POTATO RESEARCH
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2024
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IF 2.3
Xu Jian,Zeng Fankui
Total and individual carotenoid concentrations were determined in raw potato tubers of six varieties, including Kexin No. 1, Xisen No. 6, Atlantic, Xisen No. 5, Shepody, and Favorita. The relationship between colour CIE L*a*b* and total carotenoid concentration and the effect of domestic thermal treatments on the total and individual carotenoid concentrations were also investigated. The total carotenoid content in the six potato varieties ranged from 96.48 to 875.08 µg/100 g FW. The main carotenoids were lutein, zeaxanthin, violaxanthin, and antheraxanthin. The specific composition depended on the variety, and β -carotene was not detected in all tested six potato varieties. The colour value of coordinate b * was positively and significantly correlated with total carotenoid content. Boiling had the smallest effect on the decrease of total and individual carotenoids, while microwave treatment resulted with 52.67% in the highest loss of the total carotenoid in Favorita. As for the individual carotenoids, violaxanthin followed by antheraxanthin was the most heavily affected by cooking. All four thermal treatments, baking, boiling, frying, and microwaving, decreased the carotenoid contents, and boiling is recommended as a preferred method associated with the lowest loss rate of total and individual carotenoids. Through our research, we hope to deepen our understanding of the variability in nutritional content among commonly consumed potato types.
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IONICS
·
2024
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IF 2.4
Zhang Jingchun,Wang Qiqi,Chen Haoyuan,Zhang Yilin,Deng Yupei,Wang Ying,Zhao Huimin,Zhu Yu,Wang Guowei,Zhuang Linghua
It is found that ester introduction into imidazolium or pyridinium cations can significantly improve the biodegradability property of ionic liquids and also influence the viscosity and the toxicity of ionic liquids. Ionic liquids based on dicyanamide anion reveal good electrochemical properties. Four chloride and dicyanamide ionic liquids with ester groups were prepared, and the effect of anion and cation structure of ionic liquids on electrical conductivity/electrochemical stability window was discussed from experimental studies and density functional theory (DFT) simulations. The introduction of the ester group in imidazolium cation decreased the refractive index and electrical conductivity, while increasing the electrochemical stability window of ionic liquids. The refractive index, electrical conductivity, and electrochemical stability window values decreased with the increase of the alkyl chain length of the ester group from ethyl to butyl. The refractive index values of chloride imidazolium ionic liquids were higher than those of dicyanamide ionic liquids, while the electrical conductivity and electrochemical stability window values of dicyanamide ionic liquids were much higher than those of chloride ionic liquids. DFT simulations revealed that ester introduction in imidazolium cation decreased the average hydrogen bond length and increased the cation–anion interaction. The average hydrogen bond length of chloride and dicyanamide ionic liquids increased with the increase of the alkyl chain length of the ester group from ethyl to butyl, while the absolute interaction energy (Δ E ) of chlorine and dicyanamide ionic liquids decreased with the increase of the alkyl chain length of the ester group from ethyl to butyl. DFT simulations demonstrated that ionic liquid structure (ester chain length and anion) was closely related to the electrical conductivity and electrochemical stability window properties of ionic liquids. These results will shed light on the design and optimization of functional ionic liquids as electrolytes for renewable energy and energy storage applications.
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Journal of Analysis and Testing
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2024
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IF 5.5
Wang Ying,Wang Xu,Liu Ziyun,Dong Fangdi,Lin Yuqing
Phosphate plays a critical role in maintaining homeostasis and engaging in cellular metabolism and energy transduction within the human body. Dysregulation of phosphate concentration can lead to various disorders. However, current detection methods face significant challenges, including low sensitivity, narrow linear ranges, and extended response times. To address these issues, we employ a ligand-regulation strategy and adopt a bottom-up approach to synthesize a series of Ce-based metal organic frameworks (MOFs) with different substituents (–NO 2 , –OH, –NH 2 ). These materials demonstrate outstanding performance in phosphate ion detection using the fluorescence analytical method. Notably, they exhibit a broad linear range (0–250 μmol/L), low detection limit (1.8 × 10 –9 mol/L), and rapid response time (4 min). Furthermore, hydroxyl and amino-functionalized Ce-MOFs exhibit successful application in intracellular fluorescence imaging. This capability is significant for detecting phosphate in biological systems and holds promise for contributing to diagnosing and treating diseases.
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Journal of Translational Medicine
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2024
·Vol. 22
·期 1
·1-17
·
IF 6.1
Gong Sisi,Huang Rongfu,Wang Meie,Lian Fen,Wang Qingshui,Liao Zhijun,Fan Chunmei
Triple-negative breast cancer (TNBC) is known for its aggressive nature, lack of effective diagnostic tools and treatments, and generally poor prognosis. The objective of this study was to investigate metabolic changes in TNBC using metabolomics approaches and explore the underlying mechanisms through integrated analysis with transcriptomics. In this study, serum untargeted metabolic profiles were first examined between 18 TNBC patients and 21 healthy control (HC) subjects using liquid chromatography-mass spectrometry (LC-MS), identifying a total of 22 significantly differential metabolites (DMs). Subsequently, receiver operating characteristic analysis revealed that 7-methylguanine could serve as a potential biomarker for TNBC in both the discovery and validation sets. Additionally, transcriptomic datasets were retrieved from the GEO database to identify differentially expressed genes (DEGs) between TNBC and normal tissues. An integrative analysis of the DMs and DEGs was conducted, uncovering potential molecular mechanisms underlying TNBC. Notably, three pathways—tyrosine metabolism, phenylalanine metabolism, and glycolysis/gluconeogenesis—were enriched, providing insight into the energy metabolism disorders in TNBC. Within these pathways, two DMs (4-hydroxyphenylacetaldehyde and oxaloacetic acid) and six DEGs (MAOA, ADH1B, ADH1C, AOC3, TAT, and PCK1) were identified as key components. In summary, this study highlights metabolic biomarkers that could potentially be used for the diagnosis and screening of TNBC. The comprehensive analysis of metabolomics and transcriptomics data offers a validated and in-depth understanding of TNBC metabolism.
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PubMed
高影响因子
Scientific Reports
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2024
·Vol. 14
·期 1
·1-15
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IF 3.8
Wu Ying,Wu Zhiyi,Gao Yinyin,Fan Yixuan,Dong Yao,Zhang Yinan,Gai Zhonghui,Gu Shaobin
This study aimed to evaluate the safety profile and beneficial effects of Heyndrickxia coagulans strain BC99 (BC99) for potential use in functional foods and pharmaceuticals. We began with whole genome sequencing of BC99, followed by a comprehensive safety assessment comprising genome analysis, hemolysis, cytotoxicity, antibiotic susceptibility tests, and cell adhesion and tolerance studies, along with acute and subacute oral toxicity studies in animal models. BC99 was isolated from a well-characterized collection originating from the feces of a healthy infant. Our results indicated no hemolytic activity on Columbia blood agar plates and broad antibiotic sensitivity, including to gentamicin, ampicillin, chloramphenicol, ciprofloxacin, and others. Cytotoxicity testing confirmed no adverse effects on HT-29 cells and significant adhesive properties to intestinal epithelial cells. Tolerance tests demonstrated over 90% viability of BC99 under simulated gastrointestinal conditions. In vivo studies in mice and rats confirmed the absence of adverse effects following oral administration. Collectively, these findings support BC99’s robust tolerance to gastrointestinal environments, strong adhesion capabilities, and a broad spectrum of antibiotic resistance, underlining its potential as a safe and effective agent for gut microbiota modulation and host health enhancement.
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高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
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2024
·
IF 3.9
Yang Jie,Yan Zhuo,Dai Jiangdong
With the rapid industrial development worldwide, the volume of oily wastewater, including petroleum spills and industrial effluents, has increased dramatically, posing a threat to ecosystems and human health. Membrane separation technology, known for its advantages of phase-transition-free operation, low energy consumption, and simplicity, has gained rapid popularity in wastewater treatment. This study focused on modifying PVDF membranes using PVA-TA hydrogels with two distinct coordination strategies: TA-Fe 3+ coordination and APTMS covalent cross-linking. The resulting composite membranes exhibited superhydrophilic/underwater superoleophobic properties with high emulsion flux (3800–6900 and 4200–12,000 Lm − 2 h − 1 bar − 1 ) and separation efficiency (> 98.9% and > 99.3%) for various oil-water emulsions. Notably, the stability of the hydrogel network allowed the composite membranes to maintain elevated fluxes (6847.2 and 10266.7 Lm − 2 h − 1 bar − 1 ) and separation efficiencies (97.8% and 99.3%) even after 10 cycles for dichloroethylene-water emulsion. The addition of Fe 3+ and APTMS enhances hydrogel stability and roughness, with APTMS contributing to superior wetting and separation performance. This work provides valuable insights into the impact of different coordination mechanisms on hydrogel-coated membranes, offering a foundation for the development of advanced materials in efficient oil-water separation.
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Nature Protocols
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2024
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IF 13.1
Wang Aoxue,Zou Yejun,Liu Shuning,Zhang Xiuze,Li Ting,Zhang Lijuan,Wang Ruwen,Xia Yale,Li Xie,Zhang Zhuo,Liu Tiemin,Ju Zhenyu,Wang Ru,Loscalzo Joseph,Yang Yi,Zhao Yuzheng
As a key glycolytic metabolite, lactate has a central role in diverse physiological and pathological processes. However, comprehensive multiscale analysis of lactate metabolic dynamics in vitro and in vivo has remained an unsolved problem until now owing to the lack of a high-performance tool. We recently developed a series of genetically encoded fluorescent sensors for lactate, named FiLa, which illuminate lactate metabolism in cells, subcellular organelles, animals, and human serum and urine. In this protocol, we first describe the FiLa sensor-based strategies for real-time subcellular bioenergetic flux analysis by profiling the lactate metabolic response to different nutritional and pharmacological conditions, which provides a systematic-level view of cellular metabolic function at the subcellular scale for the first time. We also report detailed procedures for imaging lactate dynamics in live mice through a cell microcapsule system or recombinant adeno-associated virus and for the rapid and simple assay of lactate in human body fluids. This comprehensive multiscale metabolic analysis strategy may also be applied to other metabolite biosensors using various analytic platforms, further expanding its usability. The protocol is suited for users with expertise in biochemistry, molecular biology and cell biology. Typically, the preparation of FiLa-expressing cells or mice takes 2 days to 4 weeks, and live-cell and in vivo imaging can be performed within 1–2 hours. For the FiLa-based assay of body fluids, the whole measuring procedure generally takes ~1 min for one sample in a manual assay or ~3 min for 96 samples in an automatic microplate assay.
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Nature Photonics
·
2024
·Vol. 18
·期 2
·162-169
·
IF 32.3
Du Xinyuan,Zhao Shan,Wang Lu,Wu Haodi,Ye Fan,Xue Kan-Hao,Peng Shaoqian,Xia Jianlong,Sang Ziru,Zhang Dongdong,Xiong Zuping,Zheng Zhiping,Xu Ling,Niu Guangda,Tang Jiang
Efficient and fast scintillators are in high demand in a variety of fields, such as medical diagnostics, scientific instruments and high-energy physics. However, the trade-off between high scintillation efficiency and fast timing properties is a common challenge facing almost all scintillators. To overcome this limitation, we have developed a strategy for organic scintillators by directing all hot excitons into fast singlet emission states without involving the lowest triplet states. Our scintillator, 1,1,2,2-tetrakis(4-bromophenyl)ethylene, shows an ultrafast radiative lifetime of 1.79 ns and a light yield of ∼ 34,600 photons per MeV, exhibiting an excellent combination of high light yield and short decay time. Our work provides a method to design efficient and ultrafast scintillators, and paves the way towards exciting applications for ultrafast detection and imaging.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2024
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IF 1.5
Zhou Lu-Wei,Chen Kai-Wei,Dai Xiao-Jun,Qiao Tai-Fei,Liu Hong-Yu,Lu Ji-Gen,Wang Peng,Gong Chun-Hui,Deng Shao-Gang,Xia Ming,Ni Fei,Tang Guo-Min,Zhang Yong-Bing,Yang Yi
Cu/Cu 2 O-modified activated carbon composites (Cu/Cu 2 O@AC) were synthesized via an one-step solvothermal method. The characterization results indicated that copper was uniformly dispersed on the surface of AC as nano-sized Cu 0 and Cu(I), which allowed Cu/Cu 2 O to make full contact with I − . The high specific surface area of Cu/Cu 2 O@AC and the affinity of Cu + for I − led to the equilibrium adsorption capacity within forty minutes. Additionally, the removal of trace I − (300 μg L −1 ) at pH = 3 by Cu/Cu 2 O@AC reached 96.4%. This work provides a promising application for the inexpensive and efficient capture of trace iodine from medical wastewater. Graphical abstract We synthesized Cu/Cu 2 O@AC composites for adsorption of iodide ions in solution.
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JOURNAL OF NANOPARTICLE RESEARCH
·
2024
·Vol. 26
·期 9
·1-15
·
IF 2.1
Yin Yanbing,Zhang Xueli,Jiang Bei,Wang Zhou,Feng Yongming,Li Xueying
Developing efficient catalysts for visible light reactions is vital in the field of photocatalysis. This study focuses on the synthesis of novel ternary composites (α-DMACoPc/TiO 2 /MIL-101 (Fe)) by leveraging the excellent adsorption properties of MIL-101 (Fe), the photosensitizing capabilities of phthalocyanine, and the photocatalytic potential of TiO 2 . The nanocomposites’ structural and optical attributes were thoroughly analyzed. X-ray powder diffraction (XRD) was utilized to showcase the crystalline nature of the composites. Furthermore, Fourier transform infrared (FT-IR) studies confirmed the formation of ternary nanocomposites. Optical absorption investigations demonstrated the tuning of the optical band gap from the UV to the visible range. The results indicated that nearly 94% of the organic material was decomposed after 150 min of exposure to simulated sunlight from a xenon lamp. This high efficiency can be attributed to the synergistic interaction among the composites, enhancing light absorption. The composite’s robust stability was evidenced through cyclic tests. Valuable information was provided to advance the design and synthesis of photocatalysts consisting of metal–organic frameworks synergized with semiconductors. Exploring the possibility of mesoporous materials was based on MOFs for photodegradation of organic pollutants. The photocatalytic degradation of organic pollutants by MOFs mesoporous materials was also investigated. The potential of composite materials in the field of dye degradation of industrial waste is confirmed. The good recycling photocatalytic reusability indicates the promising application of this photocatalyst. Graphical Abstract
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高影响因子
RESEARCH ON CHEMICAL INTERMEDIATES
·
2025
·
IF 3.5
Zheng Nan,Gou Jialin,Lan Meng,Dong Xiaoli,Liu Yujun,Du Jinpeng
Photocatalytic technology has received widespread attention as an effective means of treating organic pollutants in wastewater, but the development of effective and sustainable photocatalysts remains a serious challenge. In this study, a novel Mn 0.2 Cd 0.8 S (MCS)/Bi 4 O 5 Br 2 (BOB) heterojunction photocatalyst was successfully prepared by a two-step solvothermal method. The photocatalytic activity of the MCS/BOB heterojunction photocatalyst for degrading Rhodamine B (RhB) is significantly enhanced relative to Mn 0.2 Cd 0.8 S and Bi 4 O 5 Br 2 . When the molar content of Mn 0.2 Cd 0.8 S was 15% of Bi 4 O 5 Br 2 , the prepared 15% MCS/BOB had the best photocatalytic performance toward RhB with the degradation rate of 91.7% under 60 min of visible light irradiation. The apparent rate constant of 15% MCS/BOB is 10 and 7 times higher than that of Mn 0.2 Cd 0.8 S and Bi 4 O 5 Br 2 , respectively. The excellent photocatalytic performance is associated with the increased specific surface area, extended light absorption range, and proper construction of Z-scheme heterojunction that facilitate effective charge separation and excellent redox capacity. In addition, the heterojunction photocatalyst shows remarkable photocatalytic stability. This study constructs a novel and effective Z-scheme heterojunction photocatalyst and promotes the exploration of photocatalyst in the purification of organic wastewater.
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JOURNAL OF NANOPARTICLE RESEARCH
·
2024
·Vol. 26
·期 11
·1-14
·
IF 2.1
Ma Yuying,Wu Hai,Jia Min,Zhang Zhijun,Wang Jingwei,Yue Zhenggang,Wu Hong,Yang Tiehong
This investigation is aimed to develop a novel iron supplement, iron oxide nanoparticles modified with Angelica sinensis polysaccharide (IONPs-ASP), for the treatment of iron deficiency anemia (IDA). IONPs-ASP was synthesized using the co-precipitation method and characterized for their structural features, physicochemical properties, and biocompatibility by TEM, SEM, FTIR, etc. The therapeutic effects of IONPs-ASP were assessed in a rat IDA model. IONPs-ASP was administered intravenously, and blood parameters were monitored. In addition, the preliminary safety of IONPs-ASP was evaluated by organ coefficients and histopathological staining. IONPs-ASP was successfully constructed, with a small particle size, core–shell structure, hydrophilicity, and good biocompatibility. Compared to unmodified IONPs, IONPs-ASP showed better stability and dispersion. In the IDA rat model, IONPs-ASP exhibited superior therapeutic efficacy than that of ASP or IONPs monotherapy. Furthermore, no abnormalities were observed in the organ coefficients and tissue section. IONPs-ASP not only has a superior therapeutic effect on IDA but also has the effect of the ASP on supplementing blood. Hence, it may be used as a new iron supplementing agent with double therapeutic efficacy on blood supplementation for the treatment of IDA. Graphical Abstract In this study, we constructed Angelica sinensis polysaccharide (ASP)–modified iron oxide nanoparticles (IONPs) and demonstrated the therapeutic effects of IONPs-ASP on iron deficiency anemia (IDA), which was associated with IONPs supplementation and APS-stimulated hematopoietic cell generation.
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