Sustainable Chemistry and Pharmacy
·
2023
·
IF 6
Jiahuan Xu,Lijin Peng,Jianbo Chu,Jing Shi,Qinmin Cui,Qiyuan Shi
This work aims to resolve the environmental pollution caused by petroleum ether in the production of pure nuciferine from lotus leaf by applying bio-based solvent (D-limonene) and green solvent (ethyl acetate). Some obvious advantages were observed, over 97% of nuciferine could be extracted by vortex assisted two-phase solvent extraction based on multi-stage strategy (MS-VTSE), over 90% of nuciferine could be recovered by solid phase extraction (SPE), and over 97% of nuciferine could be obtained by pH-dependent liquid-liquid extraction (pH-LLE). It follows that the newly developed method can not only avoid the use of petroleum ether, but also increase the yield of the whole process by 14% (57%) in comparing with the result of the original one (50%) reported in our previous study. As D-limonene could by recycled conveniently, solvents replacement has little effect on the cost of production. In a word, the newly proposed method has advantages in environmental protection and solvent saving, thus, is fitting for the green and low-cost production of pure nuciferine from lotus leaf.
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Advanced Science
·
2025
·
IF 14.1
Shiyang Lin,Zhongqi Cui,Qingqiong Luo,Chen Li,Yue Zhang,Fengjiao Yang,Yichuan Chen,Chuansheng Xu,Yan Gao,Shasha Zhao,Fenyong Sun,Dandan Shen,Qi Wu,Shuo Shi
The healing of bacterial biofilm-infected wounds is a complex process, and the construction of emerging therapeutic modalities that regulate the microenvironment to magnify therapeutic effects and reduce biotoxicity is still highly challenging. Herein, an engineered microneedle (MN) patch is reported to mediate the efficient delivery of black phosphorus nanosheets (BP NSs) and copper peroxide nanodots (CP NDs) for dual nanodynamic sterilization and methicillin-resistant staphylococcus aureus (MRSA)-infected wound healing. Results demonstrate that the system can eliminate biofilm, reduce cytotoxicity, promote angiogenesis and tissue regeneration by the multiple advantages of chemodynamic therapy (CDT), enhanced photodynamic therapy (PDT), and improved degradation process from BP NSs to phosphate for promoting cell proliferation. Notably, the balance between excellent photodynamic stability and rapid degradability of BP NSs is maintained, and the improved degradation mechanism of BP NSs is vividly elucidated by density functional theory (DFT)-based molecular dynamics (MD) calculations. Furthermore, the transcriptional changes of treated MRSA-infected skin are studied using RNA-seq technology to reveal the potential therapeutic mechanism. As envisaged, the proposed MN patch provides a safe, easy, also highly effective approach to achieve the temporal regulation of sterilization and tissue regeneration for bacterial biofilm-infected wounds.
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BIOCHEMICAL GENETICS
·
2024
·
IF 2.1
Wang Song,Bao Ning,Li Mohan,Liu Dongwei,Tao Liming
Proliferative diabetic retinopathy (PDR), the most common type of diabetic retinopathy, is a main cause of visual and impairment blindness. Abnormal neovascularization, endothelial dysfunction, and vascular inflammation are important mechanisms for the development of PDR. Ets2 regulates angiogenesis-related genes and inflammation, however, the effect of Ets2 in PDR procession has not been clarified. Thus, this study is performed to investigate whether Ets2 exerts key functions in PDR. In this study, 10-week-old mice were used for establishing STZ-induced diabetic mice, and Ets2 expression was analyzed in retina tissues. Besides, newborn mice were applied to construct oxygen-induced retinopathy (OIR) models. The Ets2 expression, oxidative stress, and inflammation were detected in retina tissues. We found that Ets2 was highly expressed in retina tissues both in diabetic mice and OIR mice. Oxidative stress and inflammatory processes are two factors contributing to the pathogenesis of PDR. In retinal tissues of OIR mice, Ets2 knockdown inhibited expression of inflammatory mediators VEGFA, IL-6, and IL-8, and biomarkers of oxidative stress MCP-1, VCAM-1, and iNOS. ROS production was also inhibited by silencing Ets2. Ets2 deficiency inhibited endothelial cell proliferation in the retina. Furthermore, Ets2 knockdown contributed to suppressing the expression of angiogenesis-related genes VEGFA, JUNB, MMP-9, Tie2, Ang-2, and EphB4. Our study highlights that Ets2 accelerates PDR procession by promoting the proliferation of endothelial cells, oxidative stress, and inflammation, which provides a novel target against PDR.
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MINERALS ENGINEERING
·
2025
·
IF 5
Qifang Zheng,Peilun Shen,Yuqiang Mao,Liuyang Dong,Dianwen Liu
Arsenopyrite is commonly found in pyrite concentrates. High-temperature pyrometallurgy produces highly toxic arsenic vapor, while hydrometallurgy generates arsenic-containing wastewater. Flotation is an effective pretreatment method for arsenic removal. This study investigated the selective depression behavior and mechanism of D-penicillamine (DP) on arsenopyrite flotation. Single-mineral and artificial mixed-mineral tests revealed that at a DP concentration of 7 × 10 –4 mol/L, the mixed concentrate had As grade and recovery of 7.34 % and 17.40 %, respectively. This indicates the selective depressive effect of DP on arsenopyrite, enabling effective flotation separation from pyrite. DP adsorption significantly reduced the hydrophobicity of the arsenopyrite surface, with minimal impact on pyrite. Columnar adsorption peaks were observed on the arsenopyrite surface. This suggests coordination between the N and S atoms of DP molecules and the As sites on the arsenopyrite surface, forming N–As and S–As complexes. A hydrophilic film approximately 11.03 Å thick formed on the arsenopyrite (001) surface, which hindered further collector adsorption. This study provides a green and pollution-free approach for the flotation separation of S–As.
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OPTICAL MATERIALS
·
2025
·
IF 4.2
Chenyan Lu,Dajie Zou,Yanyan Jia,Yongchang Lu,Huan Wang,Yanfeng He
In this study, a novel nitrogen-chlorine-codoped carbon quantum dots (NCl-CQDs) with low toxicity, thermal stability, good fluorescence properties, biocompatibility and high sensitivity was successfully prepared by hydrothermal carbonization. Based on the above advantages of NCl-CQDs, the NCl-CQDs was used to construct fluorescence sensing system for fluorescence probes. The maximum fluorescence emission wavelength was obtained at 470 nm when the excitation wavelength was 390 nm. The fluorescence signal was in the state of “ON”. The introduction of 2,6-Dichloroindophenol Sodium (DCIP) resulted in the quenching of fluorescence intensity due to photoinduced electron transfer between DCIP and NCl-CQDs. At this point, the color of the solution changed from brownish-yellow to light blue, indicating that the fluorescence signal was in an “OFF” state. Upon addition of ascorbic acid (AA) to the NCl-CQDs/DCIP system, the corresponding fluorescence signal was restored due to the special interaction between AA and DCIP. The color of the corresponding solution changed from light blue to colorless. The fluorescence signal was in the “on” state. Therefore, an “ON-OFF-ON” sensing system and colorimetric sensing system for AA was constructed using the NCl-CQD fluorescence probe. Under the optimized experimental conditions, the proposed methods exhibited satisfactory linear ranges. Specifically, the linear range for AA detection by the fluorescence sensor spanned from 1.2 μM to 180.33 μM, while that by the colorimetric sensor ranged from 1.32 μM to 166.55 μM. The corresponding detection limits were determined to be 0.68 μM and 0.55 μM, respectively. In summary, this sensing system could effectively enhance selectivity, sensitivity, and accuracy by preventing false positive detection results caused by environmental and system errors.
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Cell Reports Medicine
·
2024
·
IF 11.7
Lihuan Shang,Xue Jiang,Xinbao Zhao,Xi Huang,Xiaojuan Wang,Xue Jiang,Xiangzhan Kong,Mingkang Yao,Shanping Jiang,Ping-Pui Wong
Low migratory dendritic cell (DC) levels pose a challenge in cancer immune surveillance, yet their impact on tumor immune status and immunotherapy responses remains unclear. We present clinical evidence linking reduced migratory DC levels to immune-cold tumor status, resulting in poor patient outcomes. To address this, we develop an autologous DC-based nanovaccination strategy using patient-derived organoid or cancer cell lysate-pulsed cationic nanoparticles (cNPs) to load immunogenic DC-derived microvesicles (cNP cancer cell @MV DC ). This approach transforms immune-cold tumors, increases migratory DCs, activates T cells and natural killer cells, reduces tumor growth, and enhances survival in orthotopic pancreatic and lung cancer models, surpassing conventional methods. In vivo imaging reveals superior cNP cancer cell @MV DC accumulation in tumors and lymph nodes, promoting immune cell infiltration. Mechanistically, cNPs enrich mitochondrial DNA, enhancing cGAS-STING-mediated DC activation and migration. Our strategy shifts cold tumors to a hot state, enhancing antitumor immunity for potential personalized cancer treatments.
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Small
·
2025
·
IF 12.1
Jing Yang,Ruishu Xu,Haiyan Li,Hongwen Tao,Houen Zou,Wenjun Zeng,Haowen Huang
Gold nanoclusters (AuNCs) exhibit unique physicochemical properties but their functional transitions under external stimuli remain underexplored. This study reveals that ultraviolet (UV) irradiation triggers structural evolution in AuNCs, causing fluorescence loss while activating dual enzyme-mimetic activities. UV-induced particle enlargement and surface restructuring endow AuNCs with peroxidase-like (POD-like) and laccase-like functionalities. The POD-like activity enables sensitive glucose detection in human serum, while the laccase-like capability facilitates simultaneous detection and degradation of phenolic pollutants in wastewater. These light-responsive transformations demonstrate AuNCs' dynamic adaptability, bridging their intrinsic fluorescence and catalytic properties. The findings elucidate photo-regulation mechanisms in nanomaterial functionality, proposing a novel strategy for designing multifunctional nanosystems applicable in biosensing and environmental remediation. This work advances the development of adaptive nanomaterials with programmable features for biomedical and ecological applications.
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Small
·
2024
·
IF 13
Jiaqi Liu,Hongmei Liu,Shan Huang,Hong Peng,Jiamei Li,Kerong Tu,Sumin Tan,Rou Xie,Lei Lei,Qin Yue,Huile Gao,Lulu Cai
Triple-negative breast cancer (TNBC) is a highly heterogeneous subtype of breast cancer, characterized by aggressiveness and high recurrence rate. As monotherapy provides limited benefit to TNBC patients, combination therapy emerges as a promising treatment approach. Gambogic acid (GA) is an exceedingly promising anticancer agent. Nonetheless, its application potential is hampered by low drug loading efficiency and associated toxic side effects. To overcome these limitations, using mesoporous polydopamine (MPDA) endowed with photothermal conversion capabilities is considered as a delivery vehicle for GA. Meanwhile, GA can inhibit the activity of heat shock protein 90 (HSP90) to enhance the photothermal effect. Herein, GA-loaded MPDA nanoparticles (GA@MPDA NPs) are developed with a high drug loading rate of 75.96% and remarkable photothermal conversion performance. GA@MPDA NPs combined with photothermal treatment (PTT) significantly inhibit the tumor growth, and effectively trigger the immunogenic cell death (ICD), which thereby increase the number of activated effector T cells (CD8 + T cells and CD4 + T cells) in the tumor, and hoist the level of immune-inflammatory cytokines (IFN- γ , IL- 6 , and TNF- α ). The above results suggest that the combination of GA@MPDA NPs with PTT expected to activate the antitumor immune response, thus potentially enhancing the clinical therapeutic effect on TNBC.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Yanning Zheng,Dankui Liao,Bimei Xie,Jinlei Sun,Jianhua Sun,Zhangfa Tong,Guangzhi Zhou
Effective removal of antibiotic residues from water is crucial for maintaining balance and cleanliness in the ecological environment. To achieve this, we conducted a study on the development of a highly efficient catalyst from the in-situ growth of Fe 3 O 4 nanoparticles on nitrogen-doped hollow porous carbon spheres (Fe 3 O 4 @N-HollCS). We controlled the in-situ growth time to optimize its performance. Material characterization and theoretical calculations revealed that the improved catalytic performance of Fe 3 O 4 @N-HollCS is due to electron transfer from the graphitic-N in N-HollCS to the catalytic interface of Fe 3 O 4 nanoparticles. Fe 3 O 4 @N-HollCS, with an ordered mesoporous structure and high specific surface area, had remarkable adsorption capacity for NOR antibiotics, with an enrichment efficiency exceeding 60% within 10 min. Moreover, the Fe 3 O 4 @N-HollCS degraded more than 90% of fluoroquinolone antibiotics, especially norfloxacin (NOR), which was eliminated within 60 min. The Fe 3 O 4 @N-HollCS also exhibited stable catalytic recycling ability within 10 magnetic separations. Fukui function predicted the sensitive sites of NOR, and we proposed potential degradation pathways. Ecological structure activity relationship model evaluation showed that the intermediate produced by Fe 3 O 4 @N-HollCS degradation of NOR has low levels of ecotoxicity. Overall, Fe 3 O 4 @N-HollCS catalysts have great potential for antibiotic wastewater treatment.
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Materials Advances
·
2024
·Vol. 5
·期 6
·2456-2469
·
IF 5.2
Haihua Zhou,Hongyan Pan,Faisal Raza,Hajra Zafar,Yu Ge,Nan Wang,Ronglei Zheng,Degeng Zhang,Yanmin Yang
Cancer is a grave threat to human life and well-being today. Photothermal therapy, a non-invasive method that converts light energy into heat energy to eliminate tumor cells, has emerged as a promising approach. In this study, bismuth nanosheets were utilized as photothermal agents, while 5-fluorouracil and metformin served as model drugs. By designing a temperature-sensitive liposome (BiNSs/Met/5-FU@TSL) that encapsulates bismuth nanosheets, a multifunctional drug delivery system was developed, combining photothermal therapy with synergistic chemotherapy for enhanced anti-tumor effects. Through transmission electron microscopy, it was confirmed that bismuthene nanosheets were successfully encapsulated in stable and uniformly spherical liposomes. Photothermal performance tests demonstrated the system's effectiveness and stability in generating heat. In vitro release experiments further confirmed the thermosensitive liposomes’ responsiveness to photothermal stimuli. Both in vitro and in vivo studies showcased the system's excellent anti-tumor effects and the safety of the blank carriers. This research presents a novel concept, providing insights into the combination of tumor photothermal therapy with chemotherapy, opening new avenues for effective cancer treatment.
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Journal of Energy Storage
·
2026
·
IF 10.7
Xinyu He,Min Du,Wanqing Wu,Dedi Zhou,Yihang Zhao,Haokun Shi,Qinggong Zheng
In recent years, with the development of electric vehicles and electric vessels, the issues of battery thermal safety have garnered significant attention. Composite phase-change materials (CPCMs) hold great potential as passive cooling systems in battery thermal management systems (BTMS), but their high flammability remains an unresolved challenge. This study successfully developed a flexible composite phase-change material, CPCM/P-CSF@rGO, by encapsulating a eutectic phase-change material composed of mannitol and galactitol in a three-dimensional hydrogen-bonded network, self-polymerised by phosphated corn straw cellulose (P-CSF) and reduced graphene oxide (rGO). The study demonstrates that the strong hydrogen bonding network formed between the phosphate groups introduced by phosphoric acid modification and rGO constructs highly efficient thermal conduction pathways, achieving a thermal conductivity of 1.039 W/(m•K) and significantly accelerating thermal response rates. Simultaneously, the incorporation of the P-CSF@rGO framework endows the material with excellent flexibility and shape stability. Due to the in-situ flame-retardant modification of the framework, the phase-change material maintains a high latent heat of phase-change (194.7 J/g) and achieves superior flame retardancy through gas-phase and condensation-phase mechanisms. It exhibits a limiting oxygen index of up to 30.64% and rapidly extinguishes itself when exposed to open flame in atmospheric conditions. Thus, the flexible composite phase-change material (CPCM/P-CSF@rGO) supported by a phosphorylated cellulose framework emerges as a promising candidate for ensuring safety and high performance in thermal management applications.
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Materials Today Bio
·
2026
·
IF 11
Hui Zhang,Xu Zhu,Jingchun Wang,Yibo Huo,Yikai Ma,Shengzhong Rong,Yuting Lu,Yingxue Jin
To address the core issue of low clinical response rates (10%-30%) to α-PD-L1 immune checkpoint blockade therapy, this study targeted the immunosuppressive bottleneck mediated by lactate accumulation in the tumor microenvironment (TME). A targeted drug delivery system (HLC) was constructed using hyaluronic acid (HA) nanomicelles co-loaded with lactate oxidase (LOX) and copper-doped carbon dots (CuCDs). Combined with α-PD-L1, a synergistic antitumor strategy integrating lactate metabolic regulation, cuproptosis, and immune activation was established. HLC achieves targeted accumulation through specific binding between HA and CD44 receptors on tumor cells. It directionally releases LOX and CuCDs in the acidic TME via pH-responsive properties. LOX efficiently clears lactate and elevates pH, blocking the HIF-1α/PD-L1 pathway to reverse immunosuppression. It also generates H 2 O 2 in situ to provide substrates for Cu-mediated Fenton-like reactions, enhancing cuproptosis. In vitro experiments confirm that HLC promotes dendritic cell maturation and drives M2-type macrophage polarization toward the M1 phenotype. In vivo studies using CT26 tumor-bearing mouse models show that HLC combined with 808 nm laser and α-PD-L1 significantly inhibits primary and distant tumor growth. It remodels the antitumor immune microenvironment with favorable biosafety. This study elucidates the synergistic mechanism between lactate metabolic regulation and cuproptosis, establishes an association between lactate level and cuproptosis sensitivity, and provides a novel strategy and experimental basis for combined cancer immunotherapy with important clinical translation value.
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