RSC Advances
·
2023
·Vol. 13
·期 11
·7425-7431
·
IF 3.9
Wenjie Luo,Changxu Wang,Jieshu Min,Huiyu Luo
Gold nanoclusters exhibit attractive properties owing to their excellent biocompatibility and strong photostability in the biomedical domain. In this research, cysteine-protected fluorescent gold nanoclusters (Cys-Au NCs) were synthesized via decomposing Au(I)–thiolate complexes for the detection of Fe3+ and ascorbic acid in a bidirectional “on–off–on” mode. Meanwhile, the detailed characterization confirmed that the mean particle size of the prepared fluorescent probe was 2.43 nm and showed a fluorescence quantum yield of 3.31%. In addition, our results indicate that the fluorescence probe for ferric ions exhibited a broad detection scope ranging from 0.1 to 2000 μM and excellent selectivity. The as-prepared Cys-Au NCs/Fe3+ was demonstrated to be an ultrasensitive and selective nanoprobe for the detection of ascorbic acid. This study indicated that the “on–off–on” fluorescent probes Cys-Au NCs held a promising application for the bidirectional detection of Fe3+ and ascorbic acid. Furthermore, our novel “on–off–on” fluorescent probes provided insight into the rational design of thiolate-protected gold nanoclusters for biochemical analysis of high selectivity and sensitivity.
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ANALYTICA CHIMICA ACTA
·
2023
·
IF 6.2
Shengjie Ge,Gaoyang Chen,Dawei Cao,Hechuan Lin,Ziyang Liu,Meng Yu,Shiyi Wang,Zhigang Wang,Ming Zhou
Cisplatin has been widely applied in the clinical treatment of various cancers, whereas liver injury induced by its hepatotoxicity is still a severe issue. Reliable identification of early-stage cisplatin-induced liver injury (CILI) can improve clinical care and help to streamline drug development. Traditional methods, however, cannot achieve enough information at the subcellular level due to the requirement of the labeling process and low sensitivity. To overcome these, we designed an Au-coated Si nanocone array (Au/SiNCA) to fabricate the microporous chip as the surface-enhanced Raman scattering (SERS) analysis platform for the early diagnosis of CILI. A CILI rat model was established, and the exosome spectra were obtained. The principal component analysis (PCA)-representation coefficient-based k-nearest centroid neighbor (RCKNCN) classification algorithm was proposed as the multivariate analysis method to build the diagnosis and staging model. The PCA-RCKNCN model has been validated to achieve a satisfactory result, with accuracy and AUC of over 97.5%, and sensitivity and specificity of over 95%, indicating that SERS combined with the PCA-RCKNCN analysis platform can be a promising tool for clinical applications.
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Yi-Bai Sun,Miao Ni,Chen Chi,Dong-Rui Yang,Xue-Lu Chen,Qi Qi,Jian Li,Xing-Hua Xia
The development of efficient catalysts with low energy consumption has always been a key issue for sustainable hydrogen energy. Here, we report a catalyst comprising a single atomic Pd layer deposited on Au nanorods (ML-Pd@Au NRs) that shows a super-high HER activity and ultra-low overpotential under localized surface plasmon resonance condition. The Au NR plays triple determining roles in HER performance via adjusting the electronic structure and lattice strain of Pd that effectively reduces the adsorption energy of H-adatoms, eliminating the penetration of H adatoms in multilayer Pd crystal that decreases the H adatoms diffusion kinetics, and providing high energetic hot charge carriers under near-IR light irradiation that decreases the activation energy and onset potential of HER. The single atomic Pd layer on Au NRs ensures the hot electron transfer as the main dissipation pathway of the plasmonic hot charge carriers for HER. Thus, under near-IR light irradiation, HER on ML-Pd@Au NRs occurs with a high mass activity of 17.47 mA mg −1 at 100 mV and a very low overpotential of 13 mV at 10 mA cm −2 , which are superior to the commercial Pd/C and commercial Pt/C catalysts under the same conditions.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2023
·
IF 5.8
Shengnan Huang,Chengzhi Song,Jinxin Miao,Xiali Zhu,Yongyan Jia,Yafei Liu,Dongjun Fu,Benyi Li,Mingsan Miao,Shaofeng Duan,Zhenzhong Zhang,Yurong Hu
Dysregulation of microRNAs (miRNAs) expression is closely related to cancers and managing miRNA expression holds great promise for cancer therapy. However, their wide clinical application has been hampered by their poor stability, short half-life and non-specific biodistribution in vivo . Herein, a novel biomimetic platform designated as RHAuNCs-miRNA for improved miRNA delivery was prepared through wrapping miRNA-loaded functionalized Au nanocages (AuNCs) with red blood cell (RBC) membrane. RHAuNCs-miRNA not only successfully loaded miRNAs but also effectively protected them from enzymatic degradation. With good stability, RHAuNCs-miRNA had the characteristics of photothermal conversion and sustained release. Cellular uptake of RHAuNCs-miRNA by SMMC-7721 cells was in a time-dependent manner via clathrin- and caveolin-mediated endocytosis. The uptake of RHAuNCs-miRNAs was affected by cell types and improved by mild near infrared (NIR) laser irradiation. More importantly, RHAuNCs-miRNA exhibited a prolonged circulation time without the occurrence of accelerated blood clearance (ABC) in vivo, resulting in efficient delivery to tumor tissues. This study may demonstrate the great potential of RHAuNCs-miRNA for improved miRNAs delivery.
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CATALYSIS LETTERS
·
2023
·
IF 2.8
Chen Yao,Li Shuyue,Li Yuchao,Zheng Yanxia,Zuo Cuncun,Ge Tingting,Xu Rui,Huang Haofei,An Jiutao
Nano-Au particles are commonly used as an active component in oxidation esterification reactions. To inhibit the agglomeration of nano-Au particles, a series of highly stable Au@CeO 2 /MnO x core–shell structured catalysts were synthesized using inverse microemulsion technology for the oxidative esterification to prepare methyl methacrylate (MMA). The core–shell structured catalysts were prepared by using two different surfactants (CTAB and CO-520) and adjusting the molar ratio of water to oil (ω). XRD, Raman, N 2 adsorption, ICP−MS, TEM, UV–vis, FT-IR, XPS, and H 2 -TPR were applied to characterize the samples. The nano-Au particles were encapsulated by CeO 2 , forming a core–shell structure confirmed with TEM. The Au@CeO 2 /MnO x -C-ω = 10 catalyst prepared with CTAB as the surfactant has the best activity. The Au@CeO 2 /MnO x -C-ω = 10 catalyst has the highest hydrogen consumption and Ce 3+ content, indicating that the catalyst has the strongest interaction among Ce, Au, and Mn and more active oxygen. Active oxygen is beneficial to methanol activation and hemiacetal dehydrogenation, accelerating the formation of esters. The active oxygen content, Ce 3+ content, and H 2 consumption were correlated with the catalytic performance positively. After the catalyst was reused 10 times, the activity remained unchanged and the Au nanoparticles did not agglomerate due to the core–shell structure. Graphical Abstract
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Plasmonics
·
2023
·Vol. 18
·期 4
·1541-1552
·
IF 3
Gu Ciyong,Meng Delong,Yu Xiaolei,Li Lin,Zhao Zhimin
In this work, we have developed a highly sensitive surface enhanced Raman scattering (SERS) substrate consisting of gold (Au) and silver (Ag) nanoparticles (NPs) loaded on glass fiber filter paper (GFF) by a two-step process of magnetron sputtering and sessile drop method. To test the SERS properties of the substrate, crystal violet (CV) was selected as the Raman probes. The influence of the amounts of NPs on the SERS signals was studied using field-emission scanning electron microscopy and theoretical methods. It is demonstrated that the hybrid structure of optimal GFF/Au/AgNPs has a much stronger SERS enhancement than that of GFF substrate coated only with AuNPs, which can provide a SERS enhancement factor (EF) of 3.52 × 10 8 , and the limit of detection is down to 10 −14 M for CV. Moreover, the Raman signal of the CV on the GFF/Au/Ag substrate presented good homogeneity, reproducibility and stability, also reproduce the SERS spectra after 15 days. Furthermore, the GFF/Au/AgNPs substrate was applied for the rapid on-site testing and identification of malachite green (MG) residual on contaminated fish scale, and the limit of detection was approximately 10 −7 M. Flexible GFF substrate with Au/Ag bimetallic hybrid structure has great potential in rapid sampling of hazardous ingredients on real samples and in SERS applications.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2023
·
IF 4.4
Ziheng Yang,Li Jiang,Weidan Zhao,Boya Shi,Xiangwen Qu,Yekai Zheng,Pengwei Zhou
Recent years, two-dimensional transition metal carbonitrides (MXene) have attracted much attention in the field of surface-enhanced Raman scattering (SERS). However, the relatively low enhancement of MXene is a major challenge. Herein, Nb 2 C-Au NPs nanocomposites were prepared by electrostatic self-assembly method, which have a synergistically conjugated SERS effect. The EM hot spots of Nb 2 C-Au NPs are significantly enlarged and expanded, while the surface Fermi level is decreased. This synergistic effect could improve the SERS performance of the system. Consequently, for the dye molecules CV and MeB, the detection limits reach 10 −10 M and 10 −9 M, respectively, while for biomolecule adenine, the detection limit is as low as 5 × 10 −8 M. The results also show the good concentration-dependent linearity, uniformity, reproducibility and stability of SERS substrate. Nb 2 C-Au NPs could be a fast, sensitive and stable SERS platform for label-free and non-destructive detection. This work may expand the application of MXene based materials in the field of SERS.
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INORGANIC CHEMISTRY COMMUNICATIONS
·
2023
·
IF 3.8
Jingxia Wang,Xiaohan Shan,Qiang Xue,Yao Liu,Zeyu Liu,Lin He,Xiaolei Wang,Changchun Zhu
In this work, we firstly developed a laser-induced graphene (LIG) electrode modified by gold nanoparticles (AuNPs) and glycine-modified nanocarbon (Gly-C), and used it to detect nitrite by linear scanning voltammetry . The physical and electrochemical characteristics of the electrodes were characterized using scanning electron microscopy, energy dispersive spectroscopy analysis, fourier transform infrared spectroscopy , and contact angle analysis. Our findings demonstrated that the electrocatalytic oxidation of nitrite can be enhanced by the successful loading of AuNPs, and Gly-C enhances electrode hydrophilicity and promotes nitrite adsorption capacity of the electrode surface. Under optimal conditions, the linear of the sensor is 7 ∼ 700 μg/L and 700 ∼ 1050 μg/L, and the detection limit is 0.84 μg/L. The anti-interference, repeatability, and stability of this sensor are outstanding. Recovery rates of the sensor in the actual groundwater and tap water varied from 94 to 123 %, and the relative standard deviation was less than 6.06 %. Our findings offer a potentially effective method for on-site monitoring of nitrite in aquatic environments.
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Foods
·
2023
·Vol. 12
·期 4
·813
·
IF 5.2
Yunfei Xie,Xianghui Dong,Nifei Cai,Fangwei Yang,Weirong Yao,Lijun Huang
Bisphenol A (BPA) is an endocrine disruptor which is widely present in fish under the influence of environmental pollution. It is essential to establish a rapid detection method for BPA. Zeolitic imidazolate framework (ZIF-8) is a typical metal-organic framework material (MOFs) with a strong adsorption capacity, which can effectively adsorb harmful substances in food. Combining MOFs and surface-enhanced Raman spectroscopy (SERS) can achieve rapid and accurate screening of toxic substances. In this study, a rapid detection method for BPA was established by preparing a new reinforced substrate Au@ZIF-8. The SERS detection method was optimized by combining SERS technology with ZIF-8. The Raman peak at 1172 cm−1was used as the characteristic quantitative peak, and the lowest detection concentration of BPA was as low as 0.1 mg/L. In the concentration range of 0.1~10 mg/L, the linear relationship between SERS peak intensity and the concentration of BPA was good, and R2was 0.9954. This novel SERS substrate was proven to have great potential in rapidly detecting BPA in food.Keywords:SERS;metal-organic frameworks;bisphenol A;rapid detection
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JOURNAL OF NANOBIOTECHNOLOGY
·
2022
·Vol. 20
·期 1
·1-24
·
IF 9.429
Yang Xiao-Yan,Zhang Jin-Guo,Zhou Qiao-Mei,Yu Jie-Ni,Lu Yuan-Fei,Wang Xiao-Jie,Zhou Jia-Ping,Ding Xin-Fa,Du Yong-Zhong,Yu Ri-Sheng
Background Excessive extracellular matrix (ECM) deposition in pancreatic ductal adenocarcinoma (PDAC) severely limits therapeutic drug penetration into tumors and is associated with poor prognosis. Collagen is the most abundant matrix protein in the tumor ECM, which is the main obstacle that severely hinders the diffusion of chemotherapeutic drugs or nanomedicines. Methods We designed a collagenase-functionalized biomimetic drug-loaded Au nanoplatform that combined ECM degradation, active targeting, immune evasion, near-infrared (NIR) light-triggered drug release, and synergistic antitumor therapy and diagnosis into one nanoplatform. PDAC tumor cell membranes were extracted and coated onto doxorubicin (Dox)-loaded Au nanocages, and then collagenase was added to functionalize the cell membrane through lipid insertion. We evaluated the physicochemical properties, in vitro and in vivo targeting, penetration and therapeutic efficacy of the nanoplatform. Results Upon intravenous injection, this nanoplatform efficiently targeted the tumor through the homologous targeting properties of the coated cell membrane. During penetration into the tumor tissue, the dense ECM in the PDAC tissues was gradually degraded by collagenase, leading to a looser ECM structure and deep penetration within the tumor parenchyma. Under NIR irradiation, both photothermal and photodynamic effects were produced and the encapsulated chemotherapeutic drugs were released effectively, exerting a strong synergistic antitumor effect. Moreover, this nanoplatform has X-ray attenuation properties that could serve to guide and monitor treatment by CT imaging. Conclusion This work presented a unique and facile yet effective strategy to modulate ECM components in PDAC, enhance tumor penetration and tumor-killing effects and provide therapeutic guidance and monitoring. Graphical Abstract
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ChemistrySelect
·
2022
·Vol. 7
·期 45
·e202204035
·
IF 2.307
Tongyu Zhang,Gongguo Zhang,Yingying Wang,Yuhan Kong,Yiqun Zheng
Graphical For the first time, gold (Au) concave nanocubes are generated in high uniformity via a silver(Ag)-free seeded growth. Due to the advantage in pure element, they are serving as an ideal research model to investigate the exact contribution role of crystal facet in electrocatalysis. Using ethanol oxidation reaction as a model reaction, both experimental and theoretical evidences are provided. We report a silver-free synthesis of gold (Au) concave nanocubes (CNCs) that involves the direct deposition of Au atoms over spherical Au seeds under well-controlled reaction kinetics and surface capping. The elementally-pure composition makes them ideal research candidate towards validating structural advantage of concave surface in electrocatalytic oxidation of ethanol. In particular, the as-obtained Au CNCs exhibited an enhanced specific activity and reaction kinetics, but weakened long-term stability, as compared to quasi-spherical counterparts. Theoretical simulations suggest that the high-index planes represent a high catalytic performance for ethanol oxidation. The current work offers an effective synthetic strategy that successfully excludes the necessary and wide use of Ag + ions in controlled synthesis of pure Au nanocrystals with a concave cubic shape, shedding light on the rational design of fuel cell electrocatalyst from the perspective of crystal facet effect.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2023
·
IF 6.2
Junnan Wang,Minqiang Wang,Jindou Shi,Yun Zhou,Chen Zhang,Arshad Saleem Bhatti
Flexibility and self-cleaning are the main research hot-spots in the development of plasma substrates for practical applications in Surface-enhanced Raman scattering (SERS) at present. In this study, a flexible composite Au@Ag/ultrathin g-C 3 N 4 /Graphene (AUG) film based on PDMS film was reported and used as a highly sensitive SERS substrate for the detection of rhodamine 6G (R6G) molecules. The Au@Ag nanosphere array formed by self-assembly provided dense hot-spots, the ultrathin g-C 3 N 4 enabled the composite to possess excellent photocatalytic ability, and the graphene enhanced SERS detection and photocatalytic performance while improving the stability of the composite film . The results showed that the AUG flexible composite film had a detection limit of 10 −12 M for R6G molecules. After 10 photocatalytic cycles of testing, the composite film maintained 83 % of SERS activity. Benefiting from the graphene covering the surface, the composite films showed only a 5 % decrease in SERS detection performance after 30 days of storage in air. The facile fabrication process of AUG composite film enables it to be an outstanding candidate for the flexible, inexpensive, and stable wearable SERS sensing systems.
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