Journal of Agriculture and Food Research
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2026
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IF 7.2
Rongting Min,Aji Li,Houxier Li,Li Yang,Nan Zhang,Jiahui Wu,Xiang Wang,Lei Li,Maochun Xiao,Shiyao Su,Mengling Yang,Jingmei Wang,Zhiqiu Yang,Miaomiao Chang,Xueyong Wang
Salvianolic acid B (SA) has significant regulatory effects on glucolipid metabolism. Combining SA with resistant starch endowed this type of starch with unique functional properties. This study represents the first direct complexation between SA and Canna edulis type 3 resistant starch (RS3). The findings indicated that SA has a beneficial effect on the physicochemical and prebiotic properties of RS3. SA and RS3 form a complex via non-covalent interactions, thereby increasing the crystalline and gelatinization temperatures. The 1 H NMR spectrum exhibited aromatic ring signals and increased hydroxyl signal intensity. Concurrently, the solubility of SA-RS3 decreased after composite formation, while the expansion, water absorption index and resistant starch content (59.40%) increased markedly. Fermentation analysis revealed decreases in pH and increases in reducing sugar content, in vitro antioxidant activity and hypoglycemic activity. Interestingly, SA-RS3 substantially increased the relative abundance of the Firmicutes and Actinomycetes phyla, promoted the proliferation of the beneficial bacterium Bifidobacterium , inhibited the growth of Klebsiella and Sutterella , and increased the content of acetic, propionic, and butyric acids. This indicates that SA confers antioxidant properties while retaining the prebiotic properties of raw RS3. Consequently, SA-RS3 demonstrates potential for blood glucose regulation and exhibits in vitro prebiotic properties, offering a novel direction for the development of RS3-type functional foods.
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BRAIN RESEARCH BULLETIN
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2026
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IF 4.5
Feifei Chen,Lingkai Tang,Ling Yuan,Jiali Xiong,Rong Kuang,Wen Qian,Yufang Kong,Yina Yin
UB alleviates CUMS-induced depressive-like behaviors and hippocampal damage in rats. • The antidepressant effect of UB may be associated with the upregulation of SLP2 expression in hippocampal neurons of rats. • SLP2 regulates the PINK1/Parkin pathway, promotes mitophagy, and maintains neuronal energy homeostasis. • Knockdown of SLP2 in vivo reverses the antidepressant and neuroprotective effects of UB. Background Depression is a highly prevalent mental disorder, with current medications often limited by delayed onset and insufficient efficacy, underscoring the urgent need to explore novel therapeutic strategies. Urolithin B (UB), a natural ellagitannin-derived metabolite, exhibits anti-inflammatory and antioxidant activities in neuroinflammation, yet its role in depression remains unclear. Objective: The present research aimed to uncover possible effects of UB on depressive-like behavior and hippocampal neuronal damage in a rat model of depression and to preliminarily elucidate its underlying molecular mechanisms. Methods: A rat model of depression was created using the chronic unpredictable mild stress (CUMS) paradigm, after which UB intervention was applied. To evaluate depressive-like behaviors, several behavioral tests were conducted, including sucrose preference test, forced swim test, tail suspension test, and open field test. Hippocampal pathological changes and related factor expression were evaluated using histopathology, immunofluorescence, and ELISA. Potential targets were screened via single-cell RNA sequencing (scRNA-seq) data obtained from the GEO database. Subsequently, the function of the identified target gene was validated through in vitro knockdown/overexpression experiments and an in vivo rescue experiment. Results: UB significantly ameliorated depressive-like behaviors in CUMS rats and alleviated hippocampal neuronal damage, synaptic loss, and neuroinflammation. scRNA-seq analysis revealed a significant upregulation of SLP2 expression in hippocampal neurons (HNs) from the treated group, along with the enrichment of mitophagy-related pathways. Functional experiments confirmed that SLP2 regulates the PINK1/Parkin pathway, promotes mitophagy, and maintains neuronal energy homeostasis. Conversely, knockdown of SLP2 reversed the antidepressant and neuroprotective effects of UB. Conclusion: UB alleviates CUMS-induced depressive-like behavior and hippocampal neuronal damage by upregulating SLP2 and regulating the PINK1/Parkin-mediated mitophagy pathway. This study presents a new potential target and theoretical basis for developing natural compound-based therapies for depression.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Mengdi Song,Zhenjing Liu,Zhou Fang,Jiaqi Xu,Xinran Gao,Min Zhang,Kehai Liu
Olaparib (Ola) mediated maintenance therapy is regarded as the most important way to prolong the survival period of pancreatic cancer patients after chemotherapy. However, it only has a “synthetic lethal” effect on patients with BRCA mutations. This is because in tumors non-BRCA mutations, the homologous recombination repair (HRR) function still exists. Interference with the core protein RAD51 in the BRCA pathway can lead to defects in HRR, making patients with non-BRCA mutations sensitive to Ola treatment, which is expected to broaden the adaptation range of Ola. In this study, Bacillus Clausii ( B. clausii ) was utilized to obtain the engineered extracellular vesicles (eBEVs) carrying RAD51 siRNA and expressing G3-C12 polypeptide by transforming the co-expression plasmid, which will be used for embedding Ola. Therefore, a new type of oral drug delivery system eBEVs-Ola co-carrying Ola and siRNA was successfully constructed. Its gastrointestinal protection and intestinal epithelial crossing properties enable oral administration, while the G3-C12 targeting function enable pancreatic cancer concentration. After cell entry, RAD51 siRNA specifically silenced RAD51 to block HRR, and Ola simultaneously acted on the PARP enzyme and jointly inhibited DNA damage repair, thereby sensitizing non-BRCA-mutated pancreatic cancer cells to Ola through a synthetic lethal interaction. The results showed that eBEVs-Ola exhibited good targeting and maintenance therapeutic effects in the mouse model of human pancreatic tumor xenotransplantation, and had no obvious toxicity. eBEVs-Ola, as a safe and effective oral-administered drug delivery system, may provide a potential strategy for the maintenance treatment of patients non-BRCA mutations.
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Surfaces and Interfaces
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2026
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IF 6.3
Peihui Xu,Kaipeng Chen,Rongrong Li,Longjin Du,Binghong Chen,Jianzhong Liu
Addressing the inhibitory influence of the oxide layer on the ignition and combustion of aluminium particles stands as one of the pivotal factors in facilitating its utilisation as an amphibious fuel. In this investigation, leveraging the distinctive properties of oxalic acid (OA), which is prone to decomposition and gas generation and holds substantial optimisation potential, surface modification of aluminium particles was conducted in conjunction with boron and magnesium particles. Al-based amphibious energetic composites (AEC) were thereby synthesised. Subsequently, their thermal behaviour, ignition and combustion characteristics, and action mechanism were investigated. The results indicate that the thermal behaviour of AEC samples encompasses dehydration, decomposition, and oxidation stages under amphibious atmospheres (namely, air, water vapour, and their mixtures). The atmosphere exerts a minimal influence on the thermal behaviour. Additives can remarkably enhance the ignition and combustion performance of aluminium particles. Owing to the readily decomposable OA and magnesium oxalate (OM) adsorbed on its surface and the highly reactive Mg particles, the ignition delay time of AEC in amphibious atmospheres is shortened by approximately 45–67 ms. Nevertheless, OA and OM merely function in particle dispersion. Consequently, the oxidising atmosphere in the environment has a substantial impact on the combustion performance of AEC samples. When O₂ is preponderant, the surface reactions of B and Mg clusters on the surface of aluminium particles release heat, thereby facilitating the combustion (the maximum combustion temperature is increased by approximately 600 K). When H₂O is dominant, this combustion-promoting effect diminishes. During combustion, the formation of metal oxides with high melting and boiling points, such as MgO, impedes the contact between the core active metals and oxidising gases, thereby reducing the self-sustained combustion performance of AEC samples. This research will offer crucial insights for the development and application of amphibious metal fuels.
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International Journal of Biological Sciences
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2026
·Vol. 22
·期 1
·161-177
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IF 10
Huo Ran,Gu Chen-Zheng,Liu Yang,Wei Zi-Xian,Liu Te,Zhu Jie,Ding Lin,Liu Yu,Wang Chu-Yu,Li Yi-Ni,He Xin-Yi,Yang Wen-Jing,Wang Bei-Li,Wei Yun-Wei,Guo Wei
The mortality of hepatocellular carcinoma (HCC) is high. Plant-derived bioactive compounds have emerged as potential therapies for HCC. Procyanidin (PAC) has been shown to possess immune-modulating and anti-tumor properties. However, the role and mechanism of total PAC in treating HCC remain unclear. We established subcutaneous and orthotopic HCC mouse models to assess the effect of PAC on tumor growth. Multi-omics analyses and in vitro experiments were conducted to investigate the changes in the gut microbiota, related-metabolites, and the tumor microenvironment (TME). 16S rDNA sequencing revealed that PAC could reshape the gut microbiota, notably increasing Lactobacillus murinus abundance. Furthermore, transplantation of Lactobacillus murinus reduced tumor volumes in mice. Single-cell RNA sequencing showed upregulation of the MAPK pathway in B cells within the TME. Metabolomic analysis suggests that 5-Hydroxytryptophan (5-HTP) derived from Lactobacillus murinus was significantly increased in B cells from mesenteric lymph nodes (MLNs) in the PAC-treated group. In vitro experiments revealed that 5-HTP could significantly upregulate the MAPK pathway in B cells. Additionally, 5-HTP-educated B cells could activate IFN-γ+CD8+T cells through B cell-T cell interactions, indicating that 5-HTP is a key metabolite in the therapeutic effect of PAC. Finally, feeding 5-HTP to HCC mice reduced tumor volume, upregulated the MAPK pathway in B cells from MLNs, and activated IFN-γ+CD8+T cells in the TME. PAC reshapes the gut microbiota and metabolites, upregulates the MAPK pathway in B cells from MLNs, and activates CD8+T cells in the TME through the gut-liver axis, thereby inhibiting HCC progression.
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ACTA MATERIALIA
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2026
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IF 9.3
Sai Liu,Xiaopeng Hu,Guangsheng Chen,Shenxiang Luo,Yu Zou,Jinwei Guo,Wang Zhu
Despite their promise as candidates for thermal barrier coatings (TBCs), the engineering application of A 6 B 2 O 17 ( A = Hf, Zr; B = Ta, Nb) ceramics is currently limited by a lack of comprehensive understanding regarding their CMAS corrosion behavior and underlying mechanisms. This paper addresses this gap by elucidating the governing effects of compositional modulation and corrosion conditions on the CMAS corrosion performance of these ceramics, integrating experimental and first-principles theoretical approaches. The results demonstrate that while all compositions exhibit similar corrosion products and resistance mechanisms, A 6 Ta 2 O 17 (particularly Hf 6 Ta 2 O 17 ) displays superior corrosion resistance. This enhanced performance is attributed to a combination of factors, including its exceptional thermodynamic stability, reduced Ca 2+ diffusivity, the significant barrier effect of its dense corrosion product layer, and stronger interfacial bonding strength. Corrosion-induced spallation in Zr 6 B 2 O 17 primarily stems from two factors: the phase transformation of ZrO 2 and an inherently weak interfacial bonding strength. Moreover, while an elevated Ca/Si ratio increases the aggressiveness of CMAS melts, the formation of a dense corrosion product layer on the ceramic surface effectively mitigates this detrimental effect.
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Food Chemistry-X
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2026
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IF 9.2
Wenxin Chen,Jiahao Fu,Yaqi Liu,Yao Fan,Haiyan Fu,Yuanbin She
Ochratoxin B (OTB) that widely presented in food has significant cytotoxicity even at low concentration levels. Herein, a novel fluorescent sensor based on the 2-mercapto-5-benzimidazole carboxylic acid (MBI)-capped CdSe quantum dots (QDs) was established for the selective detection of OTB in food. Specifically, the synergistic effect of electrostatic interaction and intermolecular hydrogen bonds between MBI and OTB provided a direct and sensitive fluorescence signal that enables efficient recognition of OTB from other mycotoxins, even OTA with similar structures. Excellent linear detection performance for OTB is exhibited with a range from 0.037 ng/mL to 48.01 ng/mL and a detection limit of 0.016 ng/mL. Furthermore, our developed method exhibits good anti-interference stability against contaminants such as mycotoxins, inorganic salts and amino acids. Most importantly, the sensor demonstrates high sensitivity in real food samples with the recovery ranges from 96.51% to 104.7%, with an RSD of less than 2.67%.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Chunlin Chen,Zhikui Huang,Guoqing Xiao,Beibei Ren,Guirong Zhao,Shuang Qing,Ting Ma,Chunyan Chen,Chuanlin Mou
PDA@Fe was loaded onto BN surface, imparting abundant functional groups and enhancing carbonization performance. • High-phosphorus-content PA was grafted onto the BN/PDA@Fe surface to promote the cross-linking of the polymer into a char. • Co-Ni/B were uniformly loaded onto the BN/PDA@Fe surface to construct a hierarchical BN/PFPA@Co-Ni/B flame retardant. • The nano-reinforcing agent combines high P-N-B content with Fe, Co, Ni to achieve synergistic flame retardancy. Boron nitride (BN) is regarded as an effective nano-flame retardant due to its high thermal stability and thermal shielding effect. Here, Fe 3+ -doped polydopamine (PDA@Fe) was first immobilized on the BN surface to provide abundant functional groups and enhance its catalytic carbonization capability. Subsequently, high-phosphorus phytic acid (PA) and cobalt-nickel borate nanosheets (Co-Ni/B) were loaded onto the BN/PDA@Fe surface to prepare the BN/PFPA@Co-Ni/B composite flame-retardant material. Notably, this multi-level structured nano-reinforcer combines the synergistic flame-retardant effect of high P-N-B content with the highly efficient catalytic charring ability of multiple metal ions (Fe, Co, Ni). Notably, the BN/PFPA@Co-Ni/B/EP composite coating achieved the lowest back surface temperature (167.9 °C) and exhibited the highest expansion height (25.2 mm) and expansion ratio (19.69), demonstrating its excellent thermal insulation performance. Furthermore, the BN/PFPA@Co-Ni/B/EP composite coating exhibited the highest residual carbon content (29.9%) and the lowest smoke density (39.2%). This can be attributed to the strong catalytic pyrolysis effect of the multi-metal ions, which converts more pyrolysis intermediates into stable carbon, thereby increasing carbon residue while reducing smoke emissions. Microstructural analysis revealed a dense and intact carbon layer, providing strong support for its exceptional thermal protection performance. The successful preparation of this novel flame retardant, which combines high barrier properties, high phosphorus and nitrogen content, and multi-metal-catalyzed carbonization, offers a new approach for developing high-performance refractory coatings. Download: Download high-res image (430KB) Download: Download full-size image
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Zechang Liu,Meizhong Hu,Jiajun Zhang,Jie Yang,Lihui Zhang,Rensong Chen
This study developed a scalable synthesized rosette-like Co@NC-900 catalyst for the efficient degradation of Rhodamine B (RhB) via peroxymonosulfate (PMS) activation. The cobalt-organic precursor (Co-NDNP) was synthesized through a ligand-directed self-assembly strategy, followed by pyrolysis at 900℃, yielding the hierarchically porous Co@NC-900 catalyst. Comprehensive characterization revealed that this catalyst possesses a high specific surface area (659.76 m 2 /g), an abundance of mesopores, and numerous Co nanoparticles active sites, which collectively facilitate the uniform dispersion of Co nanoparticles and effectively mitigate metal leaching. During catalytic evaluation, the Co@NC-900/PMS system achieved > 90 % RhB degradation within 10 min, exhibiting a remarkably high apparent rate constant ( k obs ) of 0.0571 min −1 . Radical quenching experiments and electron paramagnetic resonance (EPR) analysis confirmed that singlet oxygen ( 1 O 2 ) served as the dominant reactive species, primarily generated via the Co 2+ /Co 3+ redox cycling kinetics on the Co nanoparticles. The system demonstrated exceptional degradation efficiency across a wide pH range (3−11), alongside robust tolerance to coexisting anions and humic acid. Degradation pathway analysis using high performance liquid chromatography-mass spectrometry (HPLC-MS) and three-dimensional excitation emission matrix fluorescence spectroscopy (3D EEM) spectroscopy elucidated the sequential breakdown of RhB through N-demethylation, ring cleavage, and mineralization. Furthermore, Ecological structure activity relationships (ECOSAR) modeling confirmed a significant reduction in the ecotoxicity of the final products. This research offers a valuable framework for designing stable and highly efficient catalysts for PMS activation.
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EUROPEAN POLYMER JOURNAL
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2026
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IF 6.8
Xiuyan Guo,Yufei Cao,Ling Sun,Yuhan Wang,Xiaohui Liu,Yuanlin Ren,Yuesheng Li
Developing high-performance epoxy resins (EP) that integrate outstanding flame retardancy, mechanical reinforcement and optical transparency is a persistent challenge, often hindered by the detrimental effects of conventional additives. Herein, a novel hyperbranched polymeric flame retardant (HPBAE) containing phosphorus and borate ester moieties was synthesized from boric acid, ethanolamine and phenylphosphonic dichloride. Remarkably, incorporation of merely 2 wt% HPBAE substantially boosted the flammability resistance of resin to the UL-94 V-0 rating with 32.9% limiting oxygen index (LOI) and a 23.4% suppression in the peak heat release rate (PHRR). The superior flame retardancy arises from dual-phase action: condensed-phase formation of a P/B-rich thermal barrier char and gas-phase release of phosphorus radicals that quench H · /HO · combustion intermediates. Relative to pure EP, the EP/HPBAE-2 exhibited a 57.9% enhancement in tensile strength while retaining the optical transparency. The synergistic effects imparted by HPBAE not only provide a balanced property profile but also offer a viable design paradigm for developing high-performance, transparent and flame-retardant epoxy composites.
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OPTICAL MATERIALS
·
2023
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IF 3.9
Zhuofan Han,Dengjie Zhong,Yunlan Xu,Haixing Chang,Yi Liu,Lin Dong,Nianbing Zhong
In this research, MIL-53(Fe)@BiOBr/TCN/Ti photoanode was created using the secondary silica sol drop coating method, and assembled with Cu cathode to form photocatalytic fuel cell (PFC) to degrade rhodamine B and generate electricity. The resulting PFC has high visible light response and photocatalytic activity . It has a rhodamine B degradation efficiency of 92.19%, a maximum power density of 6.2 μW cm −2 , and a maximum photocurrent density of 0.11 mA cm −2 . Its strong photocatalysis capabilities benefits from the wider light absorption range and lower charge carrier recombination rate of the photoanode. The double Z-scheme heterojunction formed among BiOBr, MIL-53(Fe) and TCN in the composite catalyst of the photoanode provide more transfer channels for photogenerated e − and encourage the separation of e − -h + pairs. ∙OH and ∙O - 2 are the main active substances for rhodamine B degradation. This study offers a novel approach to the development of high-efficiency photoanodes for PFC.
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RSC Advances
·
2023
·Vol. 13
·期 11
·7392-7401
·
IF 3.9
Jun Zhang,Xuxu Wei,Zifan Zhang,Caixia Yuan,Ting Huo,Fangfang Niu,Xiaoyu Lin,Chunli Liu,Hui Li,Zhenbin Chen
A magnetic chitosan/TiO2 composite material (MCT) was developed. MCT was successfully synthesized by a one-pot method using chitosan, TiO2, and Fe3O4. The absorption equilibrium time of MCT was 40 min in absorbing vanadium(V), the optimal adsorption pH was 4, and the maximum adsorption capacity of vanadium(V) was 117.1 mg g−1. The spent MCT was applied to photocatalytic reactions for reutilization. The decolorization rates for the degradation of rhodamine B (RhB) by new and spent MCT were 86.4% and 94.3%, respectively. The new and spent MCT exhibited absorption bands at 397 and 455 nm, respectively, which showed that the spent MCT was red-shifted to the cyan light region. These results indicated that the forbidden band widths of the new and spent MCT were about 3.12 and 2.72 eV, respectively. The mechanism of the degradation reaction showed that the hydroxyl radicals as oxidants in the spent MCT mediated the photocatalytic degradation of RhB. In addition, the superoxide anion radical formation of hydroxyl radicals was the main reaction, and the hole generation of hydroxyl radicals was the subordinate reaction. The N-de-ethylated intermediates and organic acids were monitored by MS and HPLC.
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