IONICS
·
2024
·Vol. 30
·期 3
·1615-1625
·
IF 2.4
Dong Jinxiu,Cui Shichuang,Wang Fei,Wei Wei,Yin Ziluo,Zhang Yuqing,Zhu Quanyao
Electrochromism (EC) is a color control technique for providing visual information, in which vanadium pentoxide (V 2 O 5 ) is a promising material for electrochromic applications due to its excellent ionic intercalation/deintercalation properties and cathodic/anodic color-changing properties. However, its poor cycling stability and color change response rate limit its practical application. Metal–organic frameworks (MOFs) combine the rigidity and flexibility of inorganic–organic materials and can meet the requirements of EC materials such as cycle stability, electrical conductivity, and stress-interference resistance. We report here a strategy to modify V 2 O 5 with Cu-MOF. Cu-doped V 2 O 5 and carbon skeleton (Cu 2 V 2 O 7 @C) composites were prepared for electrochromism. In this scheme, Cu doping can facilitate lithium ion migration by broadening and stabilizing the structure of V 2 O 5 , and the distribution of the carbon skeleton can broaden the contact of the active material with the electrolyte and improve the electron conduction. Combining these merits, it exhibits excellent long-term cycle stability (the capacity retention rate reaches 91.78% after 2000 cycles), the light transmission modulation is greatly improved compared with V 2 O 5 (Δ T = 69%, doubled), and the response time is reduced by 30.43%. This study provides a new perspective for improving the light modulation ability and long-term use stability of vanadium oxide EC materials and promotes the development of MOF materials in the field of electrochromism.
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Science China-Materials
·
2024
·Vol. 67
·期 7
·2302-2310
·
IF 6.8
Ruan Qiaohui,Cui Yanyu,Lin Zhuohan,Zhang Xue,Zhang Xin,Li Yan,Ma Xiang
Chiral colloidal semiconductor magic-sized clusters (MSCs) with dimensions less than 2 nm provide abundant surface binding sites for chiral ligands and thus have great potential for chiral semiconductor nanomaterial applications. However, the preparation and optical characterization of chiral MSCs are rarely reported in the past. In this study, chiral MSCs in a single-ensemble form, containing CdS MSCs with a unique sharp absorption peak at 366 nm and CdSe MSCs at 420 nm, were synthesized for the first time in aqueous solution at room temperature using chiral cysteine as ligands. The optical activity of the prepared chiral MSCs can be easily adjusted by varying the amount of chiral ligands added. The maximum absorption asymmetry factors of the prepared chiral CdS MSCs and CdSe MSCs reach 3.6 × 10 −4 and 5.6 × 10 −4 , respectively. The experiment results indicate that the chiral optical properties of the prepared MSCs may originate from the ligand-induced atomic rearrangement on the surface of MSCs. This study not only provides a general method for obtaining chiral MSCs, but also opens the way for research and applications of chiral MSCs.
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IONICS
·
2025
·
IF 2.6
Li Dexin,Yao Jianbo,Ren Zhong,Luo Heming,Zhang Jianqiang
The CoMn-LDH/MXene composite was fabricated via hydrothermal synthesis, with nanoscale CoMn-LDH encapsulated on MXene through surface functional groups. This effectively prevents CoMn-LDH aggregation and improves its electrochemical properties. The effects of cobalt-manganese ratio, reaction time, and temperature on the electrochemical properties of CoMn-LDH were explored, as well as the impact of MXene addition on CoMn-LDH composite properties. A comparative analysis of the structural features of pure CoMn-LDH and the composite CoMn-LDH/0.08MXene reveals that the latter exhibits a more pronounced hierarchical structure. Composite CoMn-LDH/0.08MXene has a specific capacity of 1517.8 C-g −1 at a current density of 1 A g −1 , significantly surpassing the 1186.8 C·g⁻1 achieved by pure CoMn-LDH. The asymmetric supercapacitor constructed with this composite material reached an energy density of 48.5 Wh·kg-1 and a power density of 755.3 W·kg −1 , retaining 95% of its capacity after 5000 charge/discharge cycles.The synergistic effect of CoMn-LDH and MXene enhances the capacitance and stability of the CoMn-LDH/0.08MXene composite capacitor. The simplicity of the preparation process, coupled with the excellent performance of the CoMn-LDH/MXene composites, suggests that they have considerable potential for use in advanced energy storage applications.
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RESEARCH ON CHEMICAL INTERMEDIATES
·
2025
·
IF 3.5
Du Jinpeng,Lan Meng,Xiang Yulong,Dong Xiaoli,Zheng Nan,Wang Yu
Photocatalysis has been extensively applied in organic pollutant degradation, and the key focus is on developing efficient and sustainable photocatalysts nowadays. In this work, Co 9 S 8 /Cd 0.5 Zn 0.5 S (CS/CZS) heterojunction photocatalysts were prepared by the hydrothermal method, and their photocatalytic activity was evaluated by the degradation of rhodamine B (RhB) under visible-light irradiation. Compared with pristine Co 9 S 8 and Cd 0.5 Zn 0.5 S, CS/CZS heterojunction materials demonstrated better photocatalytic activity. The optimized CS/CZS-2 sample achieved 94% degradation efficiency of RhB under visible-light irradiation within 18 min. Active species trapping experiments revealed that ·O 2 − and h + were the main active substances in the photocatalytic degradation process of RhB. The excellent photocatalytic degradation performance can be attributed to the formation of type-II heterojunction between Co 9 S 8 and Cd 0.5 Zn 0.5 S with intimate contact interface, which is conducive to the separation and migration of photogenerated carriers. This study introduces a promising strategy for the design and development of type-II heterojunction photocatalysts specifically aimed at wastewater purification.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
·
IF 3.8
Sha Dandan,Yuan Minghui,Zhang Lin,Li Hongli
Insulin bound with ligand molecules can improve its bioavailability in oral formulations. In this work, the interactions between insulin and bile acids of taurocholic acid (TCA) and glycocholic acid (GCA) are characterized using different mass spectrometry (MS) methods. Electrospray (ESI)–MS analysis revealed that GCA and TCA could interact with insulin individually or together through non-covalent bonds, and the products included mGCA-insulin, nTCA-insulin, and mGCA-nTCA-insulin complexes. Their binding stoichiometry, relative intensity ratio ( IRa ), and binding affinity were determined. ESI–MS/MS data and the calculated association constants both suggest that TCA has stronger affinity to insulin than GCA. The mixtures of various insulin, GCA, and TCA complexes with different charge states were separated, and distinct trend lines were observed using ion mobility mass spectrometry (IMMS). Moreover, liposomes containing insulin and GCA and/or TCA were prepared, and directly characterized using ESI–MS, and the interaction products of insulin with GCA and TCA were found in the liposome formulation. AutoDock was used to simulate molecular binding and select binding sites between insulin and GCA or TCA to explore the interaction mechanisms. The findings in this work could help understand the mechanism of action of insulin protection with bile acids in the body. Graphical
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-22
·
IF 12.6
Liu Yanhong,Gong Liming,Feng Jing,Xiao Congcong,Liu Chenfei,Chen Bohan,Chen Liqing,Jin Mingji,Guan Youyan,Gao Zhonggao,Huang Wei
Immune checkpoint inhibition (ICI) has become the mainstay of immunotherapy for the treatment of renal cell carcinoma (RCC). However, only a small portion of patients exhibit a positive response to PD-1/PD-L1 blockade therapy and the key reason is that RCC belongs to a vascular-rich tumor for promoting immunosuppression. Specifically, the dysfunctional tumor vasculature hinders effector T cell infiltration and induces immunosuppressive tumor microenvironment via the release of cytokine, which attenuates the therapeutic efficacy of ICI. Therefore, regulating abnormal tumor vasculature may be a promising strategy to overcome the immunosuppressive microenvironment and enhance ICI therapy. Here, we propose an NGR peptide-modified actively targeted liposome (Axi/siRNA PD−L1 @NGR-Lipo) to encapsulate the anti-angiogenic agents Axitinib and PD-L1 siRNA to promote tumor vasculature normalization and relieve immune evasion for enhanced anti-tumor immunotherapy. With NGR-mediated tumor homing and active targeting, Axi/siRNA PD−L1 @NGR-Lipo could act on tumor vascular endothelial cells to inhibit neo-angiogenesis, increase pericyte coverage and vascular perfusion, and normalize the structure and function of tumor blood vessels. Meanwhile, it also enhanced immune effector T cells and NK cells infiltration and reduced the proportion of immunosuppressive T cells including MDSC cells and Tregs, thus improving the tumor immunosuppressive microenvironment. Moreover, Axi/siRNA PD−L1 @NGR-Lipo reduced the expression of PD-L1 protein in tumor cells, restored the recognition and killing ability of cytotoxic T cells, and relieved immune evasion. As expected, Axi/siRNA PD−L1 @NGR-Lipo displayed superior anti-tumor and anti-metastatic efficacy in mice bearing RCC. Overall, this study demonstrated the important potential of regulating abnormal tumor vasculature to reshape the immunosuppressive microenvironment and boost ICI therapy, which represents a promising avenue for the synergistic anti-tumor with cancer immunotherapy. Graphical
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TRANSACTIONS OF TIANJIN UNIVERSITY
·
2024
·Vol. 30
·期 3
·238-249
·
IF 6.7
Ji Jiankun,Gu Yarong,Zhang Jianning,Yu Chongwen,Hu Xiao,Bao Yueping,Song Yujie
A major challenge is to construct ceramic membranes with tunable structures and functions for water treatment. Herein, a novel corrosion-resistant polymer-derived silicon oxycarbide (SiOC) ceramic membrane with designed architectures was fabricated by a phase separation method and was applied in organic removal via adsorption and oxidation for the first time. The pore structure of the as-prepared SiOC ceramic membranes was well controlled by changing the sintering temperature and polydimethylsiloxane content, leading to a pore size of 0.84–1.62 μm and porosity of 25.0–43.8%. Corrosion resistance test results showed that the SiOC membranes sustained minimal damage during 24 h exposure to high-intensity acid–base conditions, which could be attributed to the chemical inertness of SiOC. With rhodamine 6G (R6G) as the model pollutant, the SiOC membrane demonstrated an initial effective removal rate of 99% via adsorption; however, the removal rate decreased as the system approached adsorption saturation. When peroxymonosulfate was added into the system, efficient and continuous degradation of R6G was observed throughout the entire period, indicating the potential of the as-prepared SiOC membrane in oxidation-related processes. Thus, this work provides new insights into the construction of novel polymer-derived ceramic membranes with well-defined structures and functions.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-11
·
IF 14.7
Wang Rong,Yuan Chao,Cheng Jianxiang,He Xiangnan,Ye Haitao,Jian Bingcong,Li Honggeng,Bai Jiaming,Ge Qi
4D printing technology combines 3D printing and stimulus-responsive materials, enabling construction of complex 3D objects efficiently. However, unlike smart soft materials, 4D printing of ceramics is a great challenge due to the extremely weak deformability of ceramics. Here, we report a feasible and efficient manufacturing and design approach to realize direct 4D printing of ceramics. Photocurable ceramic elastomer slurry and hydrogel precursor are developed for the fabrication of hydrogel-ceramic laminates via multimaterial digital light processing 3D printing. Flat patterned laminates evolve into complex 3D structures driven by hydrogel dehydration, and then turn into pure ceramics after sintering. Considering the dehydration-induced deformation and sintering-induced shape retraction, we develop a theoretical model to calculate the curvatures of bent laminate and sintered ceramic part. Then, we build a design flow for direct 4D printing of various complex ceramic objects. This approach opens a new avenue for the development of ceramic 4D printing technology.
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CELL RESEARCH
·
2024
·Vol. 34
·期 1
·31-46
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IF 28.1
Shao Jiawei,Li Shichao,Qiu Xinyuan,Jiang Jian,Zhang Lihang,Wang Pengli,Si Yaqing,Wu Yuhang,He Minghui,Xiong Qiqi,Zhao Liuqi,Li Yilin,Fan Yuxuan,Viviani Mirta,Fu Yu,Wu Chaohua,Gao Ting,Zhu Lingyun,Fussenegger Martin,Wang Hui,Xie Mingqi
Here, we present a gene regulation strategy enabling programmable control over eukaryotic translational initiation. By excising the natural poly-adenylation (poly-A) signal of target genes and replacing it with a synthetic control region harboring RNA-binding protein (RBP)-specific aptamers, cap-dependent translation is rendered exclusively dependent on synthetic translation initiation factors (STIFs) containing different RBPs engineered to conditionally associate with different eIF4F-binding proteins (eIFBPs). This modular design framework facilitates the engineering of various gene switches and intracellular sensors responding to many user-defined trigger signals of interest, demonstrating tightly controlled, rapid and reversible regulation of transgene expression in mammalian cells as well as compatibility with various clinically applicable delivery routes of in vivo gene therapy. Therapeutic efficacy was demonstrated in two animal models. To exemplify disease treatments that require on-demand drug secretion, we show that a custom-designed gene switch triggered by the FDA-approved drug grazoprevir can effectively control insulin expression and restore glucose homeostasis in diabetic mice. For diseases that require instantaneous sense-and-response treatment programs, we create highly specific sensors for various subcellularly (mis)localized protein markers (such as cancer-related fusion proteins) and show that translation-based protein sensors can be used either alone or in combination with other cell-state classification strategies to create therapeutic biocomputers driving self-sufficient elimination of tumor cells in mice. This design strategy demonstrates unprecedented flexibility for translational regulation and could form the basis for a novel class of programmable gene therapies in vivo.
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 8
·1-11
·
IF 5.3
Zhang Xinyu,Wang Yue,Gong Mi,Xiong Lihao,Song Jiayi,Chen Sihan,Tong Yuqi,Liu Yu,Li Le,Zhen Deshuai
An upconversion fluorescence sensing platform was developed with upconversion nanoparticles (UCNPs) as energy donors and gold nanoparticles (AuNPs) as energy acceptors, based on the FRET principle. They were used for quantitative detection of uranyl ions (UO 2 2+ ) by amplifying the signal of the hybrid chain reaction (HCR). When UO 2 2+ are introduced, the FRET between AuNPs and UCNPs can be modulated through a HCR in the presence of high concentrations of sodium chloride. This platform provides exceptional sensitivity, with a detection limit as low as 68 pM for UO 2 2+ recognition. We have successfully validated the reliability of this method by analyzing authentic water samples, achieving satisfactory recoveries (89.00%–112.50%) that are comparable to those of ICP-MS. These results indicate that the developed sensing platform has the capability to identify trace UO 2 2+ in complex environmental samples. Graphical abstract
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-22
·
IF 14.7
Bai Mingru,Wang Ting,Xing Zhenyu,Huang Haoju,Wu Xizheng,Adeli Mohsen,Wang Mao,Han Xianglong,Ye Ling,Cheng Chong
The clinical treatments of maxillofacial bone defects pose significant challenges due to complex microenvironments, including severe inflammation, high levels of reactive oxygen species (ROS), and potential bacterial infection. Herein, we propose the de novo design of an efficient, versatile, and precise electron-donable heterojunction with synergetic Ru-Cu pair sites (Ru-Cu/EDHJ) for superior biocatalytic regeneration of inflammatory mandible defects and pH-controlled antibacterial therapies. Our studies demonstrate that the unique structure of Ru-Cu/EDHJ enhances the electron density of Ru atoms and optimizes the binding strength of oxygen species, thus improving enzyme-like catalytic performance. Strikingly, this biocompatible Ru-Cu/EDHJ can efficiently switch between ROS scavenging in neutral media and ROS generation in acidic media, thus simultaneously exhibiting superior repair functions and bioadaptive antibacterial properties in treating mandible defects in male mice. We believe synthesizing such biocatalytic heterojunctions with exceptional enzyme-like capabilities will offer a promising pathway for engineering ROS biocatalytic materials to treat trauma, tumors, or infection-caused maxillofacial bone defects.
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Journal of Neuroimmune Pharmacology
·
2026
·Vol. 21
·期 1
·53
·
IF 6.1
Zhao Jun,Bai Yiming,Wang Chao,Guo Pengfei,Wang Zhe,Du Guanhua,Liu Ailin
Therapeutic for Alzheimer’s disease (AD) remains a pressing medical challenge in the field of neuroscience. Natural compounds with structural diversity and multi-target regulatory properties have attracted increasing attention for the treatment of complex neurodegenerative disorders. Fraxetin, previously identified through computer-aided virtual screening, C. elegans assays, and in vitro cellular models as a potential anti-AD natural compound, was further investigated in this study using established in vivo and in vitro systems to evaluate its efficacy in ameliorating cognitive function and elucidate underlying mechanisms. A sporadic AD mouse model was established by intracerebroventricular injection of STZ (3 mg/kg). Fraxetin (3, 10, and 30 mg/kg/day, po.) was administered until the mouse sacrifices. Cognitive performance was evaluated using the novel object recognition, passive avoidance, and Morris water maze tests. STZ induced cerebral energy metabolism disturbances accompanied by mitochondrial dysfunction, neuroinflammation, oxidative stress, neuronal and synaptic loss, and cholinergic system impairment. Behavioral tests confirmed that fraxetin ameliorated cognitive deficits in STZ-induced mice. Further studies revealed that fraxetin preserved mitochondrial structural integrity and enhanced mitochondrial biogenesis, accompanied by upregulation of the Sirt1/PGC-1α/Nrf1/TFAM pathway. In parallel, fraxetin attenuated microglial overactivation and neuroinflammatory responses. Consistently, in LPS-stimulated BV2 microglial cells, fraxetin inhibited nitric oxide and inflammatory mediator release, which was associated with modulation of the TLR2/MYD88/NF-κB signaling pathway, while restoring cellular bioenergetic status, indicating coordinated regulation of inflammation-associated metabolic dysfunction. Importantly, fraxetin attenuated neurodegenerative alterations in STZ-treated mice, as evidenced by reduced neuronal loss and synaptic degeneration. These effects were associated with activation of the BDNF/TrkB/ERK/CREB neurotrophic pathway and inhibition of acetylcholinesterase activity, supporting preservation of synaptic and cholinergic function. This study provides experimental evidence supporting fraxetin as a promising natural multi-target candidate for the intervention of AD.
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