Nature Communications
·
2024
·Vol. 15
·期 1
·1-11
·
IF 14.7
Wang Kun,Shi Jianwei,Lai Wenxuan,He Qiang,Xu Jun,Ni Zhenyi,Liu Xinfeng,Pi Xiaodong,Yang Deren
Integrated circuit anti-counterfeiting based on optical physical unclonable functions (PUFs) plays a crucial role in guaranteeing secure identification and authentication for Internet of Things (IoT) devices. While considerable efforts have been devoted to exploring optical PUFs, two critical challenges remain: incompatibility with the complementary metal-oxide-semiconductor (CMOS) technology and limited information entropy. Here, we demonstrate all-silicon multidimensionally-encoded optical PUFs fabricated by integrating silicon (Si) metasurface and erbium-doped Si quantum dots (Er-Si QDs) with a CMOS-compatible procedure. Five in-situ optical responses have been manifested within a single pixel, rendering an ultrahigh information entropy of 2.32 bits/pixel. The position-dependent optical responses originate from the position-dependent radiation field and Purcell effect. Our evaluation highlights their potential in IoT security through advanced metrics like bit uniformity, similarity, intra- and inter-Hamming distance, false-acceptance and rejection rates, and encoding capacity. We finally demonstrate the implementation of efficient lightweight mutual authentication protocols for IoT applications by using the all-Si multidimensionally-encoded optical PUFs.
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Science China-Materials
·
2024
·
IF 6.8
Ding Baosen,Liu Shaojia,Lu Junfeng,Guo Yiran,Zheng Tian,Zhao Hewei,Guo Lin
The hierarchical structure of tooth enamel can inspire the preparation of high strength and high toughness biomimetic composites, but fully mimicking the entire hierarchy of tooth enamel is still challenging. Here, we show that synthetic hydroxyapatite (HAP) microbundles containing a long range of ordered crystalline/amorphous HAP nanowires can be spun into enamel-inspired high-performance macroscopic fiber through shear-induced assembly. The highly ordered nanowire-microbundle structure as well as the strong interfacial connection between HAP nanowires, HAP microbundles, and the polymer matrix, leads to a hierarchical energy dissipation route, which enables this enamel-inspired fiber with a high strength and toughness of 196.3 MPa and 46.3 MJ m −3 , exceeding the fracture toughness of previously reported HAP-based hybrid fibers. This hierarchical enamel-inspired design strategy provides a new sight into the development of high strength and high toughness fibers for potential engineering and bio-repair applications.
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JOURNAL OF MATERIALS SCIENCE
·
2024
·Vol. 59
·期 42
·19811-19824
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IF 3.5
Liu Weinan,Zhang Haiyang,Yuan Hang,Wang Lidong,Li Zhen
Peroxymonosulfate (PMS) is widely used in advanced oxidation processes. Fe(II) is an excellent catalyst for PMS, and organic pollutants in water can be effectively degraded in the Fe(II)/PMS system. However, the pollutant degradation efficiency is limited by the low conversion efficiency of Fe(II). Natural antioxidants exist in the water environment and have strong electron-donating ability. At present, the research on the introduction of natural antioxidants into the advanced oxidation processes to degrade pollutants focuses on a few polyphenols, and the effects of other natural antioxidants on the removal of pollutants are worth studying. In this study, natural antioxidants, proanthocyanidins (PCs), saponins (SPs), and Lycium barbarum polysaccharides (LBPs), were introduced into the Fe(III)/PMS system. The reduction ability of natural antioxidants was used to improve the conversion efficiency of Fe(III) to Fe(II), and PMS was more effectively activated to produce ROS, which promoted the degradation of ofloxacin (OFL). After the introduction of PC in the Fe(III)/PMS system, 80% of OFL was degraded at 20 min, and 90% of OFL was degraded at 120 min after the introduction of SP. The experimental results showed that the degradation of OFL was affected by the amount of antioxidants, PMS and Fe(III), pH value, and coexisting anions. Free radical quenching experiments showed that 1 O 2 , SO 4 − ·, and ·OH play an important role in the degradation of OFL in the Fe(III)/antioxidant/PMS system. This paper proves that the introduction of proanthocyanidins and saponins into the advanced oxidation processes can remove organic pollutants more efficiently. Graphical
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JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
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2011
·Vol. 73
·期 1
·237-246
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IF 1.22
He J.
In this work, the inclusion between methyl substitute β-cyclodextrin and some linear macromolecule in supercritical carbon dioxide medium was investigated. The contributions from several factors were studied; such as the hydrogen bonding interaction between the host and guest, the hydrogen bonding interaction between the neighborhood cyclodextrin rims threaded on the polymer chain, and the matching between the host cavity and the size of the polymer axis.
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CELLULOSE
·
2024
·Vol. 31
·期 6
·3645-3656
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IF 4.9
Hu Guizhen,Ning Juan,Wu Tian,Li Yuanjie,Nie Yamin,Lei Jiandu,Zhou Yanmei
Cellulose nanocrystals (CNCs) and polydopamine (PDA) have shown great application potential in the biomedical field due to their excellent biocompatibility. Using PDA@CNC as a carrier to construct functional nanocomposites for targeted fluorescence imaging of tumor cells and effective cancer treatment can expand the applications of CNCs in tumor diagnosis and treatment. Here, we conveniently modified microRNA-21 inhibitors (miRNAi) on PDA@CNC to construct a multifunctional nanocomposite (FAM-miRNAi@PDA@CNC) for achieving in situ fluorescence imaging of tumor biomarkers and photothermal effects to induce death of breast cancer cells. The overexpressed miRNA-21 in breast cancer cells hybridizes with FAM-miRNAi, triggering green fluorescence of FAM to recognize breast cancer cells. The rod-shaped morphology of FAM-miRNAi@PDA@CNC can effectively promote the endocytosis of FAM-miRNAi@PDA@CNC by the cell membrane. In addition, CNCs can stabilize the photothermal performance of PDA, and the photothermal conversion efficiency of PDA@CNC reached up to 61.66%, which will help FAM-miRNAi@PDA@CNC to achieve 70% apoptosis rate of breast cancer cells under 808 nm laser irradiation. The design of FAM-miRNAi@PDA@CNC provides a valuable pathway for CNCs utilization in biomedicine and accurate diagnosis and treatment of breast cancer.
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JOURNAL OF NANOBIOTECHNOLOGY
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2024
·Vol. 22
·期 1
·1-23
·
IF 10.6
Chen Rong,Wang Pinkai,Xie Jiajun,Tang Zinan,Fu Jinlang,Ning Yanhong,Zhong Qiang,Wang Ding,Lei Mingyuan,Mai Huaming,Li Hao,Shi Zhanjun,Wang Jian,Cheng Hao
The proficient handling of diabetic wounds, a rising issue coinciding with the global escalation of diabetes cases, poses significant clinical difficulties. A range of biofunctional dressings have been engineered and produced to expedite the healing process of diabetic wounds. This study proposes a multifunctional hydrogel dressing for diabetic wound healing, which is composed of Polyvinyl Alcohol (PVA) and N 1 -(4-boronobenzyl)-N 3 -(4-boronophenyl)-N 1 , N 1 , N 3 , N 3 -teramethylpropane-1, 3-diaminium (TSPBA), and a dual-drug loaded Gelatin methacryloyl (GM) microgel. The GM microgel is loaded with sodium fusidate (SF) and nanoliposomes (LP) that contain metformin hydrochloride (MH). Notably, adhesive and self-healing properties the hydrogel enhance their therapeutic potential and ease of application. In vitro assessments indicate that SF-infused hydrogel can eliminate more than 98% of bacteria within 24 h and maintain a sustained release over 15 days. Additionally, MH incorporated within the hydrogel has demonstrated effective glucose level regulation for a duration exceeding 15 days. The hydrogel demonstrates a sustained ability to neutralize ROS throughout the entire healing process, predominantly by electron donation and sequestration. This multifunctional hydrogel dressing, which integrated biological functions of efficient bactericidal activity against both MSSA and MRSA strains, blood glucose modulation, and control of active oxygen levels, has successfully promoted the healing of diabetic wounds in rats in 14 days. The hydrogel dressing exhibited significant effectiveness in facilitating the healing process of diabetic wounds, highlighting its considerable promise for clinical translation. Graphical Abstract
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Microbiome
·
2024
·Vol. 12
·期 1
·1-24
·
IF 13.8
Lyu Zhengtian,Yuan Gaoxiang,Zhang Yuying,Zhang Fengwenhui,Liu Yan,Li Yifan,Li Guang,Wang Ying,Zhang Ming,Hu Yongfei,Guo Yuming,Liu Dan
Background The gut microbiota is a key regulator of bone metabolism. Investigating the relationship between the gut microbiota and bone remodeling has revealed new avenues for the treatment of bone-related disorders. Despite significant progress in understanding gut microbiota-bone interactions in mammals, research on avian species remains limited. Birds have unique bone anatomy and physiology to support egg-laying. However, whether and how the gut microbiota affects bone physiology in birds is still unknown. In this study, we utilized laying hens as a research model to analyze bone development patterns, elucidate the relationships between bone and the gut microbiota, and mine probiotics with osteomodulatory effects. Results Aging led to a continuous increase in bone mineral density in the femur of laying hens. The continuous deposition of medullary bone in the bone marrow cavity of aged laying hens led to significant trabecular bone loss and weakened bone metabolism. The cecal microbial composition significantly shifted before and after sexual maturity, with some genera within the class Clostridia potentially linked to postnatal bone development in laying hens. Four bacterial strains associated with bone development, namely Blautia coccoides CML164, Fournierella sp002159185 CML151, Anaerostipes caccae CML199 (ANA), and Romboutsia lituseburensis CML137, were identified and assessed in chicks with low bacterial loads and chicken primary osteoblasts. Among these, ANA demonstrated the most significant promotion of bone formation both in vivo and in vitro , primarily attributed to butyrate in its fermentation products. A long-term feeding experiment of up to 72 weeks confirmed that ANA enhanced bone development during sexual maturity by improving the immune microenvironment of the bone marrow in laying hens. Dietary supplementation of ANA for 50 weeks prevented excessive medullary bone deposition and mitigated aging-induced trabecular bone loss. Conclusions These findings highlight the beneficial effects of ANA on bone physiology, offering new perspectives for microbial-based interventions for bone-related disorders in both poultry and possibly extending to human health.
Video Abstract Graphical Abstract
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Journal of Food Measurement and Characterization
·
2025
·
IF 3.3
Li Benyang,Shi Meng,Qin Si,Zeng Chaoxi
Fatty acids-based hydrophobic deep eutectic solvents (HDESs) have broad-spectrum antimicrobial activity. However, there is a lack of systematic studies on their antimicrobial mechanism at both experimental and molecular levels. In this work, we utilized hexanoic acid (HEA) and L-menthol (LST) to form HDES, and prepared HDES-in-water nanoemulsion, which is stable and effective in inhibiting the growth of E. coli . On this basis, we systematically investigated the antimicrobial mechanism of HDES against E. coli , examining the fluidity, integrity and permeability of cell membrane, morphological analysis of E. coli and molecular dynamics (MD) simulations. The results showed that HDES could decrease cell membrane fluidity and increase cell membrane permeability, which was further supported by MD simulations. In addition, HEA and LST can insert into the cell membrane, causing destabilization of the phospholipid bilayer, reduction of the membrane thickness, and disruption of the integrity of the cell membrane, leading to the efflux of intracellular material, which further promotes antimicrobial activity. The present work is important for the development of HDES-based natural antimicrobial agents to meet the increasing food safety challenges. Graphical
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-11
·
IF 14.7
Yin Li-Juan,Du Boyuan,Hu Hui-Yi,Dong Wen-Zhuo,Zhao Yu,Zhang Zili,Zhao Huichan,Zhong Shao-Long,Yi Chenyi,Qu Liangti,Dang Zhi-Min
Dielectric elastomers, used as driver modules, require high power density to enable fast movement and efficient work of soft robots. Polyacrylate elastomers usually suffer from low power density under low electric fields due to limited response frequency. Here, we propose a bimodal network polyacrylate dielectric elastomer which breaks the intrinsic coupling relationship between dielectric and mechanical properties, featuring relatively high dielectric constant, low Young’s modulus, and wide driving frequency bandwidth (~200 Hz) like silicones. Therefore, an ultrahigh power density (154 W kg −1 @20 MV m −1 , 200 Hz) is realized at low electric field and high resonance frequency, 75 times greater than at 10 Hz. Further, a rotary motor is developed, reaching an impressive speed of 1245 rpm at 19.6 MV m −1 and 125 Hz, surpassing previous acrylate-based motors and entering the high-speed domain of silicone-based motors. These findings offer a versatile strategy to fabricate high-power-density dielectric elastomers for low-electric-field soft actuators.
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MICROCHIMICA ACTA
·
2012
·Vol. 177
·期 1
·237-243
·
IF 3.033
Fan Yunchang,Zhang Sheli,Yang Fanming,Niu Haibo,Shi Jiajia
We have prepared the hydrophobic amino-functionalized ionic liquid (IL) 1-(2-aminoethyl)-3-butylimidazolium hexafluorophosphate and investigated its extraction behavior for copper(II) ion as a model cation. The IL, due to the presence of an amino group, is capable of complexing Cu(II) in a ratio of 6:1. The parameters affecting the extraction efficiency were optimized. The IL-based liquid–liquid microextraction was successfully applied to the analysis of Cu(II) in an environmental water standard reference material. The results are promising in terms of liquid–liquid microextraction, separation, and preconcentration of Cu(II).
A hydrophobic amino-functionalized ionic liquid (IL) [NH 2 C 2 C 4 im][PF 6 ] was synthesized. The IL exhibits good extractability for copper (II) ion due to the presence of an amino group.
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Food and Bioprocess Technology
·
2024
·
IF 5.3
Wang Chenwei,Liu Chang
In recent years, there has been a growing interest in advanced packaging films made from natural polymers. These films are integrated with pH-sensitive dyes, aiming to monitor the freshness of food. Specifically, the development of pH-adaptive intelligent packaging films, known as MC 5 /ZA 5 -Anth 3% , involves using methylcellulose (MC) and zinc alginate (ZA) as the foundational materials, with anthocyanins (Anth) serving as the freshness indicators. The production of MC 5 /ZA 5 -Anth 3% films has resulted in improved thermal stability, mechanical properties and water resistance, alongside a reduction in the transmission of ultraviolet–visible (UV–vis) light through the material. Importantly, these color-changing films undergo a noticeable change in color when subjected to pH changes or exposure to ammonia gas, making them suitable for detecting shifts in the pH of foods like pork and shrimp, the presence of volatile nitrogen compounds, and early signs of food degradation. Upon exposure to varying pH buffers, the color indicator film underwent a noticeable transition from a reddish-pink hue to blue, ultimately shifting to blue-green. Consequently, this pH-sensitive color indicator film emerges as a viable candidate for the smart, real-time monitoring of freshness in perishable foods such as pork and shrimp.
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 2
·1-11
·
IF 5.3
Zhao Zhe,Li Zhixin,Huang Jiahui,Deng Xiaoyu,Jiang Fan,Han Ray P.S.,Tao Yingzhou,Xu Shaohua
Hyaluronidase (HAase) is an important endoglycosidase involved in numerous physiological and pathological processes, such as apoptosis, senescence, and cancer progression. Simple, convenient, and sensitive detection of HAase is important for clinical diagnosis. Herein, an easy-to-operate multicolor visual sensing strategy was developed for HAase determination. The proposed sensor was composed of an enzyme-responsive hydrogel and a nanochromogenic system (gold nanobipyramids (AuNBPs)). The enzyme-responsive hydrogel, formed by polyethyleneimine-hyaluronic acid (PEI-HA), was specifically hydrolyzed with HAase, leading to the release of platinum nanoparticles (PtNPs). Subsequently, PtNPs catalyzed the mixed system of 3,3′,5,5′-tetramethylbenzidine (TMB) and H 2 O 2 to produce TMB 2+ under acidic conditions. Then, TMB 2+ effectively etched the AuNBPs and resulted in morphological changes in the AuNBPs, accompanied by a blueshift in the localized surface plasmon resonance peak and vibrant colors. Therefore, HAase can be semiquantitatively determined by directly observing the color change of AuNBPs with the naked eye. On the basis of this, the method has a linear detection range of HAase concentrations between 0.6 and 40 U/mL, with a detection limit of 0.3 U/mL. In addition, our designed multicolor biosensor successfully detected the concentration of HAase in human serum samples. The results showed no obvious difference between this method and enzyme-linked immunosorbent assay, indicating the good accuracy and usability of the suggested method. Graphical Abstract
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高影响因子
危险品化学品经营许可证（带存储）