then applied to PCBs contaminated soil collected from an e-waste recycling area. The results indicated that the hydrodechlorination of 2,2′,4,4′,5,5′-hexachlorobiphenyl by nZVI and Pd/Fe bimetallic nanoparticles followed pseudo-first-order kinetics and Pd loading was beneficial to the hydrodechlorination process. It was also found that the removal efficiencies of PCBs from soil achieved using Pd/Fe bimetallic nanoparticles were higher than that achieved using nZVI and that PCBs degradation might be affected by the soil properties. Finally, the potential challenges of nZVI application to in situ remediation were explored.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Lite Yang,Bingjie Xu,Huili Ye,Faqiong Zhao,Baizhao Zeng
A novel molecularly imprinted electrochemical sensor for quercetin (QR) was fabricated via electropolymerization of para -aminobenzoic acid (p-ABA) on a three-dimensional (3D) Pd nanoparticles-porous graphene-carbon nanotubes composite (Pd/pGN-CNTs) modified glassy carbon electrode. The 3D Pd/pGN-CNTs composite was prepared by a facile one-pot hydrothermal method and it exhibited high conductivity, large surface as well as excellent electrocatalysis. The imprinting factor (IF) of MIP sensor toward QR was 3.14, which is higher than those of its analogues (i. e. morin, catechin, rutin, luteolin, and kaempferide). Based on the synergistic effect of the nanocomposite and the molecularly imprinted poly(p-ABA), the resulting electrochemical sensor presented high sensitivity and selectivity. Its linear response range was 0.01–0.50 μM, and the low detection limit was 5.0 nM (S/N = 3). The sensor also showed good reproducibility and stability. It was successfully applied to the detection of QR in food and medicine samples. In addition, theoretical calculations based on density functional theory (DFT) was conducted, and the result indicated that there was strong hydrogen bond between the QR and p-ABA.
✓ 已验证
产品关联
DOI
高影响因子
COLLOID AND POLYMER SCIENCE
·
2017
·Vol. 295
·期 4
·703-707
·
IF 1.723
Lu Wangting,Zhang Geng,Wei Feng,Li Wenhui,Cheng Kun,Ding Fei,Zhang Jiying,Zheng Wanquan
Palladium nanocrystals (NCs) are highly useful functional materials in many applications, and the performances of Pd NCs were strongly depended on the crystalline facet exposed on their surface. In this work, Pd NCs were synthesized in aqueous solutions by using Na 2 PdCl 4 as the precursor, citric acid as the capping agent, and Pluronic F127 as both stabilizer and reductant. By adjusting the reaction parameters, Pd cuboctahedrons, octahedrons, and triangular nanoplates with well-defined facets can be produced. This study provides a new pathway for the shape-controlled preparation of noble metal NCs.
✓ 已验证
产品关联
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2015
·
IF 4.504
Shuhuai Li,Guihao Yin,Xuejin Wu,Chunhua Liu,Jinhui Luo
A novel supramolecular imprinted electrochemical sensor was developed for carbofuran (CBF) determination based on a multiwalled carbon nanotube-supported Pd-Ir nanocomposite catalyst (MWCNT/Pd-Ir) with methylene blue (MB) signal amplification. First, MWCNT/Pd-Ir composite nanoparticles were synthesized and used to modify the surface of a glassy carbon electrode; then, a molecular imprinted polymer for CBF was prepared by electropolymerization , with MB-doped o -phenylenediamine as the functional monomer and a 4-tert-butylcalix[8]arene-CBF (4TB[8]A-CBF) supramolecular complex as the template. The electrical signals were controlled though the elution and re-adsorption of CBF. Due to the double catalysis by the MWCNT/Pd-Ir and MB, the current intensity for CBF was obviously amplified. Additionally, because of the double recognition by the 4TB[8]A and MIP, the sensors showed outstanding CBF identification properties. The method was applied to detect CBF in agricultural products, and the satisfactory results were obtained.
✓ 已验证
产品关联
DOI
高影响因子
ACS Catalysis
·
2025
·
IF 13.1
Tingting Xiao,Jingrong Li,Jian Li,Qihang Gong,Peikai Luo,Xinluona Su,Haiyang Cheng,Chao Zhang,Fengyu Zhao
The hydrogenolysis of cellulose-derived 5-hydroxymethylfurfural is essential for the production of fuels and chemicals from biomass. Herein, we fabricated a phosphorus-doped Pd/P-TiO2 catalyst for the hydrodeoxygenation of 5-hydroxymethylfurfural to 2,5-dimethylfuran. A large number of defects and electron-deficient Ti4+ sites (dTi4+) were formed by doping phosphorus into the TiO2 support, which could promote hydrogen spillover and reactant adsorption. Moreover, the spilled active hydrogen induced the formation of P–O(H)-dTi4+, which acted as a “Brønsted acidic site” to promote the activation of C–O bonds. Consequently, the Pd/P-TiO2 catalyst exhibited superb activity for the hydrodeoxygenation of 5-hydroxymethylfurfural to 2,5-dimethylfuran at mild conditions of 150 °C under 1 MPa H2.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POWER SOURCES
·
2024
·
IF 8.1
Wenyi Wang,Long Tang,Cheng Chen,Xueqin Wang,Yuanyuan Wang,Wencong Sun
Efficient and stable electrocatalysts with low platinum content are crucial for the practical application of fuel cells. The development of Pt-based single atom catalysts (SACs) has emerged as a promising research direction. In this study, we design and prepare a SACs based on MoS 2 with Pt–S–Mo and Pd–S–Mo active sites (Pd, Pt–MoS 2 ) by successively occupying vacancies, while maintaining the individual characteristics of the active sites. The resulting Pd, Pt–MoS 2 catalyst exhibits excellent electrocatalytic activity for oxygen reduction reaction (ORR), long-term stability, and resistance to common poisons (SCN − , S 2− , and methanol) under neutral conditions. Meanwhile, the microbial fuel cell (MFC) equipped with Pd, Pt–MoS 2 exhibits excellent performance in terms of actual electricity generation performance and sewage purification capacity with an ultrahigh power density, average chemical oxygen demand (COD) removal rate, and coulombic efficiency (CE) of 1398.6 ± 43.5 mW m −2 , 96.2 ± 2.2 %, and 22.5 ± 0.5 %, respectively. This strategy will provide new insights into the development of advanced bimetallic as well as polymetallic doped vacancies of MoS 2 SACs.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）