CARBOHYDRATE POLYMERS
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2022
·
IF 10.723
Wangting Zhou,Tingting Yang,Weiqi Xu,Yujie Huang,Linwu Ran,Yamei Yan,Jia Mi,Lu Lu,Yi Sun,Xiaoxiong Zeng,Youlong Cao
The antidiabetic effect and potential mechanisms of the polysaccharides from the fruits of Lycium barbarum L. (LBPs) by the mouse model of high-fat diet/streptozotocin-induced diabetes were investigated. Six-week oral administration of LBPs (200 mg/kg/day) resulted in improvement in the levels of fasting blood glucose (13.51% decrease) and glycated hemoglobin and β-cell function in diabetic mice, and simultaneously induced a 3.3-fold increment in one taxon belonging to genus Allobaculum in gut bacterial community. The experiments of fecal microbiota transplantation and antibiotics treatment confirmed that the LBPs-mediated gut microbiota participated in the glycemic control of the diabetes management. Moreover, LBPs intervention guarded the intestinal barrier function via upregulating the expression of zonula occludens 1 both in vivo (analyzing the gut permeability in diabetic mice) and in vitro (using intestinal-like Caco-2/RAW264.7 cells co-culture inflammation model). Collectively, our study showed that LBPs could confer anti-diabetic effect through modifying gut microbiota and intestinal barrier.
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高影响因子
FOOD RESEARCH INTERNATIONAL
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2022
·
IF 7.425
Zuoyong Zhang,Shudong He,Luji Zhang,Xinjiang Li,Risheng Jin,Qian Liu,Shuguan Chen,Junhui Wang,Hanju Sun
Vegetable oils with different unsaturated degrees (corn > peanut > olive > palm > coconut) and corresponding enzymatic hydrolysis-thermal oxidation (ENTH) oils were added into D-xylose and L-cysteine Maillard reaction (MR) system, respectively, for potential meaty aroma production. Results indicated that coconut oil and palm oil had lower peroxide, p -anisidine, total antioxidant values, and malondialdehyde content after ENTH and MR. Corn, peanut, and olive oils after ENTH could significantly promote MR because they caused the lower pH, higher reactants depletion, and higher browning degree in the water phase separated from the oil-Maillard reaction system. Additionally, the volatiles were mainly formed from oil phase. Corn, peanut, and olive oils were beneficial to volatiles formation in the oil-MR system due to fatty acid oxidation, especially oleic acid and linoleic acid. Meanwhile, compared to raw oils, adding ENTH oils to the MR system could reduce the content of oxygen, nitrogen, and sulfur-containing heterocycles.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
·
IF 5.518
Liang Cheng,Shuilai Qiu,Jing Wang,Weijian Chen,Jingwen Wang,Wenxiang Du,Lei Song,Yuan Hu
Human health is being seriously harmed by tumors. In order to obtain excellent anti-tumor effects, platinum (Pt) nanozyme-modified black phosphorus (BP) loading with L -Arginine (LArg) (BPPL) is prepared to realize nitric oxide (NO) therapy and sonodynamic therapy (SDT), achieving a synergistic effect to therapy. In this system, BP is utilized as the sonosensitizer. Pt can catalyze the decomposition of hydrogen peroxide (H 2 O 2 ) to produce oxygen (O 2 ) and relieve the hypoxic environment of tumor tissue. The increase in O 2 concentration is conducive to the generation of ROS under ultrasound (US) stimulation. The deposition of precious metals hinders the recombination of some electrons (e ) and holes (h + ), and further improves the yield of reactive oxygen species (ROS). LArg is employed as the exogenous NO supplementation. Under the stimulation of US and ROS, NO is generated to cause further cell apoptosis. Tests in vitro and in vivo have proved the great potential of the combination of SDT and gas therapy in tumor treatment.
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JOURNAL OF SOLID STATE CHEMISTRY
·
2022
·
IF 3.656
Yue Chen,Shaobin Li,Li Zhang,Tao Jing,Jianxin Wang,Lijie Zhao,Fengbo Li,Chao Li,Jingyu Sun
Rational design and constructed new electrode material as high performance electrochemical sensor with outstanding selectivity, reproducibility and stability is an urgent demand for trace detection. Herein, a novel Ce-MOF/Ti 3 C 2 T X MXene composite as electrochemical sensor for L-Tryptophan (L-Trp) was constructed by utilizing the three-dimensional straw-sheaf-like Ce-MOF and Ti 3 C 2 T X MXene nanosheets . The combination of Ce-MOF and Ti 3 C 2 T X MXene not only significantly improves the conductivity of metal-organic framework (MOF) but also effectively prevents the stacking of Ti 3 C 2 T X MXene nanosheets. The electrochemical properties of the proposed sensor were investigated by electrochemical techniques in detail. The L-Trp sensor exhibits a wide linear range (0.2 μM–139 μM) and a low limit of detection (0.19 μM, S/N = 3). Moreover, the proposed sensor exhibits excellent selectivity, good reproducibility and long-term stability, as well as satisfactory practical ability in real blood serum samples.
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MATERIALS & DESIGN
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2022
·
IF 9.417
Fan Liu,Lei Xue,Li Xu,Jun Liu,Chungang Xie,Cen Chen,Yi Liu
The development of bioactive carrier with controlled delivery of Bone morphogenetic protein (BMP-2) is an important part in bone regeneration. Our study fabricated novel modified nanomaterials based on poly-l-lysine functionalized graphene oxide (GO-PLL) and explore its potential applications for BMP-2 delivery. GO-PLL was used to modify BMP-2 encapsulated bovine serum albumin (BSA) nanoparticles (GO-PLL/BMP-2) by self-assembling technology. The physiochemical and biological properties of GO-PLL modified BSA nanoparticles were investigated in vitro . Additionally, rabbit calvarial bone defects were created to investigate bone formation ability in the presence of GO-PLL/BMP-2 loaded alginate/gelatin scaffolds. The results suggested BSA particles were spatially interacted with GO-PLL complexes by strong electrostatic attraction. When compared with BMP-2 encapsulated BSA nanoparticles, a pronounced decrease in BMP-2 gentle release was observed in the presence of GO-PLL/BMP-2 nanoparticles, and extended to over 14-day release periods. More importantly, GO-PLL/BMP-2 nanoparticles significantly enhanced alkaline phosphatase activity (ALP) and matrix mineralization, and exhibited favorable bone formation ability when loaded into alginate/gelatin scaffolds. These results demonstrated that PLL functionalized GO complexes are considered as appropriate delivery system for BSA modification, and have great potential for BMP-2 delivery in bone regeneration.
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PLANT PHYSIOLOGY AND BIOCHEMISTRY
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2023
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IF 6.5
Haoyan Xiao,Yanji Liu,Hanxia Yu,Niraj Yadav,Jing He,Lige Zhang,Wenbing Tan
Microplastics and di-2-ethylhexyl phthalate (DEHP) are prevalent and emerging pollutants in agro-ecosystem, raising concerns due to their widespread co-presence. Nevertheless, their combined toxicity on terrestrial plants remains largely unexplored. This study investigated the impact of polypropylene microplastics (MPs), DEHP, and their mixture on the physiological and biochemical characteristics of cucumber seedlings. The changes of membrane stability index (MSI), antioxidase activities, photosynthetic pigments and chlorophyll fluorescence in cucumber seedlings were assessed. The results demonstrated that MPs alone significantly inhibited MSI, photosynthetic pigments (Chl a, Chl b, and Chl a + b), F m and q p of cucumber seedlings, and significantly promoted the carotene content and antioxidant enzyme activities of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), and ascorbate peroxidase (APX) in cucumber seedlings. While DEHP alone significantly inhibited MSI and photosynthetic pigments of cucumber seedlings, and significantly promoted antioxidant enzyme activities in cucumber seedlings. Moreover, the combined toxicity of MPs and DEHP was found to be less pronounced than that of the single action of MPs and DEHP. The interaction between DEHP and MPs may contribute to the reduced toxicity. Abbott's modeling revealed that the combined toxicity systems were all antagonistic (RI < 1). Two-factor analysis and principal component analysis further confirmed that the treatment of MPs alone contributed the most to the toxicological effects of the physiological properties of cucumbers. In summary, this study highlighted the importance of understanding the combined effects of MPs and DEHP on plant physiology, providing insights for the development of effective treatments for emerging pollutants in agricultural ecosystems.
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FUEL
·
2021
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IF 6.609
Ying Hu†,Haiwei Jiang†,Mei Hu,Yunyan Liu,Fenghua Zhao,Weiran Yang
As-enriched Pteris vittata L. (PVL, a kind of hyper-accumulator biomass) was converted into high-quality biofuel by the catalytic hydrogenolysis, aiming to achieve effective treatment and high-value utilization of hyper-accumulators. After pretreatment of PVL to remove lipids and lignin, more than 64% of heavy metals were transferred into water, and the As content in the solid biomass was reduced from 1328 mg/kg to 483 mg/kg. The multifunctional catalysts RhCl 3 /NaI/HCl/H 2 were used in a biphasic reaction system to convert PVL into biofuel with high selectivity. The main products are C5 and C6 furans and low oxygen content ketones, which have a high heating value (HHV) and can be directly used as biofuel. The highest yields of C5 and C6 products were obtained with 60.2% and 61.1% (based on the corresponding hemicellulose and cellulose) under the optimal reaction conditions (160 °C, 4 h, 300 psi H 2 , 4 mmol NaI, H 2 O/toluene = 1:1). The total biofuel yield based on dry PVL was 18.8 wt.%. After the reaction, more than 50% heavy metals (Cu, Pb, Zn, Cd, As) remained in the bio-char, while the heavy metals in the biofuel were less than 20% (As content was less than 55 mg/kg). Therefore, catalytic hydrogenolysis was perceived as a promising technique for PVL treatment to obtain high-quality biofuel and arsenic recovery.
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Foods
·
2021
·Vol. 10
·期 11
·2765
·
IF 4.35
Fanghua Guo,Rong Tsao,Chuyao Li,Xiaoya Wang,Hua Zhang,Li Jiang,Yong Sun,Hua Xiong
As a processing by-product, green pea hull (GPH) was found to be rich in phenolic components in our previous studies. In this study, UHPLC-LTQ-OrbiTrap-MS (Ultra performance liquid chromatography-linear ion trap orbitrap tandem mass spectrometry) technique was used to quantify polyphenols, and DSS (sodium dextran sulfate)-induced colitis mouse model was established to explore the effect of GPH extracts on colitis. The results showed that quercetin and its derivatives, kaempferol trihexanside and catechin and its derivatives were the main phenolic substances in the extract, reaching 2836.57, 1482.00 and 1339.91 µg quercetin/g GPH extract, respectively; GPH extracts can improved inflammatory status, repaired colonic function, regulated inflammatory factors, and restored oxidative balance in mice. Further, GPH extracts can activate Keap1-Nrf2-ARE signaling pathway, regulate downstream antioxidant protease and gut microbiota by increasing F/B value and promoting the growth ofLactobacillaceaeandLachnospiraceae, and improve the level of SCFAs (short-chain fatty acids) to relieve DSS-induced colitis in mice. Therefore, GPH may be a promising dietary resource for the treatment of ulcerative colitis.Keywords:polyphenols;colitis;UHPLC-LTQ-OrbiTrap-MS;GPH extracts;Keap1-Nrf2;gut microbiota
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Small
·
2021
·Vol. 18
·期 9
·2104550
·
IF 13.281
Hui Wang,Weitao Yang,Kexin Bian,Weiwei Zeng,Xiao Jin,Ruizhuo Ouyang,Yan Xu,Chenyu Dai,Shuang Zhou,Bingbo Zhang
Excess generation of reactive oxygen species (ROS) based on sensitizers under ultrasound (US) excitation can cause the death of tumor cells via oxidative damage, but sonosensitizers are largely unexplored. Herein, oxygen-deficient black BiOCl (B-BiOCl) nanoplates (NPs) are reported, with post-treatment on conventional BiOCl by simple UV excitation, showing stronger singlet oxygen ( 1 O 2 ) generation than commercial TiO 2 nanoparticles and their derivatives under US irradiation. Moreover, L-buthionine-sulfoximine (BSO), a GSH biosynthesis inhibitor, is incorporated into B-BiOCl NPs. The authors find that BSO can be released owing to the degradation of B-BiOCl NPs in the presence of acid and GSH, which are overexpressed in tumors. The results show that BSO/B-BiOCl-PEG NPs have a multifunctional synergistic effect on improving ROS production. In particular, BiOCl has remarkable near-infrared light absorption after UV treatment and is good for photoacoustic imaging that can guide subsequent sonodynamic therapy. This work shows that just with a simple oxygen deficiency treatment, strong 1 O 2 generation can be provided to a conventional material under US irradiation and, interestingly, this effect can be amplified by using a small inhibitor BSO, and this is clearly demonstrated in cell and mice experiments.
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BIORESOURCE TECHNOLOGY
·
2021
·
IF 9.642
Cheng Wang,Xi Chen,Yingying Jiang,Na Li,Ping Zhu,Hong Xu
Facile and green fabrication of reduced graphene oxide on loofah sponge (rGOLS) carrier was applied for cell immobilization of ε-Poly- l -lysine (ε-PL) production. Due to surface properties including large specific surface area, high polarity, and low interaction energy, rGOLS-1 was employed as the optimum rGOLS to enhance immobilization of Streptomyces albulus . Compared with raw LS, batch experiments showed rGOLS-1 facilitated superior cell vitality for ε-PL production due to the presence of reduced graphene oxide. In the sequential fed-batch cultivation of Streptomyces albulus using rGOLS-1 with an aerobic plant fibrous-bed bioreactor (rGOLS-1-AFPB), the maximum ε-PL concentration and productivity reached to 39.2 ± 0.63 g/L and 0.48 g/L/h. The cells immobilized in rGOLS-1 with high vitality and ε-PL production efficiency were reused six times over a period of 624 h. This research afforded an effective approach to enhance the fermentation performance of immobilized cells with the design of an advanced immobilization carrier.
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JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2021
·
IF 2.262
Xiaojuan Wang,Hanqing Gu,Guolin Wu
A series of poly (amino acid) with zwitterionic character was prepared for surface coating to avoid protein adsorption, by modifying the poly (aspartic acid) side chain with tertiary amine groups. An interesting and facile procedure is described with starts with polysuccinic acid which is followed by ring-opening with amino functions and finally hydrolysis of the remaining succinic acid groups achieving the polyaspartic acid structure as backbone. The degree of cationic tertiary amino group was easily varied by the degree of ring-opening with amines. The materials show isoelectric point between pH 4 and 9, have a typical zwitterionic character, and can be used to coat negatively as well as positively charged surfaces, depending on composition. The protein adsorption behavior is thus pH dependent and was studied with various proteins mainly available in blood. The adsorption test proved that a significant reduction of protein adsorption could be found for fibrinogen and albumin, and this protein-repellent behavior is strongly dependent on the amount of the absorbed polymer (adsorbed at pH = 7.4). This is a nice additional contribution to polymers with zwitterionic character used as coating reducing nonspecific protein adsorption.
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FOOD CONTROL
·
2022
·
IF 6.652
Bin Li,Zhirong Wang,Gang Yang,Shan Huang,Shenglan Liao,Kewei Chen,Muying Du,Zsolt Zalán,Ferenc Hegyi,Jianquan Kan
Aflatoxin contamination poses a significant threat to world health and has caused huge economic losses to countries worldwide. The application of volatile organic compounds (VOCs) has emerged as one of the most promising strategies for the prevention and control of fungal contamination. In this work, first, VOCs produced by six lactic acid bacteria (LAB) strains exhibited excellent inhibition activity against the growth of Aspergillus flavus . Then, gas chromatograph-mass spectrometry (GC-MS) identified 32 compounds from captured VOCs of LAB. In addition, partial least square (PLS) analysis revealed that 1-pentanal, 1-pentanol, glycidol, 1- hexanol and 1-heptanol are the compounds most related to antifungal effect in volatile profiles, demonstrating excellent inhibition against A. flavus on both potato dextrose agar (PDA) plates and red pepper powder in next antifungal assay. In vitro experiments revealed 1-pentanal to have the highest antifungal activity of the five VOCs, with a minimal inhibitory concentration (MIC) of 40 μL/L. Scanning electron microscopy (SEM) proved that exposure to 1-pentanal caused A. flavus to exhibit mycelial shriveling and failed conidia formation. Meanwhile, our results showed that fumigation with 1-pentanal had no adverse effect on the quality of red pepper powder. These results indicate that 1-pentanal, identified as the component with the highest antifungal activity in this study, is a promising bio-preservative with the potential to prevent A. flavus contamination of red pepper.
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危险品化学品经营许可证（带存储）