MICROCHIMICA ACTA
·
2017
·Vol. 185
·期 1
·1-7
·
IF 4.58
Tan Qingqing,Zhang Ruirui,Kong Rongmei,Kong Weisu,Zhao Wenzhi,Qu Fengli
The authors describe a novel method for the determination of glutathione (GSH). Detection is based on target induced release of glucose from MnO 2 nanosheet-gated aminated mesoporous silica nanoparticles (MSNs). In detail, glucose is loaded into the pores of MSNs. Negatively charged MnO 2 nanosheets are assembled on the MSNs through electrostatic interactions. The nanosheets are reduced by GSH, and this results in the release of glucose which is quantified by using a commercial electrochemical glucose meter. GSH can be quantified by this method in the 100 nM to 10 μM concentration range, with a 34 nM limit of detection.
Glucose is loaded into the pores of mesoporous silica nanoparticles (MSNs). MnO 2 nanosheets are assembled on MSNs through electrostatic interactions. Glutathione (GSH) can reduce the nanosheets, and this results in the release of glucose which is quantified by using a commercial glucose meter.
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AAPS PHARMSCITECH
·
2017
·Vol. 19
·期 3
·1141-1151
·
IF 2.451
Chen Jianmin,Huang Weiyue,Huang Ziyao,Liu Shiqi,Ye Yaling,Li Qinglian,Huang Meiping
Dissolving microneedles (MNs) offered a simple, minimally invasive method for meloxicam (MX) delivery to the skin. However, the fabrication of dissolving MNs still faced some challenges, such as significant time consumption, loss of drug activity, and difficulty in regulating MN drug loading. To address these issues, we developed the tip-dissolving (TD) MNs. Several kinds of drugs were encapsulated successfully, and the quantity of MX ranged from 37.23 ± 8.40 to 332.53 ± 13.37 μg was precisely controlled. The effects of fabrication process on biomacromolecules stability were studied, and it was found that tyrosinase kept 90.4% activity during the fabrication process. The whole process for the fabrication of MNs only takes approximately 1 h. In order to further evaluate the potential of the TD MNs, MX TD MNs were prepared for in vitro release experiments, in vivo release experiments, safety evaluation, pharmacokinetic studies, and pharmacodynamic studies. The results demonstrated that MX TD MNs offered several advantages, including rapid release of the encapsulated drug (91.72% within 30 min), efficient drug delivery to skin (79.18%), no obvious skin irritation, decent relative bioavailability (122.3%), and strong anti-inflammatory and analgesic effects. Based on these results, we envisage that the TD MNs have promising potential for transdermal drug delivery of MX.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2017
·Vol. 410
·期 2
·441-449
·
IF 3.431
Li Yuanyuan,Zhu Nan,Ma Yulong,Li Qiang,Li Peng
Material with a core–shell structure based on a porous silica core and Ag nanoparticles (AgNPs) as shell (SiO 2 @Ag) was prepared with the seed growth method. Cellulose derivatives as chiral selectors were coated on the surfaces of SiO 2 @Ag particles by means of coating and intermolecular polycondensation as chiral stationary phases (CSPs), respectively. Fifteen racemates were used to evaluate their chiral recognition ability by high-performance liquid chromatography (HPLC). The results implied that the CSPs based on SiO 2 @Ag particles obtained stronger interaction with the analytes leading to better enantioseparation due to the existence of AgNPs on the surfaces of silica gel, compared with a cellulose derivative-modified silica column. In addition, the new CSPs showed special selectivity for ketone enantiomers, and AgNPs played a synergistic effect with cellulose derivatives on enantioseparation.
Schematic of SiO 2 @Ag stationary phase
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CELLULOSE
·
2017
·Vol. 25
·期 1
·167-177
·
IF 3.417
Wu Yongli,Gao Jianping,Hao Chaoyue,Mei Shunkang,Yang Jiangbing,Wang Xiaoxue,Zhao Ruiru,Zhai Xiangang,Liu Yu
A photocatalyst consisting of a cellulose hydrogel loaded with Cd
x
Zn 1− x
S (Cd
x
Zn 1− x
S-Gel) was prepared, and its photocatalytic water splitting activity was studied. At room temperature, the Cd
x
Zn 1− x
S particles with an average size of about 3 nm were loaded in carboxymethyl cellulose hydrogel by an in situ chemical reaction. This synthesis method was simple and repeatable. Diffuse reflectance UV–vis results showed that it is possible to adjust the optical properties of the synthesized photocatalysts by adjusting their composition. Under visible light irradiation, the hydrogen production rate of the photocatalysts was greatly improved. In the absence of a co-catalyst,
Cd 0.2 Zn 0.8 S-Gel obtained the highest hydrogen production rate of 1762.5 μmol g −1 h −1 , which is almost 104 times of that of the pure CdS. Moreover, after four hydrogen production cycles, the hydrogen production rate did not decrease significantly, showing excellent stability. It is noteworthy that the Cd
x
Zn 1− x
S-Gel can easily be removed from the aqueous solution after hydrogen production. This is a new approach for manufacturing easy recoverable visible-light-driven photocatalysts, which is vital for hydrogen production through a “green” process.
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POLYMER BULLETIN
·
2017
·Vol. 75
·期 8
·3739-3751
·
IF 1.43
Zhu Xiuling,Huang Jianyu,Jin Cuihong,Zhang Shuai,Li Shuai,Jiang Ben
In this study, sulfonated organosilane graphene oxide (SSiGO) was synthesized by grafting 3-mercaptopropyl trimethoxysilane (MTPS) with graphene oxide (GO) and follow-up oxidation with hydrogen peroxide. The SSiGO was introduced into sulfonated poly (phthalazinone ether ketone) (SPPEK) to obtain composite membranes (SSiGO/SPPEK), and the physicochemical and electrochemical properties were extensively investigated. The results show that this SSiGO/SPPEK composite membranes possess excellent thermal and dimensional stability and super high proton conductivity. The proton conductivity of 10% SSiGO composite membranes was improved greatly from 0.094 to 0.22 S/cm from 30 to 80 °C, in contrast with the 0.089–0.17 S/cm from 30 to 80 °C of Nafion 212, which indicates that the SSiGO/SPPEK composite membranes have tremendous promise for proton exchange membranes fuel cells.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2018
·Vol. 29
·期 7
·6068-6076
·
IF 2.324
Zhou Jianping,Wang Jianfeng,Li Hua,Shen Fenglei
Using propylene carbonate (PC) as solvent, a hybrid gel polymer electrolyte (GPE) based on poly(propyleneglycol) bis(2-aminopropyl ether) (2-APPG) and 3-isocyanatepropyltriethoxysilane (ICS) was successfully synthesized by sol–gel method. The result shows the hybrid gel polymer electrolyte with [O]/[Li] ratio of 22 has a high ionic conductivity, good thermal stability, as well as good electrochemical stability. The ionic conductivities reach as high as 1.43 × 10 − 3 S cm − 1 at 30 °C and 3.36 × 10 − 3 S cm − 1 at 100 °C, respectively. Nearly 0 weight loss was observed up to 100 °C. The electrochromic device is fabricated by using the hybrid gel polymer as electrolyte. The results demonstrate its high coloration efficiency (267.4 cm 2 C − 1 ) and long cycle life (150 cycles with the linear potential sweep between − 3.5 and + 2.5 V), When the applying voltage is increased to as high as 5 V on the electrochromic device, a fast response is obtained (colored/bleached time are 13/19 s), which indicates its potential application under high voltage conditions.
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MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 3
·1-8
·
IF 5.705
Deng Ya’nan,Gao Qin,Ma Juan,Wang Chaozhan,Wei Yinmao
Poly(3-acrylamidophenylboronic acid) (PAAPBA) was grafted onto polydopamine-coated magnetic graphene oxide via surface-initiated atom transfer radical polymerization to obtain a new kind of boronate affinity material (BAM). The BAM possesses good water dispersity and adsorption capacities as high as 154, 357, 588 and 1111 μmol·g −1 for adenosine, salbutamol, dopamine and catechol, respectively. For the molecules without nitrogen atoms, the BAM can selectively capture the cis -diols under the interference of non- cis -diols. For molecules containing nitrogen, the non- cis -diols are also retained, but much less than the cis -diols. The selectivity can be improved by adding salts to facilitate complexation and to suppress the electrostatic interaction between cis -diols and the boronic acid ligand. The BAM was successfully employed to the enrichment of catecholamines from real urine samples. Results indicate that it is a promising material for the pretreatment of real samples.
Schematic of the preparation of an ultrahigh capacity boronate affinity material by grafting polymer brush from polydopamine coated magnetic graphene oxide. The material has good selectivity to cis -diol-containing molecules and can be applied to enrich catecholamines in urine samples.
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JOURNAL OF CLUSTER SCIENCE
·
2018
·Vol. 29
·期 3
·469-473
·
IF 1.715
Zhang Zhengyu,Yuan Ailin,Chen Chan,Zheng Chunling,Xu Hong
We have obtained a kind of simple and highly effective method for detection of calcium ions based on glutathione functionalized gold nanoparticles (GSH-GNPs) in this article. The GSH-GNPs can be induced to aggregate immediately in the presence of calcium ions that can be detected by colorimetric response of GNPs monitored by a UV–vis spectrophotometer or even naked eyes, and the detection limit could reach 20 μM. Compared to other metal ions, the GSH-GNPs bound by calcium ions shows higher sensitivity with prominent color changes. Most importantly, the probe not only can be tested the content of calcium ion in the water simply and effectively, but also can be applied to estimate calcium levels in blood with low interference and high sensitivity.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2018
·Vol. 25
·期 12
·11576-11583
·
IF 2.8
Tang Ting,Yang Chen,Wang Li,Jiang Xianying,Dang Zhi,Huang Weilin
This study quantified the complex stability constants of sulfamethazine (SMT) with cadmium (Cd 2+ ) and lead (Pb 2+ ) under different pH conditions. The UV-Vis spectrophotometer was used for acquiring the complexation data. Results showed that the complex stability constants of SMT with cadmium (Cd 2+ ) and lead (Pb 2+ ) increased as a function of the solution pH. In the investigated pH range, Cd 2+ showed stronger complex affinity with SMT than Pb 2+ . It appeared that cation - π interactions might dominate the complex between SMT with Pb 2+ and Cd 2+ at acid environment, and the covalent bonding might play a major role at neutral environment. Batch adsorption equilibrium experiment showed that the sorption capacity of Cd 2+ on goethite increased from 3.83 to 7.64 mg/g along with the addition of 1 mg/L SMT, indicating SMT can impede the transportation of Cd. In general, this study worked out the complexation constants and clarified the complexation mechanism between SMT with lead and cadmium, while sorption experiment indicated that sorption of Cd onto goethite was enhanced with SMT.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2018
·Vol. 316
·期 1
·209-219
·
IF 1.181
Chang Shuquan,Chang Ling,Han Wei,Li Zheng,Dai Yaodong,Zhang Haiqian
Novel Prussian blue/natural porous framework nanocomposites (PB@Apple, PB@Corn stalk and PB@Pomelo peel) were successfully produced in aqueous solution via an in situ γ radiation method. They have layered porous structure with 70–100 nm irregular PB, regular polygonous porous structure with 50–70 nm cubic PB and hierarchical porous structure with 10–20 nm spherical PB, respectively. They exhibit good Cs + adsorption properties and have maximal Cs + adsorption capacities of 67.3, 62.1 and 83.8 mg g −1 , which can be used to treat radioactive wastewater. This production method is simple, efficient and environmental-friendly.
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JOURNAL OF MATERIALS SCIENCE
·
2018
·Vol. 53
·期 10
·7165-7179
·
IF 2.993
Song Zhixuan,Shi Jun,Zhang Zheng,Qi Zeer,Han Shangru,Cao Shaokui
In this work, gold nanorods (AuNRs)/mesoporous silica (SiO 2 ) nanoparticles capped with thermal-responsive polymer were fabricated to couple the photothermal property of AuNRs and the thermal-/pH-responsive properties of polymer in a single nanovehicle. Aliphatic poly(urethane-amine) (PUA) was employed as the smart polymer to cap the mesopores of AuNRs/SiO 2 nanoparticles via in situ polymerization in supercritical CO 2 . Thermal-/pH-responsive PUA acted as the on–off switch to control the DOX release due to the stretch and shrinkage of the PUA polymer chains at different temperatures, whereas a remote near-infrared (NIR) light was used to activate the phase change and subsequent drug release. The in vitro drug release studies indicated that Au/SiO 2 /PUA nanoparticles exhibited distinguished pH-, thermal-, and NIR-dependent release properties. A short time exposure to NIR irradiation could distinctly increase the local temperature of nanoparticles, and the thermal-responsive polymeric cap enabled the DOX release in a significant reversible way by simply adjusting the NIR laser intensity. The present paper provides an ideal way to fabricate NIR-responsive drug carriers by combining stimuli-responsive polymer with inorganic matrix, which is highly attractive for remote controllable drug delivery.
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CELLULOSE
·
2018
·Vol. 25
·期 3
·1705-1714
·
IF 3.809
Liu Ting,Ding Enyong,Xue Feng
Polymer grafting is an efficient way to obtain functional cellulose nanocrystals. In this work, we used a “macro-RAFT (macromolecular reversible addition–fragmentation chain transfer) agent-assisted” strategy, which adds extra amount of amphiphilic macro-RAFT agent with low molecular weight to graft poly(N,N-dimethylacrylamide) (PDMA) from cellulose nanocrystals. Successful grafting was evidenced by different characterization methods, and a high weight ratio of grafted PDMA was obtained (77.6%). The grafting process was studied through the weight ratio of grafted PDMA, monomer conversion, and the molecular weight of free and grafted PDMA at different reaction time. As a result, we have suggested that there were three types of grafted polymer chains on cellulose nanocrystals in this reaction system and discussed their evolution during the grafting reaction. Finally, we summarized several key factors for successful grafting in this macro-RAFT agent-assisted strategy.
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