INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2018
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IF 3.909
Lin Wang,Yu Du,Yi Yuan,Ruo-Jun Mu,Jingni Gong,Yongsheng Ni,Jie Pang,Chunhua Wu
Intelligent hydrogels are attractive biomaterials for various applications, however, fabricating a hydrogel with both adequate self-healing ability and mechanical properties remains a challenge. Herein, a series of novel intelligent konjac glucomannan (KGM)/microcrystalline cellulose (MCC) hydrogels were prepared vis the mussel-inspired chemistry. MCC was firstly functionalized by the oxidative polymerization of dopamine, and the intelligent hydrogels were obtained by mixing aqueous solutions of KGM and functionalized MCC (PDMCC). By introducing PDMCC, a more compact interconnected porous structure formed for the resulting hydrogels. The self-healing ability and mechanical properties of intelligent hydrogels were dependence on the PDMCC content. Compared with KGM hydrogels, KGM/PDMCC hydrogels exhibited a more distinct pH sensitivity and a lower initial burst release, which was attributed to the compact structure and strong intermolecular hydrogen bond interaction between PDMCC and KGM. These results suggest that the KGM/PDMCC intelligent hydrogels may be promising carriers for controlled drug delivery.
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高影响因子
CHEMICAL PHYSICS
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2018
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IF 1.707
Jingni Fu,Luning Zhang
The protonation/deprotonation equilibrium of a fluorescent pH probe (carboxy-seminaphthorhodafluor-1, SNARF-1) within the nanoscale water layer confined in common black films (CBFs) has been studied. We find that SNARF-1 molecules feel a more acidic environment in CBFs than when they are in the bulk micellar solution, using the base/acid peak area ratio of the dye to indicate its microenvironment pH. Three surfactants are used to study the dependence of the pH drop versus charge: cationic (cetyltrimethylammonium bromide, CTAB), anionic (sodium dodecylsulphate, SDS) and nonionic (Triton X-100) species. The decrease of CBFs pH versus the pH of the micellar solution is the following: ΔpH ≈ 1.5 for CTAB (pH: 7.0–9.0), ΔpH ≈ 0.8 for SDS, and ΔpH ≈ 0.4 for Triton X-100. With the addition of electrolyte in CBFs, we observe large decrease the amplitude of the pH anomaly, thus suggesting an electrostatic origin of the pH change at nanoscale environment.
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ACS Applied Materials & Interfaces
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2018
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IF 8.097
Lina Liang,Jun Fu,Liyan Qiu
pH-responsive polymersomes have emerged as promising nanocarriers for antitumor drugs to realize their fast release and action in a weakly acidic microenvironment of tumor cells. Herein, however, we designed a remarkably pH-responsive polymersome self-assembled from amphiphilic benzimidazole-based polyphosphazenes via the incorporation of cholesteryl hemisuccinate (CholHS), a type of cholesteric molecule, into the polymersome bilayers to inhibit the drug release during blood circulation. Actually, unwanted premature drug leakage before arriving at the acidic tumor site has become a serious problem for polymersomes encapsulating water-soluble drugs, especially when the drug loading is at a high level, thus limiting the therapeutic efficacy. In this study, polymersomes displayed high loading capability of doxorubicin hydrochloride as 12.83%. More importantly, CholHS incorporation decreased the membrane permeability of the polymersome and effectively retarded the cargo release under physiological conditions but induced the fast drug-release rate at pH 5.5, demonstrating a more remarkably acid-responsive release behavior when compared to that of the CholHS-free polymersomes. Further in vivo investigations including pharmacokinetic and antitumor activity studies verified the extended circulation time and enhanced antitumor efficacy of the drug-loaded CholHS-incorporated polymersomes.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2018
·Vol. 136
·期 7
·47068
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IF 1.901
N.-C. Wang,L.-F. Fang,J. Wang,P. Zhang,W.-B. Wang,C.-E. Lin,L. Xiao,C. Chen,B. Zhao,H. Abdallah,H. Matsuyama,B.-K. Zhu
Carboxyl groups in the membranes usually contribute the hydrophilicity and antifouling properties. However, membrane performance including permeation and separation properties is not stable at different pH environments due to pH sensitivity of carboxyl groups. In this work, a series of membranes from random copolymers poly(vinyl chloride- r -acrylic acid) [P(VC- r -AA)] were fabricated via nonsolvent induced phase separation process. The morphology and surface properties were investigated. The pH-dependent property of carboxyl groups contained ultrafiltration membranes were studied in detail. The results indicated that pH sensitivity of these membrane was restrained, which was mainly attributed to the random sequential structure of VC and AA repeating unit in P(VC- r -AA) copolymer. The probable arched structures on the pore surface/wall at alkaline environment limited the obvious change of the pore size, which resulted in the stable permeation and separation properties at the varied pH environments. Therefore, it indicated that P(VC- r -AA) was a kind of promising membrane material which would be widely applied in water treatment field. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 47068.
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Micromachines
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2018
·Vol. 9
·期 6
·258
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IF 2.222
Yiting Xu,Kaiwei He,Hongchao Wang,Meng Li,Tong Shen,Xinyu Liu,Conghui Yuan,Lizong Dai
Stimuli-responsive polymeric systems containing special responsive moieties can undergo alteration of chemical structures and physical properties in response to external stimulus. We synthesized a hybrid amphiphilic block copolymer containing methoxy polyethylene glycol (MePEG), methacrylate isobutyl polyhedral oligomeric silsesquioxane (MAPOSS) and 2-(diisopropylamino)ethyl methacrylate (DPA) named MePEG-b-P(MAPOSS-co-DPA) via atom transfer radical polymerization (ATRP). Spherical micelles with a core-shell structure were obtained by a self-assembly process based on MePEG-b-P(MAPOSS-co-DPA), which showed a pH-responsive property. The influence of hydrophobic chain length on the self-assembly behavior was also studied. The pyrene release properties of micelles and their ability of antifouling were further studied.Keywords:stimuli-responsive polymer;polyhedral oligomeric silsesquioxane;self-assembly;protein adsorption resistance;controlled release
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高影响因子
TRANSACTIONS OF TIANJIN UNIVERSITY
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2018
·Vol. 25
·期 3
·226-236
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IF 0
Feng Wei,Gu Wenhao,Zhang Lühong,Tantai Xiaowei,Jiang Bin,Yang Huawei,Zhang Hongjie
An organic macromolecule, poly(1-vinylimidazole), with an appropriate polymerization degree was proposed and mixed with water to form a novel aqueous absorbent for SO 2 capture. This aqueous solution absorbent has the advantages of simple preparation, good physicochemical properties, environment-friendliness, high ability in deep removal of SO 2 , and excellent reusability. Moreover, pH-responsive behavior, pH buffering absorption mechanism, and their synergistic effect on absorption performance were revealed. The solubilities of SO 2 in the absorbent were measured in detail, and the results demonstrated excellent absorption capacity and recyclability. Then, mathematic models that describe SO 2 absorption equilibrium were established, and the corresponding parameters were estimated. More importantly, on the basis of model and experimental data, the absorption and desorption could maintain high efficiency within a wide operating region. In summary, this work provided a low-cost, efficient, and unique absorbent for SO 2 capture and verified its technical feasibility in industrial application.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2018
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IF 3.141
Ran Wei,Wanying Song,Fan Yang,Jukai Zhou,Man Zhang,Xiang Zhang,Weifeng Zhao,Changsheng Zhao
Solution pH is an important factor in the adsorptive behavior of ionizable dyes in the chemical and biotechnology industries. In this study, novel pH-responsive zwitterionic hydrogels were prepared by the copolymerization of acrylic acid and methylacryloyloxyethyl trimethylammonium chloride. The results indicated that the hydrogels showed bidirectionally pH-responsive behaviors: the swelling ratio was small in neutral pH value and increased with the increase or decrease of pH values. Meanwhile, the selective adsorption capacities of the hydrogels for anionic or cationic dyes could be controlled by adjusting the pH values. The hydrogels might be applied in many fields, such as adsorption and separation and water treatment.
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Journal of Environmental Sciences
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2018
·
IF 3.12
Jingjing Wang,Bihong He,Xiaoyan Wei,Ping Li,Jianjun Liang,Shirong Qiang,Qiaohui Fan,Wangsuo Wu
Sorption of U(VI) onto TiO 2 as functions of pH, ionic strength, contact time, soil humic acid (SHA), solid-to-liquid ratio and temperature was studied under ambient conditions using batch and spectroscopic approaches. The sorption of U(VI) on TiO 2 was significantly dependent on pH and ionic strength. The presence of SHA slightly enhanced the sorption of U(VI) on TiO 2 below pH 4.0, while it inhibited U(VI) sorption in the higher pH range. U(VI) sorption on TiO 2 was favored at high temperatures, and the sorption process was estimated to be endothermic and spontaneous. Reduction of U(VI) to lower valent species was confirmed by X-ray photo-electron spectroscopy analysis. It is very interesting to find that U(VI) sorption on TiO 2 was promoted in solutions with higher back-ground electrolyte concentrations. In the presence of U(VI), higher back-ground electrolyte made more TiO 2 particles aggregate through (001) facets, leading more (101) facets to be exposed. Therefore, the reduction of U(VI) was enhanced by the exposed (101) facets and more U(VI) removal was observed.
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International Journal of Polymeric Materials and Polymeric Biomaterials
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2018
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IF 2.127
Qian Wang,Xiao Qi Jin,Ji Hong Sun,Shi Yang Bai,Xia Wu,Hamida Panezai
The pH-responsive hollow poly(acrylic acid) (HPAA) microspheres with regulated cavity structure and various shell thicknesses were synthesized. Their structural parameters and textural properties were characterized by various techniques. The ibuprofen loading results indicate the good drug loading capabilities of HPAA microspheres from 13.81 to 17.18%. Their ibuprofen release properties demonstrated their good pH sensitivity and distance-controlled drug diffusion process. Specially, the small-angle X-ray scattering technique was used to suggest the surface roughness and structural irregularities of HPAA before and after drug loading and releasing. These findings clearly indicate the potential of HPAA microspheres to be used as promising candidates in drug delivery.
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ACS Applied Bio Materials
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2018
·
IF 0
Yajie Zhang,Wei Wang,Yahui Zhang,Mingbo Cheng,Qiang Wu,Zhi Yuan
Mesoporous silica nanoparticle (MSN)-based stimuli-responsive capped drug delivery systems have attracted extensive attention. However, most studies about capping agents only focus on the capping function. Here, a multifunctional capping agent (MFCA) was developed to integrate pore-capping, drug-loading, and tumor-targeting abilities. It was composed of phenylboronic acid (PBA)-modified sodium alginate (ALG) and doxorubicin (DOX), which were loaded in the channels and conjugated ALG via hydrazone bond through a one-pot method. Consequently, the drug-loading content of obtained nanoparticles (DOX@MSN-ALG-APBA) reached up to 10.6%, which increased by about 58.2% compared with that of ALG-APBA capped MSNs (i-DOX@MSN-ALG-APBA). The in vitro drug release at pH 7.4 was less than 10% in 3 days, which was comparable to i-DOX@MSN-ALG-APBA. More importantly, the initial accumulative drug release of DOX@MSN-ALG-APBA was about 2-fold than that of i-DOX@MSN-ALG-APBA at pH 6.0. Also, the targeting efficiency of DOX@MSN-ALG-APBA was 2.85-fold than that of DOX@MSN-ALG in vitro after introducing phenylboronic acid. Compared with free DOX and i-DOX@MSN-ALG-APBA, DOX@MSN-ALG-APBA induced remarkable cell apoptosis and inhibition effects in vitro, owing to the rapid release of drug during the initial phase. Overall, it is expected that this integrated strategy is promising to fabricate an excellent MSN-based drug delivery system.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2018
·
IF 2.829
Shuo Yang,Jie Wang,Weiyao Mao,Dawei Zhang,Yugao Guo,Yan Song,Jun-Peng Wang,Tao Qi,Guo Liang Li
Zeolitic imidazole framework (ZIF) is an emerging class of functional materials with promising nanostructures and applications in biomedicine and materials science. Herein we present a dynamic protective coating system with self-healing anticorrosion function, based on pH-responsive ZIF nanoparticles . Due to the advantage of high content of corrosion inhibitor in the ZIF-7 nanoparticles and its nature of pH-sensitivity, the ZIF-7 nanoparticles could quickly respond to the surrounding acid environment and release the linker as healing agent, led to a new barrier on scratched metal surfaces . The embedding and homogeneous distribution of the ZIF-7 nanoparticles in polymer coating system improved the corrosion resistance of carbon steel in 0.1 M hydrochloric acid solution in comparison to the control samples, as determined by electrochemical impedance spectroscopy (EIS). The self-healing anticorrosion property of dynamic polymer system was characterized during a simulated corrosion process by scanning electrochemical microscopy (SECM). The concentration of the embedded ZIF-7 nanoparticles was varied (0.5 − 7 wt %) to ascertain the optimum conditions for anticorrosion performance. The important effect of particle size and shape of ZIF-7 nanoparticles is discussed as well. The ZIF-7 based on dynamic protective polymer systems can interact with and adapt to the surrounding acid environment, leading to a new healed barrier on metal surfaces with anticorrosion functions.
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高影响因子
FUEL
·
2018
·
IF 4.908
Haiyang Tian,Hongping Quan,Zhiyu Huang,Silong Jiang
The non-hydrophobically associating water-soluble polymer (DPAM) of acrylamide (AM) and dimethylamino propyl methacrylamide (DMAPMA) was synthesized. Then pH-switchable and CO 2 ‑switchable viscoelastic liquids based on DPAM and anionic surfactant sodium dodecyl sulfate (SDS)(referred to as DPAM-SDS) were developed. When minor HCl aqueous solution was added into the DPAM and SDS aqueous mixture or CO 2 was bubbled into it, the tertiary amine groups of DPAM were protonated to form quaternary ammonium groups, some of which in the same quaternary ammonium groups of DPAM “bridged” some SDS through noncovalent electrostatic attraction, behaving like a pseudo-hydrophobically associating water-soluble polymer and forming viscoelastic fluids as checked through environmental scanning electron microscope(ESEM) and rheology. Upon removing of CO 2 or back of pH by minor NaOH aqueous solution, the quaternary ammonium species of DPAM were deprotonated back to tertiary amine groups, separating the pseudo-hydrophobically associating water-soluble polymer back to DPAM and SDS molecules, which resulted in forming low-viscosity water solution. The switchable viscoelastic conversion can be repeated.
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