DESALINATION
·
2025
·
IF 9.8
Tong Zhou,Nan Zhang,Qi Li,Guoyao Li,Haidong Sun,Chenglan Zhang,Juan Li,Hezhou Liu,Huanan Duan
The rapid increase in the commercialization of electric vehicles and portable electronics has markedly raised the demand for lithium resources. Extracting lithium from brine has become a critical pathway to address future lithium production challenges. However, the lithium extraction efficiency of conventional technologies is limited by the low levels of Li + and the high Mg 2+ /Li + ratio present in brine. A method involving one-step electrolysis with a solid-state electrolyte has been introduced for the direct and efficient extraction of metallic lithium. Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 (LATP) is considered a highly promising selective membrane for large-scale lithium extraction from brine sources due to its low cost, excellent stability, and high ionic conductivity. Herein, LATP electrolytes were synthesized through the optimization of solid-state reaction conditions. The resulting LATP pellets exhibited a high relative density of 98.29 % and an impressive ionic conductivity of 3.88 × 10 −4 S cm −1 . The lithium extraction device utilizing LATP as a selective membrane achieved a remarkable current efficiency of 97.4 % and a high lithium production rate of 40.4 μg h −1 cm −2 . After lithium extraction process, the LATP pellets retained the ionic conductivity of 2.69 × 10 −4 S cm −1 and preserved the sodium super ion conductors (NASICON) crystal structure. This study presents an efficient Li + selective membrane for extracting lithium directly from natural brine.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Caiyun Wang,Xingxing Wu,Yufan Xia,Xuan Zhang,Hongge Pan,Mi Yan,Yong Li,Yinzhu Jiang
Mg metal anodes experience significant passivation of harmful side reactions in conventional electrolyte consisting of magnesium bis(trifluoromethane sulfonyl)imide (Mg(TFSI) 2 ) in 1,2-dimethoxyethane (DME), which critically impedes the advancement of high-performance rechargeable magnesium batteries. Herein, an innovative electrolyte system comprising an ultra-dilute 0.02 M Mg(TFSI) 2 in DME with 4-chlorobutyl methyl ether (CME) as co-solvent is strategically devised. This unique formulation effectively suppresses the formation of TFSI − -derived passivation byproducts while simultaneously facilitating the establishment of protective Cl-rich interphase, thereby achieving exceptional reversibility in Mg plating/stripping processes. Remarkably, Mg electrodes demonstrate stable cycling performance with a minimal overpotential of 70 mV at 0.1 mA cm −2 in the optimized 0.02 M Mg(TFSI) 2 -DME/CME electrolyte. More impressively, the system maintains reversible electrochemical operation for 400 h even at 2 mA cm −2 . This work presents a novel electrolyte formulation for overcoming the limitations of Mg metal anode in conventional Mg(TFSI) 2 based electrolytes, offering new perspectives for the development of next-generation rechargeable magnesium batteries.
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DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2020
·Vol. 30
·期 45
·2004692
·
IF 16.836
Sheng Zhao,Yixuan Li,Quanyi Liu,Sirong Li,Yuan Cheng,Chaoqun Cheng,Ziying Sun,Yan Du,Christopher J. Butch,Hui Wei
Safe, effective, and convenient administration of therapeutic nanomaterials is one of the greatest difficulties in nanomedicine. To tackle this challenge, a system which couples multi-enzyme mimicking CeO 2 nanoparticles with clinically approved montmorillonite (MMT) for inflammatory bowel disease (IBD) therapy is reported. CeO 2 exhibits superoxide dismutase- and catalase-like activities, and hydroxyl radical scavenging activity, making it more efficient at scavenging reactive oxygen species (ROS) than non-catalytic antioxidants while being more stable than free enzymes. In addition, negatively-charged MMT can be orally administered and specifically adsorbed onto positively-charged inflamed colon tissue via electrostatic interactions for targeted delivery. When the two are assembled together by in situ growth of CeO 2 onto MMT, the optimized CeO 2 @MMT(1:9) is stable in the stomach for oral delivery, targets the inflamed colon through electrostatic interactions, and reduces inflammation through ROS scavenging, all without any significant systemic exposure as demonstrated by the relief of murine IBD in vivo.
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DESALINATION
·
2024
·
IF 8.3
Hui Yang,Baozhong Ma,Shuyang Shi,Qinqing Zhao,Chengyan Wang,Yongqiang Chen
The continuous development of lithium-ion batteries (LIBs) manufacturing industry calls for the mass production of Li 2 CO 3 , which serves as a pivotal raw material for LIBs. In our previous study, Li was successfully precipitated as intermediate product Li 2 SiO 3 from an alkaline solution containing Si by the hydrothermal precipitation method, realizing the preliminary separation of Li and impurities. In this research, H 2 SO 4 digestion-water leaching-Na 2 CO 3 precipitation process was proposed to manufacture Li 2 CO 3 from the intermediate product Li 2 SiO 3 . Firstly, the reaction feasibility of H 2 SO 4 digestion-water leaching and direct H 2 SO 4 leaching for Li 2 SiO 3 were comparatively evaluated through thermodynamic calculation and experimental research. Compared to direct H 2 SO 4 leaching, H 2 SO 4 digestion-water leaching process is preferred in view of its excellent filtration properties. Subsequently, systematic digestion and leaching experiments showed that up to 97.1 % of Li was extracted under the optimized conditions, and the concentration of Li in the leach liquor is as high as 29.33 g/L. After pH adjustment and Al removal, Na 2 CO 3 precipitation were adopted for Li 2 CO 3 production. The equilibrium relationship in Li 2 SO 4 -Na 2 CO 3 -H 2 O system was analyzed to predict the precipitation behavior of Li and select appropriate operation window for Li 2 CO 3 preparation. Finally, with an additional carbonation-decomposition process, a Li 2 CO 3 product with a purity of 99.51 % is produced. This process realizes efficient synthesis of battery-grade Li 2 CO 3 from the intermediate product Li 2 SiO 3 .
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IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
·
2025
·
IF 5.9
Zixing He,Enjun Lin,Yizhang Wen,Song Hu,Haowen Chen,Ping Zhang,Yujie Yang,Weilin Guo
The method for detecting ammonium ions (NH ${}_{4}^{+}$ ) concentrations with ion-selective electrodes (ISEs) offers the benefits of rapid response and no secondary pollution. By calculating the ratio of NH ${}_{4}^{+}$ to ammonia (NH3) via pH and temperature parameters, the concentration of ammonia nitrogen (NH3–N) can be further calculated. However, H+ can interfere with the membrane potential of ISEs in acidic solutions, especially at lower NH3–N concentration where the interference becomes more pronounced. We investigated the effect of H+ on ISEs at room temperature and proposed a pH precompensation algorithm to enhance the precision of ammonium ISEs. Additionally, we modified the membrane with 5% polytetrafluoroethylene (PTFE) micro powder to improve the hydrophobicity. Consequently, a real-time NH3–N sensor incorporated with a pH precompensation algorithm has been developed. The sensor, which is cylindrical with a diameter of 150 mm and a height of 95 mm, accurately measures NH3–N concentrations from 0.1 to 100 ppm with a relative error of $\le 10$ %.
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ACS Nano
·
2019
·
IF 13.903
Xuexiang Han,Ying Xu,Yiye Li,Xiao Zhao,Yinlong Zhang,Huan Min,Yingqiu Qi,Gregory J. Anderson,Linhao You,Yuliang Zhao,Guangjun Nie
Combining informative imaging methodologies with effective treatments to destroy tumors is of great importance for oncotherapy. Versatile nanotheranostic agents that inherently possess both diagnostic imaging and therapeutic capabilities are highly desirable to meet these requirements. Here, a simple but powerful nanoplatform based on polydopamine-coated gold nanostar (GNS@PDA), which can be easily diversified to achieve various function extensions, is designed to realize functional and anatomical imaging-guided photothermal oncotherapy. This nanoplatform intrinsically enables computed tomography/photoacoustic/two-photon luminescence/infrared thermal tetramodal imaging and can further incorporate fibroblast activation protein (FAP, a protease highly expressed in most of tumors) activatable near-infrared fluorescence imaging and Fe3+-based magnetic resonance imaging for comprehensive diagnosis. Moreover, GNS@PDA exhibits excellent photothermal performance and efficient tumor accumulation. Under the precise guidance of multimodal imaging, GNS@PDA conducts homogeneous photothermal ablation of bulky solid tumors (∼200 mm3) in a xenograft mouse model. These results suggest great promise of this extendable nanoplatform for cancer theranostics.
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PubMed
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FOOD AND AGRICULTURAL IMMUNOLOGY
·
2018
·
IF 2.568
Kai Hao,Steven Suryoprabowo,Shanshan Song,Liqiang Liu,Qiankun Zheng,Hua Kuang
Procaine (PRC) is a local anaesthetic used in the treatment of several disease related to ageing, asthma, and arthritis. In this study, we describe a rapid, sensitive, simple, and accurate method for the determination of PRC in milk, using an immunochromatographic test strip. For the immunochromatographic test, antigen (PRC-bovine serum albumin) and goat anti-mouse IgG were drawn onto a nitrocellulose membrane representing the control line and test line. The test was developed with a sensitive monoclonal antibody specific for PRC, generated by immunizing BALB/c mice with a well-characterized PRC- Keyhole limpet hemocyanin conjugate, produced in our laboratory. Under optimized conditions, the semi-quantitative test strip was able to detect PRC at concentrations down to 1 ng/mL in both 0.01 M phosphate buffer saline (pH 7.4) and milk samples. All results were obtained within 5 min. Our data indicate that the immunochromatographic assay is capable of sensitive, rapid, and specific on-site screening of PRC.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Xiangjing Yang,Xiaomin Sun,Jia Liu,Yongrui Huang,Yuehai Peng,Yingni Xu,Li Ren
Corneal transplantation is an effective treatment for corneal blindness. However, it brings risk factors for the occurrence of bacterial keratitis, which can affect the repair effect and even lead to transplantation failure. The difficulty in re-epithelialization is also a main problem faced by corneal transplantation. Herein, a collagen-GelMA composite membrane containing lysozyme (CGL) was developed as an antibacterial corneal implant to fill stromal defect and support re-epithelialization. Characterizations of physicochemical properties and in vitro biocompatibility revealed that the composite membranes have proper water content, light transmittance and mechanical strength as well as good biocompatibility. Particularly, the cell adhesion force and adhesion-related genes expression were evaluated and exhibited an improvement after the addition of GelMA. Furthermore, the formed CGL membrane could continuously release lysozyme and exhibited a bactericidal rate of 96% and 64% after 2 h and 72 h, respectively. The results demonstrated that this CGL membrane has promising application in corneal repair.
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PubMed
高影响因子
Polymer Chemistry
·
2019
·Vol. 10
·期 20
·2551-2558
·
IF 4.76
Wenyu Cheng,Hongtao Chen,Chendong Ji,Ru Yang,Meizhen Yin
Perylenediimide-cored (PDI-cored) polymers have been widely applied as fluorescent drug carriers due to their high fluorescence quantum yield and outstanding chemical/photophysical stability. However, most of these delivery systems lack detailed drug delivery specifics, especially when and where the drug is released. In this study, a PDI-based nanocarrier (PPL-B) is constructed and applied to monitor curcumin release with an “off–on” fluorescence switch. The star-shaped drug carrier has an amphiphilic structure with fluorescent PDI as the core and poly(amino acid) as the shell, which is suitable for drug delivery. A model drug curcumin is loaded to PPL-B and quenches its fluorescence significantly through photo-induced electron transfer (PET). Upon curcumin release, the fluorescence of PPL-B achieves an “off–on” switch as a result of PET interruption. In light of this, curcumin release is successfully monitored by CUR@PPL-B at the cellular level. This PDI-based nanocarrier for drug release monitoring with a PET mechanism shows great potential in the drug delivery field.
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Frontiers in Microbiology
·
2023
·
IF 5.2
Tian Li,Zhuang Jing,Li Jun-Jiao,Zhu He,Klosterman Steven J.,Dai Xiao-Feng,Chen Jie-Yin,Subbarao Krishna V.,Zhang Dan-Dan
Understanding how plant pathogenic fungi adapt to their hosts is of critical importance to securing optimal crop productivity. In response to pathogenic attack, plants produce reactive oxygen species (ROS) as part of a multipronged defense response. Pathogens, in turn, have evolved ROS scavenging mechanisms to undermine host defense. Thioredoxins (Trx) are highly conserved oxidoreductase enzymes with a dithiol-disulfide active site, and function as antioxidants to protect cells against free radicals, such as ROS. However, the roles of thioredoxins in Verticillium dahliae, an important vascular pathogen, are not clear. Through proteomics analyses, we identified a putative thioredoxin (VdTrx1) lacking a signal peptide. VdTrx1 was present in the exoproteome of V. dahliae cultured in the presence of host tissues, a finding that suggested that it plays a role in host-pathogen interactions. We constructed a VdTrx1 deletion mutant ΔVdTrx1 that exhibited significantly higher sensitivity to ROS stress, H2O2, and tert-butyl hydroperoxide (t-BOOH). In vivo assays by live-cell imaging and in vitro assays by western blotting revealed that while VdTrx1 lacking the signal peptide can be localized within V. dahliae cells, VdTrx1 can also be secreted unconventionally depending on VdVps36, a member of the ESCRT-II protein complex. The ΔVdTrx1 strain was unable to scavenge host-generated extracellular ROS fully during host invasion. Deletion of VdTrx1 resulted in higher intracellular ROS levels of V. dahliae mycelium, displayed impaired conidial production, and showed significantly reduced virulence on Gossypium hirsutum, and model plants, Arabidopsis thaliana and Nicotiana benthamiana. Thus, we conclude that VdTrx1 acts as a virulence factor in V. dahliae.
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PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2020
·
IF 7.182
Jun-Sheng Liu,Yue-Xiang Zeng,Shi-Yuan Bi,Jin-Wei Zhou,Rui Cheng,Jing Li,Ai-Qun Jia
Phomopsis liquidambari is a classical endophytic fungus with great application potential in ecology and agriculture; however, studies on its exopolysaccharides are lacking. Here, we aimed to evaluate the structure and bioactivity of PLN-1, an exopolysaccharide derived from the P. liquidambari NJUSTb1 strain. The structure was elucidated by chromatography/spectral methods and hydrolyzation. Immunomodulation, moisture absorption, and retention properties were investigated after sulfation and carboxymethylation modification. Results showed that PLN-1 contained a linear repeating unit of →[4)- α - d -Glc p -(1→6)- α - d -Glc p -(1→4)- α - d -Glc p -(1→4)- α - d -Glc p -(1→] n , with a molecular weight of 343 kDa. The degrees of substitution of sulfated polysaccharide (S-PLN-1) and carboxymethylated polysaccharide (C-PLN-1) were 1.228 and 0.903, respectively. S-PLN-1 showed stronger moisture absorption and retention properties than PLN (crude EPS), C-PLN1, and PLN-1. Furthermore, PLN, S-PLN-1, and C-PLN-1 stimulated the proliferation of RAW 264.7 cells with no cytotoxicity. The elucidation of PLN-1 in this study paves the way for future applications.
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高影响因子
ANALYST
·
2019
·Vol. 144
·期 19
·5691-5699
·
IF 4.019
Manman Li,Zhuangzhuang Guo,Xiaoke Zheng,Huaixia Yang,Weisheng Feng,Jinming Kong
Herein, a novel aptasensor was constructed for ultrasensitive detection of bisphenol A (BPA). In this method, an electrochemically mediated atom transfer radical polymerization (eATRP) signal amplification strategy was applied to BPA detection for the first time. The 5′-end modified sulfhydryl group and the 3′-end modified azide group hairpin DNA were immobilized on a gold electrode through an Au–S bond. The double-stranded DNA was formed by the hybridization of an aptamer and a single-stranded DNA partially paired with the hairpin DNA. In the presence of BPA, the aptamer combined with BPA and the single-stranded DNA was released to open the hairpin structure, making the azide groups at the 3′ end exposed. Subsequently the initiator of eATRP was introduced into hairpin DNA through click chemistry reaction and eATRP was conducted for the polymerization of the electroactive probe ferrocene methyl methacrylate (FMMA). As a result, the ultrasensitive detection of BPA was realized, and the detection limit of this aptasensor was as low as 59 aM and a good selectivity was obtained in the presence of 100-fold structural analogs. The application of this aptasensor was evaluated by detecting BPA in pure water samples, and recoveries were in the range of 95.23–98.40%, holding promising applications in biological analysis.
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