Journal of Materials Chemistry A
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2017
·Vol. 6
·期 4
·1496-1503
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IF 8.867
Xiangdong Ma,Xiaoxi Zuo,Jinhua Wu,Xiao Deng,Xin Xiao,Jiansheng Liu,Junmin Nan
A new polyethylene (PE)-supported ultra-thin blended polymer electrolyte based on polyvinylidene fluoride/hydroxyethyl cellulose (PVDF/HEC) was prepared by a simple dipping method for 5 V high voltage lithium-ion batteries (LIBs). The performances of the prepared membranes and the resulting GPEs were investigated by scanning electron microscopy, electrochemical impedance spectroscopy, linear potential sweep voltammetry, and charge–discharge cycling. The effects of the ratio of PVDF to HEC on the performance of the composite separator were further discussed. It was found that PE-supported polymer separators (PVDF : HEC = 3 : 1, by weight) present the best mechanical, thermal and wettability performance. The ionic conductivity of this GPE is 0.78 mS cm−1, which is much higher than that of PE separators (0.39 mS cm−1) at room temperature. The electrochemical stability of this GPE can reach up to 5.25 V (vs. Li/Li+). A LiNi0.5Mn1.5O4 cathode with this GPE exhibits a superior cycling stability and rate performance at room temperature. This suggests that the polyethylene (PE)-supported ultra-thin blended polymer electrolyte can be used for 5 V LIBs due to its good performance, low cost and strong operability.
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JOURNAL OF THE ENERGY INSTITUTE
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2026
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IF 6.5
Liqin Yang,Peng Lv,Jiaofei Wang,Xudong Song,Juntao Wei,Yonghui Bai,Weiguang Su,Guangsuo Yu
V 2 O 5 -modified hierarchical ZSM-5 catalysts were synthesized. • The catalysts enhanced deoxygenation during biomass pyrolysis. • The obtained bio-oil was enriched in aromatic hydrocarbons. • The bio-oil upgrading mechanism over the catalysts was elucidated. Biomass catalytic pyrolysis is a key technology for converting biomass into high-value bio-oil as a sustainable alternative to fossil resources. To address the limitations of conventional microporous zeolites, such as mass transfer constraints and insufficient deoxygenation capability during bio-oil upgrading, this study employed V 2 O 5 -modified hierarchical ZSM-5 zeolite as the catalyst and corn stover as the feedstock to investigate the catalytic upgrading process. A hierarchical ZSM-5 zeolite with intercrystalline mesopores was first prepared via a mechanical ball milling-recrystallization method, followed by V 2 O 5 loading using wet impregnation. The catalyst's structure and properties were systematically characterized. Fast catalytic pyrolysis experiments of corn stover showed that the Me 0.004 support possesses a well-defined hierarchical pore structure, which facilitates the diffusion and reaction of large molecules in bio-oil. The redox properties of V 2 O 5 promoted the catalytic deoxygenation of biomass macromolecules, yielding smaller molecular intermediates. These intermediates subsequently underwent a series of reactions, including Diels–Alder cyclization and dehydrogenative aromatization, leading to the formation of aromatic hydrocarbons (AHs) over the ZSM-5 catalyst. In particular, the V2/Me 0.004 catalyst achieved an aromatic hydrocarbon yield 1.94 times higher than that of conventional ZSM-5. Based on pyrolysis experiments with model compounds, possible reaction pathways for AHs formation from corn stover over the developed catalyst were proposed. This study provides a theoretical foundation and technical support for the production of high-value chemicals, contributing to the advancement of efficient biomass resource utilization. Download: Download high-res image (540KB) Download: Download full-size image
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MICROPOROUS AND MESOPOROUS MATERIALS
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2021
·
IF 5.455
Jingyu Liu,Chaoyue Zhang,Daiyu Song,Yihang Guo,Jiyan Leng
Brønsted acidic ionic liquid (BAIL) functionalized dendritic fibrous nanosilica sphere catalysts, [C 3 PrIm][SO 3 CF 3 ]-DFNS (C 3 = PrSO 3 H), are prepared via a hexadecylpyridinium bromide reverse micelle-directed co-condensation of tetraethoxysilane and 3-chloropropyltriethoxysilane in a water-in-oil emulsion system followed by successive chemical modification with imidazole , 1,3-propanesultone and trifluoromethane sulfonic acid , and the particle diameter, fiber thickness and fiber density of the catalysts are well-adjusted by changing the composition of the starting materials. The [C 3 PrIm][SO 3 CF 3 ]-DFNS catalysts are successfully applied in transformation of 5-hydroxymethylfurfural (HMF) to ethyl levulinate (EL). Combination of superstrong Brønsted acidity and unique open three-dimensional dendritic fibrous nanostructures , the [C 3 PrIm][SO 3 CF 3 ]-DFNS can transform HMF in ethanol media rapidly and completely; nevertheless, the selectivity to EL remarkably depends on the fiber thickness and fiber density, which affect diffusion and mass transfer of the reactants and products as well as the accessibility to the acid sites. Among the tested [C 3 PrIm][SO 3 CF 3 ]-DFNS catalysts, the [C 3 PrIm][SO 3 CF 3 ]-DFNS- 1 with the thinnest fiber sheet and considerably high fiber density exhibits the highest selectivity to EL (93.0%). The [C 3 PrIm][SO 3 CF 3 ]-DFNS catalysts also show good reusability, and they can be reused at least for five times without obvious changes of the reactivity, total selectivity, morphology, textural properties and chemical structure .
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FUEL
·
2025
·
IF 7.5
Hucheng Ge,Yufei Gu,Feifei Liu,Yanmei Huang,Yuke Liu,Silin Wu,Yunshuang Hu,Zhixia Li,Hongfei Lin
The core–shell structured MCM-22/ZSM-5 zeolite (MZCS50) was synthesized through a combination of hydrothermal crystallization (to form the MCM-22 core) and steam-assisted crystallization (to form the ZSM-5 shell). The MCM-22 core exhibited lamellar cake-like shape with a diameter of 3 ∼ 4 µm, while the ZSM-5 shell consisted of aggregated nanoparticles. MZCS50 possessed a high specific surface area, a micropore-mesopore coexisting structure, and was Brønsted acid-dominant material. MZCS50 was used as a catalyst for the cracking of low-density polyethylene (LDPE) to produce BTEX (benzene, toluene, ethylbenzene and xylenes). The results showed that 550 °C was the optimal temperature for LDPE cracking. The maximum liquid yield achieved was 23.4 %, with selectivities to BTEX, xylenes and p -xylene of 79.8 %, 43.2 %, and 21.3 %, respectively. Repeated cracking experiments demonstrated that MZCS50 exhibited good stability and superior catalytic performance in converting toluene to xylenes and further transforming xylene isomers into p -xylene. These results indicate that the core–shell structured MZCS50 is a promising catalyst for converting plastic wastes into valuable p -xylene.
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JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
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2025
·
IF 3.3
Ma Shutian,Shi Zhuang,Yang Yi,Zhang Jinglin,Zou Hongyu,Diao Enjie,Zhang Liming
Solo-bulb black garlics (SBBG) are novel foods rich in nutritional and functional ingredients. However, certain process contaminants formed during thermal processing of SBBG raise safety concerns. This study investigated the formations of 5-hydroxymethyl-2-furfural (5-HMF) and acrylamide, as well as the browning degree of SBBG during a 12-day aging period. Both 5-HMF and acrylamide contents exhibited exponential increases, with their formations well simulated by pseudo-first-order kinetic models. 5-HMF formation showed a significant positive correlation with fructose content ( p < 0.05), while acrylamide formation was strongly associated with asparagine content ( p < 0.01). Browning degree correlated significantly with acrylamide accumulation and asparagine content ( p < 0.01), but not with 5-HMF ( p > 0.05). These results indicate that fructose and asparagine accumulations play critical roles on 5-HMF and acrylamide formations in SBBG, respectively, and acrylamide accumulation promotes SBBG browning. Notably, acrylamide level in SBBG exceeded those reported in some commonly consumed foods, which is a concern considering the daily consumption of this food.
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CHEMISTRY & BIODIVERSITY
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2024
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IF 2.3
Yongchang Bi,Jingjun Wang,Xingyu Bian,Mingyue Chen,Guangyuan Zhu,Yumin Zhang,Qiang Gu
An efficient and green method for synthesizing 3-methyl-4-(hetero) arylmethylene isoxazole-5(4 H )-ones was developed using a recyclable and environmental–friendly catalyst, Na 2 S 2 O 3 , and 16 target compounds were successfully synthesized under the obtained optimal reaction condition. Using rifampicin as a positive control, the antibacterial activity of all synthesized compounds was tested by micro dilution method, among them, 3-methyl-4-[(2,4-dimethoxyphenyl) methylene]-isoxazole-5-one ( 4 m ) presented wonderful antimicrobial activity, which may contribute to the development of anti-tuberculosis drugs. Graphical
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ANALYTICAL CHEMISTRY
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2025
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IF 6.7
Xinxin Zheng,Sidi Cun,Jiatai Yin,Xue Zhao,Yunshan Wang,Jing Wang,Qian Li,Xinfeng Zhao
The sensitivity, selectivity, and accuracy of immobilized protein-based methods are critically dependent on the strategies employed for protein immobilization. Compared with random immobilization approaches, site-specific covalent methods have emerged as promising alternatives, offering enhanced analytical performance. However, these methods typically require genetic modification of the target protein to incorporate a specific tag or prior purification of the protein, posing significant challenges for immobilizing endogenous proteins. Herein, we address these limitations by using the 5-hydroxytryptamine transporter (5-HTT) as a model system. We designed a probe by conjugating fluvoxamine─a specific ligand of 5-HTT─with either a fluorescent reporter or aminopropyl-modified silica gel through an alkyl linker containing an acyl imidazole moiety as the reactive group. By introducing ligand-directed acyl imidazole (LDAI) chemistry, we achieved selective labeling of 5-HTT in live cells and endogenous 5-HTT immobilization without purification in advance. Labeling experiments confirmed the high specificity and favorable kinetics of the LDAI ligands toward 5-HTT. Chromatographic analysis revealed significant improvements in selectivity (5.7–50.9-fold), resolution (1.2–3.0-fold), and sensitivity (1.0–12.0-fold) for analyzing canonical ligands when using immobilized endogenous 5-HTT, compared to His-tagged and Halo-tagged recombinant proteins. This approach, by substituting fluvoxamine with other ligands in the probe, can be generalized for the labeling and immobilization of a wide range of endogenous proteins, offering a versatile platform for advanced protein-based analytical techniques.
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PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
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2025
·
IF 1.9
Junxin Zhao,Yiman Wu,Yuhan Yao,Tonglei Zhou,Yiming Xu,Jingyi Gui,Didi Guo,Xinshuo Yang,Deguo Wang,Xianghui Yan,Ping Yu,Zheling Zeng,Fugang Xiao
This study investigates the effects of atmospheric room temperature plasma (ARTP) mutagenesis on the morphological and genetic modifications of the lipase-producing strain Bacillus licheniformis NCU CS-5. While traditional strain improvement methods often suffer from low mutation rates and uneven mutation distribution, ARTP mutagenesis offers a powerful and efficient alternative. The significance of this study lies in its potential to enhance lipase production, a key enzyme in various industrial applications, through the generation of high-performance mutant strains. The gap in existing literature pertains to the limited understanding of ARTP-induced mutations in B. licheniformis and their impact on enzyme production. The novelty of this study is to explore the morphological and genetic changes induced by ARTP and to identify key genetic determinants contributing to these changes. Key findings include significant morphological alterations, higher intracellular Ca2+ levels, and numerous single-nucleotide variants (SNVs) and insertions/deletions (InDels) in the mutant strain. These findings imply that ARTP mutagenesis can effectively enhance lipase production, paving the way for optimized industrial microbial strains.
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JOURNAL OF DENTISTRY
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2025
·
IF 5.5
Lingkang Lin,Zhengyuan Yang,Shihui Yang,Qi Lin,Yanlin Zhu,Song Zhu
Objectives This study focused on assessing the impact of combined with glycolic acid (GA) and pyridoxal 5-phosphate (PLP) on the strength and stability of dentin bonding. Methods GA with 37% concentration was prepared as acid etch, and PLP of varying doses (0.5 wt%, 1.5 wt%, and 2.5 wt%) was used as a primer. Additionally, the demineralization ability of phosphoric acid (PA) and GA on the dentin surface was detected using scanning electron microscopy (SEM). Fourier transform infrared spectroscopy (FTIR) was used to analyze the cross-linking effect of PLP with demineralized dentin collagen, and the effect of PLP on the single bond universal’s degree of conversion. The adhesion property of dentin was assessed using testing micro-tensile bond strength (μTBS), endogenous matrix metalloproteinase (MMPs) activity, nanoleakage, and the morphology at the resin-dentin bonding interface, following 10,000 thermal cycles. Results SEM observation demonstrated that etching with 37% GA for 30 s could effectively demineralizing the dentin surface and the adhesive strength was equivalent to that of the PA group ( p > 0.05). In addition, adhesive strength after aging increased relative to the PA group ( p < 0.05). The FTIR analysis results exhibited that 1.5% PLP improved the conversion rate of adhesive and the effect of chemical binding with collagen fibers. The GA+1.5% PLP group significantly enhanced the bonding interface μTBS, effectively reducing the nanoleakage and activities of MMPs, with no significant difference before and after aging ( p > 0.05), demonstrating excellent aging resistance. Conclusions GA can effectively replace PA as an acid etching agent for treating the dentin surface. The bonding strength of the PA group and the nanoleakage results showed a significant decrease after aging. The combination of 37% GA+1.5% PLP not only demineralizes dentin rapidly but also facilitates cross-linking of collagen fibers to reduce degradation and enhance the bonding quality of the hybrid layer. Clinical significance Compared with the traditional PA etching method, the combined application of 37% GA with 1.5% PLP has made better improvements in maintaining the long-term durability of the bonding interface, providing a potential solution for etching and biologically modifying the dentin substrates.
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BIOORGANIC CHEMISTRY
·
2022
·
IF 5.307
Yongxi Dong,Mingji Liu,Yongqing Mao,Shuxia Wu,Jinlan Wen,Jun Lu,Yaxin Yang,Shiyang Ruan,Lei Li,Xinyun Liu,Jiquan Zhang,Shanggao Liao,Li Dong
Carnosic acid could disrupt the β-catenin/BCL9 protein-protein interaction and inhibit β-catenin dependent transcription, thereby reduce the incidence of colorectal cancer induced by abnormal activation of Wnt/β-catenin signalling pathway. However, its activity was weak (IC 50 for SW480: 28.2 ± 2.05 μM) and total synthesis was difficult. During the structural simplification of natural products, S0 was revealed to be the basic pharmacophore of carnosic acid. Subsequent structural optimization of S0 led to the discovery of S11 as a possible anticancer agent with prominent proliferation inhibition effect (IC 50 for SW480: 9.56 ± 0.91 μM) and best selectivity index (SI = 3.0) against Wnt hyperactive cancer cells. Futher mechanism investigation through TOP/FOP dual luciferase reporter assay, immunofluorescence, co-immunoprecipitation, microscale thermophoresis, downstream oncoprotein expression and cell apoptosis showed that compound S11 could significantly inhibit the proliferation of SW480 cells via obvioudsly decreasing the nucleus translocation of β-catenin and effectively disrupting β-catenin/BCL9 protein-protein interaction. Additionally, cell migration, molecule docking, in vitro stability and solubility assays were also conducted. Overall, S11 was worthy of in-depth study as a potential inhibitor for the Wnt/β-catenin pathway and its discovery also proved that the structural simplification of natural products was still one of the effective methods to find new lead compounds or candidate drugs.
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TOXICOLOGY AND APPLIED PHARMACOLOGY
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2021
·
IF 4.219
Long Ma,Yingying Lu,Yaqin Li,Zhizhen Yang,Yu Mao,Yi Wang,Shuli Man
Adenosine, as a naturally occurring nucleoside , plays an important role in human health maintenance. In recent years, many studies have shown that adenosine has the effect of cancer inhibition, and some of its analogs have been successfully marketed as anticancer drugs . This report mainly describes the anti-colon cancer activities and mechanism of a novel halogenated adenosine analog named 5′-bromodeoxyadenosine (5’-BrDA). As a result, 5’-BrDA concentration-dependently inhibited colon cancer cells proliferation , induced autophagy without disruption of lysosomal stability, and promoted autophagy-independently cellular mitochondrial apoptosis by increasing the accumulation of reactive oxygen species . Furthermore, 5’-BrDA inhibited the tumor growth of colon cancer in CT26 inbred mice without affecting the body weight in vivo . Collectively, the above-mentioned mechanisms contributed to the anticancer activity of 5’-BrDA. It is rare to discover novel anticancer adenosine analogs during the past couple of decades. We believe that our work will enrich the understanding of adenosine analogs, also, pave the way for adenosine analogs product based anticancer drug development.
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TOXICOLOGY AND APPLIED PHARMACOLOGY
·
2018
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IF 3.616
Yanzhuo Liu,Chenfan Duan,Honglei Chen,Chenlong Wang,Xiaoxiao Liu,Miao Qiu,Honglin Tang,Feng Zhang,Xiaoyang Zhou,Jing Yang
Cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX) and microsomal prostaglandin E synthase-1 (mPGES-1)-derived eicosanoids play an essential role in human inflammatory disorders. Here, we investigated whether inhibition of COX-2/mPGES-1 and 5-LOX in macrophages by leonurine ameliorates monosodium urate (MSU) crystal-induced inflammation. Virtual screening assay and in vitro enzyme inhibition assay showed that leonurine was a potential inhibitor of COX-2, mPGES-1 and 5-LOX. Compared with COX-2 inhibitor celecoxib , leonurine (30 mg/kg) significantly decreased ankle perimeter, gait score and neutrophil number in synovial fluid in MSU crystal-treated rats, accompanied with the decreased expression of COX-2, mPGES-1 and 5-LOX and production of prostaglandin E 2 (PGE 2 ) and leukotriene B 4 (LTB 4 ) in the synovial fluid macrophages. In addition, leonurine decreased representative M1 marker (iNOS and CD86) expression, NLRP3 inflammasome activation and M1 cytokine (TNF-α and IL-1β) production. In the in vitro cultured RAW264.7 and human monocyte-derived macrophages (MDMs), blockade of COX-2/mPGES-1 and 5-LOX by leonurine inhibited macrophage M1 polarization and NLRP3 inflammasome activation in response to MSU crystals, and thus down-regulated IL-1β and TNF-α with STAT1 and NF-κB inactivation. Conversely, these effects were partially abolished by overexpression of COX-2, mPGES-1, 5-LOX or STAT1. Furthermore, leonurine prevented a positive feedback loop between COX-2/mPGES-1/5-LOX and IL-1β/TNF-α in MSU crystal-induced inflammation. Together, simultaneous down-regulation of COX-2/mPGES-1 and 5-LOX by leonurine ameliorates MSU crystal-induced inflammation through decreasing IL-1β and TNF-α production. Our study may provide novel multi-target agents toward the arachidonic acid (AA) network for gouty arthritis therapy.
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