Nature Communications
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2025
·Vol. 16
·期 1
·1-16
·
IF 15.7
Li Yang,Lu Xuteng,Cheng Xufeng,Xia Keyu,Hu Junyan,Wang Peiyu,Pang Peiyuan,Gao Bomin,Sun Demeng,Zhang Zhuzhen,Li Dongdong,Deng Zengqin,Tian Changlin,Xie Chang,Yao Jing
Our skin safeguards the body homeostasis for health and also provides psychological consolation in social life. Natural essential oils are widely used for skin maintenance, while the molecular target and mechanism of action remain largely unknown. Here, we report that citronellal, a plant-derived acyclic monoterpene commonly used for personal care, stimulates skin renewal by promoting keratinocyte proliferation through the activation of TRPV3. We further present cryo-EM structures of human TRPV3 in complex with acyclic monoterpenes, including citronellal, citral, linalool and isodihydrolavandulal, determined at resolutions of 3.1-3.6 Å. Our structural and functional analysis unmasks consistent yet subtly different binding modes within the TRPV3 vanilloid site. Our results elucidate that essential oil ligands activate TRPV3 channels by competitively displacing endogenous lipids from the vanilloid site. Together, these findings identify TRPV3 as the molecular target of natural acyclic monoterpenes for skin renewal, and delineate the structural basis of action, thus being instrumental for moving forward skin healthcare.
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JOURNAL OF NANOBIOTECHNOLOGY
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2025
·Vol. 23
·期 1
·1-16
·
IF 12.6
Chu Hongyu,Xu Yajun,Shan Yuezhan,Sun Mengmeng,Zhao Weidong,Fang Xuedong,Shen Na,Tang Zhaohui
The vascular-disrupting agent DMXAA (5,6-dimethylxanthone-4-acetic acid) exhibits potent anticancer activity by targeting tumor vasculature and activating immune responses via the cGAS-STING pathway. However, its clinical application is hindered by nonspecific targeting and significant cardiovascular toxicity. This study introduces a novel self-amplified tumor-targeting delivery system(P@NPPD)comprising azide-functionalized poly(ethylene glycol)- b -poly-[( N -2-hydroxyethyl)-aspartamide]-DMXAA (N 3 -PEG- b -PHEA-DMXAA, NPPD) conjugated to DBCO modified platelets. Among them, NPPD was synthesized by conjugating DMXAA to N 3 -PEG- b -poly-[( N -2-hydroxyethyl)-aspartamide] through esterification. This system enhances tumor-specific drug delivery while minimizing systemic toxicity. Leveraging the natural tumor-homing properties of platelets and the coagulation cascade, P@NPPD selectively targets exposed collagen at tumor sites, initiating a self-amplifying release of DMXAA. This approach achieved a 2.61-fold improvement in targeting efficiency and an 89.1% tumor suppression rate. In addition to improving drug accumulation at tumor sites, P@NPPD significantly activated local immune responses, enhancing therapeutic efficacy and safety. These findings underscore the potential of P@NPPD as a promising platform for cancer therapy. Graphical abstract
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Advanced Composites and Hybrid Materials
·
2024
·Vol. 7
·期 2
·1-13
·
IF 23.2
Guo Jiang,Xi Shaohua,Sun Yukun,Dong Wenhao,Asiri Yazeed M.,Alqarni Nawal D.,Helal Mohamed H.,Zhou Fujian,Zhu Jianfeng
In this work, magnetoresistive nanomagnetite@polyaniline (Fe 3 O 4 @PANI) composites with a core-shell structure were prepared by in situ polymerization method with KH-550 as coupling agent. All the samples demonstrated the positive MR, and compared with PANI composites reinforced with small (diameter 80 nm) size or large (diameter 450 nm) size of Fe 3 O 4 , the PANI composites reinforced with medium (diameter 220 nm) size of Fe 3 O 4 exhibit the largest MR (8.41%) when the MK-F loading is 60 wt%. Moreover, the size effect of Fe 3 O 4 particles on the electrical conductivity and MR behavior was analyzed by the Mott VRH model and wave functional shrinkage model. The MR value of Fe 3 O 4 @PANI composites with different loading and size of Fe 3 O 4 particles mainly depends on localization length, density of state at Fermi level, and average hopping length. Moreover, the Fe 3 O 4 @PANI composites were systematically characterized by SEM, TEM, XRD, and FT-IR. This work could provide the guidance for fabrication of magnetic field sensors and information memory storage devices. Graphical Abstract The core-shell structured magnetite/polyaniline nanocomposites with tunable magnetoresistance by changing the size of magnetite nanoparticle.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-23
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IF 10.6
Zhao Pei,Hu Hua-Zhong,Chen Xiao-Tong,Jiang Qi-Yun,Yu Xue-Zhao,Cen Xiao-Lin,Lin Shi-Qing,Mai Sui-qing,Pang Wei-lin,Chen Jin-Xiang,Zhang Qun
Background Acute gouty is caused by the excessive accumulation of Monosodium Urate (MSU) crystals within various parts of the body, which leads to a deterioration of the local microenvironment. This degradation is marked by elevated levels of uric acid (UA), increased reactive oxygen species (ROS) production, hypoxic conditions, an upsurge in pro-inflammatory mediators, and mitochondrial dysfunction. Results In this study, we developed a multifunctional nanoparticle of polydopamine-platinum (PDA@Pt) to combat acute gout by leveraging mild hyperthermia to synergistically enhance UA degradation and anti-inflammatory effect. Herein, PDA acts as a foundational template that facilitates the growth of a Pt shell on the surface of its nanospheres, leading to the formation of the PDA@Pt nanomedicine. Within this therapeutic agent, the Pt nanoparticle catalyzes the decomposition of UA and actively breaks down endogenous hydrogen peroxide (H 2 O 2 ) to produce O 2 , which helps to alleviate hypoxic conditions. Concurrently, the PDA component possesses exceptional capacity for ROS scavenging. Most significantly, Both PDA and Pt shell exhibit absorption in the Near-Infrared-II (NIR-II) region, which not only endow PDA@Pt with superior photothermal conversion efficiency for effective photothermal therapy (PTT) but also substantially enhances the nanomedicine’s capacity for UA degradation, O 2 production and ROS scavenging enzymatic activities. This photothermally-enhanced approach effectively facilitates the repair of mitochondrial damage and downregulates the NF-κB signaling pathway to inhibit the expression of pro-inflammatory cytokines. Conclusions The multifunctional nanomedicine PDA@Pt exhibits exceptional efficacy in UA reduction and anti-inflammatory effects, presenting a promising potential therapeutic strategy for the management of acute gout. Graphical Abstract
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ACTA PHARMACOLOGICA SINICA
·
2024
·
IF 6.9
Yuan Nai-jun,Zhu Wen-jun,Ma Qing-yu,Huang Min-yi,Huo Rou-rou,She Kai-jie,Pan Jun-ping,Wang Ji-gang,Chen Jia-xu
Accumulating evidence shows that neuroinflammation substantially contributes to the pathology of depression, a severe psychiatric disease with an increasing prevalence worldwide. Although modulating microglial phenotypes is recognized as a promising therapeutic strategy, effective treatments are still lacking. Previous studies have shown that luteolin (LUT) has anti-inflammatory effects and confers benefits on chronic stress-induced depression. In this study, we investigated the molecular mechanisms by which LUT regulates the functional phenotypes of microglia in mice with depressive-like behaviors. Mice were exposed to chronic restraint stress (CRS) for 7 weeks, and were administered LUT (10, 30, 40 mg· kg −1 ·day −1 , i.g.) in the last 4 weeks. We showed that LUT administration significantly ameliorated depressive-like behaviors and decreased hippocampal inflammation. LUT administration induced pro-inflammatory microglia to undergo anti-inflammatory arginase (Arg)-1 + phenotypic polarization, which was associated with its antidepressant effects. Furthermore, we showed that LUT concentration-dependently increased the expression of PPARγ in LPS + ATP-treated microglia and the hippocampus of CRS-exposed mice, promoting the subsequent inhibition of the NLRP3 inflammasome. Molecular dynamics (MD) simulation and microscale thermophoresis (MST) analysis confirmed a direct interaction between LUT and peroxisome proliferator-activated receptor gamma (PPARγ). By using the PPARγ antagonist GW9662, we demonstrated that LUT-driven protection, both in vivo and in vitro, resulted from targeting PPARγ. First, LUT-induced Arg-1 + microglia were no longer detected when PPARγ was blocked. Next, LUT-mediated inhibition of the NLRP3 inflammasome and downregulation of pro-inflammatory cytokine production were reversed by the inhibition of PPARγ. Finally, the protective effects of LUT, which attenuated the microglial engulfment of synapses and prevented apparent synapse loss in the hippocampus of CRS-exposed mice, were eliminated by blocking PPARγ. In conclusion, this study showed that LUT ameliorates CRS-induced depressive-like behaviors by promoting the Arg-1 + microglial phenotype through a PPARγ-dependent mechanism, thereby alleviating microglial pro-inflammatory responses and reversing microglial phagocytosis-mediated synapse loss.
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EMBO Molecular Medicine
·
2024
·
IF 9
WangHuiting,ZhaoZiting,SongMingming,ZhangWenxiang,LiuChang,ChenSiyu
Di-(2-ethylhexyl) phthalate (DEHP), an environmental pollutant, has been widely detected in both environmental and clinical samples, representing a serious threat to the homeostasis of the endocrine system. The accumulation of DEHP is notably pronounced in the liver and can lead to liver damage. The lack of effective high-throughput screening system retards the discovery of such drugs that can specifically target and eliminate the detrimental impact of DEHP. Here, by developing a Cy5-modified single-strand DNA-aptamer-based approach targeting DEHP, we have identified luteolin as a potential drug, which showcasing robust efficacy in detoxifying the DEHP by facilitating the expulsion of DEHP in both mouse primary hepatocytes and livers. Mechanistically, luteolin enhances the protein degradation of hepatic urocanate hydratase 1 (Uroc1) by targeting its Ala270 and Val272 sites. More importantly, trans-urocanic acid (trans-UCA), as the substrate of Uroc1, possesses properties similar to luteolin by regulating the lysosomal exocytosis through the inhibition of the ERK1/2 signal cascade. In summary, luteolin serves as a potent therapeutic agent in efficiently detoxifying DEHP in the liver by regulating the UCA/Uroc1 axis.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-16
·
IF 10.6
Zheng Xiaoyi,Ouyang Yongliang,Fan Hengwei,Zhang Liying,Wang Shige,Zeng Yanbo,Hu Lianghao,Zhao Jiulong
Excess free radicals at the wound site can cause an inflammatory response, which is not conducive to wound healing. Hydrogels with antioxidant properties can prevent inflammatory storms by scavenging free radicals from the wound site and inhibiting the release of inflammatory factors. In this study, we prepared the carboxymethyl chitosan (CMCS)/polyvinyl pyrrolidone (PVP)/Molybdenum (IV) Selenide (MoSe2), and platelet-rich plasma (PRP) (CMCS/PVP/MoSe2/PRP) hydrogels for accelerating the repair of wounds. In the hydrogels, the MoSe2 can scavenge various free radicals to reduce oxidative stress at the site of inflammation, endowed the hydrogels with antioxidant properties. Interestingly, growth factors released by PRP assisted the tissue repair by promoting the formation of new capillaries. CMCS as a backbone not only showed good biocompatibility and biodegradability but also played a significant role in maintaining the sustained release of growth factors. In addition, incorporating PVP enhanced the tissue adhesion and mechanical properties. The multifunctional composite antioxidant hydrogels have good swelling properties and biodegradability, which is completely degraded within 28 days. Thus, the antioxidant CMCS/PVP/MoSe2/PRP hydrogels provide a new idea for designing ideal multifunctional wound dressings.
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JOURNAL OF FLUORESCENCE
·
2024
·
IF 2.6
Lu Guangjie,Yu Caili,Cheng Jie,Xu Jianben,Zhang Faai
Fluorescent polyurethane has been widely used as fluorescent probes and switches due to its diverse structure and properties, but most of them are solvent-based and synthesized from petroleum-based products. A new type of rosin-based anthraquinone fluorescent waterborne polyurethane (WPU-DAAQ) with good and stable fluorescence properties was synthesized by reacting rosin modified ester (RAG) as a diol and 2, 6-diaminoanthraquinone (DAAQ) as a fluorescent agent with diisocyanate. The structure of WPU-DAAQ was characterized by Fourier transform infrared spectroscopy, UV-vis absorption spectroscopy, and hydrogen magnetic resonance spectroscopy. The fluorescence properties, water resistance, and solvent resistance of WPU-DAAQ were tested. The results showed that DAAQ was successfully grafted onto the polyurethane molecular chain. The fluorescence intensity of WPU-DAAQ increases and then decreases with increasing excitation wavelengths, and increases with the increase of solvent ether content, and is significantly enhanced compared to DAAQ. The dispersion stability was good with the increase of DAAQ. The introduction of DAAQ into polyurethane improved the thermal stability, hydrophobicity, and solvent resistance of WPU-DAAQ. Therefore, WPU-DAAQ is a new type of fluorescent waterborne polyurethane with stable dispersion properties, good fluorescent properties, heat resistance and water resistance.
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RARE METALS
·
2025
·Vol. 44
·期 2
·889-900
·
IF 11
Feng Ping-Xian,Chen Qi-Liang,Yang Dong-Jie,Wang Huan
Developing high-capacity carbon-based anode materials is crucial for enhancing the performance of lithium-ion batteries (LIBs). In this study, we presented a nitrogen-doped lignin mesoporous carbon/nickel/nickel oxide (NHMC/Ni/NiO) nanocomposite for developing high-capacity LIBs anode materials through carbonization and selective etching strategies. The synthesized NMHC/Ni/NiO-0.33 composite exhibited a highly regular microstructure with well-dispersed Ni/NiO particles. The composite had a surface area of 408 m 2 ⋅g −1 , a mesopore ratio of 75.0%, and a pyridine–nitrogen ratio of 58.9%. The introduction of nitrogen atoms reduced the disordered structure of lignin mesoporous carbon and enhanced its electrical conductivity, thus improving the lithium storage capabilities of the composite. Following 100 cycles at a current density of 0.2 A⋅g −1 , the composite demonstrated enhanced Coulomb efficiency and rate performance, achieving a specific discharge capacity of 1230.9 mAh⋅g −1 . At a high-current density of 1 A⋅g −1 , the composite exhibited an excellent specific discharge capacity of 714.6 mAh⋅g −1 . This study presents an innovative method for synthesizing high-performance anode materials of LIBs. Graphical abstract
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JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
·
2024
·Vol. 43
·期 1
·1-20
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IF 11.4
Fei Xiaobin,Zhu Changhao,Liu Peng,Liu Songbai,Ren Likun,Lu Rishang,Hou Junyi,Gao Yongjia,Wang Xing,Pan Yaozhen
Background Pancreatic cancer (PC) is a highly malignant gastrointestinal tumor, which is characterized by difficulties in early diagnosis, early metastasis, limited therapeutic response and a grim prognosis. Therefore, it is imperative to explore potential therapeutic targets for PC. Currently, although the involvement of the Pellino E3 Ubiquitin Protein Ligase 1 (PELI1) in the human growth of some malignant tumors has been demonstrated, its association with PC remains uncertain. Methods Bioinformatics, qRT-PCR, Western blot and IHC were used to detect the expression of PELI1 in pancreas or PC tissues and cells at mRNA and protein levels. The effects of PELI1 on the proliferation and metastatic ability of pancreatic cancer in vitro and in vivo were investigated using CCK8, cloning formation, EdU, flow cytometry, IHC, Transwell assay, wound healing, nude mice subcutaneous tumorigenesis and intrasplenic injection to construct a liver metastasis model. The interactions of PELI1 with proteins as well as the main functions and pathways were investigated by protein profiling, Co-IP, GST-pull down, Immunofluorescence techniques, immunohistochemical co-localization and enrichment analysis. The rescue experiment verified the above experimental results. Results The mRNA and protein expression levels of PELI1 in PC tissues were upregulated and were associated with poor prognosis of patients, in vitro and in vivo experiments confirmed that PELI1 can affect the proliferation and metastatic ability of PC cells. Co-IP, GST-pull down, and other experiments found that PELI1 interacted with Ribosomal Protein S3 (RPS3) through the FHA structural domain and promoted the polyubiquitination of RPS3 in the K48 chain, thereby activates the PI3K/Akt/GSK3β signaling pathway. Moreover, ubiquitinated degradation of RPS3 further reduces Tumor Protein P53 (p53) protein stability and increases p53 degradation by MDM2 Proto-Oncogene (MDM2). Conclusion PELI1 is overexpressed in PC, which increased ubiquitination of RPS3 proteins and activates the PI3K/Akt/GSK3β signaling pathway, as well as reduces the protective effect of RPS3 on p53 and promotes the degradation of the p53 protein, which facilitates the progression of PC and leads to a poor prognosis for patients. Therefore, PELI1 is a potential target for the treatment of PC.
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International Journal of Environmental Science and Technology
·
2024
·
IF 3
Xu X.,Zhu L.,Chen C.,Luo C.,Jin Z.,Sun Z.,Fu Z.T
The study employed a direct hydrothermal method to synthesize NiO/La-KTaO 3 heterojunction photocatalysts. The photocatalytic efficiency of the composites was assessed by their ability to destroy isoamyl xanthate in the presence of Ultraviolet light, mimicking the conditions seen in flotation wastewater. The results showed a significantly greater photocatalytic activity when comparing the composite catalyst to KTaO 3 . A photocatalytic reaction was performed utilizing a 40 mg NiO/K 1−x La x TaO 3 (x = 0.04) photocatalyst at pH = 3. The reaction was carried out using 50 mL of isoamyl xanthate synthesis wastewater, which had a concentration of 20 mg/L. The degradation rate achieved after 30 min was 87.28%. The addition of nickel oxide (NiO) and the introduction of La into the K lattice position were thought to facilitate charge separation, migration, and the generation of additional active sites, hence augmenting the catalytic impact. The findings from radical capture tests indicated that the ·O 2− (superoxide ion) served as the principal active species in the photocatalytic process, playing a substantial role. The process of photodegradation of isoamyl xanthate was determined through the utilization of different analytical and testing methods. This work introduces a direct and effective approach for the eco-friendly decomposition of xanthate flotation wastewater.
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JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
·
2025
·
IF 2
Li Peining,Wang Shouren,Xiao Zhen,Li Yang,Zhang Luyu,Wang Gaoqi
Underwater vehicles can conduct underwater exploration and military rescue operations and play a significant role in marine economic development and national defense. The fluid resistance control and corrosion resistance of underwater vehicles are essential indexes for evaluating the performance of underwater vehicles in particular marine environments and harsh conditions. The 7075 aluminum alloy, widely used in spacecraft shells, was selected as the material. We prepared a drag-reduction and robust surface based on shark skin by laser-ablation and plasma electrolytic oxidation. Then, the surface free energy was further modified by chemical modification. The ceramic coating exhibited superhydrophobicity with a water contact angle of 155.6° and roll-off angle (RA) of 5.5°. Compared with Bare Al, the corrosion current density of the superhydrophobic ceramic coating was reduced by 4 orders of magnitude since ZnO-NPs could notably enhance the corrosion resistance of Al alloys. Moreover, due to the protective effect of the ceramic coating and microstructure, the superhydrophobic coating exhibited excellent mechanical durability. Based on numerical simulation, the drag reduction effect of biomimetic microstructure under different Reynolds numbers was investigated. The experimental results indicated that biomimetic microstructure demonstrated notable drag reduction capabilities compared to smooth surfaces, stabilizing at approximately 28% during laminar flow states. Thus, applying this coating method to the underwater vehicle shell was expected to reduce the fluid resistance and extend the operational lifespan in the marine corrosive environment.
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