Materials Today Bio
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2026
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IF 10.2
Yongkang Lai,Yongliang Ouyang,Xiaojing Yin,Tao Yu,Jianhua Wan,Xueyang Li,Yi Hu,Xu Shu,Huan Wang
Chronic pancreatitis (CP) is a lifelong progressive fibrotic inflammatory disorder for which no effective cure is currently available. Persistent and recurrent inflammatory stimulation induced by reactive oxygen species (ROS) is a key driver of pancreatic fibrogenesis, making oxidative stress a promising therapeutic target to halt disease progression. In this study, we developed a nanosystem, HC@CeMOF, consisting of a small-sized cerium-based metal–organic framework (CeMOF) core loaded with curcumin and coated with hyaluronic acid (HA), enabling precise targeting of inflamed pancreatic tissue. HC@CeMOF exhibits a small-sized particle size along with favorable cellular and biological safety profiles. Once administered in vivo , the nanosystem exploits the specific binding affinity of HA to CD44 receptors on macrophages to selectively accumulate at inflamed pancreatic sites. Subsequently, the cerium-based nanozyme efficiently scavenges ROS through the reversible redox cycling between Ce 3+ and Ce 4+ , while the slow release of curcumin further suppresses the NF-κB signaling pathway and modulates inflammatory cytokine levels, thereby achieving synergistic anti-inflammatory and antioxidant effects. Collectively, these mechanisms substantially attenuate CP progression. This targeted ROS-scavenging and anti-inflammatory strategy holds promise as an alternative therapeutic approach for chronic pancreatitis.
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Acta Pharmaceutica Sinica B
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2026
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IF 14.6
Mingyang Han,Hezhen Xu,Jun Yuan,Wenxiao Li,Hao Zhang,Hongkai Fang,Zhiyu Kuang,Yuanhao Yu,Danping Wang,Zhenzhen Zhao,Cong Luo,Bingjun Sun,Jin Sun
Prodrug nanoassemblies offer an innovative approach to drug delivery, but their lysosomal entrapment often impairs drug release. Notably, tertiary amine structures can undergo protonation reactions, thereby facilitating lysosomal escape through the proton sponge effect. In this study, we developed three novel paclitaxel prodrug nanoassemblies (PTX–SS–NO NPs, PTX–SS–CC NPs and PTX–SS–NC NPs) featuring distinct heterocyclic tertiary amine structures to investigate structure-activity relationships in lysosomal escape and drug delivery. Among them, PTX–SS–NC NPs demonstrated excellent lysosomal escape capability, enabling rapid drug release into the cytosol. Systematic evaluation revealed that the PTX–SS–NC NPs exhibited optimized pharmacokinetics and significant tumor accumulation, further contributing to their strong antitumor efficacy. Our findings establish heterocyclic tertiary amines as crucial design elements for overcoming lysosomal entrapment and optimizing chemotherapeutic prodrug nanoassemblies.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 13.2
Yuze Luo,Ying Wang,Cheng Jin,Ke Yang,Zefeng Wang,Yinbang Zheng,Junqin Li,Chunlei Ou,Li Wang,Dinggeng He
The treatment of bacterial wound infection, particularly that caused by methicillin-resistant Staphylococcus aureus (MRSA), presents significant challenges owing to biofilm formation, multidrug resistance, and immune evasion. Here, we have rationally designed a multifunctional composite nanozyme (FTM) consisting of tannic acid (TA) and ferric ion (Fe 3+ ) coordination compound loaded with antibiotic drug methicillin (Meth), which is capable of realizing pH-responsive self-adaptive regulation of oxidative stress for enhancing the treatment of MRSA-infected wound. During the early stages of wound infection (pH < 6.5), FTM demonstrates significant peroxidase-like activity for effectively catalyzing the conversion of endogenous H 2 O 2 into highly toxic hydroxyl radical (•OH), which not only directly damages MRSA and eliminates its biofilm for chemodynamic therapy (CDT), but also disrupts the penicillin-binding protein 2a (PBP2a) to restore the sensitivity of MRSA to methicillin. Meanwhile, FTM exhibits strong near-infrared (NIR) absorption, achieving photothermal antibacterial therapy (PTT). While in the later stages (after complete elimination of MRSA), as the infectious microenvironment of wound becomes neutral (pH 7.4), FTM mainly reveals the superoxide dismutase (SOD)-like activity for scavenging excess reactive oxygen species (ROS), ultimately reducing oxidative stress and promoting tissue repair. In vitro and in vivo experiments show that the proposed FTM nanozyme with triple bactericidal modalities achieves satisfactory antibacterial and antibiofilm therapy and accelerates wound healing process. Consequently, by adapting to the dynamic changes of wound microenvironment, this multifunctional nanoplatform offers a promising strategy for treating drug-resistant wound infections.
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POLYMER
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2026
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IF 4.5
Yiyi Xu,Hua Xin,Xinjian Wang,Yue Chen,Xinqi Li,Bo Gao,Xiaojuan Lai
Conventional waterborne polyurethanes characteristically possess a linear structure, a property that invariably leads to deficiencies in both water resistance and mechanical strength. In this study, two novel functional monomer crosslinkers, eugenol-based polyol (EUMP) and bis(mercapto)fluorine-containing binary chain extender (PTFA), were synthesised through a thiol-ene click reaction. Crosslinked network waterborne polyurethane (EUMP WPU) with different dosage of crosslinking agent EUMP was prepared by self emulsification method. The test results showed that when the amount of EUMP was 4 wt%, the contact angle of EUMP-WPU reached a maximum of 85.6° and the tensile strength reached a maximum of 23.61 MPa. Therefore, the optimum amount of cross-linking agent EUMP was selected as 4 wt%, and different amounts of dimercapto fluorinated binary chain extender PTFA were introduced into the system using the thiol-isocyanate click reaction to obtain fluorinated waterborne polyurethane (EUMP-FWPU). The EUMP-FWPU samples were characterised through a series of tests and the results showed that the mechanical strength, adhesion and hydrophobicity of the latex film were significantly improved. It was observed that when the PTFA dosage was 8 wt%, the tensile strength was 30.34 MPa, and the contact angle was 117°. The film transmittance rate is above 92 %, which can be applied to mobile phone screen protector in hydrophobic and can protect the screen without affecting the sensitivity of normal operation of the mobile phone screen.
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JOURNAL OF MEMBRANE SCIENCE
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2026
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IF 9
Hongyuan Zhu,Wangyi Zhou,Yifan Liu,Hang Jiang,Fan Feng,Shasha Yuan,Liguo Shen,Sui Zhang,Die Ling Zhao,Hongjun Lin
Electro responsive membranes offer an effective approach to actively regulate interfacial interactions and mitigate fouling during oil-water separation, yet their practical application is often limited by scalability-conductivity trade-offs and an incomplete understanding of electro-assisted antifouling mechanisms. Herein, conductive membranes were fabricated via a scalable blending strategy by incorporating Ketjen black (KB) nanoparticles into a PVDF matrix. The optimized membranes (0.5KM) exhibited high electrical conductivity (7.42 S·m -1 ), underwater superoleophobicity (UOCAs of 155°), and improved hydrophilicity, while maintaining mechanical integrity. Under a negative bias (-15 V), the membranes exhibited synergistic electroosmotic flow (EOF) and electrostatic repulsion for sodium dodecyl sulfate (SDS) stabilized oil/water emulsion, enabling high permeances (4863 L·m -2 ·h -1 ·bar -1 ) and oil rejection (> 99.60%) for multiple emulsified oils, alongside superior fouling resistance over five filtration-cleaning cycles. Positive bias, conversely, intensified fouling due to electrostatic attraction. Molecular dynamics (MD) simulations revealed that the electric field enhanced the water self-diffusion coefficient by ∼5.8-fold and facilitated net transmembrane water transfer, while reducing oil residence near pore entrances. This work demonstrates a simple and scalable route to fabricate conductive polymeric membranes, rendering new insights for electrically enhanced separation processes in oily wastewater treatment.
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Journal of Hazardous Materials Letters
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2026
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IF 8.1
Jibo Dou,Yichao Xu,Yunfei He,Ruoru Xu,Yao Yue,Feifei Chen,Yuchi Zhong,Xuetong Qu,Jiafeng Ding,Hangjun Zhang
Fe-doped carbon matrices have garnered significant attention as peroxymonosulfate (PMS) activators for the removal of refractory organic pollutants. However, the role of Fe dopant in PMS activation remains unclear, especially concerning the relative contributions and reaction pathways of high-valent iron oxidations. In this study, a series of Fe-doped carbon nitride (CN) catalysts with varying iron contents was synthesized and utilized for the catalytic degradation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Results showed that Fe doping significantly enhanced PMS activation, with the highest TCDD degradation rate achieved by Fe-CN-3, exhibiting a 4.6-fold improvement. Quenching experiment revealed that increasing Fe content shifted the degradation mechanism from a radical-dominated process (76.1%) to a Fe V =O-driven nonradical pathway (55.8%); consequently, the Fe-CN-3/PMS system exhibited significant resistance to common environmental interferents. Theoretical calculations further confirmed that the Fe(III)-PMS interaction weakened both the O 2 -O 3 and O 3 -H bonds, thereby enabling their thermodynamically feasible cleavage and the subsequent generation of Fe V =O via a coupled electron-proton transfer pathway, which ultimately enhanced the electrophilic σ-attack on TCDD. These findings highlight the criticality of the metal dopant's local coordination environment in steering persulfate activation pathways, guiding the rational design of catalysts for selective oxidant generation.
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Applied Materials Today
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2026
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IF 6.9
Gao Pan,Qi Zhong,Donglan Zhang,Tiantian He,Huixing Li,Xiuwen Gao,Shun Hu,Xinhua Lan,Cijun Shuai,Yang Shuai
Molybdenum disulfide (MoS 2 ), a sonosensitizer material, shows promising application potential in the fields of piezoelectric catalytic antibacterial activity and electrical stimulation-induced regeneration. However, MoS 2 has two major limitations: the difficulty in separating electron-hole pairs, which results in low antibacterial catalytic activity; and the inability to form chemical bonds with biopolymers, leading to the failure of its composite scaffolds to effectively transmit mechanical stimuli. To address these issues, we propose a three-in-one strategy: in-situ growth of Cu-BTC (the abbreviation for HKUST-1, a MOF structure) on the surface of MoS 2 to construct a Type-II heterojunction, which can form a built-in electric field to accelerate electron-hole separation; the excited electrons form a current loop in the MoS 2 matrix to stimulate bone regeneration; Cu-S bonds are formed between MoS 2 and Cu, while Cu ions form coordination bonds with carboxyl groups in the polylactic acid polymer chains, thereby constructing a “plane-point-line” ternary structure. This structure hinders the movement of polylactic acid polymer chains through “mechanical interlocking” of the layered structure and chemical bonding, thus improving the mechanical properties of the composite scaffold. Experimental results showed that the compressive strength of the scaffold was increased by 140%; the inhibition rates against Staphylococcus aureus ( S.aureus ) and Escherichia coli ( E.coli ) reached 99.3% and 99%, respectively. Notably, the ultrasound-induced sonocurrent could stimulate the expression of osteogenic factors such as BMP-2, RUNX-2, and Wnt-10b, increased the differentiation efficiency of osteoblasts by 37.5% in the late stage of osteogenesis.
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Analytical Methods
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2026
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IF 2.6
lidi Gao,Jiawen Yu,Dongsheng Zhao,Xinyu Liang,Jun Wang,Fuquan Zhao,Ming Zhao,Hongtao Chu,Shili Qin
In this work, a novel Ti-based MOF (NH2-MIL-125) bonded open-tubular (OT) column was firstly prepared via one-step in-situ growth method for capillary electrochromatography (CEC). The stationary phase was characterized by Fourier transform-infrared spectroscopy, scanning electron microscopy, X-ray diffraction spectroscopy, and nitrogen adsorption-desorption measurements. The results showed that the stationary phase exhibited a large specific surface area (1247.57 m²/g) with microporous and mesoporous structure and no obvious changes in the morphology/size inside and outside the column. Baseline separation of three β-adrenergic receptor blockers (Prop, Sot, and Lab), three β-adrenergic receptor agonists, and four sulfonamide antibiotics were obtained under the optimized CEC conditions with the shortest analysis time of 2.52 min and a maximum resolution of 11.52. The separation mechanisms were mainly attributed to polarity and electrophoretic mobility of the analytes, as well as π-π interactions and hydrogen bonding interaction between the stationary phase and the analytes. A quantitative detection method of three β-adrenergic receptor blockers in pork samples was established using the NH2-MIL-125 bonded OT column. Good linearity (R² > 0.999) was obtained over the concentration range of 0.01-1.00 mg/mL with limits of detection of 0.0044-0.0084 mg/mL and recoveries of 90.27-106.74%. Thus, the developed method was simple, rapid and high efficiency, and could be applied for the simultaneous separation and detection of the three β-adrenergic receptor blockers in real samples.
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MICROCHEMICAL JOURNAL
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2026
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IF 5.1
Rongkun Zhu,Mengting Cai,Qiuyu Liao,Xiaobin Meng,Hong Yu,Huanghui Zeng,Zhuomiao Lin,Guicui Zhang
In this study, graphene quantum dots (GQDs) with a high density of carboxyl groups were synthesized via a thermal dissolution method. The surface carboxyl groups of the GQDs were then conjugated with the amino groups of dopamine (DA) through an amidation reaction, yielding a novel fluorescent prob.(GQDs@DA), which features catechol groups. Leveraging the distinctive catechol moiety of vancomycin (VAN) as a functional handle, we employed GQDs@DA and a sol-gel process to construct molecularly imprinted polymers (MIPs@GQDs@DA) on a SiO₂ matrix. This resulted in the formation of highly selective recognition cavities complementary to the VAN template molecule in the final MIPs@GQDs@DA probe.When we used excitation light with a wavelength of 360 nm to excite the composite material, MIPs@GQDs@DA emits a stable fluorescence peak at 460 nm. Vancomycin can sensitively and rapidly bind to MIPs@GQDs@DA, thereby quenching the fluorescence generated at 460 nm. Calculations revealed that the quenched fluorescence intensity at 460 nm exhibits a good linear relationship with the concentration of vancomycin, within a linear range of 0–80 μg/mL, and a detection limit of 0.83 μg/mL (S/N = 3). This probe was applied to detect vancomycin in real human serum samples, and the experimental results were consistent with the expected outcomes.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Yuedong Li,Hongdan Wu,Zhihui Zhou,Xianyuan Fan,Wenming Fu,Guoyuan Lei,Qiuyang Huang,Junlin Peng
To address the structural defects and performance limitations caused by nanoparticle aggregation and insufficient interfacial compatibility in conventional thin-film nanocomposite polyamide (PA) nanofiltration membranes, an interfacial engineering strategy was developed to construct organic solvent nanofiltration membranes via the in situ growth of amino-functionalized ZIF-8 (ZIF-8-NH 2 ) nanoparticles. A continuous and well-anchored ZIF-8-NH 2 interlayer was introduced between the polyimide support and the PA selective layer, which effectively mitigated nanoparticle aggregation and enhanced interfacial integrity, thereby promoting the formation of a dense and uniform PA layer. Performance evaluation demonstrated that, at an optimized ZIF-8-NH 2 growth cycle of three, the resulting membrane exhibited a pure-water permeance of 41.3 L·m −2 ·h −1 ·bar −1 and a methanol permeance of 16.9 L·m −2 ·h −1 ·bar −1 , while achieving rejection values of 65.1 % for NaCl and 99.9 % for Na 2 SO 4 . In ethanol, the membrane exhibited a low molecular weight cutoff of 456 g·mol −1 and maintained Congo red rejection above 99 % during continuous operation for 5 days, confirming its structural stability and operational durability.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2026
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IF 6.3
Rong Qiang,Yuancheng Ding,Yulong Shao,Lei Rong,De Zhang,Rui Hao,Rui Xue,Na Xiao,Hongchen Liu,Jiawen Qiu
Driven by the rapid advancement of electronic devices and wireless communication technologies, there is an urgent demand for high-performance microwave absorbing materials. In this work, one-dimensional MoO 2 /C composites were synthesized through an in-situ polymerization-pyrolysis strategy. By precisely tuning the pyrolysis temperature, remarkable microwave absorption performance was achieved. The resulting material exhibits a minimum reflection loss of −59.1 dB at a matching thickness of 1.7 mm and delivers an effective absorption bandwidth of 5.6 GHz at 2.0 mm. Furthermore, it demonstrates a radar cross-section of 27.08 dB·m² at a 0° scattering angle. Comprehensive experimental and theoretical analyses reveal that the enhanced electromagnetic wave attenuation is primarily attributed to one-dimensional interfacial polarization at the interfaces between MoO 2 nanorods and porous carbon layers, as well as efficient axial electron transport pathways. This work presented a viable strategy for the preparation of one-dimensional MoO 2 -based dielectric microwave absorption materials.
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FOOD CHEMISTRY
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2026
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IF 9.8
Xian Chen,Guangsen Fan,Wanying He,Peng Wang,Jingzhang Geng,Chunmei Gou,Ping Zhan,Honglei Tian
The characteristic flavor of mutton, commonly described as “muttony” or “goaty”, limits consumer acceptance and market potential. This study evaluated the effects of four thyme phenolics, including gallic acid (GA), rosmarinic acid (RA), scutellarin (SCU), and apigenin-7-O-glucuronide (A7G), on the interaction between myofibrillar protein (MP) and six key off-flavor compounds. Gas chromatography-mass spectrometry showed that all four phenolics reduced MP binding with odorants and enhanced their release, with SCU and RA showing the strongest effects. Spectroscopic analyses demonstrated that phenolics induced MP conformational changes, such as decreased α-helix and β-sheet content, reduced surface hydrophobicity, and lower sulfhydryl levels. Docking and simulation confirmed that hydrophobic interactions and hydrogen bonding dominated phenolic-MP binding, and SCU exhibited the highest binding stability among tested phenolics and was likely to competitively displace 4-methyloctanoic acid. These findings provide molecular insights into how thyme phenolics promote off-flavor release and support their application in improving mutton sensory quality.
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危险品化学品经营许可证（带存储）