INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2022
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IF 6.51
Xiaoying Wang,Yaling Zheng,Liangzhen Qiu,Huizhi Ouyang,Xueya Xu,Wen Xu,Yuqin Zhang,Wei Xu
D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS)-modified carboxymethyl chitosan-rhein (TCR) polymeric micelles (PMs) self-assembled by TCR conjugate were constructed for oral delivery of paclitaxel (PTX). PTX-loaded TCR PMs with a drug loading capacity of 47.52 ± 1.65 % significantly improved the intestinal absorption and oral bioavailability of PTX. TCR PMs loaded with PTX displayed time- and concentration-dependent cytotoxicity in Caco-2, MCF-7 and Taxol-resistant MCF-7 (MCF-7/Taxol) cells. In MCF-7/Taxol cells, PTX-loaded TCR PMs promoted apoptosis and changed cell cycle, and TCR conjugate exhibited a P-gp inhibition ability and caused ATP depletion. Moreover, confocal imaging of intestinal sections, Caco-2 cell uptake assay and in vivo bioimaging using environmental response fluorescence probe suggested that TCR PMs loaded with drugs can be absorbed as a whole through the intestinal epithelium after oral administration, enter systemic circulation, and then get to the tumor site. Remarkably, PTX-loaded TCR PMs displayed a significant antitumor effect in H22 tumor xenograft mice and the MCF-7 or MCF-7/Taxol xenograft zebrafish model, which was related to the inhibitory function of TCR conjugate for P-gp activity and P-gp and MDR1 expression. Functionalized TCR PMs are expected to improve the oral therapeutic efficacy of poorly water-soluble antitumor drugs and treat drug-resistant tumors.
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MICROCHEMICAL JOURNAL
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2022
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IF 5.304
Siyi Li,Die Gao,Jing Lin,Zeng Wen,Kailian Zhang,Zhining Xia,Dandan Wang
A double-network hydrogel was prepared with the chitosan-cellulose composite as the rigid network and polyacrylamide as the flexible network (abbreviated as CCP hydrogel). A deep eutectic solvent synthesized by choline chloride and malic acid was used as the assistant solvent to dissolve cellulose for preparation of the CCP hydrogel. The obtained CCP hydrogel was characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, thermal gravimetric analysis, and stress-strain test. The properties of the CCP hydrogel are obviously better than those of the single network hydrogel. The compressive strength of CCP hydrogel is 2.8 times that of the chitosan-cellulose single network hydrogel. The CCP hydrogel exhibits the favorable swelling performance (swelling ratio of 955 %–1377 %), water-locking ability (water retention value of 40 %), and stability in aqueous system. Moreover, the CCP hydrogel performs the excellent adsorption capacity, fast adsorption efficiency, and good selective towards tetracyclines. The effects of temperature and solution pH on the adsorption properties of CCP hydrogel were assessed. The Langmuir, Freundlich, pseudo-first-order, pseudo-second-order, and thermodynamic models were applied to explore the adsorption characteristics of CCP hydrogel. After multiple adsorption/desorption cycles, the CCP hydrogel still maintains 84.3 %–93.4 % of adsorption capacity. Finally, the CCP hydrogel combined with ultra-performance liquid chromatography-mass spectrometry were used to analyze tetracyclines in food samples. The tetracycline (0.14 μg/mL) and minocycline (0.080 μg/mL) in milk, tetracycline (0.082 μg/mL) and minocycline (0.089 μg/mL) in fish, and tetracycline (0.078 μg/mL) and demeclocycline (0.10 μg/mL) in chicken were detected by CCP-hydrogel method with a high accuracy (recoveries of 75.82 %–108.8 %). Furthermore, for comparison with the CCP-hydrogel method, the traditional precipitation method was also applied to detect the tetracyclines in foods. The CCP-hydrogel method possesses a higher accuracy than traditional method, and can more accurately and satisfactorily detect tetracyclines in foods.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Yumin Wu,Ying Ma,Yiliang Gao,Yuetao Liu,Chuanhui Gao
A poly (lactic acid) (PLA) -based functional partition composite membrane (PLA/CA) containing chitosan (CS) and alizarin (AL) was designed by solution casting method. The PLA/CA membrane contains the antibacterial zone of the edge part (PLA/CS) and the pH response detection zone of the central part (PLA/AL). At the same time, the environmentally friendly plasticizer tributyl citrate (TBC) was added to make the prepared PLA/CA composite membrane have good flexibility and high transparency. The results of FE-SEM and FTIR showed that CS and AL were uniformly dispersed in PLA matrix and had good compatibility with PLA. The antioxidant activities of PLA/CS and PLA/AL composite films were 43.3 % and 72.8 %, respectively. At the same time, the inhibitory rates of PLA/CS membrane against Escherichia coli and Staphylococcus aureus were as high as 87.91 % and 75.17 %, respectively. PLA/AL films exhibit excellent UV barrier properties. When the environmental pH (ammonia and acetic acid vapor) changed repeatedly, the PLA/AL membrane showed reversible color change of yellow under acidic condition and purple under alkaline condition. During the packaging and storage of chicken breast meat, the freshness of chicken breast meat can be detected by the color change of functional PLA/CA composite membrane.
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Polymer-Plastics Technology and Materials
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2022
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IF 2.439
Yuxian Su,Teng Li,Yingyan Mao,Li Liu,Shipeng Wen
Natural rubber (NR) latex gloves serve as a very important barrier protection for health care workers. It is of great significance to study the barrier and antibacterial properties of NR latex products. Herein, a small amount of graphene oxide (GO) with in situ grown silver (Ag) nanoparticles was self-assembled in the NR latex by carboxymethyl chitosan (CMCS) as a cross-linking agent to form a novel NR/GO-Ag-CMCS composite with three-dimensional filler networks. The filler networks in the NR/GO-Ag-CMCS composite were formed by a strong interfacial interaction between NR macromolecules and GO-Ag-CMCS hybrids. The tensile strength and tear strength of NR/GO-Ag-CMCS composite were higher than those of pure NR film. With the increase of GO content, the filler network of NR/GO-Ag-CMCS film tended to be more complete and its barrier was stronger. Moreover, the NR/GO-Ag-CMCS composite showed excellent antibacterial performance against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The minimal inhibitory concentration values of GO-Ag-CMCS hybrid to E. coli and S. aureus were 8 and 16 μg/mL, respectively. For the NR/GO-Ag-CMCS composite with 0.1 phr GO, the diameters of its inhibition zone were 15.6 mm for E. coli and 13.6 mm for S. aureus.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Xiya Yang,Lingyuan Chen,Dong Ren,Shixing Wang,Zhaogang Ren
An O -hydroxyphenyl thiourea-modified chitosan ( OTCS ) with excellent Pb(II) adsorption performance and selectivity was prepared as an adsorbent. The structure and morphology of the adsorbent were systematically investigated by SEM, BET, FTIR, EDX , zeta-potential measurements, XPS and XRD. The impacts of the initial Pb(II) concentration, reaction time, temperature, pH value, and coexisting ions were explored. At pH 7 and 303 K, the maximal adsorption capacity of OTCS for Pb(II) was 208.33 mg/g, which was greater than those of other adsorbing materials reported in the literature. The metal ion adsorption kinetics and isotherm models were found to obey pseudo-second-order kinetics and the Langmuir isothermal model, indicating that the adsorption process was monolayer chemisorption. The adsorption process could proceed spontaneously, and the thermodynamic results revealed that the adsorption mechanism was an endothermic reaction. The ion exchange and chelation between the sulfur, nitrogen and oxygen groups on the adsorbent and lead ions endowed the material with excellent adsorption properties. Significantly, OTCS showed excellent selectivity toward Pb(II). Therefore, the adsorbent OTCS is expected to promote the wider application of chitosan in the adsorption of Pb(II).
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SEPARATION AND PURIFICATION TECHNOLOGY
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2022
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IF 9.136
Youcai Hu,Jianhua Ding,Guangyuan Ren,Tianxiang Jin,Zhirong Liu,Yong Qian
Efficient separation and enrichment of thorium from aqueous solutions is an important subject in the field of energy and ecological environment. In this study, a novel polymer-based xerogel was prepared by a crosslinking reaction of 2-carboxyethyl phosphonic acid functionalized chitosan(CCS-TCEP) and was applied to the adsorption of Th(IV) ions. The maximum adsorption capacity of CCS-TCEP could reach 311.6 mg/g with an excellent selectivity due to the abundant binding sites for thorium provided by TCEP. Moreover, this material has a high adsorption rate and the adsorption equilibrium could be reached within 60 min. After 5 cycles of reuse, the adsorption capacity of CCS-TCEP still retained more than 80 % of its initial value. Furthermore, the extraction mechanism of CCS-TCEP for Th(IV) ions was also analyzed in detail by FT-IR, XPS and DFT calculation. This study indicates that CCS-TCEP can be used as a potential adsorbent for efficient extraction of thorium from aqueous waste.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Yalei Liu,Jie Mao,Zhiyong Guo,Yufang Hu,Sui Wang
Hydrogel materials are gradually increasing research in biological aspects due to their unique properties. In order to prepare hydrogels with the potential to be used in clinical wound therapy, the authors prepared a bifunctional hydrogel with antibacterial and self-healing properties. The hydrogel was composed of borax cross-linked polyvinyl alcohol (PVA) and carboxymethyl chitosan (CMCS), which realizes self-healing between polymers through hydrogen bonds and borate ester bonds. The double cross-linking of hydrogen bonds and borate ester bonds also endows the hydrogel with better mechanical properties (toughness and tensile stress can reach 22.30 MJ/m 3 and 70.35 KPa, respectively). On this basis, adding highly stable silver nanoparticles (AgNPs) to the hydrogel can effectively inhibit the growth of E. coli and S. aureus . This idea provides the possibility for the application of hydrogels in the process of biological wound healing.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2021
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IF 6.953
Dongyan Shen,Qiaobin Hu,Jing Sun,Xinyi Pang,Xiangfei Li,Yingjian Lu
We incorporated oxidized dextran (Odex) into nanoparticles composed of gallic acid-modified chitosan (GA-CS) and sodium caseinate (NaCas). The mass ratio of GA-CS to NaCas and the pH of the reaction solution were optimized to obtain nanoparticles with excellent performance and stability. The interactions among various nanomaterials were confirmed by Fourier-transform infrared spectroscopy (FT-IR) and fluorescence spectrometer. The optimized complex nanoparticles had a diameter of approximately 131.2 nm with a polydispersity index (PDI) of 0.14, and a zeta potential of 26.2 mV. Our results showed that Odex enhanced the stability and function of GA-CS/NaCas nanoparticles (NP). At a curcumin loading of 10%, the encapsulation efficiency of Odex-crosslinked GA-CS/NaCas (NP (Odex)) was 96.2%, whereas that for uncrosslinked nanoparticles was 66.9%. Compared to the burst release profile of free curcumin in simulated GI fluids, the sustained release profile of encapsulated curcumin was observed. Radical-scavenging assays confirmed that the nanoparticles had excellent antioxidant activity themselves due to the grafting of phenolic acid on chitosan backbone. Overall, NP (Odex) with good GI stability and antioxidant activity hold promising for the oral delivery of hydrophobic bioactives.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2021
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IF 7.312
Jian Chen,Jinbo Ouyang,Weixin Lai,Xiaohong Xing,Limin Zhou,Zhirong Liu,Wenqian Chen,Di Cai
A novel non-template method was used to prepare ultralight composite aerogel globules that were exploited for the removal of anti-inflammatory drug ketoprofen (KTP) from aqueous solution. The composite aerogel globules were synthesized by freeze-drying and characterized with FESEM, BET, FTIR, XRD and Zeta potential. Swelling behavior of these aerogel globules was strongly affected by the solution pH. The results showed that the presence of 10% activated biochar (ABC) in chitosan (CS), which was named CS-ABC2, was the most desirable aerogel globules as it had high mechanical property and remarkable sorption performance. The sorption kinetics and isotherms of KTP onto composite aerogel globules were studied in detail. In addition, the effects of ion strength and regeneration on sorption performance were investigated, indicating decent environment tolerance, complete recovery rate and excellent reusability of the composite aerogel globules. The composite aerogel globules also exhibited other outstanding advantages such as biodegradability, economy and ease of separation.
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Royal Society Open Science
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2021
·Vol. 8
·期 9
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IF 2.963
Bingxian Lin,Kaiming Liu,Yunren Qiu
Polysulfone (PSF) works potentially in haemodialysis due to its great mechanical and chemical stability, but performs poorly in haemocompatibility. For promoting the unpleasant haemocompatibility, sulfonated citric chitosan (SCACS) with the structure and groups similar to heparin was primarily synthesized by acylation and sulfonation. Furthermore, the chloroacylated PSF was pretreated by electrophilic chloroacetyl chloride to achieve more active sites for further reaction; the following membranes underwent the amination and were named amination polysulfone (AMPSF) membranes. Moreover, SCACS with abundant carboxyl and sulfonic groups was covalently grafted at the surface of pretreated PSF membranes, called PSF-SCACS membranes. The PSF-SCACS membranes were successfully synthesized and characterized by 1H NMR, ATR-FTIR and XPS. In addition, the water contact angle of PSF-SCACS membranes decreased by 47° and the morphologies of the membranes changed little compared with the unmodified PSF membranes. The haemocompatible testing results, including protein adsorption, platelet adhesion, haemolysis rate, plasma recalcification time, activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT), demonstrated that the PSF-SCACS membranes possessed excellent haemocompatible performances, and SCACS played an important role in the modification.
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DESALINATION
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2021
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IF 9.501
Yuxuan Zheng,Yuhua Gao,Haihua Li,Meifang Yan,Junping Zhao,Zhenfa Liu
A biodegradable and non-phosphorus chitosan derivative (CTS-AA-PSI) was synthesized with chitosan, acrylic acid and polysuccinimide, which can be used as a new environmentally friendly scale and corrosion inhibitor . The structure of CTS-AA-PSI was confirmed by FTIR , 1 H NMR and 13 C NMR. The CTS-AA-PSI showed outstanding scale inhibition performance with a scale inhibition rate of 87.96% at the concentration of 25 mg/L. The electrochemical impedance results indicated that CTS-AA-PSI showed a significant corrosion inhibition effect in a 3.5% NaCl solution with a corrosion inhibition rate of 71.17% when the dosage was 500 mg/L. In addition, the biodegradability experiment showed that its degradation rate was 72.32% on the 28th day. It was demonstrated that the CTS-AA-PSI is a readily biodegradable material . The possible scale inhibition mechanism was explored by SEM, XRD , XPS and EEM. The results indicated that the excellent scale inhibition performance of CTS-AA-PSI was related to its chelating and lattice-distortion ability, which inhibited the formation and precipitation of CaCO 3 crystal. These findings suggest that CTS-AA-PSI is a quite promising candidate for an environmentally friendly scale and corrosion inhibitor.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2021
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IF 6.953
Wanwen Kang,Jiacheng Liang,Ting Liu,Hui Long,Langhuan Huang,Qingshan Shi,Jingxian Zhang,Suiping Deng,Shaozao Tan
We synthesized a temperature-sensitive antibacterial hydrogel, defined as NIPAM-CG/GM hydrogel. First, vinyl carboxymethyl chitosan (CG) was synthesized as a crosslinking carrier and silane dispersed graphene (GM) was synthesized as a reinforcer. Then, the N-isopropylacrylamide (NIPAM) monomer was free-radical polymerized with the vinyl groups of CG and GM to form a NIPAM-CG/GM hydrogel without any crosslinking agent. The influences of different hydrogel compositions on the microstructure, compressive properties, swelling, drug loading, and drug release properties of the hydrogels were discussed, and its temperature sensitivity was also demonstrated. The results showed that the lower critical solution temperature (LCST) and mechanical properties of the hydrogel could be adjusted by controlling the amount of CG and GM. Next, its biocompatibility was characterized, and its antibacterial performance was tested against Escherichia coli and Staphylococcus aureus . The antibacterial mechanism was explained by measuring the difference in the ion concentration outside the membrane and changes in the morphology of live/dead bacteria. NIPAM-CG/GM had a high drug loading and nearly complete drug release at a physiological temperature of 37 °C. Its moderate mechanical properties, excellent biocompatibility, and antibacterial effects give NIPAM-CG/GM great potential applications as a wound dressing.
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