TALANTA
·
2017
·
IF 4.162
Shihua Yu,Zhigang Liu,Weixian Wang,Li Jin,Weiqing Xu,Yuqing Wu
The technique of solid phase micro-extraction (SPME) is an important method for sample pretreatment in analytical chemistry , especially for the analysis in micro-systems. Surface enhanced Raman scattering (SERS) is an ultra-sensitive and fast detection technique. Both are particularly important in qualitative analysis of trace amount of substance. In this study, combining the magnetic nanoparticles with magnetic SPME device, we develop a high efficient new pretreatment method named as disperse magnetic solid phase micro-extraction (Dis-MSPME). In comparison to the traditional SPME, the proposed Dis-MSPME realizes solid phase micro-extraction from dispersive system, which improved the extraction efficiency largely. Conjunction the advantages both of Dis-MSPME and SERS is proposed as Dis-MSPME-SERS as a new detection method, which realize enrichment, magnetic separation and detection all-in-one. Making it a simpler, more efficient and sensitive approach in identifying the illegal additives. Sildenafil citrate (SC) in 500 μL health wine as an example of illegal additive was successfully detected in a LOD of 1.0 × 10 −8 M. Moreover, comparative study on the extract efficient of Dis-MSPME-SERS with SPME-SERS shows it takes only 10 min to detect sildenafil citrate in the health wine, from enrichment to detection by Dis-MSPME-SERS.
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ANALYTICAL CHEMISTRY
·
2017
·
IF 6.32
Yulong Wang,Zhenhe Su,Limin Wang,Jinbo Dong,Juanjuan Xue,Jiao Yu,Yuan Wang,Xiude Hua,Minghua Wang,Cunzheng Zhang,Fengquan Liu
We have developed a rapid and ultrasensitive surface-enhanced Raman scattering (SERS) assay for Cu2+ detection using the multiple antibiotic resistance regulator (MarR) as specific bridging molecules in a SERS hot-spot model. In the assay, Cu2+ induces formation of MarR tetramers, which provide Au nanoparticle (NP)–AuNP bridges, resulting in the formation of SERS hot spots. 4-Mercaptobenzoic acid (4-MBA) was used as a Raman reporter. The addition of Cu2+ increased the Raman intensity of 4-MBA. Use of a dual hot-spot signal-amplification strategy based on AuNP–AgNP heterodimers combined through antigen–antibody reactions increased the sensitivity of the sensing platform by 50-fold. The proposed method gave a linear response for Cu2+ detection in the range of 0.5–1000 nM, with a detection limit of 0.18 nM, which is 5 orders of magnitude lower than the U.S. Environmental Protection Agency limit for Cu2+ in drinking water (20 μM). In addition, all analyses can be completed in less than 15 min. The high sensitivity, high specificity, and rapid detection capacity of the SERS assay therefore provide a combined advantage over current assays.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2025
·
IF 4.6
Yansheng Liu,Mengqi Wang,Guofu Wang,Xiaobo Jia,Jin Zhou,Hongqi Li,Haixin Chang,Zhaoxu Li
This work reported a surface-enhanced Raman spectroscopy (SERS)-based microfluidic chip that detects mercury ions (Hg 2+ ) in water with high sensitivity and good reproducibility. Silver nanoparticles (AgNPs) are easily fabricated on a Si substrate using a thin, thermally treated Ag film. Cy3 functionalized single-stranded DNA (Cy3-ssDNA) serves as the probe, which is immobilized on the AgNPs (Cy3-ssDNA/AgNPs), generating a SERS-based sensing surface. Due to the strong interaction between thymine (T) bases and Hg 2+ , in the presence of these ions, the ssDNA forms a T-Hg 2+ -T hairpin structure, which enhances the SERS signal. This method exhibits a limit of detection (LOD) of 1 × 10 −13 M. Furthermore, the proposed SERS chip demonstrates exceptional selectivity for mercury ions, as well as good reusability. The reusability of the SERS microfluidic chip was evaluated using the L-cysteine, which has a stronger affinity than T for Hg 2+ . By applying L-cysteine, the chip can be reused 10 times for the detection of Hg 2+ at concentrations as low as 1 × 10 −8 M. The method proposed in this study shows good sensitivity and holds good potential for application in the detection of Hg 2+ .
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2025
·
IF 4.6
Junkui Li,Chen Li,Wang Guo,Yiqing Guo,Xiaobo Zou,Zongbao Sun
The development of a capsaicin detection system that integrates facile preliminary evaluation with high sensitivity and accuracy across a wide detection range is crucial for the discrimination of gutter oil and the protection of human health. In this study, we constructed a novel colorimetric/SERS dual-mode detection system utilizing peroxidase-like Au@Pt nanoparticles (NPs) that exhibit SERS-activity. The Au@Pt NPs feature a spherical gold nanoparticle core with synapse-like platinum nanoparticles distributed intermittently on their surface, this structure enhances the catalytic activity of the PtNPs and the SERS activity of the AuNPs, making them ideal for designing colorimetric/SERS dual-mode probes. Based on the colorimetric assay, we achieved a capsaicin detection range from 1 to 10,000 μM, with a limit of detection (LOD) of 3.48 μM, as determined by absorption spectroscopy analysis. Additionally, a linear calibration curve for capsaicin ranging from 10 −9 to 10 −5 M was established using the SERS method, yielding an LOD of 7.38 nM. By integrating the advantages of facile detection through colorimetric analysis with the high-sensitivity trace assay provided by SERS, this proposed dual-mode detection system demonstrates excellent sensitivity, reliability, selectivity, and wide detection range compared to previous probes and methods. Consequently, this method can serve as an efficient tool for monitoring oil quality.
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ACS Applied Nano Materials
·
2025
·
IF 5.5
Xingzi Han,Rongxin Zhao,Yitao Zhu,Jingxuan Lu,Lin Geng,Wenzhong Yang,Hui Xu
The self-organization of gold nanoparticles (AuNPs) into a closely packed film is of great interest for both basic research and practical applications in surface-enhanced Raman spectroscopy (SERS). Here, we report an approach to facilitate the self-assembly of AuNPs at the oil–water interface, driven by cross-linking of two block copolymers. The diblock copolymer poly(ethylene glycol)-block-poly(acrylic acid) (PEG-b-PAA) in the aqueous phase and the diblock copolymer poly(ethylene glycol)-block-poly(4-vinylpyridine) (PEG-b-P4VP) in the oil phase form a cross-linked polymer network (CPN) at the water–oil interface. Meanwhile, due to the electrostatic adsorption of P4VP chains on the citrate-capped AuNPs, the AuNPs in the water are also drawn to the water–oil interface and confined within the physically cross-linked network formed by PEG-b-PAA and PEG-b-P4VP. This technique efficiently produces a two-dimensional (2D) AuNP-polymer composite film suitable for SERS sensing applications. The physically cross-linked network acts as a robust framework that significantly enhances the flexibility of the film through hydrogen-bonding interactions between PEG-b-PAA and PEG-b-P4VP. In addition, compared to AuNP films prepared by traditional methods, this 2D cross-linked polymer network film imbued with closely packed AuNPs (i.e., AuNPs@CPN) exhibits significantly improved mechanical strength, making it less prone to fracture. Thus, it can exist as a free-standing film and be transferable to various solid substrates, which is very convenient for practical use.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Yunpeng Shao,Yue Niu,Wenlong Deng,Zicheng Zhang,Ruien Yu,Linyu Mei
In this study, we prepared large-area polydimethylsiloxane (PDMS) 3D flexible films deposited with silver nanoparticles (Ag NPs) by assembling Ag NPs on ordered micron-column (MC) arrays fabricated using SU-8 colloidal lithography (Ag NP@SU-8-MC). The large-scale, highly ordered 3D MC array flexible film offers numerous adsorption sites for densely packed Ag NPs. High-density sub-nanometer gaps between Ag NPs create spatial hot spots, enhancing the electromagnetic field. The results indicate that this flexible substrate achieves a detection limit of 10 −15 M for rhodamine 6G (R6G), with a relative standard deviation of less than 8 %, demonstrating excellent SERS sensitivity and uniformity. Furthermore, leveraging its high viscosity and flexibility, the ‘pasting-extraction’ method was employed to detect carbendazim and thiram on the surfaces of tomatoes and apples, achieving detection limits of 10 −10 M and 10 −11 M, respectively. Overall, this work presents a practical approach for preparing flexible and sensitive SERS substrates for food safety applications.
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APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Mingyin Zhang,Qifan Zhang,Dongjie Zhang,Zhenhuan Tian,Qiang Li,Feng Yun
A versatile surface-enhanced Raman spectroscopy (SERS) substrate capable of responding to excitation by both visible and ultraviolet (UV) lasers is challenging. Herein, an ultrasensitive and long-term stable SERS substrate suitable for both visible and UV excitation is realized by a structure of hexagonal boron nitride (hBN) nanosheet film-veiled Ag nanoparticles (hBN/Ag substrate). Utilizing the hBN/Ag substrate, the detection limit for crystal violet (CV) under a 532 nm laser is remarkably low at 1.0 × 10 -15 M; adenine, a biomarker, can be detected under UV excitation (a 325 nm laser) with a low limit of 1.0 × 10 -7 M. The hBN/Ag substrate provides abundant electromagnetic (EM) hotspots and multiple charge transfer paths under both 532 nm and 325 nm lasers. This cooperation of EM and chemical enhancement confers ultrasensitive and versatile SERS performance to the substrate. Furthermore, the hBN/Ag substrate demonstrates excellent reproducibility and stability even after 6 months in air, maintaining the SERS intensity of CV at over 86 % of that on the freshly prepared substrate, with a relative standard deviation of 6.57 %. These results indicate that the hBN/Ag substrate can be employed in visible and UV SERS for widespread and practical applications.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Xiaohan Wang,Jingru Wang,Wenshi Zhao,Rui Guo,Sicheng Cui,Jie Huang,Jiaxin Lu,He Liu,Yang Liu
Tetracycline (TC) is widely distributed in environment and a significant environmental pollutant. It has been challenging to rapidly identify and effectively remove TC contaminants. This work produced a multifunctional Fe 3 O 4 -Cu 2 O-Au-MIPs nanocomposite (FCAu-MIPs NCs) based on molecular imprinting technology for selective SERS detection and photocatalytic degradation of TC. We synthesized FCAu NCs with various Au contents and analyzed the relationship between Au content and SERS performance using finite-difference time-domain (FDTD) technique. Exceptional SERS performance could be attributed to the dense distribution of multiple hotspots on the SERS substrate. The photocatalytic mechanism of FCAu-MIPs NCs towards TC was also discussed. The combination of the narrow-bandgap semiconductor Cu 2 O and noble metal Au with localized surface plasmon resonance (LSPR) effect facilitated efficient light absorption and enhanced charge carrier transfer efficiency. Both SERS detection limits as low as 10 −9 M and selective photocatalytic degradation of TC in soil were achieved. Furthermore, FCAu-MIPs NCs were successfully recovered and reused with assistance of external magnetic field. After six cycles, outstanding SERS and photocatalytic capacities from FCAu-MIPs NCs could still be maintained. The FCAu-MIPs NCs with selective recognition ability to TC should thus hold tremendous applicative possibilities for highly sensitive detection and efficient degradation of TC.
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ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Yujun Cheng,Jianping Guan,Zhipeng Zhang,Ruili Li,Yao Yao,Xiaotong Sun,Qi Liu,Xiaoqing Chen
Constructing materials that possess both catalytic properties and surface plasmonic active structures presents an essential requirement in the field of in situ surface-enhanced Raman spectroscopy (SERS) monitoring. In this work, we developed a novel black raspberry-like bifunctional nanoreactor platform (HPRS@Au–Pd) with enhanced surface-enhanced Raman spectroscopy (SERS) activity (EF = 3.11 × 109) and excellent catalytic performance (e.g., |K| = 1.72 × 10–2 s–1 for 4-BTP). This platform enables sensitive and real-time monitoring of Suzuki reactions, providing an efficient and stable system for mechanistic investigations. By fitting a first-order kinetic model, we quantitatively analyzed the reaction kinetics of haloarenes on Pd NPs, revealing the direct involvement of surface-bound Pd NPs in the catalytic process. Furthermore, 4MPBA-blocking experiments using haloarenes devoid of functional groups demonstrated the absence of catalytic activity from dissolved Pd species, conclusively supporting the heterogeneous nature of the reaction. This work extends the applicability of the conclusion regarding heterogeneous catalysis to a broader range of substrates, offering valuable insights into the design and optimization of dual-functional nanoreactors. Beyond the Suzuki reactions, the versatility of this platform opens avenues for applications in other catalytic reactions, showcasing its potential in advanced catalytic studies and real-time monitoring.
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MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 2
·1-8
·
IF 5.705
Chen Ying-Chu,Hsu Jui-Hung,Hsu Yu-Kuei
This study introduces a two-step method for the deposition of branched silver nanowires (AgNWs) on fluorine-doped tin oxide (FTO) glass. This material serves as both an active surface-enhanced Raman-scattering (SERS) substrate and as an enzyme-free electrochemical sensor for H 2 O 2 . This dual functionality is systematically studied. The AgNWs as the main trunk were first deposited on FTO by spray-coating. Silver branches were then electrochemically produced on the preformed NWs. Scanning electron microscopy, X-ray diffraction and X-ray photoelectron spectrometry were employed to characterize morphology, composition and microstructure. SERS experiments show that the branched AgNW/FTO substrate exhibits excellent performance in detecting 4-aminothiophenol at an ultra-low concentration of 0.1 fM. Simultaneously, this material displays an excellent electrocatalytic response to H 2 O 2 reduction at a concentration as low as 1 μM. The sensor has a rapid response and two linear analytical ranges that extend from 0.25 to 300 μM, and from 0.3 to 2.6 mM of H 2 O 2 , respectively. The ultrahigh sensitivity and satisfactory reproducibility highlights the merit of this hierarchical AgNW dendritic structure for sensing applications.
Branched silver nanowires can serve as both an active surface-enhanced Raman scattering substrate and as an electrochemical sensor for H 2 O 2 . This dual functionality is systematically investigated.
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MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 3
·1-10
·
IF 5.705
Li Hongji,Wang Xiaonan,Wang Zirun,Wang Yan,Dai Jiangdong,Gao Lin,Wei Maobin,Yan Yongsheng,Li Chunxiang
A new method is described for the determination of the pesticide λ-cyhalothrin (LC). It combines SERS detection with molecular imprinting and largely improves selectivity. A multilayer surface imprinted nanocomposite was synthesized in two steps on a nanostructure of type SiO 2 @rGO@Ag acting as a substrates. Firstly, the surface of the SiO 2 @rGO@Ag composite was modified with self-polymerized dopamine. Secondly, surface-initiated polymerization was carried out to prepare a molecularly imprinted polymer (MIP) using LC as the template. The use of this SiO 2 @rGO@Ag-MIP allows for excellent SERS based detection and has high selectivity for LC. The Raman intensity and LC concentration present perfect linear relationship between 10 −5 to 10 −9 mol L −1 and the detection limit is 3.8×10 −10 mol L −1 . All the procedures are conducted in aqueous or ethanol solution.
Schematic of a new method for determination of the pesticide λ-cyhalothrin. It combines SERS detection with molecular imprinting and largely improves selectivity. A multilayer surface imprinted nanocomposite was synthesized in two steps on a nanostructure of type SiO 2 @rGO@Ag acting as a substrates.
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ANALYST
·
2018
·Vol. 143
·期 4
·883-890
·
IF 3.864
Shihua Yu,Zhigang Liu,Hongwei Li,Jianpo Zhang,Xin-xin Yuan,Xiangyu Jia,Yuqing Wu
Surface enhanced Raman scattering (SERS) is an ultra-sensitive spectroscopy technique, which can provide rich structural information for a great number of molecules, while solid phase micro-extraction (SPME) is an efficient method for sample pretreatment in analytical chemistry, particularly in a micro-system. In the present report, a silver-loaded and graphene-based magnetic composite (Fe3O4@GO@Ag) was fabricated for use as both a SERS-active substrate and SPME material. The π–π stacking and fluorescence quenching abilities of GO make the composite a perfect candidate for SERS in analyzing real-world samples. Therefore, through combining the magnetic nanoparticles with a SPME device, we have developed a pretreatment method named as disperse magnetic solid phase micro-extraction (Dis-MSPME). In comparison to traditional SPME, the proposed Dis-MSPME realized solid phase micro-extraction from a dispersive system and largely improved the extraction efficiency. Furthermore, by combining the advantages of both Dis-MSPME and SERS we have proposed a new detection method called Dis-MSPME-SERS. Finally, as an example, the illegal additive chloramphenicol (CAP) was successfully detected in aqueous solution with low LOQ and LOD values (1.0 × 10−8 and 1.0 × 10−10 M, respectively), which was finalized within 10 min based on the proposed Dis-MSPME-SERS method. Therefore, a simpler, more efficient and sensitive approach to realize enrichment, magnetic separation and detection, all-in-one, for the detection of illegal additives has been reported, which will be promising towards the detection of trace amounts of substance in micro-systems.
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