JOURNAL OF FLUORESCENCE
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2025
·
IF 3.1
Guo Zongning,Zeng Shaohan,Zhang Hui,Zhang Xiaolin,Wang Shouhui,Hu Jiwan,Huang Xuelin,Yang Li,Jiao Zhe
Benzene, toluene ethylbenzene and xylene (BTEX), known for their high toxicity and volatility, are key targets for air quality monitoring. Fluorescent probes based on the luminescence intensity of one transition is not efficient for probing BTEX. In this work, we have synthesized a luminescent RhB@MOF sensor array to realize the probing of different BETX by excellent fingerprint correlation between the BTEX and emission peak-height ratio of ligand to dye moieties. Three kinds of RhB@MOF were synthesized simultaneously by varying concentrations of Rhodamine B (RhB) in the solvothermal reaction of (E)-4-(2-carboxyvinyl)benzoic acid (H 2 L) and Cd(NO 3 ) 2 ·4H 2 O (RhB@MOF1, RhB@MOF2, RhB@MOF3). These sensors exhibited two characteristic emission peaks at 430 nm for the host CdMOF and 570 nm for guest RhB, and the emission peak height ratio I 430 /I 570 were constant for each RhB@MOF. Upon reaction with BTEX, due to gap-gap reaction between ligand and different BETX as well as the different swelling effect of BTEX on RhB, the two emission peaks height ratio of three kinds of RhB@MOF showed specific change to different BTEX. The sensor array exhibited a unique pattern of fluorescence variations of BTEX. Principal component analysis (PCA) was applied and achieved complete separation of BTEX. Linear discriminant analysis (LDA) was then applied to discriminate between individual, binary, ternary, and quaternary mixtures of BTEX, resulting in a 100% accuracy rate. Further study also indicated that concentration gradients did not affect the clustering outcomes of BTEX. Compared to traditional methods, the developed fluorescent sensor array offered a more efficient and economical strategy for the identification of BTEX.
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Journal of Bionic Engineering
·
2025
·
IF 5.8
Teng Xiangyu,Yu Shuxuan,Qiao Zezheng,Ge Zhixing,Yang Wenguang
In recent years, robots used for targeted drug delivery in the stomach have received extensive attention. Inspired by tumbleweeds, we have designed a dual-responsive soft robot based on poly(N‑isopropylacrylamide) and MoS 2 . Under the action of an adjustable magnetic field, it can achieve steady motion at a frequency that allows it to move up to 35 mm/s, demonstrating high flexibility and controllability. It can also roll along a predetermined path, traverse mazes, climb over obstacles, among other functions. In addition, by harnessing the photothermal conversion effect of MoS 2 , the robot can be opened and closed using light, enabling controlled drug release. Targeted drug delivery is achieved in a gastric model using our designed soft robot, marking a significant clinical advancement expected to revolutionize future medical treatments and enhance the efficacy of drug therapy.
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NATURE
·
2024
·
IF 50.5
Duan Chenghao,Zhang Kaicheng,Peng Zijian,Li Shiang,Zou Feilin,Wang Feng,Li Jiong,Zhang Zheng,Chen Chang,Zhu Qiliang,Qiu Jianhang,Lu Xinhui,Li Ning,Ding Liming,Brabec Christoph J.,Gao Feng,Yan Keyou
All-inorganic perovskites prepared by substituting the organic cations (e.g. methylammonium (MA + ) and formamidinium (FA + )) with inorganic cations (e.g. Cs + ) are effective concepts to enhance the long-term photo- and thermal-stability of perovskite solar cells (PSCs) 1,2 . Hence, inorganic perovskite tandem solar cells (IPTSCs) are promising candidates for breaking the efficiency bottleneck and addressing the stability issue as well 3,4 . However, challenges remain in fabricating 2-terminal (2T) IPTSCs due to the inferior film formation and deep trap states induced by tin cations 5-7 . Herein, a ligand evolution (LE) strategy with p-toluenesulfonyl hydrazide (PTSH) is employed to regulate film formation and eliminate deep traps in inorganic narrow bandgap (NBG) perovskite, enabling the successful development of 2T IPTSCs. Accordingly, the 1.31 eV CsPb 0.4 Sn 0.6 I 3 :LE device delivers a record efficiency of 17.41%. Combined with the 1.92 eV CsPbI 2 Br top-cell, 2T IPTSCs exhibit a champion efficiency of 22.57% (certified 21.92%). Additionally, IPTSCs are engineered to deliver remarkable durability under maximum power point (MPP) tracking, maintaining 80% of the initial efficiency at 65 °C for 1510 h and at 85°C for 800 h, respectively. We elucidate that LE deliberately leverages multiple roles for inorganic NBG perovskite growth and anticipate our study provides insightful guideline for developing high-efficiency and stable IPTSCs.
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Nano-Micro Letters
·
2024
·Vol. 17
·期 1
·1-15
·
IF 31.6
An Li,Li Jianyi,Sun Yuanmiao,Zhu Jiamin,Seow Justin Zhu Yeow,Zhang Hong,Zhang Nan,Xi Pinxian,Xu Zhichuan J.,Yan Chun-Hua
Demonstrate that the key factor to determine the activity of reconstructed surfaces is the surface chemistry, instead of reconstruction degree using the popular perovskite LaNi 1-x Fe x O 3 oxides as model materials.
Fe content can influence both the surface reconstruction degree, the activation degree, and the activity of reconstructed surfaces.
The oxygen evolution reaction activity of reconstructed catalysts is primarily governed by the chemistry of the reconstructed surface species.
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AAPS PHARMSCITECH
·
2025
·Vol. 26
·期 1
·1-14
·
IF 4
Fan Fan,Zhou Feng,Zhang Jiayu,Yang Junhui,Zhuang Kai,Shan Yudong,Jiang Lei,Zhang Jiantao
Amorphous solid dispersion (ASD) is one of the most studied strategies for improving the dissolution performance of poorly water-soluble drugs, but ASDs often have low drug loadings, thereby necessitating larger dosage sizes. This study intended to create Soluplus® (SOL)-based microparticle ASDs with high drug loading (up to 60 w/w%) and long-term stability (at least 16 months) using electrospraying to enhance the dissolution of poorly water-soluble celecoxib (CEL). X-ray diffraction (XRD) and differential scanning calorimetry (DSC) analyses showed that the electrosprayed SOL-CEL microparticles were amorphous, and Fourier transform infrared spectroscopy (FTIR) data indicated the presence of hydrogen bonding between SOL and CEL in the microparticles, which helped stabilize the ASDs. In vitro dissolution studies demonstrated that these ASDs improved the CEL dissolution rate by up to 8.2-fold compared to the crystalline form. Electrospraying presents a promising alternative to conventional methods like hot-melt extrusion (HME) and spraying drying (SD) for the production of ASDs, providing simplicity, high drug loading capability and long-term stability, thus catering to a variety of poorly water-soluble drugs. Graphical
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CATALYSIS LETTERS
·
2025
·Vol. 155
·期 3
·1-12
·
IF 2.4
Yu Shuxiu,Yuan Shixiong,Li Liang,Wang Ling,Chen Jianjun
Electro-reduction of CO 2 (CO 2 RR) to formic acid is one of the most efficient and promising technologies for the utilization of CO 2 , however, designing catalysts with high reactivity and selectivity to achieve the conversion of CO 2 to formic acid is still a great challenge. Therefore, in this study, Bi 2 O 3 -ZnO/ZnAl 2 O 4 composite oxide catalysts were constructed using layered double hydroxides as precursors to enhance the interfacial stability and utilize the synergistic effect of zinc-bismuth dual active sites for the efficient electrocatalytic reduction of CO 2 to formate. The product formate bias current density reached up to 25.8 mA·cm − 2 at -1.3 V (vs. RHE) in an H-type electrolytic cell and the Faraday efficiency of formate was maintained at about 93% under stability tests up to 14 h, which was superior to most other reported catalysts. In the formation of the Bi 2 O 3 -ZnO/ZnAl 2 O 4 interface, zinc promotes the electroreduction of CO 2 to produce *CO 2 − intermediates, while bismuth reduces CO production and improves formic acid selectivity by providing more reactive sites. In addition, the interface between zinc and bismuth optimizes electron and proton flow, helping to maintain a lower energy threshold during the reaction and thus improving catalytic efficiency. This interface engineering approach utilizes zinc-bismuth dual active sites to achieve high selectivity and stability of CO 2 electrocatalytic reduction, providing insights for the development of large-scale efficient CO 2 RR catalysts in the future. Graphical
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 11
·1-12
·
IF 5.3
Ji Lei,Wang Fengyang,Qi Yan,Qiao Fanglin,Xiong Xiaohui,Liu Yuanjian
Real-time, label-free detection of gram-negative bacteria with high selectivity and sensitivity is demonstrated using a bipolar electrode-electrochemiluminescence (BPE-ECL) platform. This platform utilizes anode luminescence and cathode modification of antimicrobial peptides (AMPs) to effectively capture bacteria. Magainin I, basic AMP from Xenopus skin, boasting an α -helix structure, exhibits a preferential affinity for the surface of gram-negative pathogens. The covalent attachment of the peptide’s C-terminal carboxylic acid to the free amines of a previously thiolated linker ensures its secure immobilization onto the surface of the interdigitated gold-plated cathode of BPE. The AMP-modified BPE sensor, when exposed to varying concentrations of gram-negative bacteria, produces reproducible ECL intensities, allowing for the detection of peptide-bacteria interactions within the range 1 to 10 4 CFU mL −1 . Furthermore, this AMP-modified BPE sensor demonstrates a selective capacity to detect Escherichia coli O157:H7 amidst other gram-negative strains, even at a concentration of 1-CFU mL −1 . This study underscores the high selectivity of Magainin I in bacterial detection, and the AMP-modified BPE-ECL system holds significant promise for rapid detection of gram-negative bacteria in various applications. The AMP-modified BPE sensor generated reproducible ECL intensity that detected peptide-bacteria interactions in the range 1 to 10 4 CFU mL −1 . The AMP-modified BPE sensor also selectively detected E. coli O157:H7 from other gram-negative strains at a concentration of 1-CFU mL −1 . In this paper, AMP demonstrated high selectivity in bacterial detection. The AMP-modified BPE-ECL system prepared has a great potential for application in the field of rapid detection of gram-negative bacteria. Graphical Abstract
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ANALYTICAL SCIENCES
·
2025
·
IF 2
Wei JunJie,Shen Yong,Ouyang GangFeng
The rapid and simple detection of circulating tumor cells (CTCs) can help with early diagnosis of tumor diseases and assist clinical judgment of tumor disease development status and prognosis. An important alteration in cancer progression is a significant increase in sialic acid (SA) levels, making sialic acid one of an interesting biomarker for cancer type diversity. Here, novel SERS nano-biosensors were fabricated employing molecularly imprinted polymers (MIPs) particles loaded with Ag nanoparticles (AgNPs) to form high affinity toward sialic acid on CTCs. In this work, the glycol-specific MIPs are produced using precipitation polymerization. The nanocomposite was characterized by Fourier transform infrared spectroscopy (FTIR), zeta potential, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Consequently, CTC can be rapidly detected in mouse blood in a specific and sensitive manner, as low as 1 cells/ml. In addition, a good linear relationship was observed between CTC concentration and signal intensity ( R 2 = 0.9881). Moreover, the SERS nano-biosensors was used to detect CTC with excellent precision (relative standard deviation, RSD = 3.9%) and good repeatability (RSD = 6.8%). Therefore, this inexpensive, highly sensitive, and rapid method using SERS nano-biosensors can quickly detect CTCs and may prove to be a new platform to be an early diagnostic tool for cancer patient detection. Graphical abstract
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Journal of Inorganic and Organometallic Polymers and Materials
·
2024
·
IF 3.9
Xie Lina,Li Yuhu,Liu Yushuai,Hu Wenjing,Fang Shiqiang,Chen Xue-Qiang
Adhesives are widely used to join fragments in the preservation and restoration of cultural heritage made of pottery. However, research into the inorganic adhesive for archaeological pottery bonding is scarce and is even non-existent for the comparison study between organic and inorganic adhesives. Nowadays, a novel environmental-friendly inorganic phosphate-based adhesive has been developed. To evaluate the adhesive scientifically and objectively, three epoxy resin adhesives have also been prepared and applied to the fractured specimens, tested and compared in laboratory to check their compatibility and durability in this experimental study. The compatibility characterization results indicate that the bonding strength of inorganic phosphate-based adhesives is closest to that of the pottery matrix. From the perspective of contact angle change, permeability and morphology, the epoxy resins showed a dense structure after curing, which obstructs the breathing channel of the pottery matrix, and therefore the water vapor permeability and water absorption are greatly reduced. Additionally, the cured adhesive specimens also undergo three types of artificially accelerated aging: dry-thermal, hygrothermal and UV irradiation. These adhesives’ long-term stability and durability have been monitored and compared in terms of weight change, chromatic variation, bonding strength measurements, microscopic observations and FTIR analysis. After a dry-thermal aging, the inorganic phosphate-based adhesive shows the highest strength retention rate (81%), the lowest weight change rate (-9.106 × 10 − 5 %) and the lowest color variation (ΔE* = 5.46). The findings suggest that the inorganic phosphate-based adhesive may offer advantages over commonly used epoxy resins in terms of physical-chemical compatibility with the pottery substrate and long-lasting resistance to aging. The purpose of this study is to reveal the benefits of using inorganic phosphate-based adhesive to bond shattered pottery through a comparative experiment, hoping to provide useful bonding materials and innovative research ideas for archaeological pottery conservation. Graphical Abstract
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CELLULOSE
·
2024
·
IF 4.9
Xiong Jing,Wu Liang,Xiao Gang,Ma Yan,Ran Ruilong,Sun Wei,Wang Wei,Mao Cuiping,Qiao Yan,Lu Zhisong
A microfluidic thread/paper-based analytical device (µTPAD) is of great significance in biomedical analysis and point-of-care diagnostics. Nevertheless, the research has not been done on the ion distribution on the thread and how it affects sensing so far. Inspired by the sweat stains on the clothes, a high-performance µTPAD based on the evaporation-induced ion enrichment is presented for glucose monitoring in salty solutions. In comparison to the multi-ply cotton thread, the single-ply cotton thread exhibits the most significant ion-enrichment capability at the rear segment, which could be attributed to the balance between the water evaporation and the solution replenishment in the thread. The salts accumulated at the rear segment could increase the ionic strength of the solution passed through the thread, promoting the colorimetric reaction on the paper-based sensing unit. The single-ply thread with strong ion-enrichment capability was integrated with a paper-based glucose sensor to prepare a µTPAD for highly sensitive glucose detection in both PBS and artificial sweat (-0.673µM −1 in PBS and − 0.253 µM −1 in artificial sweat). Moreover, the system could detect glucose in human sweat samples with high accuracy and precision. This work may provide a strategy to prepare a highly sensitive µTPAD for precise analysis of substances in bio-fluids, particularly human sweat. Graphical Abstract
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Nano Research
·
2024
·
IF 9.5
Ma Xiaolu,Bian Qiong,Xu Yihua,Hu Jingyi,Hu Weitong,Wang Ruxuan,Zhang Yunting,Ye Yuxian,Sheng Xiaoxia,Zhang Tianyuan,Gao Jianqing
Psoriasis is a chronic skin disease characterized by the hyperproliferation of keratinocytes and an overactive autoimmune response. Photodynamic therapy (PDT) has been established as a promising intervention for alleviating psoriasis. However, the current transdermal delivery of photosensitizers is inefficient and imprecise. In this study, we developed a foamed microemulsion nanodroplets system containing chlorin e6 (Ce6 FM), exhibiting precise epidermal targeting and retention, which targeted the aberrantly proliferating epidermal cells at psoriatic skin lesions and avoided the damage to the normal cutaneous cells. Upon application in a psoriatic mouse model, Ce6 FM efficiently induced keratinocyte apoptosis by generating reactive oxygen species under laser. Furthermore, Ce6 FM-based PDT activated the cyclooxygenase-2-induced immunosuppressive pathway in keratinocytes, resulting in the amelioration of the autoimmune microenvironment in psoriatic skin. Additionally, Ce6 FM-based PDT did not induce skin damage or atrophy associated with non-targeted halometasone treatment. Overall, Ce6 FM-based PDT holds promise as an effective, safe and compliant strategy for psoriasis treatment.
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Scientific Reports
·
2025
·Vol. 15
·期 1
·1-11
·
IF 3.9
Lu Pengpeng,Xu Jingyang,Liu Shuyan,Fu Lili,Wu Shengxian,Liu Ze,Hou Tu,Liu He,Huang Dongyan
The application of flexible hydrogel sensors in extreme environments, such as low temperatures, underwater, or significant mechanical deformations, poses considerable challenges. Here, we present a simple one-pot method to fabricate ultra-tough, swelling- and freezing-resistant conductive organohydrogels without external conductive and freeze-resistant fillers. During gelation, by-products (C 6 H 15 NHCl, KCl) provide both conductivity and antifreeze properties, thus eliminating compatibility issues and dispersion challenges associated with external fillers. The resulting gel exhibits super toughness, with tensile strength reaching 10.2 MPa and stretchability up to 800% in the dry state. Following covalent crosslinking, the gel demonstrates excellent anti-swelling properties, with a swelling ratio of only 15.4% after 24 h of water immersion, while maintaining a tensile strength of 5.8 MPa and an elongation of up to 1000%. When fabricated into flexible sensors, these gels display stable electrical responsiveness and desired Gauge Factor (0.58–2.25), effectively detecting limb movements. Furthermore, the gel’s superior resistance to freezing and swelling ensures reliable signal stability under both − 20 °C and underwater conditions. These combined properties render the conductive gel a promising candidate for flexible sensing components in robotic and bionic applications.
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