JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 42
·16309-16321
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IF 4.5
Shi Kaiyang,Wang Fulin,Li Xiangwei,Huang Weiya,Lu Kangqiang,Yu Changlin,Yang Kai
Developing artificial N 2 fixation and hydrogen production using mild, green, clean, and reliable sunlight is of great significance. In this study, the photocatalytic nitrogen fixation and hydrogen production performances of WO 3− x were improved by oxygen vacancies engineering. WO 3− x nanosheets with oxygen-rich defects were readily synthesized by hydrogen reduction treatment. WO 3− x exhibits a two-dimensional nanosheets structure, and the introduction of oxygen defects affects its energy band structure. The slight narrowing of the band gap and the increase of the conduction band facilitate the transfer of photogenerated charges and increase the reducibility of WO 3− x . Electron paramagnetic resonance (EPR) and N 2 -temperature programmed desorption (N 2 -TPD) prove that oxygen vacancies can regulate the adsorption and activation of N 2 molecules. W500 specimen has a photocatalytic nitrogen fixation activity of 28.4 μmol g −1 h −1 and a hydrogen production activity of 60.4 μmol g −1 h −1 under the full spectrum. It is hoped that oxygen vacancies engineering can provide some inspiration for the rational design and optimization of efficient photocatalytic fixation of N 2 and hydrogen production.
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FIBERS AND POLYMERS
·
2023
·
IF 2.5
Zhong-xiao Sun,Yue Yu,Chong-pan Ma,Ai-jun Gao,Yu Wang
Carbon fibers (CFs) used as resin matrix composites need to be treated by surface activation owing to their surface inertness. In this study, the effects and mechanisms of modification of CF by polyethyleneimine (PEI) alone and co-modification by PEI and dopamine (DA) were investigated. PEI alone was not effective in CF modification. However, introduction of DA and the NaIO 4 oxidant allowed PEI molecules to be grafted onto the CF surfaces by the Schiff base reaction. When PEI and DA were simultaneously added for CF surface modification (i.e., one-step modification), different PEI ( m PEI ) to DA ( m DA ) mass ratios showed different copolymerization effects in solution. For m PEI : m DA = 6:1, copolymers with polydopamine (PDA) cores and PEI branched chains were generated. For m PEI : m DA = 1:1, copolymers with PEI cores and PDA branched chains were generated. The interfacial shear strengths (IFSSs) of the modified CFs and epoxy resin obtained for the two m PEI : m DA ratios were significantly higher than that of the unmodified CFs. And the IFSS of the modified CFs and polyimide (PI) resin was first increasing and then decreasing. Two-step modification of the CF surfaces with DA before PEI grafting was also performed. PEI was grafted onto the outermost layer of the CFs, and the IFSS of the modified CFs and PI resin reached 73.94 MPa. The IFSS was 31.61% higher than that of the unmodified CFs and 22.67% higher than that of the DA-modified CFs. The advantage of the two-step branched PEI structure on the modified CF surfaces combined with PI was demonstrated.
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CELLULOSE
·
2023
·Vol. 30
·期 18
·11425-11437
·
IF 5.7
Ruan Hong,Chen Xin,Lv Chunzi,Gu Xingshuai,Zhou Zhijian,Lu Shaorong,Li Yuqi
Cellulose-based composites typically have poor water resistance because they are cross-linked through non-covalent bonds, such as hydrogen bonds. Herein, furan group was grafted onto sisal microcrystalline cellulose fiber (F-MSF) and a dynamic thermally reversible cross-linked network structure was formed with maleimide modified CaCu 3 Ti 4 O 12 (D-CCTO) to obtain recyclable D-CCTO/F-MSF composites (DFF) through the Diels-Alder reaction. The results showed that the mechanical properties of DFF composites were improved due to the improvement of the cross-linked structure between D-CCTO and F-MSF. At 1 wt% D-CCTO content, the tensile strength of DFF was 5.53 MPa, which increased by 346% compared with that of pure MSF. At 5 wt% D-CCTO content, the short-circuit current, open circuit voltage, transferred charge of DFF-based triboelectric nanogenerators (DF-TENG) were 3.2 µA, 85 V and 26 nC, respectively. Additionally, the DF-TENG was able to maintain its electrical performance of more than 60% at an ambient humidity of 90% and was able to light up more than 30 LED bulbs. This research provides new insights into addressing the challenge of poor water resistance in conventional cellulose-based composites, while also designing a recyclable TENG device that can harvest energy in high humidity environments. Graphical abstract
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JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-21
·
IF 10.2
Wu Xiaoyu,Ni Su,Dai Ting,Li Jingyan,Shao Fang,Liu Chun,Wang Jiafeng,Fan Shijie,Tan Yadong,Zhang Linxiang,Jiang Qiting,Zhao Hongbin
Conventional electrospinning produces nanofibers with smooth surfaces that limit biomineralization ability. To overcome this disadvantage, we fabricated a tetramethylpyrazine (TMP)-loaded matrix-mimicking biomineralization in PCL/Gelatin composite electrospun membranes with bubble-shaped nanofibrous structures. PCL/Gelatin membranes (PG), PCL/Gelatin membranes containing biomineralized hydroxyapatite (HA) (PGH), and PCL/Gelatin membranes containing biomineralized HA and loaded TMP (PGHT) were tested. In vitro results indicated that the bubble-shaped nanofibrous surface increased the surface roughness of the nanofibers and promoted mineralization. Furthermore, sustained-release TMP had an excellent drug release efficiency. Initially released vigorously, it reached stabilization at day 7, and the slow-release rate stabilized at 61.0 ± 1.8% at 28 days. All membranes revealed an intact cytoskeleton, cell viability, and superior adhesion and proliferation when stained with Ghost Pen Cyclic Peptide, CCK-8, cell adhesion, and EdU. In PGHT membranes, the osteogenic and vascularized gene expression of BMSCs and human vascular endothelial cells was significantly upregulated compared with that in other groups, indicating the PGHT membranes exhibited an effective vascularization role. Subsequently, the membranes were implanted in a rat cranium defect model for 4 and 8 weeks. Micro-CT and histological analysis results showed that the PGHT membranes had better bone regenerative patterns. Additionally, the levels of CD31 and VEGF significantly increased in the PGHT membrane compared with those in other membranes. Thus, PGHT membranes could accelerate the repair of cranium defects in vivo via HA and TMP synergistic effects. Graphical Abstract
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PubMed
高影响因子
IONICS
·
2023
·
IF 2.8
Zeng Qinqin,Huang Qiannan,Luo Zihao,Liu Ao,Li Haoqin,Zhong Mingfeng,Zhang Zhijie
Silicon(Si) is one of the anode materials to replace graphite electrodes due to large specific capacity. However, the volume expansion of silicon anode material and instability of solid electrolyte interphase (SEI) layer greatly limits their practical applications. Herein, we demonstrate a novel sandwich network structure silicon-carbon anode composites and explored as electrode material for lithium-ion batteries (LIBs). The CBC/Si/NC composites were synthesized by using bacterial cellulose (BC) as the structural template and retains the three-dimensional network structure of BC and has a high specific surface area which ease the volume expansion of silicon during the charge-discharge process. Meanwhile, silicon nanoparticles covered with dopamine, the outer carbon, uniformly attached to the cellulose surface. The internal and external carbon layers improve the conductivity of the composite and can accelerate the diffusion and electronic transmission of lithium ions. The sandwich network structure composite anode demonstrates excellent cycle stability and a high reversible specific capacity of 889mAh·g −1 after 200 cycles at a current density of 0.5 A·g −1 .
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-12
·
IF 16.6
Cao Peike,Quan Xie,Nie Xiaowa,Zhao Kun,Liu Yanming,Chen Shuo,Yu Hongtao,Chen Jingguang G.
Direct hydrogen peroxide (H 2 O 2 ) electrosynthesis via the two-electron oxygen reduction reaction is a sustainable alternative to the traditional energy-intensive anthraquinone technology. However, high-performance and scalable electrocatalysts with industrial-relevant production rates remain to be challenging, partially due to insufficient atomic level understanding in catalyst design. Here we utilize theoretical approaches to identify transition-metal single-site catalysts for two-electron oxygen reduction using the *OOH binding energy as a descriptor. The theoretical predictions are then used as guidance to synthesize the desired cobalt single-site catalyst with a O-modified Co-(pyrrolic N) 4 configuration that can achieve industrial-relevant current densities up to 300 mA cm − 2 with 96–100% Faradaic efficiencies for H 2 O 2 production at a record rate of 11,527 mmol h − 1 g cat − 1 . Here, we show the feasibility and versatility of metal single-site catalyst design using various commercial carbon and cobalt phthalocyanine as starting materials and the high applicability for H 2 O 2 electrosynthesis in acidic, neutral and alkaline electrolytes.
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MEDICINAL CHEMISTRY RESEARCH
·
2012
·Vol. 22
·期 5
·2524-2530
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IF 1.271
Guo Yibing,Zheng Cheng,Xu Wen,Si Yongxing,Dou Sufeng,Yang Yumin
Abstract Salidroside, a phenylpropanoid glycoside isolated from a traditional Chinese medicinal plant Rhodiola rosea L. displays a broad spectrum of pharmacological properties. It has been found to play a hepatoprotective role in liver diseases through inhibiting apoptosis of hepatocytes and proliferation of hepatic stellate cells, decreasing serum aminotransferase, reversing hepatic fibrosis, and improving liver function. In this study as an ongoing study on the discovery and development of new hepatoprotective agents, about 12 novel glycosides were synthesized, and 2,2-diphenyl-1-picrylhydrazyl radical scavenge activity of each glycoside was evaluated. 2-(3,4,5-trihydroxyphenyl)ethyl β- d -glucopyranoside ( 4g ) and 2-(3,4,5-trihydroxyphenyl)ethyl β- d -galactopyranoside ( 4h ) exhibited significant activity prior to salidroside with an IC 50 value of 38.05 and 35.85 μM, respectively. The hepatoprotective effect of compounds 4g and 4h on CCl 4 -induced cytotoxicity in LO2 cells was assessed for further research. Graphical abstract 2-(3,4,5-Trihydroxyphenyl)ethyl β- d -glucopyranoside ( 4g ) and 2-(3,4,5-trihydroxyphenyl)ethyl β- d -galactopyranoside ( 4h ) exhibited significant hepatoprotective activity prior to salidroside.
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MEDICINAL CHEMISTRY RESEARCH
·
2012
·Vol. 22
·期 2
·986-994
·
IF 1.271
Zhang Mao,Lu Xiang,Zhang Hong-Jia,Li Na,Xiao Yu,Zhu Hai-Liang,Ye Yong-Hao
A series of derivatives of cinnamic amide (compounds 2a – 2v ) were synthesized and evaluated for antiproliferative activities against the human breast cancer cell line MCF-7- and EGFR-inhibitory activities. The structures of compounds 2b and 2i were determined by single-crystal X-ray diffraction analysis. Compounds 2f and 2j showed moderate EGFR inhibitory activity with IC 50 values of 5.16 and 7.37 μM, respectively. Docking simulation of compound 2f was carried out to illustrate the binding mode of the molecule into the EGFR active site. Structure–activity relationship analysis found that the N -phenyl rings are required for enhancing the activities.
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JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
·
2023
·
IF 2.3
Liu Yurong,Zhang Rui,Jing Hongling,Yu Daheng,Pan Renming,Chen Ruiyu
The macroscopic and microscopic surface morphology, products, kinetics, and reaction mechanism of one typical aero-engine material 0Cr18Ni9 in the cases of high-temperature oxidation and hot corrosion by a novel superhydrophobic and oleophobic ultrafine dry powder extinguishing agent (SHOU DPEA) are studied in a simulated aircraft engine compartment working environment. The results demonstrate that the oxidation and corrosion products both contain FeCr 2 O 4 , Fe 2 O 3 , and Fe 3 O 4 . However, the presence of SHOU DPEA accelerates the corrosion within the alloy. The 0Cr18Ni9 substrate shows a L-shaped segregation phenomenon and a chromium-poor layer. Furthermore, the oxidation and corrosion kinetic curves of 0Cr18Ni9 are both parabolic. In particular, the high-temperature oxidation behavior of 0Cr18Ni9 can be divided into two stages: a rapid oxidation stage (0-96 hours) and an oxidation equilibrium stage (96-192 hours), and the hot corrosion process can be divided into two stages: an initial slow incubation stage from 0 to 48 hours, and an accelerated corrosion stage from 48 to 192 hours. Additionally, the chemical reaction mechanisms for oxidation/corrosion are illustrated. Graphical Abstract
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Scientific Reports
·
2023
·Vol. 13
·期 1
·1-9
·
IF 4.6
Wu Yalin,Yin Yuanjian,Chen Xin,Zhou Yeping,Jiang Shan,Zhang Mingming,Cai Guangcheng,Gao Quan
Fusarium head blight (FHB) is a critical fungal disease causes serious grain yield losses and mycotoxin contaminations. Currently, utilization of chemical fungicides is the main control method which has led to serious resistance. Development of novel synergist is an important strategy to reduce the usage of chemical fungicides and postpone the development of resistance, while natural components are interesting resources. In this study, the synergistic effect of Taxodium 'zhongshansha' essential oil (TZEO) was determined and the best synergistic ratio (SR) of 3.96 in laboratory which was observed when the weight ratio of TZEO and prothioconazole was 1 : 1 with the corresponding EC 50 (half maximal effective concentration) value of Fusarium graminearum was 0.280 mg L −1 . Subsequently, an increase of 6.31% on the control effect to FHB index in field test was observed when compared to the treatment with prothioconazole alone, though there was no significant difference between these treatments. Furthermore, we established an effective method to detect the mycotoxin contaminations in wheat grain with the limits of quantifications (LOQs) value of 5 µg kg −1 (DON, ZEN, 3-DON, and 15-DON) and 1 µg kg −1 (OTA) and the contents were less to the maximum residue limit (MRL) values. It was also shown that the application of 20% TZEO EW led to a 20% reduction in the use of prothioconazole, which was calculated based on the control effect values of 86.41% and 90.20% between the treatments of 30% prothioconazole OD (225 g a.i ha −1 , recommend dosage) and 30% prothioconazole OD (180 g a.i ha −1 ) + 20% TZEO EW (225 mL ha −1 ), significantly. The initial residue of prothioconazole and prothioconazole-desthio was increased in the treatment with TZEO, which may play an important role in the synergistic effect on FHB. Moreover, none of the treatments posed a prothioconazole residue risk in the wheat grain and the environment. In addition, the essential oil has no any negative influence on wheat growth, which was revealed by a study of the chlorophyll content. These results provide an important botanical synergist for use with prothioconazole to control Fusarium head blight, and in-depth study to the synergistic mechanism of this oil is necessary in our future research.
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CELL BIOLOGY AND TOXICOLOGY
·
2022
·
IF 6.819
Pang Xuefeng,Guan Qigang,Lin Xue,Chang Ning
Histone deacetylases (HDACs) has been implicated in cardiac diseases, while the role of HDAC6 in dilated cardiomyopathy (DCM) remains obscure. The in silico analyses predicted potential association of HDAC6 with autophagy-related genes and DCM. Thus, we evaluated the functional relevance of HDAC6 in DCM in vivo and in vitro. We developed a rat model in vivo and a cell model in vitro by doxorubicin (DOX) induction to simulate DCM. HDAC6 expression was determined in myocardial tissues of DCM rats. DCM rats exhibited elevated HDAC6 mRNA and protein expression as compared to sham-operated rats. We knocked HDAC6 down and/or overexpressed NLRP3 in vivo and in vitro to characterize their roles in cardiomyocyte autophagy. It was established that shRNA-mediated HDAC6 silencing augmented cardiomyocyte autophagy and suppressed NLRP3 inflammasome activation, thus ameliorating cardiac injury in myocardial tissues of DCM rats. Besides, in DOX-injured cardiomyocytes, HDAC6 silencing also diminished NLRP3 inflammasome activation and cell apoptosis but enhanced cell autophagy, whereas ectopic NLRP3 expression negated the effects of HDAC6 silencing. Since HDAC6 knockdown correlates with enhanced cardiomyocyte autophagy and suppressed NLRP3 inflammasome activation through an interplay with NLRP3, it is expected to be a potential biomarker and therapeutic target for DCM. Graphical abstract 1. HDAC6 was up-regulated in DCM rats. 2. HDAC6 knockdown promoted cardiomyocyte autophagy to relieve cardiac dysfunction. 3. HDAC6 knockdown inhibited NLRP3 inflammasome and promoted cardiomyocyte autophagy. 4. Silencing HDAC6 promoted autophagy and repressed apoptosis in cardiomyocytes. 5. This study provides novel therapeutic targets for DCM.
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BMC Chemistry
·
2023
·Vol. 17
·期 1
·1-13
·
IF 4.6
Li Yuanlin,Chen Hongqin,Yan Heng,Xu Yangyong,Tang Jinwen,Wang Runsen,Yan Mengru,Dai Yuqiao,Huang Yongguang,Liu Xiongmin
Biofuels are renewable alternatives to fossil fuels. Levopimaric acid‒base biofuels have attracted increasing attention. However, their stability remains a critical issue in practice. Thus, there is a strong impetus to evaluate the thermal stability of levopimaric acid. Through thermogravimetry (TG) and a custom-designed mini closed pressure vessel test (MCPVT) operating under isothermal and stepped temperature conditions, we investigated thermal oxidation characteristics of levopimaric acid under oxygen atmosphere. Thin-layer chromatography (TLC) and iodimetry were used to measure the hydrogen peroxides generated by levopimaric acid oxidation. A high pressure differential scanning calorimeter (HPDSC) was used to assess hydroperoxide thermal decomposition characteristics. Gas chromatography-mass spectrometry (GC-MS) was used to characterize the oxidation products. The thermal decomposition kinetics of levopimaric acid were thus elucidated, and a high peroxide value was detected in the levopimaric acid. The decomposition heat (Q DSC ) and exothermic onset temperature (T onset ) of hydroperoxides were 338.75 J g −1 and 375.37 K, respectively. Finally, levopimaric acid underwent a second-stage oxidation process at its melt point (423.15 K), resulting in complex oxidation products. Thermal oxidation of levopimaric acid could yield potential thermal hazards, indicating that antioxidants must be added during levopimaric acid application to protect against such hazardous effects.
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危险品化学品经营许可证（带存储）