Polymer Chemistry
·
2019
·Vol. 10
·期 20
·2551-2558
·
IF 4.76
Wenyu Cheng,Hongtao Chen,Chendong Ji,Ru Yang,Meizhen Yin
Perylenediimide-cored (PDI-cored) polymers have been widely applied as fluorescent drug carriers due to their high fluorescence quantum yield and outstanding chemical/photophysical stability. However, most of these delivery systems lack detailed drug delivery specifics, especially when and where the drug is released. In this study, a PDI-based nanocarrier (PPL-B) is constructed and applied to monitor curcumin release with an “off–on” fluorescence switch. The star-shaped drug carrier has an amphiphilic structure with fluorescent PDI as the core and poly(amino acid) as the shell, which is suitable for drug delivery. A model drug curcumin is loaded to PPL-B and quenches its fluorescence significantly through photo-induced electron transfer (PET). Upon curcumin release, the fluorescence of PPL-B achieves an “off–on” switch as a result of PET interruption. In light of this, curcumin release is successfully monitored by CUR@PPL-B at the cellular level. This PDI-based nanocarrier for drug release monitoring with a PET mechanism shows great potential in the drug delivery field.
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FOOD AND AGRICULTURAL IMMUNOLOGY
·
2018
·
IF 2.568
Kai Hao,Steven Suryoprabowo,Shanshan Song,Liqiang Liu,Qiankun Zheng,Hua Kuang
Procaine (PRC) is a local anaesthetic used in the treatment of several disease related to ageing, asthma, and arthritis. In this study, we describe a rapid, sensitive, simple, and accurate method for the determination of PRC in milk, using an immunochromatographic test strip. For the immunochromatographic test, antigen (PRC-bovine serum albumin) and goat anti-mouse IgG were drawn onto a nitrocellulose membrane representing the control line and test line. The test was developed with a sensitive monoclonal antibody specific for PRC, generated by immunizing BALB/c mice with a well-characterized PRC- Keyhole limpet hemocyanin conjugate, produced in our laboratory. Under optimized conditions, the semi-quantitative test strip was able to detect PRC at concentrations down to 1 ng/mL in both 0.01 M phosphate buffer saline (pH 7.4) and milk samples. All results were obtained within 5 min. Our data indicate that the immunochromatographic assay is capable of sensitive, rapid, and specific on-site screening of PRC.
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DALTON TRANSACTIONS
·
2018
·Vol. 47
·期 15
·5459-5464
·
IF 4.099
Mengmeng Zhu,Yunjie Zhou,Yue Sun,Cheng Zhu,Lulu Hu,Jin Gao,Hui Huang,Yang Liu,Zhenhui Kang
The oxygen evolution reaction (OER) is a promising energy conversion system, which has been studied a lot in recent years. However, owing to the high overpotential and sluggish kinetics of the OER, an efficient electrocatalyst is necessary to lower the overpotential and accelerate the reaction. In this paper, we report a cobalt phosphide (CoP)/carbon dots (CDs) composite as an electrocatalyst for the OER for the first time. A facile two-step method was used to synthesize the CoP/CDs composite and the concentration of CDs in the composite was further regulated. The experimental results show that when the amount of CDs in the composite is 6 mg (28.79 wt%C), the obtained CoP/CDs composite exhibits optimal electrocatalytic activity (with an overpotential of 400 mV in 1 M KOH at a current density of 10 mA cm−2) and high stability towards the OER. The good electrocatalytic activity of the composite is attributed to the small size of CoP and CDs and rapid electron transfer of CDs.
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PubMed
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MINERALS ENGINEERING
·
2022
·
IF 5.479
Sihui Wu,Jianjun Wang,Liming Tao,Ruihua Fan,Cong Wang,Wei Sun,Zhiyong Gao
In the flotation separation of chalcopyrite and pyrite, the commonly used high-lime process often causes problems such as losses of precious metals, blockage in pipelines and environmental pollution. In this study, acetylacetone (AA) was used as a novel collector to separate chalcopyrite from pyrite without adding limes. The flotation results indicate that AA can selectively separate chalcopyrite from pyrite without depressants at pH 9.0. Flotation kinetics and entrainment calculations show that compared with potassium ethyl xanthate (KEX), AA reduces pyrite entrainment and produces the concentrate with a higher Cu grade and a higher separation efficiency. Solution chemistry calculations show that enolate (AAE - ) and ketone (AAK) are the dominant species of AA at pH 9.0. Contact angle measurements, zeta potential measurements and Fourier transform infrared (FTIR) analysis indicate that the dominant species of AA chemically adsorb onto chalcopyrite surfaces at pH 9.0 while the adsorption on pyrite is minimal. Density functional theory (DFT) analysis reveals that the Fe atoms on chalcopyrite are the active sites interacting with AA to form six-membered ring complexes. The selective adsorption of AA relies on the spatial distribution and reactivity of Fe atoms on the commonly exposed cleavage surfaces of chalcopyrite and pyrite. After surface relaxation, a layer of Fe atoms appears on the outermost layer of chalcopyrite (1 1 2) surface, which is beneficial for the adsorption of AA species while a layer of S atoms for pyrite (1 0 0) surface. The Fe (III) on chalcopyrite (1 1 2) surface has a higher reactivity than the Fe (II) on pyrite (1 0 0) surface, leading to a higher adsorption energy of AA species on the chalcopyrite. Therefore, this acetylacetone-based lime-free process has a great potential for industrial application in the separation of chalcopyrite from pyrite.
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JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2021
·Vol. 168
·期 11
·112508
·
IF 4.316
Yun Xue,Jianzhang Gao,Zhenchao Ma,Jiadong Wang,Meng Cao,Chen Guo,Peng Liu,Fuqiu Ma,Yongde Yan,Min Qiu
The redox mechanism of U(VI) to U(IV) in carbonate system was studied by cyclic voltammetry. Based on the analysis of cyclic voltammograms at different pHs and switching potentials, combined with the speciation analysis of uranyl at different pHs, the two-step reactions of U(VI) to U(V) and U(V) to U(IV) were confirmed at pH 8.0. The determination results of U(Ⅴ) diffusion coefficient and U(Ⅴ) to U(IV) reaction kinetic rate constant under different pHs showed that pH 8.0 has certain advantages over other pHs. The calculated results of these two parameters at different temperatures revealed that the increase of temperature promotes the diffusion coefficient of U(V) and the kinetic rate constants of U(V) to U(IV) reaction. The SEM and EDS analysis of the electrodeposited samples showed that uranyl can be rapidly, stably, and uniformly deposited on the Pt electrode surface by potentiostatic deposition in carbonate system. The XRD results confirmed the complexity of the deposited samples under different pHs, not just the UO2. The fitting results of XPS spectra under different potentials proved that the deposition samples contained uranium-containing oxides, uranium-containing carbonates, and uranium-containing hydroxides. In addition, the deposition mechanism of the potentiostatic deposition in different potential intervals has been established.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Chengyu Duan,Jianyu Wang,Qikai Liu,Yi Zhou,Yanbo Zhou
Salbutamol (SAL) and Atenolol (ATL), two common medical ingredients acting on adrenal receptor, are often used for treating chronic illnesses. However, the incomplete metabolism in organism and widespread utilization lead to unneglected problems of water pollution, which the traditional treatment plant cannot satisfactorily deal with. For efficient removal of SAL and ATL, a kind of silanized β-cyclodextrin compound adsorbents (GD-EDTS) was designed based on the ionization features of two pollutants. Through an introduction of rich carboxyl groups by N-[(3-Trimethoxysilyl)propyl]ethylenediamine triaceticacid trisodium salt (EDTS), GD-EDTS surface obtains an appropriate electronegativity to meet different forms of IOCs and maintain a good adsorption performance in a wide pH range. The maximum adsorption capacities of SAL and ATL are 140.24 mg/g and 236.92 mg/g, respectively. And a remarkable rise is known from the adsorption capacity of SAL and ATL increasing to 162% and 706%, respectively, after EDTS modification. Adsorption data fit the Sips adsorption isotherms and the pseudo second-order kinetic model, and a weak competitive behavior between SAL and ATL indicates two pollutants can be removed simultaneously by GD-EDTS in their binary system. In this work, GD-EDTS is suggested to be an efficient adsorbent in the removal of SAL and ATL.
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JOURNAL OF FLUORESCENCE
·
2022
·Vol. 32
·期 2
·669-680
·
IF 2.525
Liu Ziping,Liu Shasha,Gao Decai,Li Yanan,Tian Ye,Bai Edith
In this work, a convenient and dual-signal readout optical sensing platform for the sensitively and selectively determination of beta-glucosidase (β-Glu) activity was reported using protein-inorganic hybrid nanoflowers [BSA-Cu 3 (PO 4 ) 2 ·3H 2 O] possessing peroxidase-mimicking activity. The nanoflowers (NFs) were facilely synthesized through a self-assembled synthesis strategy at room temperature. The as-prepared NFs could catalytically convert the colorless and non-fluorescent Amplex Red into colored and highly fluorescent resorufin in the presence of hydrogen peroxide via electron transfer process. β-Glu could hydrolyze cyanogenic glycoside, using amygdalin (Amy) as a model, into cyanide ions (CN − ), which can subsequently efficiently suppress the catalytic activity of NFs, accompanied with the fluorescence decrease and the color fading. The concentration of CN − was controlled by β-Glu-triggered enzymatic reaction of Amy. Thus, a sensing system was established for fluorescent and visual determination of β-Glu activity. Under the optimum conditions, the present fluorescent and visual bimodal sensing platform exhibited good sensitivity for β-Glu activity assay with a detection limit of 0.33 U·L −1 . The sensing platform was further applied to determinate β-Glu in real samples and satisfactory results were attained. Additionally, the optical sensing system can potentially be a promising candidate for β-Glu inhibitors screening.
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BIOSENSORS & BIOELECTRONICS
·
2022
·
IF 12.545
Jianwei He,Xiaoyan Zhang,Yuanyi Qian,Qiyao Wang,Yunpeng Bai
The environmental accumulation of organophosphates is a serious threat to public health. To detect these xenobiotics , a broad range of sensors has been developed in past decades. However, sensors with high sensitivity and a capability for degrading organophosphates are rare. In this study, “smart” whole-cell biosensors were created by combining synthetic biology approaches with the bacterial quorum sensing (QS) mechanism. The engineered whole-cell biosensor pUC57-QS-DSF-F42 L/E coli DH5α can sense a wide array of phenolic compounds including phenol and p -nitrophenol (p-NP). By optimizing the genetic circuits, the phenol and p-NP detection limits reached 0.1 and 1 μM, respectively. Importantly, by replacing the fluorescence-generated reporter sf GFP with MP-degrading enzyme Po OPH M2 , the whole-cell biosensor pUC57-OPH-QS-DSF-F42 L/E coli DH5α actively degraded 10 and 100 μM methyl parathion (MP), a typical organophosphate pesticide , which was artificially added to the cell culture at different time points in five consecutive degrading experiments, demonstrating its MP sensing and degrading capabilities. The universal design of this new biosensor can be used to create more efficient biosensors to detect and degrade various pollutants in the environment for rapid testing and bioremediation.
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STAR Protocols
·
2022
·
IF 0
Cong Niu,Jianjing Yang,Kelu Yan,Jiafang Xie,Wei Jiang,Bingwen Li,Jiangwei Wen
Here, we present a protocol to decyanopyridate inert N-heterocycles access to N-fused heterocycles via the mechanism of dual proton-coupled electron transfer (PCET). We describe a detailed guide to performing an electrochemical gram-scale protocol for decyanopyridation of inert N-heterocycles. The desired pyridylated quinolone is synthesized in a 5.0 mmol scale with a yield of 76%. The protocol is limited to cyanopyridines. For complete details on the use and execution of this protocol, please refer to Niu et al. (2022) .
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PubMed
ACS Sustainable Chemistry & Engineering
·
2014
·
IF 0
Yutong Gong,Haiyan Wang,Zhongzhe Wei,Lei Xie,Yong Wang
Hydrothermal carbonization of biomass is regarded as the most sustainable technique to fabricate functional carbonaceous materials. The absence of nanoporous structures in the as-obtained materials remains a stumbling block to their wide applications. A hard-templating method and KOH activation are mostly frequently applied to introduce porous structures into HTC materials, but they always suffer from either tedious synthetic processes or massive use of a strong base. Here, the hierarchically porous structure was developed by heat treatment in the static air atmosphere. The textual properties were investigated by TEM and N2 sorption analyses. The structural order and surface chemistry were characterized by XRD, Raman, and XPS. The results show that the activated HTC carbons are rich in micropores and mesopores with high surface areas up to 1704 m2/g. The mesopore volume would reach over 50% of the total pore volume. In addition, these carbons show high performance in CO2 and dye adsorption.
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Shu Zhang,Rui Sun,Pengxin Guan,Yaofeng Wang,Ling Wang,Yanli Zhu,Lijun Han,Jiayu Xin
Alkoxycarbonylation of alkene has been an important basis in modern chemical industry. As the cheapest noble metal, the potential of ruthenium furnishes significant innovations in the homogeneous catalysis. However, the competitive hydrogenation of alkenes to alkanes represents the most challenge in the alkoxycarbonylation of alkene. Herein, the chloride anions-assisted Ru-catalyzed methoxycarbonylation of methyl pentenoate was investigated. The chemoselectivity of methoxycarbonylation can be improved by controlling the ratio of LiCl/Ru 3 (CO) 12 . Mechanistic experiments show that the activation energy of hydrogenation is increased due to the change of the active species by increasing the amount of LiCl, which hinders the hydrogenation of methyl pentenoate. The di-methoxycarbonylation of 1,7-octadiene indicates that this methodology has the potential to develop the Ru-catalyzed di-methoxycarbonylation of diene substrates.
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RSC Advances
·
2021
·Vol. 11
·期 5
·3003-3011
·
IF 3.361
Jian Wang,Cheng Zhang,Xiao-Qing Ye,Wenting Du,Shenxin Zeng,Jian-Hong Xu,Hong Yin
An efficient and practical benzylic aerobic oxidation catalyzed by cheap and simple N-hydroxyimide organocatalyst has been achieved with high yields and broad substrate scope. The organocatalyst used can be recycled and reused by simple workup and only minute amount (1 mol% in most cases) of simple iron salt is used as promoter. Phenyl substrates with mild and strong electron-withdrawing group could also be oxygenated in high yields as well as other benzylic methylenes. Influence of substituents, gram-scale application, catalysts decay and general mechanism of this methodology has also been discussed.
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