INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Xin Yan,Huacai Ge
In this study, a novel modified chitosan composite adsorbent (UNCS) was prepared by crosslinking between chitosan and metal organic frameworks (MOFs) material UiO-66-NH 2 using epichlorohydrin as crosslinker. The influence of the prepared conditions was investigated. The structure and morphology of the composite were characterized by FT-IR, XRD, SEM, TGA, BET and zeta potential analysis. Effects of different variables for adsorption of Hg(II) on this adsorbent were explored. The kinetic studies indicated that the adsorption process followed the pseudo-second-order kinetic model and the adsorption equilibrium could be reached within 2 h. The adsorption was mainly controlled by chemical process. Adsorption isothermal studies illustrated that the adsorption fitted Langmuir isotherm model, implying the homogeneous adsorption on the surface of the adsorbent. The adsorbent exhibited high uptake and the maximum capacity from Langmuir model could reach 896.8 mg g −1 at pH 6. Thermodynamic studies showed the spontaneous nature and exothermic nature of the adsorption process. Additionally, the removal of Hg(II) on UNCS could achieve over 90 %. The adsorption-desorption cycled experiments indicated the appropriate reusability of the adsorbent. Hence, this adsorbent would be promising for the removal of Hg(II) from wastewater.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
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IF 8.2
Yuan Xu,Zhicheng Deng,Yun Chen,Fang Fang Wu,Chao Huang,Yong Hu
A novel mussel-inspired adhesive hydrogel with enhanced adhesion based on methacrylated catechol-chitosan (MCCS) and dopamine methacrylate (DMA) was prepared via photopolymerization. The structure and morphology of the MCCS/DMA adhesive hydrogel were investigated by using FTIR , NMR, XRD, TG, and SEM. The rheological and texture properties, swelling and degradation characteristics, as well as the adhesion mechanism of the hydrogels were also examined. These results revealed that the MCCS/DMA hydrogels have a dense double cross-linking network structure with porous internal microstructures, and exhibited controllable swelling and degradation properties, good thermostability , and stable rheological characteristics. Furthermore, the adhesive mechanism of MCCS/DMA hydrogel has been confirmed by the FTIR and 2D correlation FTIR spectroscopy . Additionally, the results of in vitro cytotoxicity assessment indicated that the resulting hydrogels have good cytocompatibility. Overall, the MCCS/DMA adhesive hydrogel may have potential applications in medical bioadhesives.
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ACS Biomaterials Science & Engineering
·
2022
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IF 5.395
Xujie Zhou,Qing Zhou,Qiang Chen,Yahao Ma,Zhenfang Wang,Lei Luo,Qiang Ding,Hang Li,Shunqing Tang
Local causes of slow wound healing include infection and wound hemorrhage. Using sodium bicarbonate as a neutralizer, a variety of carboxymethyl chitosan–tannic acid (CMC-TA) composite hydrogels solidify through hydrogen bonding in this study. The best-performing hydrogel was synthesized by altering the concentration of TA and exhibited remarkable mechanical properties and biocompatibility. Following in vitro characterization tests, the CMC-TA hydrogel exhibited remarkable antibacterial and antioxidant properties, as well as quick hemostasis capabilities. In the in vivo wound healing study, the results showed that the CMC-TA hydrogel could relieve inflammation and promote the recovery of skin incision, re-epithelialization, and collagen deposition. Overall, this multifunctional hydrogel could be an ideal wound dressing for the clinical therapy of full-thickness wounds.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2023
·Vol. 24
·期 3
·2447
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IF 5.6
Shunxian Ji,Yushuang Zhao,Xinrang Zhai,Lu Wang,Huali Luo,Zhiyong Xu,Wei Dong,Bingbing Wu,Wei Wei
The skin is the largest organ of the human body. Skin injuries, especially full-thickness injuries, are a major treatment challenge in clinical practice. Therefore, wound dressing materials with therapeutic effects have great practical significance in healthcare. This study used photocrosslinkable gelatin methacryloyl (GelMA) and sulfhydrylated chitosan (CS-SH) to design a double-crosslinked hydrogel for wound dressing. When crosslinked together, the resulting hydrogels showed a highly porous inner structure, and enhanced mechanical properties and moisture retention capacity. The compression modulus of the GelMA/CS-SH hydrogel (GCH) reached up to about 40 kPa and was much higher than that of pure GelMA hydrogel, and the compression modulus was increased with the amount of CS-SH. In vitro study showed no cytotoxicity of obtained hydrogels. Interestingly, a higher concentration of CS-SH slightly promoted the proliferation of cells. Moreover, the double-crosslinked hydrogel exhibited antibacterial properties because of the presence of chitosan. In vivo study based on rats showed that full-thickness skin defects healed on the 15th day. Histological results indicate that the hydrogel accelerated the repair of hair follicles and encouraged the orderly growth of collagen fibers in the wound. Furthermore, better blood vessel formation and a higher expression of VEGFR were observed in the hydrogel group when compared with the untreated control group. Based on our findings, GCH could be a promising candidate for full-thickness wound dressing.Keywords:sulfhydrylated chitosan;hydrogel;wound healing
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
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IF 8.2
Rong Rong,Hao Li,Xiangyang Dong,Liqun Hu,Xiaowen Shi,Yumin Du,Hongbing Deng,Yue Sa
Proper bone scaffolds should be biocompatible, mechanically robust and porous for cell migration. Here, pure silk fibroin (SF)- chitosan (CS) aerogel scaffolds reinforced with different amount of SF nanofibers (SF-CS/NF 1% , SF-CS/NF 2% and SF-CS/NF 3% ) are prepared for bone regeneration. Surface morphology and composition were analyzed to ensure successful integration of each component. Incorporating 3 % nanofibers endowed the aerogels with a resistance to 3.5 times the compressive stress of the pure SF-CS aerogels. The benefits of nanofibers were also confirmed by the high porosity of 72.3 ± 1.3 %, the regulated pore size and the high-water uptake ratio of 1770.4 ± 156.8 %. Enhanced cell viability of the aerogel scaffolds was verified with Cell Counting Kit-8 (CCK-8) assays, and confocal microscopy and scanning electron microscopy (SEM) images were taken to assess the cell migration and distribution. The cell differentiation on the aerogel scaffolds was evaluated with enzyme-linked immunosorbent assay (ELISA). Significantly higher level of Collagen type I (Col-I), osteocalcin (OCN), osteopontin (OPN), and alkaline phosphatase (ALP) expression was observed on SF-CS/NF 3% aerogels. This biocompatible nanofiber-reinforced aerogel scaffold facilitates osteogenic differentiation by rougher surface, enhanced mechanical strength and well-regulated pores. Thus, as-prepared scaffolds may be further applied in bone regeneration field.
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IONICS
·
2023
·Vol. 29
·期 3
·951-961
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IF 2.8
Qi Jiawei,Yu Xiaobo,Chen Bingshuai,Zhuo Haitao,Chen Shaojun
Si/Gr anodes have high specific capacity but their cycle stability is not ideal due to excessive volume expansion during discharge/charge cycling, thereby limiting the commercialization of lithium-ion batteries (LIBs). In this paper, a chitosan-polyvinyl alcohol (CS-PVA) water-based binder was prepared. Unlike conventional one-dimensional structural adhesives, CS-PVA adhesives are rich in hydroxyl and amino polar groups. The polar groups induced interactions with Si–OH on silicon particles, further enhancing the structural stability of Si/Gr anode to maintain long-term stable cycling of LIBs. In addition, the Si/Gr anode formed a stable solid electrolyte interface (SEI) during the activation process, leading to long-term stable cycling Si/Gr anodes. The first Coulomb efficiency of Si/Gr@PC11 anode reached 85.5%. And at the current density of 0.5C, the discharge capacity stabilized at 505mAh g −1 after 200 cycles, and reached 433mAh g −1 after 500 cycles. In summary, the success of this work provides a promising avenue to develop high-capacity lithium battery packs with extended cycle life.
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FOOD HYDROCOLLOIDS
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2023
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IF 10.7
Lihui Zhang,Min Zhang,Benu Adhikari,Lujun Zhang
High salt intake is one of the reasons causing dietary risk for death from noncommunicable diseases. In this study, citric acid-crosslinked chitosan (CsC) was prepared using chitosan and citric acid under radio frequency (RF) assisted method, which was considered to absorb Cl − in NaCl and further produce high-saltiness microspheres to regard as a low-sodium salt. The characterization and in vitro bioaccessibility of salt microspheres treated with RF (CsC-RF-NaCl) were investigated. The maximum Na + release capacity of CsC-RF-NaCl occurred for 3 h at 30 mm of plate spacing, pH 4 and NaCl-to-CsC-RF mass ratio of 2:1. Electrostatic attraction was responsible for the formation of CsC-RF-NaCl microparticles. CsC-RF-NaCl microparticles exhibited an irregular spherical shape, the surface of microspheres showed a more homogeneous Na + and Cl − dispersion and higher ratio of Na: Cl. CsC-RF-NaCl microparticles were excellent thermal stability, and pleasantly hygroscopic. In addition, the CsC-RF-NaCl microparticles showed the higher release of Na + during oral digestion and lower bioaccessibility in intestinal digestion. The Na + content of CsC-RF-NaCl microparticles was decreased up to 61.80% compared to NaCl at the same saltiness. Therefore, CsC-RF-NaCl microparticles were considered as a low-sodium salt for surface-salted foods.
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International Journal of Bioprinting
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2023
·
IF 8.4
Zhijing He,Chen Jiao,Junnan Wu,Jiasen Gu,Huixin Liang,Lida Shen,Youwen Yang,Zongjun Tian,Changjiang Wang,Qing Jiang
Porous hydroxyapatite (HA) scaffolds prepared by three-dimensional (3D) printing have wide application prospects owing to personalized structural design and excellent biocompatibility. However, the lack of antimicrobial properties limits its widespread use. In this study, a porous ceramic scaffold was fabricated by digital light processing (DLP) method. The multilayer chitosan/alginate composite coatings prepared by layer-by-layer method were applied to scaffolds and Zn 2+ was doped into coatings in the form of ion crosslinking. The chemical composition and morphology of coatings were characterized by scanning electron microscope (SEM) and X-ray photoelectron spectroscopy (XPS). Energy dispersive spectroscopy (EDS) analysis demonstrated that Zn 2+ was uniformly distributed in the coating. Besides, the compressive strength of coated scaffolds (11.52 ± 0.3 MPa) was slightly improved compared with that of bare scaffolds (10.42 ± 0.56 MPa). The result of soaking experiment indicated that coated scaffolds exhibited delayed degradation. In vitr o experiments demonstrated that within the limits of concentration, a higher Zn content in the coating has a stronger capacity to promote cell adhesion, proliferation and differentiation. Although excessive release of Zn 2+ led to cytotoxicity, it presented a stronger antibacterial effect against Escherichia coli (99.4%) and Staphylococcus aureus (93%).
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Zehao Li,Haibo Li,Xianglong Zeng,Shuming Liu,Yongsheng Yang
The world faces increase in water scarcity and water pollution. A combined effect of adsorption and photodegradation is potential way to remove pollutants from water. In this work, mannose grafted chitosan (CSMan) films were synthesized due to Schiff base. To improve the adsorption and photodegradation capacity of films, graphite carbon nitride-zinc oxide (gCNMZnO0.3) was introduced into a system through solvent volatilization to remove tetracycline (TC). Comfortingly, the composite films of CSMan-gCNMZnO0.3-1 displayed outstanding adsorption capacity and excellent activity of degrading organic pollutant by visible light in water. The maximum adsorption capacity of CSMan-gCNMZnO0.3-1 was 164.627 mg g −1 through surface complexation, cation exchange, electrostatic attraction, hydrogen bonding, π–π interaction and plane strengthening effect. The analysis revealed that OH and h + were the crucial radicals in photodegradation process. Meanwhile, CSMan-gCNMZnO0.3-1 possessed superior reusability and broad applicability in five distinct types of water. The simulation experiment of silicone tube showed the combined effect had a removal ratio of 84.3 % in 120 min, and the adsorption-photodegradation efficiency was constant in operating after five continuance usages.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Qing Yu,Yonggan Yan,Jun Huang,Qianyu Liang,Jianhua Li,Bing Wang,Baojin Ma,Alberto Bianco,Shaohua Ge,Jinlong Shao
Bacterial infection often leads to inflammatory responses and delays wound healing. Chitosan (CS)-based composite hydrogels can hold desirable mechanical properties and maintain excellent antibacterial abilities, and thus may be promising as wound dressings. Although CS-based hydrogels have been widely studied on the antibacterial and wound-healing abilities, their immunomodulatory abilities were rarely evaluated. Herein, we developed a multifunctional CS/Poly[2-(methacryloyloxy)ethyl] trimethyl ammonium chloride (PMETAC) hydrogel. In vitro , this hydrogel exhibited self-healing ability and excellent biocompatibility, promoted macrophage polarization towards M2 phenotype, and showed desirable antibacterial activity. In vivo , this hydrogel accelerated the wound regeneration process by reducing bacterial burden, increasing collagen deposition, stimulating angiogenesis, promoting macrophage polarization to M2 direction, and shifting the balance of T helper type 17 (Th17) cells towards anti-inflammatory regulatory T (Treg) cells. This work revealed the potential immunomodulatory effect of CS-based wound dressings and thus may provide a novel target for developing efficient wound healing tools.
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CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Yucheng Song,Hui Li,Tianhang Shan,Peipei Yang,Songwei Li,Zhong Liu,Chuntai Liu,Changyu Shen
In this study, a composite hydrogel with a low swelling ratio, excellent mechanical properties, and good U (VI) adsorption capacity was developed by incorporating a metal-organic framework (MOF) with a poly (acrylamide- co -acrylic acid)/chitosan (P(AM-co-AA)/CS) composite. The CS chain, which contains NH 2 , reduces the swelling ratio of the hydrogel to 4.17 after 5 h of immersion in water. The coordinate bond between the MOF and carboxyl group on the surface of P(AM-co-AA)/CS improves the mechanical properties and stability of P(AM-co-AA)/CS. The U(VI) adsorption capacity of P(AM-co-AA)/CS/MOF-808 is 159.56 mg g −1 at C 0 = 99.47 mg L −1 and pH = 8.0. The adsorption process is well fitted by the Langmuir isotherm and pseudo-second-order model. The P(AM-co-AA)/CS/MOF-808 also exhibits good repeatability and stability after five adsorption–desorption cycles. The uranium adsorption capacity of the developed adsorbent after one month in natural seawater is 6.2 mg g −1 , and the rate of uranium adsorption on the hydrogel is 0.21 mg g −1 day −1 .
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CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Yongsheng Li,Chengnan Chu,Chuntao Chen,Bianjing Sun,Jingjing Wu,Shujun Wang,Weiwei Ding,Dongping Sun
Management of noncompressible torso hemorrhage is an urgent clinical requirement, desiring biomaterials with rapid hemostasis , anti-infection and excellent resilient properties. In this research, we have prepared a highly resilient cryogel with both hemostatic and antibacterial effects by chemical crosslinking and electrostatic interaction . The network structure crosslinked by quaternized chitosan and genipin was interspersed with oxidized bacterial cellulose after lyophilization. The as-prepared cryogel can quickly return to the original volume when soaking in water or blood. The appropriately sized pores in the cryogel help to absorb blood cells and further activate coagulation, while the quaternary ammonium salt groups on quaternized chitosan inhibit bacterial infections. Both cell and animal experiments showed that the cryogel was hypotoxic and could promote the regeneration of wound tissue. This research provides a new pathway for the preparation of double crosslinking cryogels and offers effective and safe biomaterials for the emergent bleeding management of incompressible wounds.
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