Foods
·
2022
·Vol. 11
·期 18
·2747
·
IF 5.561
Yongshuai Jing,Yameng Zhang,Wenjing Cheng,Mingsong Li,Beibei Hu,Yuguang Zheng,Danshen Zhang,Lanfang Wu
Most proteins given orally have low bioavailability and are easily eliminated by rapid metabolism in vivo. In order to immobilize the drug at the site of administration and delay its release, a natural, gentle release system was designed. In this study, a heteropolysaccharide (ZOP) was isolated fromZingiber officinaleusing an ultrasonic assisted extraction method. ZOP Ara = 1.97: 1.15: 94.33: 1.48: 1.07. The ZOP/Chitosan (CS) composite hydrogel was synthesized using epichlorohydrin (ECH) as a cross-linking agent. The structure, morphology, and water-holding capacity of the composite hydrogel were characterized. The data showed that the addition of ZOP improved the hardness and water-holding capacity of the material. A swelling ratio test showed that the prepared hydrogel was sensitive to pH and ionic strength. In addition, the degradation rate of the hydrogel in a phosphate-buffered saline (PBS) solution with a pH value of 1.2 was higher than that in PBS with pH value of 7.4. Similarly, the release kinetics of Bovine serum albumin (BSA) showed higher release in an acidic system by the hydrogel composed of ZOP/CS. The hydrogel prepared by this study provided a good microenvironment for protein delivery. In summary, this composite polysaccharide hydrogel is a promising protein-drug-delivery material.Keywords:Zingiber offtcinale;polysaccharide;chitosan;hydrogels;drug release;degradation
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Marine Drugs
·
2022
·Vol. 20
·期 11
·688
·
IF 6.085
Jingmin Cui,Yan Sun,Linqing Wang,Qin Miao,Wenqiang Tan,Zhanyong Guo
We successfully prepared a series ofl-arginine Schiff bases acylated chitosan derivatives, aiming to improve the antioxidant activity and antimicrobial activity of chitosan by introducing a furan ring, pyridine ring, andl-arginine structure. The accuracy of the structures of ten compounds was characterized by FT-IR and1H NMR. In terms of DPPH radical scavenging activity, except for compound CR3PCA, the scavenging rate of other compounds was higher than chitosan, especially CRCF and CRBF had strong scavenging abilities. At the same time, in the superoxide-radical scavenging activity assay, CRCF, CRBF, CR3PCA, CR2C3PCA, and CR2B3PCA were comparable to positive control at 1.60 mg/mL. Simultaneously, CRFF, CRCF, and CRBF had a certain inhibitory effect onBotrytis cinerea. Furthermore, the inhibitory effect of CRFF, CRCF, and CR3PCA onStaphylococcus aureuswas very well, close to the positive control at 1.00 mg/mL. CRCF and CR2B3PCA showed better inhibitory effects onEscherichia colithan other compounds. The MTT assay was used to determine the cytotoxicity of the chitosan derivatives, which proved their safety to fibroblast cells. In summary, the study indicated that some of these compounds have the potential for further development and utilization in the preparation of antioxidants and antimicrobial agents.Keywords:chitosan;l-arginine Schiff bases;heterocyclic compounds
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomolecules
·
2022
·Vol. 12
·期 11
·1601
·
IF 6.064
Weiyan Quan,Puwang Li,Jinsong Wei,Yuwei Jiang,Yingye Liang,Weilin Zhang,Qizhou Chen,Kefeng Wu,Hui Luo,Qianqian Ouyang
Creation of bio-multifunctional wound dressings with potent hemostatic, antibacterial, anti-inflammatory, and angiogenesis features for bolstering the healing of full-thickness wounds is sought after for clinical applications. We created bio-multifunctional composite sponges by coupling alginate and chitosan withSargassum pallidumpolysaccharides through electrostatic interactions, calcium ion (Ca2+) crosslinking, and lyophilization. Alginate/chitosan (AC) sponges with different concentrations ofSargassum pallidumpolysaccharides were obtained and termed AC, ACS—1%, ACS—2.5%, and ACS—5%. ACS—1% and ACS—2.5% sponges exhibited uniform porosity, high water vapor transmission rate, high water absorption, as well as good hemostatic and antibacterial abilities. ACS—2.5% sponges facilitated wound closure and promoted angiogenesis and re-epithelialization in the dermis. These data suggest that ACS sponges containing a certain amount ofSargassum pallidumpolysaccharides could be employed for treatment of full-thickness skin wounds.Keywords:Sargassum pallidumpolysaccharides;bio-multifunctional;composite sponges;wound healing;alginate;chitosan
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CONSTRUCTION AND BUILDING MATERIALS
·
2022
·
IF 7.693
Junxian Huang,Yu Liu,Yaseen Muhammad,Jia Qing Li,Yuting Ye,Jing Li,Zhuang Li,Ruinan Pei
Composite material using glutaraldehyde (GA) cross-linked chitosan (CTS) and graphene oxide (GO-CTS-GA) was designed applying electrostatic interaction strategy under strong alkali environment. GO-CTS-GA was in turn applied to prepare styrene butadiene styrene (SBS) GO-CTS-GA/SBS composite modified asphalt (MA)_binder. The effect of GO-CTS-GA on the physical properties of SBS modified asphalt binder was investigated and its mechanism of action was analyzed. Scanning electron microscopy (SEM), transmission electron microscopy (TEM) and atomic force microscopy tests confirmed the retainment of GO flakes microscopic dimensions while compensating for the chemical structural defects and mechanical property damage of GO. The results of dynamic shear rheometer and multi-stress creep recovery tests indicated that the GO-CTS-GA/SBS-MA binder exhibited better viscosity performance and elasticity performance, rutting resistance and high temperature thermal stability. At 64 °C, the loss modulus of 0.10 % GO-CTS-GA/SBS-MA was 29.5 % and 25.2 % higher than that of SBS-MA and GO/SBS-MA, respectively. SEM and TEM analyses of the four components of asphalt binder before and after modification revealed that the change of asphaltene microscopic morphology seriously affects the stability of asphalt colloidal system. Fourier transform infra-red analysis of the MA binder revealed that the change of saturation fraction and colloidal polarity by GO-CTS-GA is responsible for the dispersion and cross-linking of SBS chain segments in the asphalt binder phase. This study provides important reference information for nanomaterials to change the macroscopic mechanical properties by modulating the microstructure, physical and chemical properties of asphalt binder at the micro and nano-scale.
✓ 已验证
产品关联
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2022
·
IF 11.504
Ya-Ru Wang,Qin Yang,Ya-Nan Du,Han-Qing Chen
Food protein fibrils display superior mechanical and interfacial properties compared to the native protein. During processing, protein fibrils are stored for a long time and undergo pH shifts, which accelerate their degradation. In this study, the effects of chitosan on the morphology, structural and rheological properties of ovalbumin (OVA) fibrils after storage at pH higher than isoelectric point were studied. The results showed that OVA fibrils prepared at pH 2.0 remained stable after 7 days of storage. However, after storage at pH 8.0 for 7 days, the turbidity of OVA fibrils increased, the contour length and ThT fluorescence intensity decreased. Furthermore, OVA fibrils became stable again by interacting with chitosan via electrostatic interaction, which was confirmed by zeta potential . In addition, based on the results of Fourier transform infrared spectroscopy , sodium dodecyl sulfide polyacrylamide gel electrophoresis , and fluorescence spectra, it could be concluded that chitosan could interact with OVA fibrils at pH 8.0 during storage. Transmission electron microscope images indicated that the structure of OVA fibrils was maintained by the addition of positively charged chitosan. Finally, the viscosity and storage modulus of OVA fibrils after storage at pH 8.0 increased with the addition of chitosan. These findings implied that OVA fibrils were degraded when stored at pH above isoelectric point, but this degradation could be ameliorated by the addition of chitosan.
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Hongli Lyu,Yao Han,Rui Zhang,Yundi Wu,Xilong Wu
Significant amounts of radioactive wastewater including uranium are discharged into the environment as a result of the expansion of large-scale nuclear power. Due to uranium's toxicity and bioaccumulation, it is crucial to develop efficient and long-lasting adsorbents with functional groups for improving the selective removal of U(VI). By successfully introducing amidoxime and phosphate groups into quaternary ammonium chitosan (QCS-AO/P, i.e., QAP), an antimicrobial composite nanofiber adsorbent (PQAP) composed of polyvinyl alcohol (PVA) and the as-prepared QAP was synthesized via the solution blow spinning technology (SBS) technique for the highly efficient recovery of uranium from wastewater. The influence of initial pH, contact time, and sorbent composition on the uranyl ion absorption and the antibacterial assay was studied. The PQAP composite fiber mat had the highest adsorption capacity of uranyl ions at pH 8 (559.26 mg/g), and showed excellent antibacterial activities. After six adsorption–desorption cycles, PQAP still retained a high uranium adsorption capacity of 420 mg/g and elimination efficiency (84%). The novel integrated sorption and antibacterial strategy provides new insights for highly efficient treatment of radioactive wastewater.
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Youcai Hu,Jianhua Ding,Guangyuan Ren,Tianxiang Jin,Zhirong Liu,Yong Qian
Efficient separation and enrichment of thorium from aqueous solutions is an important subject in the field of energy and ecological environment. In this study, a novel polymer-based xerogel was prepared by a crosslinking reaction of 2-carboxyethyl phosphonic acid functionalized chitosan(CCS-TCEP) and was applied to the adsorption of Th(IV) ions. The maximum adsorption capacity of CCS-TCEP could reach 311.6 mg/g with an excellent selectivity due to the abundant binding sites for thorium provided by TCEP. Moreover, this material has a high adsorption rate and the adsorption equilibrium could be reached within 60 min. After 5 cycles of reuse, the adsorption capacity of CCS-TCEP still retained more than 80 % of its initial value. Furthermore, the extraction mechanism of CCS-TCEP for Th(IV) ions was also analyzed in detail by FT-IR, XPS and DFT calculation. This study indicates that CCS-TCEP can be used as a potential adsorbent for efficient extraction of thorium from aqueous waste.
✓ 已验证
产品关联
DOI
高影响因子
RARE METALS
·
2022
·Vol. 42
·期 2
·430-437
·
IF 6.318
Xu Hao-Hang,Yue Liang,Tang Yang,Liu Fan,Zhu Hong-Jiu,Bao Shu-Juan
Quasi-solid electrolytes promote the development of safe and flexible energy storage devices. In this work, a chitosan and citric acid crosslinked membrane is prepared by a freeze–thaw cross-linking method, in which the chemical crosslinking of chitosan and citric acid increase the viscoelastic behavior of the polymer membrane, and the freeze–thaw assist freeze drying process to create abundant interconnected open-pores and three-dimensional (3D) network. Due to the good viscoelasticity, excellent electrolyte loading capacity (596%) and high ion conductivity (7.7 × 10 –3 S·cm −1 ), as quasi-solid electrolyte, our proposed chitosan and citric acid crosslinked membrane helps Zn|CCFT-ZnSO 4 |AC hybrid supercapacitor to delivers wide operating voltage, high specific capacity of 100.5 F·g −1 and stable cycle life (93% after 1000 cycles), which suggests that our proposed freeze–thaw assisted freeze drying method has great potential in designing quasi-solid state electrolyte for energy storage device. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Siyi Li,Die Gao,Jing Lin,Zeng Wen,Kailian Zhang,Zhining Xia,Dandan Wang
A double-network hydrogel was prepared with the chitosan-cellulose composite as the rigid network and polyacrylamide as the flexible network (abbreviated as CCP hydrogel). A deep eutectic solvent synthesized by choline chloride and malic acid was used as the assistant solvent to dissolve cellulose for preparation of the CCP hydrogel. The obtained CCP hydrogel was characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, thermal gravimetric analysis, and stress-strain test. The properties of the CCP hydrogel are obviously better than those of the single network hydrogel. The compressive strength of CCP hydrogel is 2.8 times that of the chitosan-cellulose single network hydrogel. The CCP hydrogel exhibits the favorable swelling performance (swelling ratio of 955 %–1377 %), water-locking ability (water retention value of 40 %), and stability in aqueous system. Moreover, the CCP hydrogel performs the excellent adsorption capacity, fast adsorption efficiency, and good selective towards tetracyclines. The effects of temperature and solution pH on the adsorption properties of CCP hydrogel were assessed. The Langmuir, Freundlich, pseudo-first-order, pseudo-second-order, and thermodynamic models were applied to explore the adsorption characteristics of CCP hydrogel. After multiple adsorption/desorption cycles, the CCP hydrogel still maintains 84.3 %–93.4 % of adsorption capacity. Finally, the CCP hydrogel combined with ultra-performance liquid chromatography-mass spectrometry were used to analyze tetracyclines in food samples. The tetracycline (0.14 μg/mL) and minocycline (0.080 μg/mL) in milk, tetracycline (0.082 μg/mL) and minocycline (0.089 μg/mL) in fish, and tetracycline (0.078 μg/mL) and demeclocycline (0.10 μg/mL) in chicken were detected by CCP-hydrogel method with a high accuracy (recoveries of 75.82 %–108.8 %). Furthermore, for comparison with the CCP-hydrogel method, the traditional precipitation method was also applied to detect the tetracyclines in foods. The CCP-hydrogel method possesses a higher accuracy than traditional method, and can more accurately and satisfactorily detect tetracyclines in foods.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2022
·
IF 6.51
Xiaoying Wang,Yaling Zheng,Liangzhen Qiu,Huizhi Ouyang,Xueya Xu,Wen Xu,Yuqin Zhang,Wei Xu
D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS)-modified carboxymethyl chitosan-rhein (TCR) polymeric micelles (PMs) self-assembled by TCR conjugate were constructed for oral delivery of paclitaxel (PTX). PTX-loaded TCR PMs with a drug loading capacity of 47.52 ± 1.65 % significantly improved the intestinal absorption and oral bioavailability of PTX. TCR PMs loaded with PTX displayed time- and concentration-dependent cytotoxicity in Caco-2, MCF-7 and Taxol-resistant MCF-7 (MCF-7/Taxol) cells. In MCF-7/Taxol cells, PTX-loaded TCR PMs promoted apoptosis and changed cell cycle, and TCR conjugate exhibited a P-gp inhibition ability and caused ATP depletion. Moreover, confocal imaging of intestinal sections, Caco-2 cell uptake assay and in vivo bioimaging using environmental response fluorescence probe suggested that TCR PMs loaded with drugs can be absorbed as a whole through the intestinal epithelium after oral administration, enter systemic circulation, and then get to the tumor site. Remarkably, PTX-loaded TCR PMs displayed a significant antitumor effect in H22 tumor xenograft mice and the MCF-7 or MCF-7/Taxol xenograft zebrafish model, which was related to the inhibitory function of TCR conjugate for P-gp activity and P-gp and MDR1 expression. Functionalized TCR PMs are expected to improve the oral therapeutic efficacy of poorly water-soluble antitumor drugs and treat drug-resistant tumors.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Yumin Wu,Ying Ma,Yiliang Gao,Yuetao Liu,Chuanhui Gao
A poly (lactic acid) (PLA) -based functional partition composite membrane (PLA/CA) containing chitosan (CS) and alizarin (AL) was designed by solution casting method. The PLA/CA membrane contains the antibacterial zone of the edge part (PLA/CS) and the pH response detection zone of the central part (PLA/AL). At the same time, the environmentally friendly plasticizer tributyl citrate (TBC) was added to make the prepared PLA/CA composite membrane have good flexibility and high transparency. The results of FE-SEM and FTIR showed that CS and AL were uniformly dispersed in PLA matrix and had good compatibility with PLA. The antioxidant activities of PLA/CS and PLA/AL composite films were 43.3 % and 72.8 %, respectively. At the same time, the inhibitory rates of PLA/CS membrane against Escherichia coli and Staphylococcus aureus were as high as 87.91 % and 75.17 %, respectively. PLA/AL films exhibit excellent UV barrier properties. When the environmental pH (ammonia and acetic acid vapor) changed repeatedly, the PLA/AL membrane showed reversible color change of yellow under acidic condition and purple under alkaline condition. During the packaging and storage of chicken breast meat, the freshness of chicken breast meat can be detected by the color change of functional PLA/CA composite membrane.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Xiya Yang,Lingyuan Chen,Dong Ren,Shixing Wang,Zhaogang Ren
An O -hydroxyphenyl thiourea-modified chitosan ( OTCS ) with excellent Pb(II) adsorption performance and selectivity was prepared as an adsorbent. The structure and morphology of the adsorbent were systematically investigated by SEM, BET, FTIR, EDX , zeta-potential measurements, XPS and XRD. The impacts of the initial Pb(II) concentration, reaction time, temperature, pH value, and coexisting ions were explored. At pH 7 and 303 K, the maximal adsorption capacity of OTCS for Pb(II) was 208.33 mg/g, which was greater than those of other adsorbing materials reported in the literature. The metal ion adsorption kinetics and isotherm models were found to obey pseudo-second-order kinetics and the Langmuir isothermal model, indicating that the adsorption process was monolayer chemisorption. The adsorption process could proceed spontaneously, and the thermodynamic results revealed that the adsorption mechanism was an endothermic reaction. The ion exchange and chelation between the sulfur, nitrogen and oxygen groups on the adsorbent and lead ions endowed the material with excellent adsorption properties. Significantly, OTCS showed excellent selectivity toward Pb(II). Therefore, the adsorbent OTCS is expected to promote the wider application of chitosan in the adsorption of Pb(II).
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）