DIAMOND AND RELATED MATERIALS
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2026
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IF 5.1
Zhenfei Lv,Xuejia Zhang,Chong Lan,Jiahua Gao,Junchi Weng,Haotian Fan,Xu Lu,Xiulin Shen
The intensifying electromagnetic pollution in the 5G era urgently demands the development of highly efficient electromagnetic wave (EMW) absorbing materials. This study employs a surfactant-assisted solvothermal method, utilizing methylene blue-saturated woody activated carbon (SWAC) as a sustainable carbon matrix, to successfully synthesize a series of cobalt-doped Co x Mn 1-x Fe 2 O 4 /SWAC composites with tunable molar ratios. By optimizing the Co/Mn molar ratio, the composite exhibits outstanding microwave absorption performance at an ultra-thin thickness of just 1.34 mm when x = 0.6: minimum reflection loss (RL min ) reaches −55.67 dB, and effective absorption bandwidth (EAB) spans 2.16 GHz (15.84–18 GHz). Its matched thickness was significantly reduced by 57% compared to the control sample. The performance enhancement stems from multiscale synergistic effects induced by cobalt doping: cobalt enhances hysteresis loss and optimizes the natural resonant frequency; the difference in ionic radii between Co 2+ and Mn 2+ ions induces lattice distortion, promoting interfacial polarization. These mechanisms collectively optimize the material's impedance matching and attenuation capabilities, realizing a synergistic magnetoelectric loss mechanism. This study provides a novel strategy for designing lightweight, high-performance, and sustainable broadband electromagnetic wave absorbers.
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Frontiers in Pharmacology
·
2026
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IF 4.8
Huabing Yuan,Lu Han,Hao Deng,Yue Tan,Yi Yang,Yi Liu,Jiaxin Ying,Mengqi Fang,Hui Wei,Zhihe Tao
Brain-targeted drug delivery remains a major challenge in pharmaceutical research. In this study, four types of polysorbate 80 and cholesterol-modified pullulan polymers (CHPP) were synthesized and self-assembled into nanoparticles (CHPP NPs) for brain drug delivery. The properties of these NPs, including brain targeting efficiency, were systematically evaluated to investigate the influence of polymer modification on their performance. The hydrophobicity of the polymers increased with the degree of cholesterol substitution, which in turn led to a reduction in nanoparticle size. Furthermore, higher hydrophobicity contributed to an increased drug loading capacity for paclitaxel (PTX) and a more sustained drug release profile. In vivo fluorescence imaging revealed that formulations with higher levels of polysorbate 80 and cholesterol modification exhibited significantly enhanced brain targeting efficiency compared to other variants. The PTX-loaded CHPP NPs (PTX-CHPP NPs) demonstrated potent cytotoxicity and inhibitory effects against SJ-GBM2 glioma cells in vitro, underscoring their potential as a promising platform for brain-targeted drug delivery. These findings provide valuable insights for the rational design of brain-targeting nanocarriers.
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Journal of Energy Storage
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2026
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IF 9.8
Yuan Qin,Lu Huang,Xufeng Wang,Liang Luo,Zihao Ou,Youcun Bai,Bin Xiang,Yang Zhou,Xuefeng Zou,Hujun Shen
MnO anodes face serious limitations in high performance lithium–ion batteries due to their intrinsically low electronic conductivity and significant volume expansion during cycling. Here, we propose a simple lattice–engineering strategy to precisely control the degree of lattice contraction and induce an in situ electrochemical amorphization process. Existing strategies can partially buffer mechanical stress and enhance charge transfer but still fail to overcome the intrinsically poor conductivity of MnO and the limited ability of conventional carbon matrices to accommodate electrochemical amorphization. In our design, we establish a hierarchical stabilization system governed by lattice engineering. Specifically, the lattice contraction introduces controllable oxygen vacancies, which serve as the trigger for a cycle-driven in-situ amorphization mechanism. This intrinsic structural reconstruction, synergized with the extrinsic protection of an N-doped adaptive carbon interface, enables the superior long-term cycling stability and enhanced capacity of MET(5Mn)-700. The MET(5Mn)-700 half–cell retains over 90% of its initial capacity after 500 cycles at 1.0 A g −1 , while an NCM811‖MET(5Mn)-700 full cell maintains 93% capacity retention after 200 cycles at 1C. This multilevel structure–interface–dynamics design overcomes the performance degradation bottleneck of traditional Mn–based anodes, providing a new paradigm for developing high–stability lithium–ion battery anodes.
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Journal of Food Measurement and Characterization
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2026
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IF 3.3
Liu Yong,Deng Yejun,Wang Xiang,Zhang Caihong,Huang Lixin,Xie Pujun
Inhibiting α-glucosidase activity by secondary metabolites has been confirmed as an effective strategy for treating type 2 diabetes mellitus (T2DM). α-Glucosidase inhibitory activity was determined by different parts of Gleditsia sinensis Lam. (GSL) extracts. The thorn of the GSL methanol extract exhibited the highest activity (IC 50 = 0.21 mg/mL). Eleven potential α-glucosidase inhibitors were detected by Ultra Performance Liquid Chromatography Quadrupole Time of Flight Mass Spectrometry, and fisetin was screened as the dominant compound (IC 50 = 0.211 µM) through virtual screening, correlation analysis, and inhibitory assay. Fluorescence quenching experiment explained that fisetin inhibited α-glucosidase through hydrogen bonds and hydrophobic forces in a reversible and non-competitive mode. Three-dimensional fluorescence and circular dichroism demonstrated that fisetin modified the amino acids’ microenvironment and disrupted the hydrogen-bonded network of α-glucosidase. α-Glucosidase was bounded with fisetin by hydrogen (Thr448, His515, Asp346, and Gln531) and hydrophobic residues (His515, Lys352, and Ala349) simulated by molecular docking. This study points out the fisetin’s inhibitory mechanism of α-glucosidase, indicating that it is a promising natural ingredient in T2DM treatment.
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Materials Today Bio
·
2026
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IF 10.2
Zhaorong Ouyang,Siyu Li,Ao Zhang,Shu Ye,Wanqiu Ye,Guolei Wen,Tao Wei,Biao Cai,Houli Liu
Ganoderma lucidum polysaccharide (GLP) holds considerable promise for tumor therapy, but its clinical application is limited by its poor tumor-targeting capability. Herein, we report the development of an immunoregulatory nano-bioconjugate formed by conjugating GLPs with low-pH culture medium reprogrammed CT26 tumor cell-derived extracellular vesicle (LTEV). Specifically, 4-carboxybenzeneboronic acid (CPBA), used as an intermediate coupling agent, is conjugated with the amino group of LTEV via its carboxyl group to obtain CPBA-LTEV. GLP is then covalently linked via boric ester linkages between its hydroxyl groups and the boronic acid groups of CPBA. After systemic administration, GLP@LTEV accumulates in homologous tumor tissues derived from the LTEV parent cells, remodeling the immunosuppressive tumor microenvironment (TME) by repolarizing M2-like macrophages towards the M1 phenotype, promoting dendritic cell (DC) maturation, activating cytotoxic T lymphocytes (CTLs), and inhibiting immunosuppressive regulatory T cells (Tregs). The synergism of tumor-targeting delivery and potent immunomodulatory effects in this combined manner therefore significantly inhibits subcutaneous tumor growth and lung metastasis with minimal side effects, providing a novel combination of polysaccharide and nanovesicle for robust tumor immunotherapy.
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PLoS One
·
2026
·Vol. 21
·期 1
·e0337192
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IF 2.6
Yonghao Xiao,Han Wang,Yuhao Jiao,Yuehao Xing,Lin Ye,Ai-ying Zhang,Xue Geng,Fanshan Qiu,Zengguo Feng,Hongbo Chen,Yongquan Gu
Cardiovascular disease has become the leading cause of death. It is the common goal for researchers worldwide to develop small-diameter vascular grafts (SDVGs) which could meet clinical needs. In this study, PLGA@PCL core-shell structural fibrous SDVGs was fabricated by coaxial electrospinning process, and then the surface heparinization of the vascular material was carried out after H2N-PEG-NH2 fixed on sodium hydroxide-treated electro-spun PCL tubes. Finally, the long-term patency and tissue regeneration of the grafts were evaluated in vivo through the rabbit carotid artery replacement model. The results indicate that the heparin-modified PLGA@PCL core-shell structural fibrous SDVGs achieved long-term patency and the arrangement of collagen and elastin in the neointima was similar to the native vessel in the rabbits after 9 months. After 3 months postoperatively, endothelialization was almost complete, and vascular calcification was also observed. It can be concluded that surface heparinization is a feasible modification method for in situ tissue-engineered vascular grafts, and controlling the occurrence of vascular calcification is another important issue to be solved in the development of SDVGs, and it is also the focus of our next research work.
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ANALYTICAL CHEMISTRY
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2026
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IF 6.7
Yi Yang,Licheng Yu,Haiyang Wang,Liang He,Pengli Bai,Xiwen He,Langxing Chen,Yukui Zhang
Natural cell systems with multiple isolated compartments possess controllable signal transduction pathways, which can segregate a series of complex substances and confine them from each other to allow for feedback-driven reactions. By biomimicking the ingenuity of cell systems, we herein designed spatially compact metal–organic frameworks (MOFs) as a hierarchical host for complex substances at isolated locations for the development of reaction pathway-regulated glycoprotein assay. The well-defined zeolitic imidazolate framework-8 (ZIF-8) matrices were fabricated via epitaxial growth to organize the multishelled integration of multiple guest substances including redox reactant substrates (i.e., resazurin and amplex red) and Pt-shelled Au (AuPt) entities. In addition, the micropore nature and enclosed space of the ZIF-8 matrix can prohibit the surpassed contact between fluorogenic substrates and catalytic AuPt converters, inherently, while the immediate signal generator pattern can be harvested through textural collapse of the ZIF-8 skeleton in a controllable manner. Our proposed glycoprotein assay can be conducted with on-demand redox reactions for signal generators: a reductive N-deoxygenation of resazurin and an oxidative N-deacetylation of amplex red, respectively. Due to the distinct catalytic behavior of AuPt converters involved in the fluorogenic redox reactions, the detection limit of the reaction pathway-regulated glycoprotein assay can reach 14.27 pM for the reductive N-deoxygenation reaction and 71.63 pM for the oxidative N-deacetylation reaction, respectively. Collectively, our proposed method may offer an innovative inspiration of reaction pathway-regulated glycoprotein assay, and it can also be adapted for rational substitution of substrate molecules to broaden its signal reflections in versatile glycoprotein analysis.
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Nature Communications
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2026
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IF 15.7
Chen Chuanli,Yang Yuezhen,Zhang Lutong,Dai Wenbo,Lei Yunxiang,Liu Miaochang,Wu Huayue,Huang Xiaobo,Yan Dongpeng
Molecular room-temperature phosphorescence (RTP) materials with compact and ordered structures organized by intermolecular interactions have proven to be a newly-emerged strategy for high-performance luminescence. However, typical crystalline materials exhibit intrinsic brittleness and compromised optical transparency due to their highly ordered packing, thereby restricting their applicability in diverse functional systems. Herein, a universal non-conjugated molecule (1,2,3,4-butane tetracarboxylic acid) with abundant hydrogen-bonding positions is introduced as a host matrix for supramolecular glasses (SGs) through a convenient evaporation-induced self-assembly procedure. A series of SGs doped with aromatic anhydride derivatives is fabricated, exhibiting highly efficient ultralong phosphorescence with afterglow up to 40 s and quantum yields of 56.8%. Experimental and computational studies show that the multiple hydrogen bonds synergistically facilitate glass formation by stabilizing disordered structures while establishing a rigid molecular matrix, which effectively suppressed non-radiative decay of triplet excitons. The doped SGs demonstrate largely enhanced phosphorescent performance, including high temperature afterglow up to 200 o C and robust tolerance in various extreme environments compared with crystal counterparts. Particularly, a large-scale fabrication (25 cm × 25 cm) and shaping capability that is unattainable by traditional crystals. This work thus offers significant potential of these SGs for advanced displays and anti-counterfeiting applications.
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Frontiers in Molecular Biosciences
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2026
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IF 4
Xingwei Yu,Hongao Tan,Yunqiu Gao,Dandan Qiu,Yan Zhu,Haixin Qi
Background: Given the lack of effective treatment for chronic nonbacterial prostatitis (CNP) and the anti-inflammatory property of natural bioactive compound forsythiaside A (FTA), the therapeutic potential of FTA on CNP is worthy of investigation.Methods: CNP rat models were established using complete Freundʼs adjuvant, followed by a 4-week administration of FTA at different concentrations (40 and 80 mg/kg/d). The body and prostate of rats were weighed to calculate the prostatic index. Prostate damage and inflammatory infiltration were assessed using histological analysis and immunohistochemistry staining. Levels of inflammation-related cytokines, autophagic markers as well as the protein kinase C alpha (PKCα)/NF-κB pathway in prostate tissues were detected using enzyme-linked immunosorbent assay and western blot.Results: No significant change was observed in the body weight of CNP rat models administered with or without FTA. FTA treatment reduced the prostatic index and mitigated prostate damage and inflammatory infiltration of CNP rat models. FTA treatment decreased the number of CD3-positive cells and CD45-positive cells, while downregulating interleukin 1 beta (IL-1β), IL-2, IL-6, IL-17A, monocyte chemoattractant protein-1, and tumor necrosis factor alpha in prostate tissues of CNP rat models. FTA treatment promoted Beclin-1 and LC3B II/LC3B I expressions, and inhibited PKCα and p-p65/p65 expressions in prostate tissues of CNP rat models.Conclusion: FTA alleviates inflammation and facilitates autophagy in CNP rat models by blocking the PKCα/NF-κB pathway.
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Human Cell
·
2026
·Vol. 39
·期 2
·36
·
IF 3.1
Hu Xiwen,Sha Rui,Yang Feiran,Chai Jinwen,Liu Bin,Xu Xiaoqing
Lung adenocarcinoma (LUAD), the most prevalent and aggressive form of non-small cell lung cancer. Natural compounds have gained increasing attention as potential anti-cancer agents. The therapeutic potential of chebulagic acid (CA)—a hydrolysable tannin with documented anti-proliferative properties—has not been investigated in LUAD. In the present study, functional experiments revealed that CA treatment markedly suppressed proliferation and induced mitochondrial-dependent apoptosis of LUAD cells. In addition, CA augments natural killer (NK) cell migration by enhancing LUAD CCL5 production. Quantitative proteomics identified FBXO38 as the most significantly upregulated protein following CA treatment. FBXO38 silencing abrogated CA-induced CCL5 production and NK cell migration in LUAD cells. The in vivo experiments showed that CA significantly inhibited tumor growth and enhanced NK cell infiltration in mice, accompanied by decreased Ki67 + proliferating cells, increased cleaved caspase-3 + apoptotic cells, and upregulated FBXO38 expression. Collectively, our findings demonstrate that CA may be exert anti-LUAD effects through FBXO38/CCL5-mediated NK cell recruitment.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 13.2
Huiru Guo,Long Ren,Yuan Ji,Fangzhi Mou,Ningyan Cheng,Xianghua Wu,Zheng Zhao,Yi Du,Jianguo Guan
Metal ions are potent antibacterial agents, but suffer from uncontrolled ion release and toxicity. Here, we present Janus liquid metal nanorobots (J-LMNRs) with microenvironment-responsive ion release for precise antibacterial therapy. The J-LMNRs feature a gallium-based liquid metal (Ga-LM) core encapsulated in a Janus platinum (Pt)-polymer shell. The polymer shell modulates ion release thresholds from Ga-LM nanodroplet core, preventing premature activation in healthy tissues, while the asymmetric Pt in the shell amplifies subtle bacterial signals, such as acidic pH (~6.2) and trace hydrogen peroxide levels (~150 μM), into reactive oxide species (ROS) to trigger Ga 3+ ion release. This design enables autonomous chemotaxis towards infection sites and achieves 95% Staphylococcus aureus eradication within 12 h. By coupling signal amplification with adaptive chemical responsiveness, J-LMNRs minimize off-target toxicity and offer a paradigm shift for intelligent antibacterial systems.
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CARBOHYDRATE POLYMERS
·
2026
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IF 12.5
Xiaokang Zhang,Shaojing Jiang,Gong Ma,Huijiao Tang,Jing Ma,Yunheng Liu,Longqing Si,Shihao Zhang,Yan Yu,Yuhao Liu,Xiao Jiang,Xiangzhan Jiang,Jing Chen,Jinghui Hu
Current soft tissue repair membranes have insufficient wet adhesion, postoperative adhesion risk, and limited therapeutic functionality. Therefore, we adopted a multiscale biomimetic design using mussel adhesion chemistry and the interfacial robustness of 3,4,5-trihydroxyphenylalanine (TOPA) in the tunicate epidermis to construct a biodegradable bilayer hydrogel membrane (PLCL-CSs@PADT). This design enables interfacial water displacement, robust tissue adhesion (21 kPa strength, 110 J m −2 fracture energy), antibacterial hemostasis (>80%), and a topological hydrophobic barrier for adhesion prevention. Methacrylated gelatin is introduced as a photocurable interfacial bridging phase, achieving seamless mechanical continuity, while gradient cyclic elution eliminates residual monomers. The membrane rapidly achieved hemostasis in rat hepatic hemorrhage models (<20 s) and reduced blood loss by 83%. In postoperative abdominal adhesion models, the material completely prevented adhesion formation, attributed to the combined shielding effect of the outer layer and regulation of t-PA/PAI-1 expression. In vitro experiments demonstrated that the membrane exhibits a preliminary trend of controlled biodegradation over an 8-week period, aligning with typical soft-tissue healing timelines. This work establishes a multifunctional, bioinspired platform that combines instant tissue sealing, infectious risk mitigation, and sustained anti-adhesion performance and contributes to the development of next-generation intelligent bioactive membranes for complex soft-tissue repair.
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