SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2019
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IF 2.931
Xiaomei Zhang,Zhiming Gou,Yujing Zuo,Weiying Lin
Polythioether has good chemical stability and biocompatibility and is a kind of promising polymers for the application of optical materials, medical materials and energy conversion materials. However, the fluorescent probe based on polythioether is still rare. Herein, a series of polythioether based polymer fluorescent probes were synthesized by successive thiol click reaction under ultraviolet light at room temperature . The poly(thioether)s have good selectivity and responsiveness to iron ions and can be applied in cell imaging, which indicate that the broad application prospects of polythioether-based fluorescent probes in ion detection and bioimaging.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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2020
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IF 5.573
Zelin Yang,Xin Huang,Wenfang Lai,Yuheng Tang,Junjie Liu,Yingzheng Wang,Kedan Chu,John Brown,Guizhu Hong
Salidroside [(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-hydroxyphenethoxy)tetrahy-dro-2H-pyran-3,4,5-triol] is an antioxidant , anti-inflammatory and neuroprotective agent , but its drug-like properties are unoptimized and its mechanism of actions is uncertain. We synthesized twenty-six novel derivatives of salidroside and examined them in CoCl 2 -treated PC12 cells using MTT assay . pOBz, synthesized by esterifying the phenolic hydroxyl group of salidroside with benzoyl chloride , was one of five derivatives that were more cytoprotective than salidroside, with an EC 50 of 0.038 μM versus 0.30 μM for salidroside. pOBz was also more lipophilic , with log P of 1.44 versus −0.89 for salidroside. Reverse virtual docking predicted that pOBz would bind strongly with monoamine oxidase (MAO) B by occupying its entrance and substrate cavities, and by interacting with the inter-cavity gating residue Ile199 and Tyr435 of the substrate cavity. Enzymatic studies confirmed that pOBz competitively inhibited the activity of purified human MAO-B (K i = 0.041 μM versus K i = 0.92 μM for salidroside), and pOBz was highly selective for MAO-B over MAO-A. In vivo, pOBz inhibited cerebral MAO activity after middle cerebral artery occlusion with reperfusion in rats, and it reduced cerebral infarct volume, improved neurological function and NeuN expression, and inhibited complement C3 expression and apoptosis . Our results suggest that pOBz is a structurally novel type of competitive and selective MAO-B inhibitor, with potent neuroprotective properties after cerebral ischemia-reperfusion injury in rats.
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高影响因子
Advanced Science
·
2023
·Vol. 11
·期 5
·2305439
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IF 15.1
Fucheng Zhang,Huanhuan Dong,Yi Li,Dengjiang Fu,Lu Yang,Yupeng Shang,Qiuyang Li,Yuwen Shao,Wu Gang,Tao Ding,Tao Chen,Wenkun Zhu
Photo-assisted uranium reduction from uranium mine wastewater is expected to overcome the competition between impurity ions and U(VI) in the traditional process. Here, B-TiO 2 @Co 2 P-X S-scheme heterojunction with metal-oxygen-hydrogen (M-O-H) is developed insitu modification for photo-assisted U(VI) (hexavalent uranium) reduction. Relying on the DFT calculation and Hard-Soft-Acid-Base (HSAB) theory, the introduction of metal-oxygen-hydrogen (M-O-H, hard base) metallic bonds in the B-TiO 2 @Co 2 P-X is found to enhance the hydrophilicity and the capture capability for uranyl ion (hard acid). Accordingly, B-TiO 2 @Co 2 P-500 hybrid nanosheets exhibit excellent U(VI) reduction ability (>98%) in the presence of competing ions. By self-consistent energy band calculations and in-situ KPFM spectral analysis, the formation of the internal electric field between B-TiO 2 and Co 2 P at the heterojunction is proven, offering a strong driving force and atomic transportation highway for accelerating the S-scheme charge carriers directed migration and promoting the photocatalytic reduction of uranium. This work provides a valuable route to explore the functionally modified photocatalyst with high-efficiency photoelectron separation for U(VI) reduction.
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JOURNAL OF MEDICINAL CHEMISTRY
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2020
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IF 6.205
Weikai Guo,Yajing Xing,Qiansen Zhang,Jiuqing Xie,Dongxia Huang,Haijun Gu,Peng He,Miaoran Zhou,Shifen Xu,Xiufeng Pang,Mingyao Liu,Zhengfang Yi,Yihua Chen
The transcriptional repressor B-cell lymphoma 6 (BCL6) is frequently misregulated in diffuse large B-cell lymphoma (DLBCL) and has emerged as an attractive drug target for the treatments of lymphoma. In this article, a series of N-phenyl-4-pyrimidinamine derivatives were designed and synthesized as potent BCL6 inhibitors by optimizing hit compound N4-(3-chloro-4-methoxyphenyl)-N2-isobutyl-5-fluoro-2,4-pyrimidinediamine on the basis of the structure–activity relationship. Among them, compound 14j displayed the most potent activities, which significantly blocked the interaction of BCL6 with its corepressors, reactivated BCL6 target genes in a dose-dependent manner, and had better effects compared with the two positive controls. Further studies indicated that a low dose of 14j could effectively inhibit germinal center formation. More importantly, 14j not only showed potent inhibition of DLBCL cell proliferation in vitro but also strongly suppressed the growth of DLBCL in vivo.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2023
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IF 7.2
Huifang Gong,Defeng Zhou,Xiaofei Zhu,Ning Wang,Jinghe Bai,Ling Hu,Youjie Zhang,Yunlong Chen,Cunzhi Luo,Wenfu Yan
Cathode materials play a crucial role in enabling the widespread adoption of intermediate-temperature solid oxide fuel cells (IT-SOFC) for commercial applications. This study utilized the sol-gel method to prepare a range of perovskite oxides, specifically Sc-doped La 2 Ni 1-x Sc x O 4+δ (x = 0, 0.05, 0.10, and 0.15), without the use of cobalt. The investigation focused on making a study of how the introduction of Sc doping affected the thermal stability, electrochemical properties , and structure of cathode materials. XRD , FE-SEM, and electrochemical workstations were subjected to structural characterization and performance testing of materials . The findings indicate that all the prepared materials have a typical Ruddlesden-Popper structure, and an abundance of additional oxygen can be generated in close proximity to the interstitial by incorporating Sc into the cathode of La 2 Ni 1-x Sc x O 4+δ to increase the oxygen vacancy and improve the catalytic activity of ORR . La 2 Ni 0.9 Sc 0.1 O 4+δ has the highest oxygen surface exchange kinetics, the dissociative adsorption of oxygen is the rate-limiting step at the cathode. At a temperature of 700 °C, the lowest polarization resistance of La 2 Ni 0.9 Sc 0.1 O 4+δ is 0.1298 Ω cm 2 , while the single cell with La 2 Ni 0.9 Sc 0.1 O 4+δ as the cathode achieves an impressive peak power density of 0.462 W cm −2 , thus demonstrating exceptional long-term stability. La 2 Ni 0.9 Sc 0.1 O 4+δ is expected to be a potential high-performance IT-SOFC cathode material.
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Surfaces and Interfaces
·
2023
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IF 6.2
Anhua Ren,Min Kang,Xiuqing Fu,Fan Zhang,Wanting Yang,Tianyu Pan
This work aims to improve nanoparticle agglomeration, which hinders the application of nanoparticles in enhancing coating properties. Superhydrophobic and corrosion-resistant Ni–B– MoS 2 @WC composite coatings were prepared with the help of a simple and inexpensive combination of hydrothermal and electrodeposition techniques. Hydrothermal treatment at 180°C for 24h greatly reduced the specific surface area and improved the hydrophobicity of WC@MoS 2 powder. The WC@MoS 2 powder showed good dispersion stability in the electrolyte solution. Ni–B/WC@MoS 2 composite coatings were prepared through codeposition with metallic Ni 2+ under the action of ultrasonic waves. WC@MoS 2 powder doping induced the coatings to exhibit a selective orientation of the (111) crystal plane. Ultrasound-induced cavitation increased the participation of nanopowders in the adsorption codeposition of Ni ions. After WC@MoS 2 powder doping, the surface roughness of the prepared composite coatings furthered significantly, facilitating the wettability transition. This work investigated the relationship between the surface wettability of the coatings prepared via jet electrodeposition and WC@MoS 2 powder doping under auxiliary ultrasonic power. In addition, the effect of surface hydrophobicity on corrosion resistance was examined through electrochemical corrosion tests. The enhanced corrosion resistance of the composite coatings benefits from their enhanced surface roughness and superhydrophobicity. This research offers a proven strategy for improving nanopowders' wettability and composite coatings' corrosion resistance.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Huanggen Yang,Pei Zhang,Qi Zheng,Muhammad Usman Hameed,Saleem Raza
The presence of pollutants in drinking water has become a significant concern recently. Various substances, including activated carbon, membranes, biochar, etc., are used to remove these pollutants. In the present study, a new composite comprising cotton fabric and a mixture of Metal-Organic Frameworks (MOFs) was synthesized and used as an adsorbent for eliminating pollutants from wastewater. At first, the UiO-66 MOFs were prepared by a simple method of reacting Zirconium (IV) chloride (ZrCl 4 ) and p-Phthalic acid (PTA) after successful preparation of UiO-66 then modified its surface with amino functional groups by reacting with APTES to obtain UiO-66-NH 2 . Moreover, the cellulose cotton fabric (CF) surface was modified with Polydopamine (PDA) and obtained CF@PDA. Further, with the help of EDC-HCl and NHS, the UiO-66-NH 2 grafted on the surface of the CF@PDA and finally obtained CF@PDA/UiO-66-NH 2 . In addition, the adsorption study was performed toward RhB dye and Pb(II) metal ion pollutants. The maximum adsorption toward RhB dye was 68.5 mg/g, while toward Pb(II) metal ions was 65 mg/g. In addition, the kinetic study was also conducted and the result favoured the Pseudo-second order kinetic study. The adsorption isotherm was also studied and the Langmuir model was more fitted as compared with the Freundlich model. Moreover, the material has excellent regeneration and recycling ability after ten cycles. The significant adsorption ability, the novel combination of cotton and MOFs, and the recycling feature make our material CF@PDA/UiO-66-NH 2 a promising potential absorbent material for wastewater treatment and even in other important areas of water research.
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MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
·
2023
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IF 4.1
Tingting Du,Congzhi Hu,Yuye Li,Youyong Pang,Ming Li,Botian Liu,Ling Li,Yongping Liu,Huidan Lu,Bin Huang
This paper discusses the photocatalytic properties of Ag/Ag 3 PO 4 /Ti 3+ -TiO 2 composites. The nanostructured composites were synthesized by gas-phase hydrolysis, precipitation, and photoreduction methods. The photocatalytic performance of the photocatalysts was evaluated by degrading RhB and TC under visible light. The degradation efficiency of AT4 for RhB and TC reached 99.9 % and 78.2 % under visible light irradiation for 20 min and 2.5 min, respectively. The superior performance of AT4 is facilitated by the combined influence of the heterojunction and the SPR . The free radical capture test proved that h + and •O 2 − were the major reactive groups, and in conjunction with UV–vis DRS curves and Mott-Schottky curves, a probable reaction mechanism was proposed.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2021
·
IF 3.764
Shichao Han,Pan Liu,Ye Ma,Qinming Wu,Xiangju Meng,Feng-Shou Xiao
Calcination-free fabrication of highly b-oriented silicalite-1 (S-1) zeolite films in the absence of organic structure-directing agents (OSDAs) is attractive but still challenging. Herein, for the first time, we show a novel route for calcination-free synthesis of a b-oriented S-1 zeolite film in the absence of OSDAs. The key to this success is a rational secondary growth of zeolite crystals on the surface of supports by avoidance of the formation of zeolite nuclei in the system due to the absence of OSDAs. Because of OSDA-free synthesis of S-1, it not only reduces the cost of zeolite films but also avoids the calcination of OSDAs in the synthesis, thus avoiding the formation of cracks in the zeolite films. In addition, the calcination-free fabrication is favorable for reduction of zeolite film defects such as a terminal OH group. As a result, the zeolite films obtained from this work exhibit higher hydrophobicity than the conventional one. Furthermore, the current polarization curve of this S-1 zeolite film shows excellent corrosion resistance. The aforementioned features would be potentially important for industrial application of zeolite films in the near future.
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ELECTROCHIMICA ACTA
·
2020
·
IF 6.215
Lu Luo,Yalan Zhou,Wen Yan,Xi Wu,Shirui Wang,Weigang Zhao
A series of nitrogen and boron co-doped porous carbon composites (BNCs) were obtained using quick, easy and environmentally microwave-assisted hydrothermal treatment combined with a pyrolysis process subsequent. Biomass waste of fir bark is used as the carbon precursor, while ammonium pentaborate tetrahydrate is used as both boron (B) and nitrogen (N) source. The synthesis process and characteristics of the developed BNCs are investigated, and the results show that the N and B is successfully doped, generating a synergetic effect on the structure, surface characteristics and electrochemical properties. The BNCs achieves specific surface area up to 955 m 2 g −1 with mainly microporosity, and possess 10–13 % of B and 15~20 % of N content. The gravimetric capacitance values for the electrodes containing BNC-20 active materials is 188 F g −1 at 0.5 A g −1 , 2 times that of non-doped carbon, while maintaining 90% capacitance retention capability after 10,000 charge/discharge cycles. Furthermore, the assembled symmetric cell yielded high performance of volumetric capacitive of 91 F cm −3 at 0.5 A g −1 , superior energy density of 9.33 Wh kg −1 at 400 W kg −1 with 91% capacitance retention after 10,000 charge/discharge cycles at 1 A g −1 . Our work offers a potential relatively low-cost, effective and environmentally design of heteroatoms doped electrode materials with enhanced supercapacitors performance.
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CHEMOSPHERE
·
2020
·
IF 5.778
Juan Liu,Pingxiao Wu,Fang Wang,Wenchao Niu,Zubair Ahmed,Meiqing Chen,Guining Lu,Zhi Dang
The reuse of polymyxin B (PMB) has attracted extensive attention. Although the resistance mechanism to PMB is clear, there are few reports on the regulation mechanisms and effects of clay minerals on bacteria induced by PMB. The focus of this study is to investigate the multidrug resistance, cell morphology and physiological modification of Escherichia coli ( E. coli ) exposed to PMB in the presence and absence of clay minerals. To be specific, E. coli was cultured serially for 15 days in the increasing concentration of PMB, with or without halloysite or kaolinite . The potential influence mechanisms of halloysite and kaolinite on E. coli was analyzed by proteomics , antibiotic resistance testing, confocal laser scanning microscopy, scanning electron microscopy and Fourier transform infrared. The results showed that kaolinite could obviously promote the growth of bacteria. Moreover, compared with halloysite, kaolinite could stimulate the overexpression of PMB resistance-related proteins ArnA, ArnB and EptA in E. coli exposed to PMB, and promote the synthesis of peptidoglycan and activate glycolysis pathway to produce energy. In contrast, halloysite was able to regulate the production of low molecular weight thiols by E. coli to prevent bacteria from producing excessive reactive oxygen species , activate the oxidative phosphorylation pathway to supply energy for bacterial life activities, and reduce multidrug resistance of E. coli in a variety of ways. These findings are essential for exploring the impacts of clay minerals on the emergence and spread of multi-drug resistant strains in the environment.
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Results in Physics
·
2020
·
IF 4.019
Yuan Zhao,Xiaoliang Liu,Guangdi Feng,Lu Lyu,Lin Li,Shitan Wang,Jie Jiang,Youzhen Li,Dongmei Niu,Haipeng Xie,Yongli Gao
The modification of C 60 nano-interlayers on the organic field-effect transistors (OFETs) based on 2,7-diocty[1]benzothieno-[3,2-b]benzothiophene (C8-BTBT)/SiO 2 was addressed at both the electronic structure and device level. It is observed that a band bending occurs in C8-BTBT layer with the insertion of C 60 , which induces a strong hole accumulation at the interface region, facilitating the formation of high concentration conducting channel when the interface is incorporated into OFETs. The strong acceptor C 60 may cause charge transfer from the trap states in C8-BTBT, resulting in a field-effect operation with decreased threshold voltage. However, the increasing disorder in C8-BTBT induced by the C 60 nano-interlayer may reduce the hole mobility at the C8-BTBT/SiO 2 interface region and change the growth model of C8-BTBT. In addition, as confirmed by the transfer characteristic of the OFETs, the thin C 60 insertion layer isn’t continuous enough to induce an ambipolar transport behavior despite its high mobility. The competition between the two opposite effects results in compromised performance in such OFETs. The device performance parameters deteriorate generally with increasing the C 60 nano-interlayer thickness. So, it is inferred that the C 60 interlayer alone cannot improve the performance of the C8-BTBT/SiO 2 -based OFETs without further optimization. Importantly, the device performance exhibits an abnormal improvement with a 6 nm C 60 interlayer, which might be ascribed to a higher energy level shift of C8-BTBT caused by a quasi-continuous C 60 film at this thickness.
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