SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Li Yuan,Xueqian Wang,Xiang Li,Jianhong Wang,Langlang Wang,Yiran Xiong,Yuhang Xiao,Ping Ning
The performance of FeOOH for the removal of hydrogen sulfide (H 2 S) has been widely investigated. However, the harsh conditions of use and the difficulty of regeneration limit its practical application. In this study, FeOOH was loaded on activated carbon (AC) by a hydrothermal method to obtain a series of XF-AC catalysts for the removal of H 2 S from blast furnace gas (BFG). Among these catalysts, 3F-AC exhibited a high penetrating sulfur capacity of 482.3 mg/g and good regeneration performance. It is noteworthy that the use of AC as the support induced the transformation of α-FeOOH crystals into amorphous FeOOH and affected their morphology, and uniformly dispersed nanoparticles rather than agglomerated acicular crystals appeared on the surface of AC. The presence of amorphous FeOOH modulated the basic sites and surface hydroxyl groups of the catalysts while generating hydroxyl radicals during the reaction, thus improving the adsorption and oxidation of H 2 S. More importantly, the structural properties (surface area and pore volume) of 3F-AC enhanced the storage capacity of elemental sulfur and reduced the formation of by-products. The cyclic catalytic role of Fe 3+ /Fe 2+ played an important role in the oxidation process. This work provides a simple and effective strategy for the design of BFG desulfurization catalysts.
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CARBOHYDRATE POLYMERS
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2011
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IF 3.463
Quan Li,Bing Xia,Mickey Branham,Wei Ha,Hao Wu,Shu-Lin Peng,Li-Sheng Ding,Bang-Jing Li,Sheng Zhang
The self-assembly of rod–coil carboxymethyl konjac glucomannan-graft-poly(ethylene glycol) (CKGM- g -PEG) and α-cyclodextrin (α-CD) complexes were investigated and used as encapsulating hollow nanospheres for the enzyme glucose oxidase (GOX) in aqueous solution. These hollow nanospheres exhibited “cell-like” semi-permeability allowing enzyme substrates to pass through the surface while restricting the encapsulated enzyme (i.e. GOX) to the interior. Encapsulated GOX exhibited higher thermostability , optimal enzymatic activity over a wider pH range and improved storage stability in comparison to free un-encapsulated GOX. In addition, these CKGM- g -PEG/α-CD hollow nanospheres showed in vitro biocompatibility when exposed to L929 cells when tested using MTT viability assay. These studies suggested that self-assembly of CKGM- g -PEG and α-CD to form stable nanospheres may be an effective method for enzyme encapsulation with numerous biomedical applications.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2025
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IF 6.2
Aijiang Liu,Jun Ma,Zengguang Liu,Tianyuan Qiu,Qixuan Zhao,Guangquan Li,Xiao Liang,Quanshun Li
Current treatment of inflammatory bowel disease (IBD) relies on anti-inflammatory and immunosuppressive agents. However, this concept is considered outdated due to its restricted efficacy and unavoidable side effects. Herein, a polynorepinephrine-coated programmable probiotic expressing α-aminoadipate aminotransferase (NE-EcN-pA) was constructed to improve the levels of kynurenic acid and xanthurenic acid in the intestine by modulating the endogenous tryptophan metabolism. The NE layer could protect EcN-pA against the harsh environment of the gastrointestinal tract, enhancing its survival and colonization. In UC mice, oral administration of NE-EcN-pA effectively alleviated intestinal inflammation and restored the intestinal epithelial barrier owing to the activation of the aryl hydrocarbon receptor pathway. Furthermore, NE-EcN-pA promoted the diversity of intestinal flora, improved the imbalance of flora, and enhanced the content of short-chain fatty acids in the colon. Overall, NE-EcN-pA can regulate endogenous tryptophan metabolism and gut microbiota, showing promise in the treatment of gastrointestinal disorders.
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Frontiers in Bioengineering and Biotechnology
·
2024
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IF 4.3
Feng Kai,Di Ya,Han Meng,Yan Weitao,Guo Yulin,Huai Xiangqian,Wang Yimin
A novel photoelectrochemical (PEC) aptasensor based on a dual Z-scheme α-Fe2O3/MoS2/Bi2S3 ternary heterojunction for the ultrasensitive detection of circulating tumor cells (CTCs) was developed. The α-Fe2O3/MoS2/Bi2S3 nanocomposite was prepared via a step-by-step route, and the photoproduced electron/hole transfer path was speculated by conducting trapping experiments of reactive species. α-Fe2O3/MoS2/Bi2S3-modified electrodes exhibited greatly enhanced photocurrent under visible light due to the double Z-scheme charge transfer process, which met the requirement of the PEC sensor for detecting larger targets. After the aptamer was conjugated on the photoelectrode through chitosan (CS) and glutaraldehyde (GA), when MCF-7 cells were presented and captured, the photocurrent of the PEC biosensing system decreased due to steric hindrance. The current intensity had a linear relationship with the logarithm of MCF-7 cell concentration ranging from 10 to 1×105 cells mL−1, with a low detection limit of 3 cell mL−1 (S/N = 3). The dual Z-scheme α-Fe2O3/MoS2/Bi2S3 ternary heterojunction-modified PEC aptasensor exhibited high sensitivity and excellent specificity and stability. Additionally, MCF-7 cells in human serum were determined by this PEC aptasensor, exhibiting great potential as a promising tool for clinical detection.
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JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
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2024
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IF 5.8
Ji Liu,Hao Fu,Bin Hu,Guan-zheng Zhou,Shou-gang Wei,Zhen-xi Zhang,Qiang Lu
Pyrolysis, a promising thermochemical conversion technique, can convert lignocellulosic biomass into various value-added products. Herein, the selective production of 1,4:3,6-dianhydro-α- d -glucopyranose (DGP) was achieved through fast pyrolysis of cellulose based on oxalic acid-assisted torrefaction (OAT) pretreatment. The mixture of cellulose and oxalic acid first underwent torrefaction, followed by fast pyrolysis to yield DGP. Simultaneously, the air atmosphere was considered to facilitate the formation of esterification intermediates, thereby promoting the formation of DGP. The effects of torrefaction temperature, oxalic acid amount, as well as pyrolysis temperature were carefully explored for DGP production. A yield of 9.6 wt% and a selectivity of 57.5 % for DGP were achieved from the micro-scale pyrolysis of cellulose under the optimized conditions. In lab-scale tests, the DGP yield reached 12.5 wt% from cellulose. The OAT-based pyrolysis was confirmed to be applicable to the waste cellulose-rich materials, with a DGP yield of 8.2 wt% from waste cotton and 6.0 wt% from spent paper in lab-scale experiments. Additionally, the OAT-based pyrolysis also showed the potential for poly-generation of DGP and formic acid at different stages.
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MOLECULES
·
2024
·Vol. 29
·期 10
·2363
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IF 4.2
Tao Li,Mingzu Zhang,Jinlin He,Peihong Ni
Graft copolymers have unique application scenarios in the field of high-performance thermoplastic elastomers, resins and rubbers. β-myrcene (My) is a biomass monomer derived from renewable plant resources, and its homopolymer has a low glass transition temperature and high elasticity. In this work, a series of tapered copolymers P(My-co-AMS)k(k = 1, 2, 3) were first synthesized in cyclohexane by one-pot anionic polymerization of My and α-methyl styrene (AMS) using sec-BuLi as the initiator. PAMS chain would fracture when heated at high temperature and could endow the copolymer with thermal degradation property. The effect of the incorporation of AMS unit on the thermal stability and glass transition temperature of polymyrcene main chain was studied. Subsequently, the double bonds in the linear copolymers were partially epoxidized and hydroxylated into hydroxyl groups to obtain hydroxylated copolymer, which was finally used to initiate the ring-opening polymerization (ROP) of ε-caprolactone (ε-CL) to synthesize the graft copolymer with PCL as the side chain. All these copolymers before and after modifications were characterized by proton nuclear magnetic resonance (1H NMR), gel permeation chromatography (GPC), thermogravimetry analysis (TGA), and differential scanning calorimeter (DSC).
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2024
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IF 3.8
Shuaifeng Liu,Edouard Asselin,Zhibao Li
The disposal of titanogypsum, also known as red gypsum, which is generated during the titanium dioxide sulfate process, has become a significant environmental challenge. We propose a new process to recover iron impurities such as FeCl2·4H2O and to convert titanogypsum to saleable hemihydrate gypsum. For this purpose, we use HCl–FeCl2 solution generated via the reaction of H2SO4–FeSO4 with CaCl2 to leach iron hydroxide from titanogypsum. The hemihydrate precipitation and phase-transition kinetics of the reaction of HCl–H2SO4–FeSO4 with CaCl2 are experimentally investigated at 353 K. The common ion effect of CaCl2 in the FeCl2 solution for FeCl2·4H2O crystallization is predicted by NRTL modeling of the solid–liquid equilibria of the FeCl2–CaCl2–H2O system. High-quality, saleable α-gypsum and FeCl2·4H2O solids obtained by treating titanogypsum samples provided by a commercial processing plant further shows that the new process is feasible.
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CHEMISTRY & BIODIVERSITY
·
2025
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IF 2.5
Shulei Liu,Fanfan Jia,Xiuchao Xie,Sirui Kang,Mingke Feng,Xiaofei Xiong,Beiei Lin,Xinxin Li,Lubna Khan,Xiaoying Zhang,Chen Chen
Edible mushrooms exhibit a range of pharmacological activities, including anticancer, antimicrobial, antioxidant, anti-obesity, and hepatoprotective effects, thereby holding significant potential for applications in the development of functional foods. This study aimed to evaluate the bioactivities of methanolic extracts from various edible mushrooms (MEMs) found in the Qinling Mountains, China, with the following species used as materials: Suillus granulatus (L.) Roussel ( S. granulatus (L.) Roussel), Ramaria botrytoides (Peck) Corner ( R. botrytoides (Peck) Corner), Flammulina velutipes (Curtis) Singer ( F. velutipes (Curtis) Singer), Agrocybe cylindracea (DC.) Maire ( A. cylindracea (DC.) Maire), Lentinula edodes (Berk.) Sing. ( L. edodes (Berk.) Sing.), Hericium erinaceus (Bull.) Pers. ( H. erinaceus (Bull.) Pers.), White Hypsizygus marmoreus (White H. marmoreus ), Auricularia auricular (L.ex Hook.) Undew ( A. auricular (L.ex Hook.) Undew), Hypsizygus marmoreus (white cultivar) ( H. marmoreus (white cultivar)), Pleurotus eryngii (DC. Fr) Qu. ( P. eryngii (DC. Fr) Qu.), Cordyceps militaris (L.) Link ( C. militaris (L.) Link), Lentinula edodes (Berk.) Pegler ( L. edodes (Berk.) Pegler), Hypsizygus marmoreus (brown cultivar) ( H. marmoreus (brown cultivar)), and Morchella esculenta (L.) Pers. ( M. esculenta (L.) Pers.). We examined the total polyphenol, total flavonoid, and total polysaccharide content of MEMs. And quantified the 12 monomeric phenolic substances contained in the MEMs by high-performance liquid chromatography. The antioxidant activity in vitro was studied by determining the DPPH• scavenging capacity, ABTS + • scavenging capacity, and Fe 2+ reduction capacity, whereas the inhibition rates of α-amylase and pancreatic lipase were used to evaluate the enzyme-inhibiting capacity of each edible mushroom. Significant differences were found in the chemical composition and in vitro activity of the extracts from different sources. Our results showed that R. botrytoides (Peck) Corner had the highest total polyphenols and flavonoid content, which were 28.57 ± 0.85 and 32.33 ± 0.37 mg/g, respectively, among the edible mushrooms. Among the 14 edible mushrooms, Pleurotus eryngii (DC. Fr) Qu had the highest total polysaccharide content of 503.73 ± 0.24 mg/g. The antioxidant activity and pancreatic lipase inhibition of R. botrytoides (Peck) Corner methanol extract were superior to other edible mushrooms, while A. auricular (L.ex Hook.) Undew showed the highest inhibition of α-amylase activity. These results reveal that the active substances in R. botrytoides (Peck) Corner are abundant and have good antioxidant and enzyme inhibitory capacity, which can provide theoretical support for the subsequent development and utilization of R. botrytoides (Peck) Corner. These findings help to inform and guide the exploration and development of the species of edible mushrooms, which can serve as a theoretical basis for the advancement of natural functional foods possessing antioxidant, hypoglycemic, and hypolipidemic effects. Graphical Edible mushrooms are nutritious, low in calories, and extremely high in biologically active substances, making them an important source of nutraceuticals as well as biologically active metabolites for use as drugs.
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Microbiome
·
2025
·Vol. 13
·期 1
·1-23
·
IF 12.7
Lin Chunxiu,Lin Yugui,Xiao Rui,Guo Min,Zhang Hao,Chen Wei,Wang Gang
Background Recent studies suggest a role of gut microbiota in the development of neonatal hyperbilirubinemia, with bifidobacteria showing promise in alleviating symptoms. However, uncertainties persist regarding gut bifidobacterial species composition and their effects on bilirubin metabolism. Therefore, the study investigated the association between the gut microbiota and neonatal hyperbilirubinemia, assessing the potential and underlying mechanisms of Bifidobacterium in managing the condition. Results Compared to the high-risk group (requiring clinical intervention), low-risk neonates (designated as controls without therapeutic needed) demonstrated a higher abundance of breastfeeding-associated Bifidobacterium species, including Bifidobacterium longum subsp. infantis , B. bifidum , and B. breve . In an experimental neonatal hyperbilirubinemia rat model, these Bifidobacterium species’ protective effects were demonstrated by reducing serum bilirubin levels, maintaining growth and development, and improving neurobehavioral reflexes. These benefits are associated with improved liver and intestinal barrier functions and reduced enterohepatic circulation of bilirubin. Among the various treatment groups, B. longum subsp. infantis exhibited the most potent effect, followed by B. bifidum and B. breve . Intestinal metabolism analysis revealed that the levels of arachidonic acid and docosahexaenoic acid were increased and negatively correlated with bilirubin levels. These findings were further confirmed in the neonatal cohort study. Direct supplementation of these metabolites into the colon of neonatal rats improved disease phenotypes. In addition, both in vitro and in vivo experiments demonstrated the specific inhibitory effect of arachidonic acid and docosahexaenoic acid on β-glucuronidase enzyme activity. Notably, both in vitro intestinal fermentation models and genomic analyses demonstrated that the three Bifidobacterium species cannot synthesize these unsaturated fatty acids due to the lack of related genes. However, data suggested that these species might promote the accumulation of arachidonic acid and docosahexaenoic acid by regulating the gut microbiota’s structure and function. Moreover, these species show species-specific genomic distribution patterns, which might influence the gut microbiota's α-linolenic and linoleic acid metabolism pathways, thereby affecting bilirubin levels. Conclusions The results indicate that Bifidobacterium species associated with breastfeeding can prevent neonatal hyperbilirubinemia by regulating the gut microbiota–α-linolenic and linoleic acid metabolism–enterohepatic circulation axis, increasing gut metabolites arachidonic acid and docosahexaenoic acid, and reducing the enterohepatic circulation of bilirubin.
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Food Chemistry-X
·
2025
·
IF 8.2
Jing Liang,Jiayan Xie,Yue Gu,Jianhua Xie,Yi Chen,Bing Zheng,Yue Qiu,Xiaobo Hu,Qiang Yu
Vigna umbellata is an important homologous medicinal and food legume, and its fruit is rich in polyphenols. Acidic, alkaline (highest yield) and enzymatic methods were used to release bound polyphenols from rice bean skin dietary fiber. 44 compounds were identified from the alkaline hydrolysis products. With the increase of polyphenol concentration within a specific range, the scavenging rate of DPPH• and ABTS + • radicals and the reduction ability of ferric ions were increased. Rice bean skin dietary fiber bound polyphenols (RBSDF-BP) showed significant α -glucosidase inhibitory activity. The results showed that Hydrogen bonding and hydrophobic forces were the binding forces for RBSDF-BP to form a stable polyphenol-enzyme complex with α -glucosidase. Molecular docking revealed that the three polyphenols of RBSDF-BP had a strong affinity for the active site in the hydrophobic cavity of the enzyme. This study provides valuable discoveries for the potential application of RBSDF-BP as natural inhibitors of α -glucosidase. Chemical compounds Protocatechuic acid (PubChem CID: 72); Malic acid (PubChem CID: 525); Isoferulic acid (PubChem CID: 736186); p-Hydroxybenzoic acid (PubChem CID: 135); Citric acid (PubChem CID: 311), (+)-Catechin (PubChem CID: 9064), Fumaric acid (PubChem CID: 444972), Gallic acid (PubChem CID: 370), Azelaic acid (PubChem CID: 2266), (−)-Epicatechin (PubChem CID: 72276).
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BBA Advances
·
2025
·
IF 3
Xueliang Lu,Xu Wang,Mingyue Xiong,Pengbo Wang,Yingkang Zhu,Xiangyu Wang,Xia Liu,Hanjie Yu,Ruiyu Liu
Purpose Osteonecrosis of the femoral head (ONFH) is one of the most common and devastating articular cartilage diseases worldwide. The role of glycosylation in cartilage degeneration of ONFH is not yet fully understood. Patients and methods The expression of glycogens in cartilage from ONFH patients was determined using our own whole-genome expression dataset. Moreover, the altered glycosylation associated with ONFH cartilage and methylprednisolone (MPS)-induced cell models was investigated by lectin microarrays. The synthesis of α-2,3 sialylation was repressed by silencing ST3GAL2, and the effect of α-2,3-sialylation on ONFH-associated molecular events was assessed. Results Our findings revealed that the expression of 18 glycogens (including ST3GAL2) were significantly changed in ONFH cartilage compared with those in fracture control cartilage. Moreover, the level of α-2,3 sialylation, which is catalyzed by ST3GAL2, was significantly increased in ONFH cartilage and cell models compared to their corresponding controls. Silencing the expression of ST3GAL2 not only reduced the level of α-2,3 sialylation but also suppressed the expression of proinflammatory cytokines, reduced apoptosis-related proteins, and inactivated the NF-κB signaling pathway. Conclusion Our study highlighted the important role of α-2,3 sialylation in the development of ONFH, providing valuable insights into the molecular mechanisms underlying the pathogenesis of ONFH.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Tao Guo,Danjun Mao,Xiufeng Lu,Wenhao Ma,Heyun Fu,Huan He,Cheng Sun,Shourong Zheng,Zhifeng Jiang,Xiaolei Qu
Inadequate contact interface, lack of direct electron-transfer paths and low substrate affinity are considered as the main obstacle inhibiting the heterostructure activity for the sustainable photosynthesis of value-added fine chemicals. Herein, a novel 0D/2D Step-scheme (S-scheme) α-Fe 2 O 3 /PbBiO 2 I (FO/PBOI) composite with abundant interface Fe O bonds were initially synthesized via an in-situ growth approach. The created built-in field as a powerful driving force, efficiently steering the migration of photogenerated electrons. The interfacial Fe O bonds act as atomic-level transfer highway, lowering charge transfer energy barrier between the interfaces and further accelerating the S-scheme spatial charge separation. Moreover, the Fe O bonds bridged FO/PBOI can effectively enhance the activation of O 2 and benzylamine, significantly reducing the dehydrogenation barrier for the rate-limiting C 6 H 5 CH 2 NH* intermediate. The optimized FO/PBOI exhibits remarkably improved catalytic activity and general applicability for the dehydrocoupling of primary amines to imines. This work offers an atomic-scale perspective on precise charge flow steering based on interface bond for advanced organic transformations.
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