NANOTECHNOLOGY
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2018
·Vol. 29
·期 50
·505101
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IF 3.404
Lijia Wang,Ying Cai,Zhengbin An,Wenhong Gu,Ping Chen,Qingyun Cai
Here we report a novel drug delivery system using mesoporous inner-empty upconversion microspheres carrying drugs with ZnO quantum dots (UCMPS@ZnO) acting as a 'door-keeper' for pH-triggered drug release. Compared to other upconversion drug delivery systems, it is smarter, simpler, more efficient and more biocompatible. In particular, the UCMPS@ZnO microspheres show low cytotoxicity, are simple to produce and have a high drug loading rate (15%). Promisingly, a mice treatment experiment demonstrated that the multifunctional nanoparticles have efficient inhibition of tumor growth after a 14-day treatment. This makes UCMPS@DOX–ZnO microspheres a promising theranostic candidate in cancer treatment and clinical trials.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2018
·
IF 5.091
Ying Liu,Fei Yang,Wei Qin,Guowei Yang
The Co 2 P@NiCo 2 O 4 bi-functional electrocatalyst was fabricated for hydrogen evolution reaction and oxygen evolution reaction in acidic, neutral and alkaline media. The Co 2 P@NiCo 2 O 4 in alkaline media exhibites an extremely low overpotential of 170 mV in oxygen evolution to achieve a current density of 10 mA cm −2 and produces stable water splitting nearly 30 h. The anchored-Co 2 P can enhance the electrochemical performance of pristine NiCo 2 O 4 as well as increase the tolerance in acidic media of NiCo 2 O 4 . Additional, the Co 2 P is oxidized to oxides/hydroxides species during the electrocatalytic reaction , which acts as the active centers of the electrocatalysis . The Co 2 P@NiCo 2 O 4 catalyst can be used as an effective bifunctional synergistic center in a wide range of pH values (from 0 to 14).
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JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS
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2018
·Vol. 56
·期 24
·1636-1644
·
IF 2.499
Yixia Li,Jianhao Si,Haiyan Fan,Xiaodong Ye
The micelles formed by reduction-sensitive amphiphilic copolymer have emerged as promising drug nanocarriers due to the controlled drug release and effective anticancer activity triggered by the reducing stimulation. However, the effect of pH on the stability and guest exchange of the micelles formed by reduction-sensitive copolymer have not been systemically investigated. Herein, the micelles formed by a reduction-sensitive copolymer poly(ε-caprolactone)- b -poly[oligo(ethylene glycol) methyl ether methacrylate] (PCL–SS–POEGA) with a single disulfide group at different pH values loaded with dyes 3,3′-dioctadecyloxacarbocyanine perchlorate/1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate (DiO/DiI) were prepared through the precipitation-dialysis method. In addition, mixed micelles formed by different contents of reduction-sensitive and reduction-insensitive copolymers encapsulated with DiO/DiI at pH 7.5 were also prepared by the similar approach. The effects of pH and the content of reduction-sensitive copolymer on guest exchange of these micelles were studied by the fluorescence resonance energy transfer method. Results show that the pH value in the environment has great influence on the guest exchange rate of reduction-sensitive micelles in the presence of 10 mM dithiothreitol (DTT) and slight effect on that in the absence of DTT. Under a reducing environment, the guest exchange rate of the micelles containing various contents of disulfide-linked copolymer increases with the increasing content of PCL–SS–POEGA. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2018 , 56 , 1636–1644
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International Journal of Polymeric Materials and Polymeric Biomaterials
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2018
·
IF 2.127
Qian Wang,Xiao Qi Jin,Ji Hong Sun,Shi Yang Bai,Xia Wu,Hamida Panezai
The pH-responsive hollow poly(acrylic acid) (HPAA) microspheres with regulated cavity structure and various shell thicknesses were synthesized. Their structural parameters and textural properties were characterized by various techniques. The ibuprofen loading results indicate the good drug loading capabilities of HPAA microspheres from 13.81 to 17.18%. Their ibuprofen release properties demonstrated their good pH sensitivity and distance-controlled drug diffusion process. Specially, the small-angle X-ray scattering technique was used to suggest the surface roughness and structural irregularities of HPAA before and after drug loading and releasing. These findings clearly indicate the potential of HPAA microspheres to be used as promising candidates in drug delivery.
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ACS Biomaterials Science & Engineering
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2018
·
IF 4.432
Ke-Feng Liu,Yan-Xue Liu,Chun-Xiao Li,Lu-Ying Wang,Jing Liu,Jian-Du Lei
To face the growing demand of polymeric nanoparticles with biocompatibility and a drug release profile, in this work, a novel carboxymethylcellulose-based pH and redox dual-responsive polymeric nanoparticle, carboxymethyl cellulose-dithiopropionate hydrazide-8arm-polyethylene glycol-pterostilbene/10-hydroxy camptothecin (CTPP/HCPT), was prepared for efficient drug codelivery. These well-dispersed CTPP/HCPT NPs were prepared with a dimension of around 144 nm and exhibited high binary drug loading capacity and good biocompatibility. The biggest advantage of this design is that these nanoparticles can rapidly release the drug payload responding to intracellular acidic or reductive stimuli, while maintaining sufficient stability under normal physiological conditions. The in vitro drug release study revealed that the HCPT payload released from nanoparticles in a weakly acidic environment with 10 mM reductive glutathione was about 74.8%, which was 3.8-fold higher than under normal physiological conditions (∼19.6%). Further in vitro and in vivo investigation demonstrated that such dual-responsive CTPP/HCPT NPs could potently kill cancer cells and suppress tumor growth with lower adverse effects. All these results suggested that CTPP/HCPT NPs were suitable as potential and effective candidates for cancer therapy.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2018
·Vol. 136
·期 7
·47068
·
IF 1.901
N.-C. Wang,L.-F. Fang,J. Wang,P. Zhang,W.-B. Wang,C.-E. Lin,L. Xiao,C. Chen,B. Zhao,H. Abdallah,H. Matsuyama,B.-K. Zhu
Carboxyl groups in the membranes usually contribute the hydrophilicity and antifouling properties. However, membrane performance including permeation and separation properties is not stable at different pH environments due to pH sensitivity of carboxyl groups. In this work, a series of membranes from random copolymers poly(vinyl chloride- r -acrylic acid) [P(VC- r -AA)] were fabricated via nonsolvent induced phase separation process. The morphology and surface properties were investigated. The pH-dependent property of carboxyl groups contained ultrafiltration membranes were studied in detail. The results indicated that pH sensitivity of these membrane was restrained, which was mainly attributed to the random sequential structure of VC and AA repeating unit in P(VC- r -AA) copolymer. The probable arched structures on the pore surface/wall at alkaline environment limited the obvious change of the pore size, which resulted in the stable permeation and separation properties at the varied pH environments. Therefore, it indicated that P(VC- r -AA) was a kind of promising membrane material which would be widely applied in water treatment field. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 47068.
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ACS Applied Bio Materials
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2018
·
IF 0
Wen Cao,Faheem Muhammad,Yuan Cheng,Min Zhou,Qian Wang,Zhangping Lou,Zhe Li,Hui Wei
Bioresponsive drug delivery systems that can modulate drug release profiles according to different tumor microenvironment are highly desired for improving cancer therapy. In this work, a pH-responsive nanocarrier, layered double hydroxide (LDH) nanoplates coated with ultrathin mesoporous silica layer (LDH@MS), was fabricated with total thickness of around 9 nm. The coating of ultrathin porous silica significantly improved the stability of nanoplates. Moreover, the LDH@MS exhibited pH responsive functionality due to the degradation of silica shell and LDH under moderately acidic pH condition. Notably, the curcumin loaded LDH@MS displayed nearly five-fold greater antitumor efficacy against human breast cancer cells in vitro and marked tumor inhibition in vivo compared to free curcumin under the same drug dosage, most likely due to high dispersibility of the nanocarrier, as well as responsive and steady release of drug molecules. This study opens new avenues to design safer and more effective drug delivery systems with improved therapeutic outcomes.
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Journal of Environmental Sciences
·
2018
·
IF 3.12
Jingjing Wang,Bihong He,Xiaoyan Wei,Ping Li,Jianjun Liang,Shirong Qiang,Qiaohui Fan,Wangsuo Wu
Sorption of U(VI) onto TiO 2 as functions of pH, ionic strength, contact time, soil humic acid (SHA), solid-to-liquid ratio and temperature was studied under ambient conditions using batch and spectroscopic approaches. The sorption of U(VI) on TiO 2 was significantly dependent on pH and ionic strength. The presence of SHA slightly enhanced the sorption of U(VI) on TiO 2 below pH 4.0, while it inhibited U(VI) sorption in the higher pH range. U(VI) sorption on TiO 2 was favored at high temperatures, and the sorption process was estimated to be endothermic and spontaneous. Reduction of U(VI) to lower valent species was confirmed by X-ray photo-electron spectroscopy analysis. It is very interesting to find that U(VI) sorption on TiO 2 was promoted in solutions with higher back-ground electrolyte concentrations. In the presence of U(VI), higher back-ground electrolyte made more TiO 2 particles aggregate through (001) facets, leading more (101) facets to be exposed. Therefore, the reduction of U(VI) was enhanced by the exposed (101) facets and more U(VI) removal was observed.
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Acta Biomaterialia
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2012
·
IF 4.865
H.-J. Shen,H. Shi,K. Ma,M. Xie,L.-L. Tang,S. Shen,B. Li,X.-S. Wang,Y. Jin
Polyelectrolyte multilayer capsules, promising candidates for multifunctional drug delivery systems, have recently received increased interest. However, the low encapsulation efficiency of drugs and the lack of reports about animal experiments have greatly slowed down their development for drug delivery. Here, a polyelectrolyte multilayer capsule filled with bovine serum albumin gel (BSA-gel-capsule) was constructed by a layer-by-layer assembly technique and thermally induced gelation of BSA. Owing to the charge variability of BSA with change in pH, BSA-gel-capsules not only showed a pronounced accumulation effect of drugs into capsules, but also displayed excellent pH-controlled loading and release properties. Moreover, a remarkable targeting action to the lung was discovered after intravenous injection of fluorescein isothiocyanate (FITC)-labeled BSA-gel-capsules into mice. After treatment with doxorubicin-loaded BSA-gel-capsules, effective cytotoxicity against B16-F10 cells and inhibition of the pulmonary melanoma growth were revealed. This paper introduces a new type of smart microstructure with notable pH-responsive ability. This material renders feasible the intravenous administration of polyelectrolyte microcapsules, which will be a big step towards their application as drug delivery vehicles.
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ACS Applied Materials & Interfaces
·
2014
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IF 5.9
Yunhai Zhang,Guicai Liu,Shuili Yu,Jun Zhang,Yulin Tang,Pan Li,Yifei Ren
Surface functionalization of multiwalled carbon nanotubes (MWCNTs) was performed using mixed acid and ethylenediamine. The materials were characterized by electron microscope, X-ray diffraction, Raman spectra, Fourier transform infrared, N2 adsorption–desorption, and X-ray photoelectron spectroscopy. The pH-dependent sorption of tetrabromobisphenol A (TBBPA) onto raw and functionalized MWCNTs was investigated. A decrease in TBBPA uptake was found to be dependent on the adsorptive pKa in alkaline conditions. Two types of MWCNTs exhibited rapid binding kinetics for TBBPA sorption within 20 min. The kinetics of TBBPA sorption onto MWCNTs were analyzed using a pseudo-second-order model, an intraparticle diffusion model and Boyd model. The results showed that TBBPA sorption on MWCNTs and N-MWCNTs could be well described by the pseudo-second-order model, and the external diffusion (boundary layer diffusion) was the rate-limiting step. The extended Derjaguin–Landau–Verwey–Overbeek (XDLVO) theory was applied to calculate interfacial free energies and to explain the sorption characteristics between the sorbent and solute. This analysis revealed that hydrophobic attractive interactions (i.e., interfacial AB interactions) were dominant in TBBPA sorption onto MWCNTs.
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CARBOHYDRATE POLYMERS
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2015
·
IF 4.074
Yakun Ma,Xiaohui Fan,Lingbing Li
A doxorubicin conjugated prodrug incorporated acid-sensitive linkage between drug and Pluronic F127-chitosan (F127-CS) polymer was successfully synthesized. Subsequently a pH-sensitive polymeric micelle system was designed based on the conjugated prodrugs (F127-CS-DOX) to co-deliver doxorubicin and paclitaxel. Paclitaxel (PTX) was physically entrapped in the hydrophobic inner core of the micelles simultaneously. The structures of conjugates were analyzed by means of 1 H NMR and UV–vis spectrum. Size distribution and morphology of the micelles were observed by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The results indicated that obtained micelles had good dispersity and the diameter was between 56.3 and 403.4 nm. The loading of PTX into the micelle increased with higher DOX content. DOX and PTX release from polymeric micelles followed an acid-triggered manner. Furthermore, in vivo pharmacokinetic study also showed that the area under the plasma concentration time curve (AUC 0–∞ ) values of PTX and DOX for PTX-loaded F127-CS-DOX micelles in rats were 3.97 and 4.38-fold higher than those for PTX plus DOX solution. These results suggested the PTX-loaded F127-CS-DOX micelles would be a promising carrier for co-delivering DOX and PTX.
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Materials
·
2015
·Vol. 8
·期 2
·379-391
·
IF 2.651
Yanchao Liang,Zhihui Su,Yao Yao,Na Zhang
A novel polymer-drug conjugate was prepared by the chemical reaction between the copolymer Pluronic P123 and the docetaxel via a pH sensitive hydrazone bond. These pluronic P123-docetaxel (DTX) conjugates (P123-DTX) could form the stable drug-loaded materials that can self-assemble into the defined nano-micelles in aqueous solution because of their obvious amphiphilic property and low critical micelle concentration. The spherical morphology and particle size of the prepared nano-micelles were characterized by transmission electron microscopy and dynamic light scattering, respectively. Moreover, after the introduction of pH sensitive hydrazone bond, P123-DTX micelle showed a pH dependent drug release behavior. At pH 5.0 (in 48 h), the cumulative release amount of DTX were ~84.9%, which is about six times higher than that at pH 7.4. The prepared novel p123-DTX conjugates may offer a great benefit for drug delivery and controlling the drug release.Keywords:docetaxel;conjugates;nano-micelles;stability;pH controlled release
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