TALANTA
·
2018
·
IF 4.244
Miaoduo Deng,Meng Li,Yu Zhao,Zhen Jiang,Xingjie Guo
With native β-cyclodextrin (β-CD) added into the polymerization mixture directly, a novel, convenient and low-cost one-pot strategy was developed to prepare the β-CD functionalized organic polymer monolithic capillary column. Diazabicyclo[5.4.0]undec-7-ene (DBU) as a basic catalyst for the ring opening reaction between β-CD and glycidyl methacrylate (GMA) was introduced into the polymerization system for the first time. Thereby, two consecutive reactions namely the in situ methacrylation of β-CD and copolymerization reaction can be achieved in one pot. The preparation conditions including the type and composition of porogens，the ratio of functional monomer to crosslinker and amount of 2-acrylamido-2-methyl propane sulfonic acid (AMPS) were optimized. The specific surface area and morphology of the prepared monolith were characterized using scanning electron microscopy (SEM) and nitrogen adsorption analysis, respectively. Raman spectroscopy and nuclear magnetic resonance (NMR) spectroscopy confirmed that β-CD was covalently bonded onto the monolith successfully. Then, the monolithic column was applied to enantioseparation of six basic drugs in capillary electrochromatography (CEC). Under the optimal conditions, tropicamide , homatropine , homatropine methylbromide, brompheniramine , chlorpheniramine and clorprenaline were all totally separated with the resolution (Rs) values of 2.84, 4.70, 4.61, 3.01, 2.57 and 2.33, respectively. Furthermore, the column demonstrated satisfactory stability and repeatability of retention time and enantioselectivity using homatropine as model analyte.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2020
·
IF 4.192
Danping Wang,Hao Chen,Binglei Song,Tingting Yan,Zhaolan Zhai,Xiaomei Pei,Zhenggang Cui
The rational combination of natural molecules is expected to provide new soft material building blocks. Herein, a rosin-based amino acid surfactant was synthesized using dehydroabietic acid and l-serine as the starting materials (denoted as R-6-Ser). Supramolecular hydrogels were formed when β-cyclodextrin (β-CD) was mixed with R-6-Ser at molar ratios of over 0.5:1 and above certain concentrations. The hydrogels were investigated using rheometry, small-angle X-ray scattering, CD spectroscopy, and cryo-transmission electron microscopy (cryo-TEM). The β-CD associated with the isopropyl benzyl group of the dehydroabietic acid unit in R-6-Ser and formed R-6-Ser@β-CD complexes. The complexes and R-6-Ser self-assembled to form elongated right-handed rigid fibers with a diameter of approximately 7–8 nm, which were responsible for the elasticity of the hydrogels. This work demonstrated the feasibility of preparing supramolecular hydrogels from a diterpenoid-based surfactant and β-CD and provides a new means of utilizing the secretions of pine trees.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Xiaoyu Zhu,Chen Cheng,Xingao Qin,Ying Wang
Per- and polyfluoroalkyl substances (PFAS) have raised significant concerns; however, their accurate detection in aqueous environments remains a major challenge. In this study, a host-guest molecularly imprinted polymer-based electrochemical sensor with enhanced antifouling properties were developed using β-cyclodextrin embedded with methylene blue (βCD-MB MIP). This sensor demonstrated sensitive and selective quantification of perfluorooctanoic acid (PFOA) in real water samples. The βCD-MB MIP was fabricated by electro-polymerizing βCD and MB in the presence of the target molecule, PFOA, where βCD served as the functional monomer and MB as the signaling probe. The incorporation of βCD endowed the MIP with a stable hydration layer, promoting hydrophilicity and inhibiting fouling, while ensuring effective electron transfer from MB, resulting in significant current responses and outstanding antifouling performance. This sensor exhibits excellent sensing capabilities towards PFOA with a detection limit of 1.57 pg mL −1 , covering a wide concentration range from 4.14 ng mL −1 to 41.4 mg mL −1 . It also displayed high selectivity for PFOA with an imprint factor of 6.5, which is five to seven times higher than that of other perfluorinated analogs. This study introduces an innovative platform for the rapid quantification of PFAS using redox-active MIPs and sets the groundwork for developing integrated sensors for continuous PFAS monitoring in water.
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DOI
PubMed
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 45
·28052-28060
·
IF 3.361
Xuan Chen,Na Li,Yanqin Rong,Yuli Hou,Yu Huang,Wenting Liang
A three-dimensional reduced graphene oxide nanomaterial with β-cyclodextrin modified glassy carbon electrode (3D-rGO/β-CD/GCE) was constructed and used to detect the electrochemical behavior of dopamine (DA). The nanocomposite materials were characterized by scanning electron microscopy (SEM), infrared spectrometry (FT-IR), Raman spectrogram and thermogravimetric analysis (TGA), which showed that β-CD was well modified on 3D graphene with a porous structure. The electrochemical properties of different modified electrodes were investigated by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), proving the highest electron transfer rate of the 3D-rGO/β-CD modified electrode. The experimental conditions such as scan rate, pH, enrichment time and layer thickness were optimized. Under the best experimental conditions, DA was detected by differential pulse voltammetry (DPV) by 3D-rGO/β-CD/GCE with excellent electrocatalytic ability and satisfactory recognition ability, resulting in a wide linear range of 0.5–100 μM and a low detection limit (LOD) of 0.013 μM. The modified electrode based on 3D-rGO/β-CD nanocomposites is promising in the field of electrochemical sensors due to its high sensitivity and other excellent properties.
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DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2014
·
IF 6.451
Zhen Zhang,Shuqing Gu,Yaping Ding,Mingju Shen,Lin Jiang
A mild and novel preparation tactics based on electrochemical techniques for the fabrication of electro-deposited graphene (E-GR) and polymerized β-cyclodextrin (P-βCD) nanocomposite film were developed. The structure and morphology of GR-based nanocomposite were investigated by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Raman spectroscopy . Simultaneously, the electrochemical properties of this nanocomposite were characterized by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Based on the synergistic effect of E-GR and P-βCD, a super-sensitive electrochemical sensor for quercetin was successfully fabricated. Under optimum conditions, the determination range for quercetin was from 0.005 to 20 µM with a low detection limit of 0.001 µM ( S / N =3). Moreover, this sensor also displays excellent sensitivity, fine reproducibility and stability. To further study the practical applicability of the proposed sensor, the determination of real samples was carried out with satisfactory results.
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DOI
高影响因子
NEUROREPORT
·
2020
·
IF 1.394
Liu Zhen,Hao Kai-Min,Wang Hao-Yu,Qi Wen-Xiu
The aim of this study was to investigate the effects of histone deacetyltase (HDAC) 6 on the functional and pathological changes of the amyloid beta (Aβ)-induced cognitive dysfunction rats by regulating protein tyrosine kinase 2 beta (PTK2B). Ninety Sprague-Dawley rats were randomly divided into nine groups, consisting of five experimental groups and four control groups. In five experimental groups, Aβ 1–42 was infused intracerebroventricularly and 3 days later, rats in each group were infused intracerebroventricularly with tubastatin A hydrochloride (TSA), the histone deacetyltase 6 (HDAC6)-specific inhibitor (Aβ + TSA group), theophylline, the HDACs agonist (Aβ + theophylline group), PF431396, the PTK2B inhibitor (Aβ + PF group), the combination of PF431396 and theophylline (Aβ + PF + theophylline group) and normal saline (Aβ + normal saline group), respectively. Rats in four control groups took normal saline that was equivalent to the volume of Aβ 1–42 , and 3 days later, TSA group, theophylline group, PF431396 (PF group), or normal saline group was given at a volume of 5 µL for rats in each group. Our results showed that HDAC6 may not only lead to the deterioration of learning and memory abilities but also elevate the levels of Aβo and Tau phosphorylation in Aβ-induced cognitive dysfunction rats via up-regulating PTK2B.
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DOI
高影响因子
Communications Chemistry
·
2022
·Vol. 5
·期 1
·1-8
·
IF 7.211
Xu Jiacheng,Zhang Tiantian,Fang Shiyu,Li Jing,Wu Zuliang,Wang Wei,Zhu Jiali,Gao Erhao,Yao Shuiliang
Understanding of the roles of oxygen species at reducible metal oxide surfaces under real oxidation conditions is important to improve the performance of these catalysts. The present study addresses this issue by applying a combination of operando diffuse reflectance infrared Fourier transform spectroscopy with a temperature-programmed reaction cell and mass spectrometry to explore the behaviors of oxygen species during H 2 oxidation in a temperature range of 25–400 °C at β-MnO 2 surfaces. It is revealed that O 2 is dissociated simultaneously into terminal-type oxygen (M 2+ -O 2– ) and bridge-type oxygen (M + -O 2– -M + ) via adsorption at the Mn cation with an oxygen vacancy. O 2 adsorption is inhibited if the Mn cation is covered with terminal-adsorbed species (O, OH, or H 2 O). In a temperature range of 110–150 °C, OH at Mn cation becomes reactive and its reaction product (H 2 O) can desorb from the Mn cation, resulting in the formation of bare Mn cation for O 2 adsorption and dissociation. At a temperature above 150 °C, OH is reactive enough to leave bare Mn cation for O 2 adsorption and dissociation. These results suggest that bare metal cations with oxygen vacancies are important to improve the performance of reducible metal oxide catalysts.
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DOI
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2019
·Vol. 43
·期 5
·946-953
·
IF 2.516
Chenning Zhang,Jialin Qu,Xiaoyuan Lv,Jianbin Zhang,Linlin Fang
Enantioselective open tubular capillary electrochromatography with carboxymethyl-β-cyclodextrin conjugated gold nanoparticles as stationary phase was developed. This novel open tubular column was fabricated through layer-by-layer self-assembly of gold nanoparticles on a 3-mercaptopropyl-trimethoxysilane-modified fused-silica capillary and subsequent surface functionalization of the gold nanoparticles through self-assembly of 6-mercapto-β-cyclodextrin. The 6-mercapto-β-cyclodextrin was firstly synthesized and determined by extensive spectroscopic data. Scanning electron microscopy, energy dispersive X-ray analysis spectroscopy, and electroosmotic flow experiments were carried out to characterize the prepared open tubular column. Then, the separation effectiveness of the open tubular column was verified by two pairs of ɑ-tetralones derivatives enantiomers and two pairs of basic drug enantiomers (tramadol hydrochloride and zopiclone) as mode analytes. Factors that influence the enantioseparation were optimized, and under the optimized conditions, satisfactory separation results were obtained for the four enantiomers: compound A, compound B, tramadol hydrochloride, and zopiclone with resolutions of 3.79, 1.56, 1.03, 1.60, respectively. For the combination of gold nanoparticles and negatively charged carboxymethyl-β-cyclodextrin, the open tubular column exhibited wider separation range for neutral and basic drugs. Moreover, the repeatability and stability of the column were studied through the run-to-run and day-to-day investigations.
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DOI
高影响因子
OPTICAL MATERIALS
·
2022
·
IF 3.754
Tingxia Wu,Ying Hong,Lingyu Song,Yongbao Zhu,Jinling Wang,Yuanyuan Zhu,Jing Fang,Guosong Chen
Smuggling has caused serious adverse effects on the global market and national security, among which drug smuggling is increasingly rampant. Thus, the development of high-tech security strategies has become an urgent challenge for customs supervision. Recently, lanthanide ions (Ln 3+ ) doped upconversion nanoparticles (UCNPs) have opened up new ways for security and anti-fake applications due to their unique optical properties under near-infrared excitation. Here, we propose a novel upconversion microcrystal composed of hexagonal phase NaYF 4 :Ln 3+ capped by sodium hexametaphosphate (SHMP), successfully used in customs supervision. The addition of SHMP can not only regulate the morphology of microcrystals, but also significantly improve the luminescence properties of UC. The absolute quantum yield is up to 7% at the low power density of 30 W∙cm −2 , above most currently reported levels. Without adding any organic additives, the precise control of particle phase and morphology (e.g., microrod, hexagonal prism and hollow sphere) would be achieved by adjusting the doping ratio of SHMP/Ln 3+ . As the reaction time extends, the morphology of NaYF 4 :Ln 3+ changes from ellipsoid to microrod, while cubic phase transforms into hexagonal phase. Under the excitation of 980 nm laser, the green upconversion emission of hexagonal NaYF 4 :Ln 3+ microrods is significantly strengthened, which is more powerful than other observed particles with other shapes. This strong upconversion emission that depends on morphology and phase has huge application potential in security anti-counterfeiting and photonic devices .
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DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Jianfeng Fan,Jiarong Huang,Liming Cao,Shiheng Yin,Yukun Chen
Recyclable polyvinylidene fluoride/silicone rubber (PVDF/SR) thermoplastic vulcanizates (TPVs) containing a high mass ratio of SR (50%) with excellent mechanical performances and shape memory behavior were fabricated. The inert PVDF was first dehydrofluorinated via β-H elimination reaction to introduce reactive double bonds. Then, the functional groups were initiated by dicumyl peroxide (DCP) during dynamic vulcanization to realize interfacial grafting (SR-g-PVDF) simultaneously. In situ grafted PVDF chains tightly bridge the immiscible phases, leading to the excellent interfacial adhesion. Consequently, the tensile strength, elongation at break, and tensile toughness were significantly increased to 14.5 MPa, 174.6%, and 12.3 kJ/m3, respectively, which were almost 2.0, 13.6, and 10.3 times than that without interfacial grafting reaction (7.2 MPa, 12.8%, and 1.2 kJ/m3). Also, their excellent mechanical properties were almost perfectly maintained after multiple repetitive processing. Furthermore, the chemical anchoring structure of SR-g-PVDF across the interface could effectively and quickly transfer the force, contributing to the shape memory performances. The obtained TPVs (m60 and m80) showed an impressive shape recovery ratio (>80%) even after two fixing-recovery cycles.
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DOI
高影响因子
JOURNAL OF FOOD PROCESSING AND PRESERVATION
·
2021
·Vol. 45
·期 11
·e15961
·
IF 2.19
Qianwen Ru,Sheng Geng,Chungang Chen,Guizhao Liang,Benguo Liu
Tartary buckwheat bran (TBB), which is rich in proteins, is the main waste of tartary buckwheat processing. To improve the value of TBB, the noncovalent and covalent Tartary buckwheat bran protein (TBBP)/rutin complexes were prepared, and their capacities to fabricate β-carotene nanoemulsions were compared. The results indicated that the covalent complex exhibited the highest emulsifying performance, and the corresponding nanoemulsion had the lowest droplet size and polymer dispersity index (PDI) and the highest absolute value of ζ-potential, which could remain stable for four weeks. The high–temperature–short–time treatment and freeze–thaw processing had little influence on this nanoemulsion. However, it was very sensitive to high salt concentrations. Compared with the nanoemulsion prepared by the noncovalent complex, it had higher protein and rutin concentrations at the oil-water interface, which explained the improved stability of β-carotene against high temperature and UV irradiation. Practical applications In this study, the fabrication and characterization of β-carotene nanoemulsion stabilized by the complexes of tartary buckwheat bran protein and rutin are introduced. It can provide a reference for the utilization of other low-value cereal proteins and prompt the development of nutraceutical delivery systems based on food-derived protein-polyphenol complexes.
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高影响因子
Polymers
·
2018
·Vol. 10
·期 4
·385
·
IF 2.935
Lei Zhu,Bojie Li,Shan Wang,Wei Wang,Liansheng Wang,Liang Ding,Caiqin Qin
The first example of an environmentally-benign chitosan supported copper catalyzed conjugate silylation of α,β-unsaturated acceptors was accomplished in water under mild conditions. This protocol provides an efficient pathway to achieve an important class of β-silyl carbonyl compounds and the desired products were obtained in good to excellent yields. Gram-scale synthesis and easy transformation of obtained β-silyl products were also been demonstrated. Remarkably, this chitosan supported copper catalyst can be easily recycled and reused six times without any significant decrease of catalytic activity. The advantages of this newly developed method include operational simplicity, good functional group tolerance, scale-up ability, ready availability, and easy recyclability of catalyst.
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高影响因子
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