SEPARATION AND PURIFICATION TECHNOLOGY
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2023
·
IF 8.6
Yuanchuan Ren,Jun Wang,Guangfei Qu,Nanqi Ren,Ping Lu,Xiuping Chen,Zuoliang Wang,Yuyi Yang,Yan Hu
Three-dimensional electrochemical reactor (3DER) is an efficient technology for the treatment of printing and dyeing wastewater. The particle electrode between anode and cathode is the core unit of 3DER, which determines the treatment efficiency of wastewater. However, the deactivation of the particle electrode caused by the coverage of the catalytic sites seriously hindered the continuous operation of 3DER. In this work, γ-Fe 2 O 3 @CNTs particle electrode was prepared by immersion calcination , and its performance was evaluated by degradation of Rhodamine B (RhB) wastewater in 3DER. The study showed that in γ-Fe 2 O 3 @CNTs/Mn@FNE-3DER, the removal rate of RhB reached the best of 99.16% within 7 min under the conditions of γ-Fe 2 O 3 @CNTs dosage of 1.00 g·L -1 , initial RhB concentration of 100 mg·L -1 , pH 7.0, and current density of 20 mA·cm −2 . The superior catalytic activity of the system is mainly due to the charge transfer channel in γ-Fe 2 O 3 @CNTs structure, which improves the mass transfer efficiency of electrons. According to LC-MS analysis, the degradation process of RhB can be divided into five stages: deethylation, chromophore cracking, debenzylation and deamination, ring opening and mineralization. Hydroxyl radicals play an important role in this process. After the reaction, most RhB is converted into CO 2 and H 2 O. In addition, the study also showed that the Fe 3+ /Fe 2+ circulating system formed between the anode and cathode was the important reason for the high degradation efficiency of RhB. After five cycles of experiments, the degradation efficiency of 92.55% was still maintained, indicating that the particle electrode has significant stability and reusability in the catalytic process. To sum up, the excellent performance of γ-Fe 2 O 3 @CNTs particle electrode in three-dimensional electrochemical system provides a promising idea for the actual treatment of printing and dyeing wastewater.
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Journal of Manufacturing Processes
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2023
·
IF 6.2
Shuye Zhang,Jincheng Lin,Ce Wang,Peng He,Wei Wang,Xinfei Zhang,Tong Wu,Han Mei,Yue Liu,Panpan Lin,Tiesong Lin
The brazed joint of sapphire transparent ceramic and Kovar alloy was prepared using AgCuTi and AgCuTiB composite filler, and the main focus was the effect of B element on the wetting behavior, interface composition and joint mechanical performance. The reliable joint of sapphire transparent ceramic and Kovar alloy was obtained by vacuum brazing with AgCu28-6Ti-0.45B (wt%) composite filler. The typical interfacial structure of the joint brazed at 825 °C for 10 min was determined as sapphire/Ti 3 Cu 3 O/Ag(s,s) + Cu(s,s) + disperse TiB/TiFe 2 + TiNi 3 /Kovar. The results showed that the addition of B could contributed to an optimized interfacial structure via (i) in-situ forming fine TiB whisker reinforcement phase and refining the interface structure and (ii) reducing the diffusion degree of alloy side elements to inhibit the generation of brittle phase, and the maximum shear strength of the joint with AgCu28-6Ti-0.45B (wt%) reached 125 MPa more than twice the joint without B additive. On the other hand, the wetting experiment showed that the addition of B as a solid particle decreased the fluidity of the composite filler, and when the addition of B was excessive, no dense TiB whiskers were produced in the interface. This study provides ideas for the optimization and improvement of sapphire composite connection, and points out that the generation of reinforcing phase is accompanied by the reduction of fluidity, so it is necessary to reasonably control the proportion of reinforcing phase.
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Food & Function
·
2023
·Vol. 14
·期 4
·1971-1988
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IF 6.1
Ya-Li Wang,Song-Xia Lin,Yuan Wang,Tao Liang,Tao Jiang,Peng Liu,Xiao-Yi Li,Deng-Qin Lang,Qiang Liu,Chun-Yan Shen
Oxidative stress and inflammation play important roles in the development of diabetes mellitus. p-Synephrine, the primary pharmacologically active protoalkaloid in Citrus species, has been popularly consumed as a dietary supplement for weight loss management. However, the effects of p-synephrine on diabetes mellitus and the action mechanisms have not been clearly elucidated. In this study, the in vitro antioxidant effects of p-synephrine were evaluated. The data showed that p-synephrine treatment exhibited significant scavenging effects against DPPH, ABTS and OH radicals and showed high reducing power. Diabetic mice were developed by alloxan injection, followed by p-synephrine administration to investigate its hypoglycemic effects in vivo. The results showed that p-synephrine intervention significantly prevented alloxan-induced alteration in body weight, organ indexes, serum uric acid content and serum creatinine content. Meanwhile, p-synephrine application significantly improved the lipid profiles, superoxide dismutase (SOD) and catalase (CAT) activities and glutathione (GSH) contents in the serum and kidneys of diabetic mice and reduced the malondialdehyde (MDA) content in the serum of diabetic mice. Further assays suggested that p-synephrine treatment improved alloxan-induced decreases of glucose tolerance and insulin sensitivity. Also, p-synephrine supplementation altered histopathological changes in the kidneys and interscapular brown adipose tissues in diabetic mice. In addition, p-synephrine administration inhibited renal inflammation through suppressing tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) gene expression levels, as well as CD45 expression levels. The anti-inflammatory effects were probably involved in the regulation of nuclear factor-κB (NF-κB) activation and mitogen-activated protein kinase (MAPK) phosphorylation. In conclusion, p-synephrine application significantly ameliorated alloxan-induced diabetes mellitus by inhibiting oxidative stress via suppressing the NF-κB and MAPK pathways.
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PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 31
·14828-14839
·
IF 3.3
Lin Dong,Yunlan Xu,Dengjie Zhong,Nianbing Zhong,Zhuofan Han,Yi Liu,Haixing Chang
The low electron–hole separation in the photoanode generally restricts the visible light response of photocatalytic fuel cell (PFCs). In this study, 5% NH2-MIL-125/g-C3N4/Bi2O3/Ti photoanode was synthesized and assembled with a PFC with Cu cathode to degrade rhodamine B and generate electricity. With visible light irritation, the maximum photocurrent density, maximum power density, and degradation rate of the PFC were 0.59 mA cm−2, 29.88 μW cm−2, and 97.48% (1 h), respectively. The major active species in the PFC were h+, ˙O2−, and ˙OH. The good performance of the PFC was ascribed to the formation of a double Z-type heterojunction in the 5% NH2-MIL-125/g-C3N4/Bi2O3/Ti photoanode so that the photoelectrons of NH2-MIL-125 and Bi2O3 directly combine with the photoholes of g-C3N4, making the photoholes of NH2-MIL-125 and Bi2O3 and the photoelectrons of g-C3N4 directly or indirectly involved in the RhB degradation process and generating electricity. Thus, the separation rate of the e−–h+ pairs in the photoanode and the capability of the PFC are greatly improved.
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International Journal of Electrochemical Science
·
2023
·
IF 1.5
Shuang Chen,Lingqian Kong,Chaolei Ban,Jinsheng Zhao,Hongmei Du
Four copolymers, poly(fluorene-pyrido[3,4-b]pyrazine) (PFPP), poly(benzotriazole-fluorene-pyrido[3,4-b]pyrazine) (PBTFPP), poly(benzotriazole-fluorene-benzothiadiazole) (PBTFBD), poly(benzothiadiazole-fluorene-benzothiadiazole) (PBDFBD)were synthesized successfully. Afterwards, a series of characterization, including cyclic voltammetry (CV), spectroelectrochemistry, kinetics, colorimetry and thermal gravimetric analysis were carried out to fully investigate the properties of the copolymers we got. Their band gaps are 1.87 eV, 1.91 eV, 1.97 eV and 1.98 eV, respectively. From neutral state to oxidized state, PFPP changes from thistle to transparent gray, PBTFPP changes from tan to transparent gray, PBTFBD changes from sienna to lightslategray, and PBDFBD changes from rosybrown to lightgrey. The coloration efficiencies are 269.91cm 2 ·C -1 for PFPP, 177.45cm 2 ·C -1 for PBTFPP, 241.92cm 2 ·C -1 for PBTFBD, and 174.67cm 2 ·C -1 for PBDFBD in near infrared region. Except for PFPP, all the other three copolymers are stable and could be good candidates in electrochromic application.
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Translational Oncology
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2022
·
IF 4.803
Yongxiu Du,Yanlan Yang,Wenbo Zhang,Chenxi Yang,Pu Xu
Oral squamous cell carcinoma (OSCC) is a usual oral cancer. Therefore, it's essential to identify targets for its early diagnosis and therapy. This research aimed to explore the roles of human β-defensin-3 (hBD-3) and nuclear factor-kappa B (NF-κB) p65 in the pathogenesis and progression of OSCC. The connection between NF-κB p65 and the carcinogenesis of oral cancer was analyzed by immunohistochemical staining. The relative expressions of hBD-3 and NF-κB p65 in OSCC cells were evaluated by qRT-PCR and Western blot. Afterward, hBD-3 was knocked down, and NF-κB p65 was overexpressed. The cell viability and invasion were tested via CCK-8 and Transwell experiment, and the expression of hBD-3, NF-κB p65, and its downstream molecules was evaluated by Western blot. The expression of NF-κB p65 was increased with the aggravation of the oral submucosal fibrosis. HBD-3 and NF-κB p65 were high-expressed in OSCC cells. The viability and invasion abilities of OSCC cells that knocked down hBD-3 were markedly decreased, while they were restored by the overexpression of NF-κB p65. The expressions of NF-κB p65 and c-myc were diminished while IκB and p21 were raised with the knockdown of hBD-3. After overexpression of NF-κB p65, the expression of hBD-3 and IκB did not change markedly, while c-myc was increased and p21 was decreased dramatically. HBD-3 and NF-κB p65 facilitate the proliferation and invasion of OSCC cells, and hBD-3 may promote this process by governing the expression of NF-κB p65 and its downstream c-myc and p21.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
·
IF 5.518
Guoxian Chen,Zhiwei Hu,Huiqiang Su,Jie Zhang,Dewei Wang
Heavily heteroatoms doped carbons are highly attractive for electrochemical energy storage and electrocatalysis applications. We report herein a versatile coordination chemistry strategy for the producing of B, N co-doped carbon nanosheets (BCN-Mg) with an ultrahigh doping level (15.26 % for N, 10.18 % for O, and 3.21 % for B) though pyrolysis of nitrogen-rich Mg-based complex in the presence of boric acid . In this protocol, hexamethylenetetramine , which acts as both carbon and nitrogen source, can easily complex with magnesium ion to form a nitrogen-rich Mg-based complex in aqueous solution due to the presence of plentiful amino groups with strong complexation capability. Benefiting from the ultrahigh doping level and moderate specific surface area of 428 m 2 g −1 , the as-obtained B, N co-doped carbon nanosheets display a high specific capacity of 130.7 mA h g −1 (at 0.1 A g −1 ), and good stability of 87.3 % after 10,000 cycles when serves as the cathode for aqueous Zn-ion hybrid capacitors. More importantly, change details of the N and B containing functional groups during the charge-discharge process have been fully evaluated by ex-situ X-ray photoelectron spectroscopy characterization technique and density functional theory calculations. This work not only offers a new way to develop B, N co-doped carbon nanosheets with an ultrahigh doping level but also shed some new insight on the roles of heteroatoms containing functional groups for electrochemical energy storage applications.
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Cell Communication and Signaling
·
2022
·Vol. 20
·期 1
·1-11
·
IF 7.525
Yang Jing,Tang Xujiao,Li Baiqiang,Shi Jinsong
In acute pancreatitis, activation of inflammatory signaling, including the nuclear factor-kappa B (NF-κB) pathway, within acinar cells is known to be an early intracellular event occurring in parallel with pathologic trypsinogen activation. Sphingosine 1-phosphate receptor 2 (S1PR2) plays a critical role in endothelial inflammation, and our previous studies reported that S1PR2 deficiency significantly reduced the inflammatory response in liver injury under cholestasis conditions. However, the role of S1PR2 in inflammatory signaling activation within acinar cells and inflammatory responses during acute pancreatitis has not been elucidated. Here we report that S1PR2 was upregulated in the whole pancreas during acute pancreatitis. Blockade of S1PR2 by pharmacologic inhibition of S1PR2 by JTE-013 or AAV-mediated knockdown of S1PR2 improved the severity of pancreatic injury, as indicated by a significant reduction in inflammation and acinar cells death in acute pancreatitis mice. Moreover, S1PR2 is the predominant S1PRs expressed in pancreatic acinar cells and mediates NF-κB activation and the early inflammatory response within acinar cells under acute pancreatitis conditions via ROCK signaling pathways, not extracellular signal-regulated kinase pathways or p38 mitogen-activated protein kinase pathways. In addition, S1PR2 mediated macrophage NF-κB activation, migration and polarization toward the M1 phenotype. Therefore, these results demonstrated that the S1PR2-mediated early inflammatory response in acinar cells promotes the progression of acute pancreatitis, successfully linking local events to the systematic inflammatory response and leading to a novel therapeutic target for acute pancreatitis aimed at halting the progression of the inflammatory response.
Video Abstract
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高影响因子
POLYMER
·
2022
·
IF 4.432
Hanwen Lai,Xiaohui Zhang,Guangcheng Huang,Yadong Liu,Weihua Li,Shengxiang Ji
Directed self-assembly (DSA) of block copolymers (BCPs) is an effective approach for the fabrication of sub-10 nm features for semiconductor devices. Although many high-χ BCPs have been developed for DSA, the majority of them has a significant difference in surface energies (γs) between two blocks. Here we report the synthesis and self-assembly of poly (styrene- b -vinyl acetate) (PS- b -PVAc). PS- b -PVAc has a higher Flory-Huggins interaction parameter (χ) than poly (styrene- b -methyl methacrylate) (PS- b -PMMA) and the smallest achievable period ( L O ) is 18.2 nm. PS and PVAc have nearly equal γs and a perpendicular orientation of domains is obtained on random copolymer brushes under thermal annealing. DSA of PS- b -PVAc (SV-1 and SV-2) is successfully demonstrated in the thin films on chemical patterns, and the feature size down to 9.5 nm is obtained in DSA of SV-4 with 2 × density multiplication. These results demonstrate that PS- b -PVAc could be a candidate BCP for next-generation DSA lithography.
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2022
·
IF 7.425
Shaoying Gong,Jiachen Zheng,Junjie Zhang,Yucong Wang,Zhixin Xie,Yubao Wang,Jianchun Han
Intestinal epithelial barrier dysfunction can cause several intestinal diseases. Flavonoids have been shown to be beneficial to the intestinal epithelial barrier function. However, the effects of taxifolin (TAX), a naturally occurring flavonoid, on the intestinal epithelial barrier function are unclear. Thus, the aims of this study were to investigate the protective effect and potential mechanism of TAX against lipopolysaccharide (LPS)-induced intestinal epithelial barrier dysfunction in a Caco-2 cell monolayer model. Our results showed that TAX increased the transepithelial electrical resistance (TEER) and decreased the fluorescein isothiocyanate (FITC)-dextran (4 kDa) flux in the damaged intestinal epithelial barrier. Meanwhile, TAX inhibited an LPS-induced decrease in mRNA and protein expression of tight junction (TJ) proteins (claudin-1, zonula occludens [ZO]-1, and occludin), and ameliorating the continuous distribution pattern disrupted of TJs. These results suggested that TAX ameliorated intestinal epithelial barrier dysfunction. Regarding the underlying mechanism, TAX reduced the LPS-induced secretion of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in Caco-2 cell monolayers. In addition, TAX suppressed the phosphorylation of nuclear factor kappa-B (NF-κB), inhibitor protein of NF-κBα (IκBα), and myosin light chain (MLC), and downregulated the expression of myosin light chain kinase (MLCK) in LPS-treated Caco-2 cells. In summary, TAX can maintain TJ proteins by inhibiting the NF-κB/MLCK pathway and pro-inflammatory factor secretion to ameliorate LPS-induced intestinal epithelial barrier dysfunction. Thus, TAX is a promising candidate agent for use in functional food to ameliorate intestinal barrier dysfunction.
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PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2022
·
IF 7.968
Xingmin Liu,Jianfeng Zheng,Kun Peng,Guozhen Qin,Yatao Yang,Zhanggen Huang
Constructing effective photocatalysts with visible-light-driven for degrading VOCs including formaldehyde remains a challenge. The TiO 2 (B) photocatalyst with a two-dimensional lamellar structure was prepared and modified by surface engineering. The DFT calculation results showed new impurity levels appeared among the energy bands of the modified TiO 2 (B) materials. These photocatalysts exhibited different rates of HCHO degradation under visible light. A variety of characterizations demonstrated that the surface defects greatly reduced the bandgap and enhanced the absorption of visible light. And the recombination of photogenerated electron-hole (e - -h + ) pairs was suppressed to varying degrees in the modulated TiO 2 (B) catalysts revealed in the photoelectrochemical analysis. It is necessary to match the band structure of photocatalysts with the frontier orbital of HCHO for achieving effectual photocatalytic oxidation (PCO). Remarkably, the separation and transport of photogenerated carriers were inhibited when excessive metal Cu was doped. The results in this work provide a deeper understanding of the relationship between the surface engineering of TiO 2 (B)-based catalysts and catalytic performance.
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高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2023
·
IF 3.3
Jianglu Qian,Xichen Mi,Haotian Dong,Jiaqian Lv,Na Ma,Wei Dai
Copper-based metal-organic framework (e.g. Cu-BTC) suffer from water instability issue, restricting its practical applications in the adsorptive removal of dyes from aqueous solution. In this exploration, a innovative core-shell porous composite with spherical porous carbon (SPC) and Cu-BTC units, boosting its water stability and Rhodamine B (RhB) uptake capacity. Those novel Cu-BTC@SPC composites have undergone comprehensive characterization, and their structural features have been further evaluated through various analytical techniques, including N 2 adsorption-desorption tests, X-ray diffraction analysis, scanning electron microscopy image, Fourier transform infrared spectroscopy analysis, X-ray photoelectron spectroscopy, etc. Remarkably, the structural integrity of the Cu-BTC@SPC composite remained intact even after being immersed in water for a duration of 7 days or subjected to boiling water for 6 h. Through a series of batch tests, we observed that the Cu-BTC@SPC composite exhibited a high capacity for RhB adsorption. The observed phenomenon can be ascribed to the synergistic effects of π-complexation and acid-base interactions present within the SPC and Cu-BTC components. The maximum RhB uptakes over Cu-BTC@SPC can reach 81 mg/g, exceeding some other adsorbents prior publications. Especially, the RhB uptakes capacity of Cu-BTC@SPC decreased by less than 10% after the fifth cycle. The distinctive core-shell structure of Cu-BTC@SPC might be a hopeful adsorbent for dye (e.g. RhB) removal from water.
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