DESALINATION
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2022
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IF 11.211
Jie Liu,Yewei Wang,Zhuo Li,Xin Liu,Weiyi Li
Scaling of sparingly soluble salts is a challenge standing in the way of enhancing water recovery of desalination via an approach based on membrane distillation (MD). Improvement of anti-scaling strategies is dependent on understanding various mechanisms accounting for evolution of the scaling layer. This study made efforts to address a fundamental concern as to how bulk precipitation is competing with surface growth to form a layer of crystalline particles in the process of MD. When concentrating a feed containing calcium sulfate , scaling was induced in a series of MD processes with a varied transmembrane temperature difference. In addition to the measurements of flux decline and electrical conductivity , optical coherence tomography (OCT) was explored to simultaneously monitor the formation of crystals in the feed bulk and resolve the scaling layer evolving on the membrane surface . Comparison of these characterization results revealed the key role of surface growth in initiating the scaling, while suggesting that the cake development could be gradually dominated by the deposition of crystals formed in the feed bulk. A further analysis of the local growth rates provided deeper insights into the mechanistic transition; effects of varying the degree of supersaturation were also discussed in the context of redistributing the size of deposits and inducing the crystal-membrane interactions. This study refines the picture of developing a scaling layer in MD, which would be of great value in advancing applications of MD-based desalination.
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ACS Applied Bio Materials
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2022
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IF 0
Hean Zhang,Rui Peng,Yufeng Luo,Qianling Cui,Fang Gong,Lidong Li
In this work, ultrasmall gold nanoclusters (AuNCs) have been in situ synthesized in nanopores of covalent organic framework (COF) nanoparticles, which exhibited enhanced fluorescence, improved photosensitizing capabilities, and promising antibacterial performance. A small organic molecule, 1-vinylimidazole (Vim), was diffused into the nanopores of imine-based COFs and served as a reducing agent and capping ligand for the in situ synthesis of ultrasmall AuNCs. The as-obtained AuNCs were homogeneously distributed throughout the COF nanoparticles whose fluorescence intensity was enhanced remarkably. Due to the efficient electron transfer between AuNCs and COFs and increased separation of photogenerated electron–hole pairs, the light-triggered reactive oxygen species (ROS) production of COFs was prominently enhanced by AuNCs. Moreover, the obtained nanocomposites exhibited an efficient photodynamic killing behavior on Escherichia coli under visible light exposure. Thus, we provide a facile strategy to prepare COF/AuNC nanocomposites for ROS-related applications.
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CATALYSIS TODAY
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2022
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IF 6.562
Lidan Deng,Qiao Chen,Xingmao Jiang,Xiaowei Liu,Zheng Wang
Propane dehydrogenation is a promising way to produce propylene . Catalysts with high propane conversion, selectivity to propylene , and stability are vital to this technology. In this work, we determined that the catalytic performance of Pt/SBA-15 can be significantly enhanced by introducing an appropriate amount of indium . A too low ratio of In/Pt (1/8) or too high of a ratio (2/1) is detrimental to the activity of the catalyst. When the nominal ratio of Pt to In is 1/1, the initial propane conversion and selectivity towards propylene over 1Pt1In/SBA-15 are highest among all catalysts tested at 57.06 % and 99.04 %, respectively. The conversion rate decreased to 39.63 % after 28 h of reaction, but selectivity was retained at greater than 99 %. Very little coke was deposited on the used 1Pt1In/SBA-15 catalyst. With catalyst characterization, it was proposed that Pt 1 In 1 alloy nanoparticles with surface-enriched In 2 O 3 were responsible for the selective dehydrogenation of propane.
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APPLIED SURFACE SCIENCE
·
2022
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IF 7.392
Li Sun,Yuanyuan Diao,Yuejin Shan,Yuan Zhi,Hua Zhang,Binlin Dou,Weijia Huang
Based on a normal copper wire, an effective photocatalyst (ACW) for the 4-nitrophenol (4-NP) reduction is successfully synthesized by an in-situ redox method. The constitution of ACW is similar to “ants on a tree”, i.e., dense Au and Cu nanoparticles (NPs) are loaded on the copper wire surface covered by submicro-sized Cu cubes. Employing ACW as photocatalyst, the conversion efficiency of 4-NP can achieve to 100% at 2.5 min and the rate constant for the 4-NP reduction can reach up to 1.45 min −1 . Moreover, ACW exhibits satisfactory reusability for 25 cycles and stability in 12 months. These excellent performance can be attributed to the synergistic effect of Au NPs, Cu NPs and the Cu wire surface covered with submicro-sized cubes. Clearly, the above in-situ redox method provides a facile route to prepare metal NPs-supported bulk photocatalysts. Meanwhile, as-synthesized ACW can be a promising photocatalyst candidate for the practical treatment of 4-NP.
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Polymers
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2022
·Vol. 14
·期 12
·2410
·
IF 4.967
Guoliang Ma,Zhiming Zheng,Han Wang,Li Wang,Genhai Zhao,Hengfang Tang,Xiumin Ding,Peng Wang
Nutritional food supplements and pharmaceutical products produced with vitamin K2as raw materials a very promising market in the global scope. The main production method of vitamin K2is microbial fermentation, but approximately 50% of vitamin K2synthesized by the main production strainBacillus subtilis nattoexists in extracellular form, which is not easy to separate and extract. In order to solve this problem, in this study, we synthesized a novel cellulose flocculant, MCC-g-LMA, by grafting reaction using microcrystalline cellulose (MCC) and lauryl methacrylate (LMA) as monomers, and ammonium persulfate as an initiator to flocculate VK2from the fermentation supernatant. The flocculant was characterized by Fourier transform infrared spectroscopy (FTIR), elemental analysis, and scanning electron microscopy (SEM), and the grafting reaction was successful. When the flocculant dosage was 48.0 mg/L and pH was 5.0, the flocculation rate of the MCC-g-LMA on the fermentation supernatant reached 85.3%, and the enrichment rate of VK2reached 90.0%. Furthermore, we explored the flocculation mechanism of VK2by the MCC-g-LMA and speculated that the flocculation mechanism mainly included adsorption bridging, hydrophobic association and net trapping and sweep effect. In this study, the extraction method for trace high-value biological products in the fermentation supernatant was improved, which provided a method and theoretical basis for the efficient separation and purification of VK2and other terpenoids.Keywords:cellulose;flocculant;Bacillus subtilis nattofermentation supernatant;vitamin K2
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高影响因子
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
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2022
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IF 7.926
Amina,Qumber Abbas,Awais Shakoor,Mu Naushad,Balal Yousaf
Calcium peroxide (CaO₂) and persulfate (PS) dual oxidant system is an innovative in-situ chemical oxidation (ISCO) technique for the restoration of contaminated groundwater. Several field applications also confirm its efficacy in remediating the groundwater, however, published articles are rarely present. In this work, the performance of the CaO₂/PS system was examined for the degradation of sulfamethoxazole (SMX) in the SMX polluted soil and water. Results indicated that SMX could be efficiently degraded with CaO₂ and PS (2 g/L dosages for each oxidant) around neutral pH (7), and 95.8% pollutant removed after 36 h of reaction time. The removal efficiency of SMX improved as the concentrations of CaO₂ and PS were increased. Moreover, SMX removal was significantly decreased with the increase of initial solution pH. This dual oxidant system at 30 °C was also used for the remediation of SMX (10 mg/kg) spiked soil. Soil degradation experiment was performed at 150 rpm of shaking speed using soil slurry (soil/water; 1/1 ratio) at pH 7. Dual oxidant dosage was kept at 2 g/L CaO₂ and 2 g/L PS. The results showed that this dual oxidant system is also very efficient for the antibiotics SMX degradation in the soil system. Overall, an insight knowledge and practical information gained from this work will help in the treatment of SMX contaminated soil and water as well as wastewater with CaO₂/PS dual oxidant system.
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Nanomaterials
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2022
·Vol. 12
·期 12
·2072
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IF 5.719
Tsogzolmaa Ganbold,Qingming Bao,Hai Xiao,Dolgorsuren Zurgaanjin,Caifeng Liu,Shuqin Han,Agula Hasi,Huricha Baigude
Ischemic stroke activates toll-like receptor 4 (TLR4) signaling, resulting in proinflammatory polarization of microglia and secondary neuronal damage. Herein, we report a novel lipid-nanoparticle (LNP)-mediated knockdown of TLR4 in microglia and amelioration of neuroinflammation in a mouse model of transient middle cerebral artery occlusion (tMCAO). siRNA against TLR4 (siTLR4) complexed to the novel LNP (siTLR4/DoGo310), which was based on a dioleoyl-conjugated short peptidomimetic (denote DoGo310), was readily internalized by the oxygen–glucose-deprived (OGD) mouse primary microglia, knocked-down TLR4, and polarized the cell to the anti-inflammatory phenotype in vitro. Systemic administration of siTLR4/DoGo310 LNPs in the tMCAO mice model resulted in the accumulation of siRNA mainly in the Iba1 positive cells in the peri-infarct. Analysis of the peri-infarct brain tissue revealed that a single injection of siTLR4/DoGo310 LNPs led to significant knockdown of TLR4 gene expression, reversing the pattern of cytokines expression, and improving the neurological functions in tMCAO model mice. Our data demonstrate that DoGo310 LNPs could be a promising nanocarrier for CNS-targeted siRNA delivery for the treatment of CNS disorders.Keywords:lipid nanoparticles;siRNA delivery;microglia;neuroinflammation;stroke
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高影响因子
CELL AND TISSUE RESEARCH
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2022
·Vol. 390
·期 2
·293-313
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IF 4.051
Li Zhen-Fang,Hao Shuang-Li,Wang Lan-Min,Qi Hong-Yu,Wang Jia-Ming,Tan Fu-Qing,Yang Wan-Xi
Spermatogenesis is a finely regulated process of germ cell proliferation and differentiation that leads to the production of sperm in seminiferous tubules. Although the mammalian target of rapamycin (mTOR) signaling pathway is crucial for spermatogenesis in mammals, its functions and molecular mechanisms in spermatogenesis remain largely unknown in nonmammalian species, particularly in Crustacea. In this study, we first identified es-Raptor (the core component of mTOR complex 1) and es-Rictor (the core component of mTOR complex 2) from the testis of Eriocheir sinensis . Dynamic localization of es-Raptor and es-Rictor implied that these proteins were indispensable for the spermatogenesis of E. sinensis. Furthermore, es-Raptor and es-Rictor knockdown results showed that the mature sperm failed to be released, causing almost empty lumens in the testis. We investigated the reasons for these effects and found that the actin-based cytoskeleton was disrupted in the knockdown groups. In addition, the integrity of the testis barrier (similar to the blood-testis barrier in mammals) was impaired and affected the expression of cell junction proteins. Further study revealed that es-Raptor and es-Rictor may regulate spermatogenesis via both mTORC1- and mTORC2-dependent mechanisms that involve es-rpS6 and es-Akt/es-PKC, respectively. Moreover, to explore the testis barrier in E. sinensis , we established a cadmium chloride (CdCl 2 )–induced testis barrier damage model as a positive control. Morphological and immunofluorescence results were similar to those of the es-Raptor and es-Rictor knockdown groups. Altogether, es-Raptor and es-Rictor were important for spermatogenesis through maintenance of the actin filament network and cell junctions in E. sinensis.
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CHEMICO-BIOLOGICAL INTERACTIONS
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2022
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IF 5.168
Kaichao Song,Liping Zhou,Cuicui Wang,Zhixin Yuan,Qilong Cao,Xianggen Wu,Mengshuang Li
A novel nanoformulation with the small molecule phytochemical dipotassium glycyrrhizinate as a nanomaterial was developed for the oral delivery of luteolin (Lut), a widely used phytochemical, but it suffered from poor water solubility and low oral bioavailability . This novel nanoformulation, named [email protected] , can be fabricated with a simple process. [email protected] can instantly dissolve into aqueous mediums and formulate through self-assembly a clear phytomicelle solution with a Lut encapsulation efficiency of 99.16 ± 0.90%, a small micelle size of 30.32 ± 0.12 nm , and a narrow polydispersity index of 0.138 ± 0.024. The optimized formulation demonstrated that Lut had solubility in up to 50 mg/ml of water as a result of its encapsulation within DG phytomicelles. [email protected] exhibited excellent characteristics, including good storage stability, a fast in vitro release profile, improvement in in vitro antioxidant activity , and high safety potential. In the oral bioavailability evaluation, a shorter Tmax, increased Cmax, and improved AUC0-t were obtained with [email protected] when compared to bare Lut. The distribution evaluation further showed that [email protected] could effectively increase the concentrations of Lut in all the tested organs and gastrointestinal segments. In the protection efficacy evaluation, 100 mg/kg [email protected] demonstrated strong effects against acetaminophen-induced hepatotoxicity. The mechanisms of inhibiting high-mobility group box 1 signaling and suppressing oxidative stress were involved in this strong treatment effect. These results showed that simple but novel Lut [email protected] provided a new, promising nano-delivery system for Lut with a significantly improved in vivo profile.
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高影响因子
NEUROPHARMACOLOGY
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2022
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IF 5.273
Ji Chuan Zhou,Jian Bo Jiang,Han Guo,Su Rong Yang,Chun Feng Liu,Wei Min Qu,Zhi Li Huang,Feng Fei Ding
Both human and rodent studies suggest the link between non-rapid eye movement (NREM) sleep and cognition. Recent study indicated that selective activation of cholinergic neurons in basal forebrain inhibits electroencephalogram (EEG) delta power and shortens NREM sleep. In the current study, we aimed to test the pharmacological effect of trihexyphenidyl (THP), a selective muscarinic M1 receptor antagonist, on EEG power spectra and sleep with or without the selective activation of basal forebrain cholinergic neurons. THP (1, 2, and 3 mg/kg) was administrated intraperitoneally in natural sleep phase. Basal forebrain cholinergic neurons expressing modified G protein-coupled muscarinic receptors (hM3Dq) were activated by intraperitoneal injection of clozapine- N -oxide in ChAT-IRES-Cre mice. EEG and electromyogram (EMG) signals were recorded in freely moving mice to analyze EEG power spectrum and sleep hypnogram. Y-maze and novel object recognition tests were used for testing cognition. THP 1 mg/kg significantly increased EEG delta power and facilitated NREM sleep in wildtype mice, while THP 3 mg/kg was required in ChAT-IRES-Cre mice treated with clozapine- N -oxide. THP with dosage up to 8 mg/kg did not induce cognitive impairments in wildtype mice. EEG delta power of NREM sleep is often used as an indicator of sleep depth or sleep quality, which tightly link with sleep-dependent cognition. Taken together, the data collected from rodents hinted that, THP could possibly be used as the NREM sleep facilitator in humans.
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APPLIED SURFACE SCIENCE
·
2021
·
IF 6.707
Tao Ke,Shuyi Shen,Kun Yang,Daohui Lin
Developing visible-light-driven photocatalysts with high charge separation and transfer efficiency to degrade organic pollutants in wastewater remains a major issue. In this work, quaternary Bi 2 O 3 /C 3 N 4 /TiO 2 @C (BCTC) hybrids were successfully fabricated by hydrothermal and calcination two-step method using Bi(NO 3 ) 3 ·5H 2 O, C 3 N 4 , and Ti 3 C 2 as precursors. The optimized BCTC hybrids with the dosage of 1 g L −1 (BCTC-2%) exhibited high photocatalytic activity, degrading 100% sulfamethoxazole (SMZ, 5 mg L −1 ) within 100 min under visible light irradiation. Moreover, the photocatalytic degradation rate of SMZ by the quaternary junction was found to be 5.12-, 2.87-, and 1.35-fold higher as compared with Bi 2 O 3 /C 3 N 4 , C 3 N 4 /TiO 2 @C, and Bi 2 O 3 /TiO 2 @C junctions, respectively. The enhanced photocatalytic performance of BCTC hybrids could be attributed to the formation of a double Z-scheme photocatalytic system and the photosensitization of Bi 2 O 3 and C 3 N 4 . The photogenerated hole (h + ) was the primary reactive species that degraded SMZ. The plausible intermediates during the photocatalytic degradation of SMZ were identified by high-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry and the degradation pathway was postulated. Importantly, BCTC-2% had a good photocatalytic activity for degrading SMZ in natural water samples, indicating the high potential of BCTC hybrids for wastewater treatment applications.
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CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Xiaolin Luo,Zhenggang Gong,Guangxu Yang,Liulian Huang,Lihui Chen,Li Shuai
Practical, high-yield conversion of lignocellulosic biomass to bulk chemicals is the goal of a profitable biorefinery. However, the development of current biorefining industries is highly restricted by process complexity and processing cost. In this article, we developed a one-pot oxidative process and a one-pot reductive process that allowed selective conversion of lignocellulosic biomass (e.g. hardwood) to multiple bulk chemicals such as monophenolics, diols, and organic acids in total yields of up to 96.8 wt%. Alkali was used to catalyze the disruption of biomass components via retro -aldol reactions to small active intermediate molecules, which were in-situ oxidized or reduced to stable products. As a result, monophenolics, which were derived from lignin, reached an unprecedented yield of 59.3 wt% (71.9 mol%, on the basis of lignin content). Organic acids also reached an unprecedented yield of 111.7 wt% (77.8 C%, on the basis of polysaccharide content). The diverse chemicals could meet broad needs of our society. Cost analysis indicates that the current processes could be profitable in the petrochemical-dominated market.
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危险品化学品经营许可证（带存储）