ANALYST
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2026
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IF 3.6
Huiqi Zhu,Ying Chen,Weiqing Yang,Zunxiang Zeng,Yuling Hu,Ji Zhang
The inherently weak Raman signals from molecules with small scattering cross-sections pose a significant challenge for surface-enhanced Raman scattering (SERS), a technique that is further limited by its reliance on costly precious metal substrates and exogenous labeling strategies. To address these limitations, this study constructs a Ti3C2–CoFe2O4 heterostructure by anchoring oxidase (OXD)-like CoFe2O4 nanoparticles (NPs) on two-dimensional (2D) conductive Ti3C2 MXene nanosheets. The resulting interface forms a Mott–Schottky junction, which facilitates rapid charge transfer and synergistically enhances both catalytic and SERS performance. Structurally, the 2D Ti3C2 framework provides abundant anchoring sites for the uniform dispersion of CoFe2O4 NPs. This effectively prevents particle aggregation and maximizes the exposure of catalytic active sites, thereby enhancing both stability and catalytic activity. Additionally, the Ti3C2–CoFe2O4 heterojunction effectively suppresses the recombination of charge carriers and promotes the separation of photogenerated charges, generating abundant superoxide anion radicals that oxidize 3,3′,5,5′-tetramethylbenzidine (TMB) for catalytic signal amplification. Therefore, the ingenious combination of nanozymes and SERS technology enables the generation of SERS-active reporters via nanozyme-catalyzed reactions, thus avoiding the need for external labeling modifications. The strategy simultaneously enhances Raman signals through the synergistic effect of photoinduced charge transfer and localized surface plasmon resonance. This Ti3C2–CoFe2O4 heterojunction exhibits integrated OXD-like activity and SERS enhancement, enabling sensitive glutathione (GSH) detection in human serum samples. Through catalytic oxidation of TMB to oxidized TMB, a distinct Raman peak emerges at 1615 cm−1, with its intensity reduction quantitatively correlating with GSH concentration via competitive reactive oxygen species scavenging. Quantitative analysis demonstrates a linear response range of 0.50–200 μmol L−1 and a detection limit of 0.073 μmol L−1, with serum sample recoveries ranging from 94.7%–115%. This study provides a paradigm for designing non-precious metal nanozyme materials with integrated catalytic and SERS capabilities, demonstrating significant potential for practical applications in clinical diagnostics and biosensing.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2026
·
IF 7.1
Jingran Liu,Hao Yang,Shuning Yi,Yingyuan Zhao,Xianhui Chang,Qingyun Lyu,Lei Chen,Qian Shen,Wenping Ding,Xi Chen
This study preliminarily confirmed that the primary cause for the low bioavailability of Dihydromyricetin (DHM) was its rapid structural alteration induced by pH fluctuation during digestion, using the in vitro digestion model with HPLC-ESI-MS/MS analysis. Thus, for stable gastrointestinal delivery, DHM was encapsulated using bovine serum albumin (BSA) - chitosan nanocarrier. Physicochemical characterization revealed spherical DHM loaded BSA-chitosan nanoparticles (DBC-NPs, 217.3 ± 3.2 nm) with high encapsulation efficiency (86.66%). In vitro stability tests confirmed their resistance to upper gastrointestinal pH variations and indicated the potential to reach the colon intact. Untargeted metabolomics and 16S rRNA sequencing were performed using in vitro colonic fermentation (three replicates in each group) of gut bacteria from the pooled stools of 6 donors, applying a statistical threshold of p-value <0.05. Furthermore, DBC-NPs modulated gut microbiota (increasing Dorea / Bifidobacterium / Akkermansia , reducing Escherichia-Shigella / Clostridium ) and their corresponding metabolites (such as promoting beneficial phenyllactic acid while inhibiting harmful metabolites such as 3-Oxocholic acid). This study revealed the capability of BSA-chitosan in protecting DHM integrity during digestion and regulative effect on the gut microbiome and their metabolites, offering new strategies for functional foods and precision nutrition interventions.
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Materials Today Bio
·
2026
·
IF 11
Zheng Peng,Xiao-Jian Li,Yu-Long Xi,Xiao-Long Zhu,Yue Lu,Yan Zhou,Hui-Ying Yan,Juan Wang,Zheng-Mao Yang,Chun-Hua Hang,Yi-Nan Ding,Jing-Lin Wang,Wei Li
Subarachnoid hemorrhage (SAH) is a type of stroke mainly caused by the bursting of brain aneurysms, releasing iron ions into the subarachnoid space and subsequently inducing ferroptosis. Despite the utilization of various ferroptosis-inhibiting pharmacological agents to enhance neurological outcomes post-SAH, challenges such as inadequate targeting and suboptimal drug utilization persist. In response to these limitations, we have developed a novel spatiotemporal cascade reaction liposome that recombinant proteins incorporating neuron-targeting peptides and the functional structural domain of ferroptosis suppressor protein 1 (FSP1) were immobilized on the external surface of liposomes, which were internally loaded with coenzyme Q10 (CoQ10) to construct FSP1-Lipo-CoQ10.The purpose of this study is to investigate the neuroprotective effects of FSP1-Lipo-CoQ10 following SAH. As a result, FSP1-loaded liposomes enable targeted delivery to neurons in the lesion area and increase FSP1 levels on the cell membrane. Among the three liposomal formulations, FSP1-Lipo-CoQ10 demonstrated the most potent anti-ferroptosis effects and the greatest improvement in neurological function. FSP1-Lipo-CoQ10 provides a new approach for the therapeutic management of ferroptosis post-SAH and ameliorates associated pathological conditions.
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Scientific Reports
·
2026
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IF 4.9
Wang Jinghan,Hou Peng,Yao Qingwei,Fu Shuang,Chao Liyuan,Sui Huimin,Han Lu,Wang Jiafeng,Wang Guowei,Zhang Hongguang
Surface-enhanced Raman scattering (SERS) technology has emerged as a powerful analytical tool for trace-level environmental pollutant detection, with its performance critically dependent on the physicochemical properties of substrate materials. While noble metal substrates (e.g., Au/Ag) demonstrate superior SERS enhancement through surface plasmon resonance (SPR), their practical deployment is hampered by inherent limitations including high material costs and susceptibility to oxidation-induced degradation. Herein, we report the rational design of Ag 2 O/TiO 2 composite substrates via a facile wet-chemical precipitation method, wherein Ag 2 O nanoparticles are uniformly decorated onto pre-synthesized TiO 2 nanospheres. Upon application in crystal violet (CV) detection, the optimized Ag 2 O/TiO 2 composite substrate exhibits remarkable SERS performance with an enhancement factor (EF) of 6.7 × 10 6 and an ultra-low detection limit (LOD) of 1.0 nM (1.0 × 10⁻ 9 M). Systematic investigations reveal that the Ag 2 O modification induces photogenerated electron accumulation on the TiO 2 surface, promoting photoinduced charge transfer (PICT) between the substrate and adsorbed CV molecules. This work not only presents a cost-effective and stable SERS platform for environmental contaminant monitoring but also provides mechanistic insights into the rational engineering of semiconductor-based SERS substrates with enhanced sensitivity and durability.
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Polymer Chemistry
·
2026
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IF 3.9
Jie Liu,Li Xiang,Jiang Xu,Qian Jiang,Jiahao Deng,Jin Wang,Jun Yang,Anlian Pan
With the rapid advancement of flexible display technology, stricter requirements are imposed on the high-temperature resistance and optical performance of flexible display substrates. Highly transparent, high-temperature-resistant polyimide (PI) is one of the most promising substrates, yet enhancing heat resistance via single molecular structure design often compromises transparency, making it difficult to balance the two properties. To balance the thermal stability and optical transparency of polyimide (PI), three diamine monomers (3F–P, 3F–M, and 3F–O) containing amide bonds and trifluoromethyl groups (–CF3) were synthesized through molecular design, followed by the preparation of PI-1 to PI-6. Amide-derived intermolecular hydrogen bonds restricted molecular chain mobility and enhanced rigidity to improve heat resistance, while the electron-withdrawing property of –CF3 inhibited electron transfer, thereby blocking the charge transfer complex (CTC) effect to boost transparency. Systematic characterization showed that the PI materials had a glass transition temperature (Tg) of 294.8–332.6 °C due to amide bonds. The meta-substituted PI exhibited optimal performance (Tg = 317.9 °C, transmittance = 88.73%, and b* = 2.16). Transfer characteristic curve tests on carbon nanotube thin film transistors (CNT TFTs) fabricated with PI-2 as the substrate confirmed the potential of PI-2 as a flexible electronic substrate. This work provides crucial insights and data for PI flexible substrate optimization and its flexible electronic applications.
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 2
·122009
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IF 7.5
Xingyu Guo,Haiyan Song
Photocatalytic H 2 O 2 production from O 2 using covalent organic frameworks (COFs) is a promising solar-to-chemical energy conversion route. However, existing design strategies for COF-based photocatalysts are constrained by various issues, making it difficult to achieve synergistic optimization of both photogenerated charge separation efficiency and catalytic activity. In addition, compared with pure water medium, achieving efficient H 2 O 2 production in alcohols is of great significance for alcohol-mediated organic synthesis and direct alcohol fuel cells. Herein, two amide-linked COFs were fabricated via site-specific benzene ring functionalization, focusing on precise amino group incorporation. Aligned with recent advances in photocatalytic structure property relationships, amino group introduction induces significant charge density differentials in COFs, modulating donor acceptor interactions and efficiently promoting photogenerated charge separation/transport. Consequently, the 2-aminoterephthalic acid-based COF (PPTD-COF) exhibits superior photocatalytic H 2 O 2 production performance. PPTD-COF achieves a H 2 O 2 productivity of 16.23 mmol h −1 g −1 in ethanol within 0.5 h, 16-fold higher than the unmodified terephthalic acid-based COF (PTA-COF). Ethanol acts as an efficient electron-proton donor, supplying abundant H + for the oxygen reduction reaction (ORR) and facilitating proton-coupled electron transfer (PCET) for efficient H 2 O 2 generation. This work develops a site-specific functionalization strategy to tune COF electronic structures, optimize donor-acceptor interactions, and enhanced charge dynamics, highlighting potential applications in sustainable energy and environmental remediation.
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FOOD CHEMISTRY
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2026
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IF 10.4
Zihan Xu,Ziyi Guo,Shengran Yu,Xinyi Shen,Yanqing Cong,Tong Wei,Wenming Pei,Shi-Wen Lv
Herein, a novel porous S-CoO/C composite with spatial confinement effect is synthesized. Notably, doped sulfur can have the reaction with Co site of CoO and trigger the d-p orbital hybridization between 3p orbital of sulfur and 3d orbital of cobalt. The d-p orbital hybridization effect can not only increase the content of oxygen vacancy, but also drive the transformation of Co sites from low to high spin states. Benefitting from these changes, more unpaired electrons are generated in S-CoO/C. As a result, the S-CoO/C exhibits moderate oxidase-like property and excellent peroxidase-like activity. In view of the superb peroxidase-like activity of S-CoO/C, a colorimetric assay is proposed for detecting H 2 O 2 and hydroquinone using TMB as the substrate, and developed detection methods have great advantage being a low LOD, a high recovery and a broad linear range. Furthermore, established colorimetric assay displays excellent analysis performance even in real samples.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
·
IF 9.6
Yue Wu,Haiyan Song
Visible light-driven hydrogen peroxide (H 2 O 2 ) production from natural seawater over covalent organic frameworks (COFs) is becoming a challenge. In this work, a polarization strategy via incorporating oxo-ether ( O ) functional groups into COFs architecture was attempted and demonstrated to significantly enhance photocarriers separation. The strategy interestingly transformed the COFs morphology from rod-like flower clusters to sheet-like flower clusters. Furthermore, the monomer 4,4′-oxydianiline (OD) of the oxo-ether functionalized COFs (TpOD-COF) obtained a cost efficiency that was about 1794 times higher than the monomer benzidine (BD) formed non-functionalized COFs (TpBD-COF). TpOD-COF in real seawater achieved 4598 μmol·g −1 ·h −1 of H 2 O 2 productivity, and 10.2% of apparent quantum yield (AQY) without electron-proton donors and pure oxygen (O 2 ), which was 1.91 times higher than TpBD-COF. Mechanism studies revealed that TpOD-COF not only satisfies the thermodynamic requirement for the 2e − oxygen reduction reaction, but also indirectly enhances H 2 O 2 production through water oxidation, thereby establishing a cycle system that goes from water (H 2 O) to O 2 and then indirectly to H 2 O 2 , which promotes the overall reaction kinetics. More importantly, the catalyst did not deactivate in seawater; instead, the presence of ions further promoted electron transfer. Furthermore, the polar oxygen atoms served as additional hydrogen bond acceptors, enhancing the hydrogen-bonding network architecture. The system suggested a powerful functional-groups-mediated polarization engineering for the development of highly efficient metal-free photocatalysts.
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PROGRESS IN ORGANIC COATINGS
·
2026
·
IF 7.9
Jinqiu Jiang,Xinhui Cao,Meng Sun,Xujie Guo,Junhao Shen,Hui Zhang,Liying Zhang,Jianyong Yu
With the rapid development of detection technologies, including visible (VIS) imaging and infrared (IR) sensing, the detectability of targets in complex environments has been significantly enhanced, driving the urgent demands on coating systems capable of simultaneously achieving VIS and IR stealth. Conventional coatings that use metallic fillers for low IR emissivity often exhibit high lightness ( L* ), impairing visual camouflage. Conversely, incorporating pigments to regulate visual features usually increases IR emissivity, making it challenging to balance both VIS and IR stealth performance. To address this challenge, we developed a bilayer low- L* VIS-IR compatible stealth coating system (C S ) that synergistically combined spectral modulation with thermal management. SiO 2 -coated Al composite fillers (SiO 2 @Al) were employed in the upper layer to reduce L* while maintaining low IR emissivity, and Cr 2 O 3 pigments were introduced for precise chromaticity regulation to achieve effective color matching with a standard forest green background. The lower layer consisted of a silica aerogel (SA) based thermal-insulating coating, which effectively blocks heat transfer, thereby reducing thermal radiation. The resulting C S achieved an IR emissivity below 0.4 across the 8–14 μm spectrum, a low L* of 33.0, and a color difference of 2.1 relative to the target. Moreover, the IR emissivity and ΔE of C S remained nearly unchanged after environmental durability tests and demonstrated excellent adhesion (grade 0), providing a practical and engineering-feasible strategy for VIS-IR compatible stealth.
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POLYMER
·
2026
·
IF 5.1
Yongliang Ding,Lieshun Cai,Siyu Liu,Jindong Li,Qihao Huang,Yu Fang,Qingmin Yang,Xi Li,Zhongkai Wang,Xiankun Wu
The design of sustainable polymers that combine high strength, ductility, and compatibility with existing bioplastics remains a critical challenge. Here we report a castor-oil-derived sulfur-containing copolyamide (PAS-X) synthesized via thiol-ene click reaction followed by melt polycondensation, providing a scalable route for high-performance bio-based materials. The incorporation of flexible thioether linkages and strongly hydrogen-bonding amide motifs enables precise control over chain mobility, crystallinity, and mechanical response. The optimized copolymer, PAS-50, exhibits a tensile strength of ≈39.8 ± 2.4 MPa and a work-to-fracture of ≈120.7 ± 8.0 MJ m −3 . When blended with polylactic acid (PLA) at low loadings (≤5 wt%), PAS-50 forms robust hydrogen-bond-mediated interfaces that induce a brittle-to-ductile transition, increasing fracture toughness from 9.2 MJ m −3 to 60.7 MJ m −3 without sacrificing yield stress. This work establishes a chemically simple and industrially viable approach to transform renewable plant-oil derivatives into multifunctional polyamides, offering a general framework for hydrogen-bond-assisted design of strong and tough bio-based polymers.
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NEW JOURNAL OF CHEMISTRY
·
2026
·
IF 2.6
Tahseen Ahmed,Ling Zhang,Runzhi Wang,Yiling Bai,Xuehua Zhang,Yu Sun,Lili Fu,Bin Li,Menglei Yuan,Guangjin Zhang
Electrocatalytic nitrate reduction to ammonia (NO3⁻RR) provides a promising approach for converting nitrate pollutants to ammonia under mild conditions. Metal phthalocyanine-based conjugated polymers, with their well-defined structures and tunable functionality, are emerging as efficient two-dimensional (2D) catalysts for this reaction. Herein, we report a 2D-conjugated nickel phthalocyanine polymer (NiPcP) that demonstrates high efficiency and selectivity towards NO3⁻RR. The material features high-density, well-defined Ni–N4 sites and the nitrogen-bridged tetra-isoindole structures create a hydrophobic microenvironment and electron-rich Ni centers, which facilitate nitrate adsorption and electron transfer, and suppress the hydrogen evolution reaction (HER). As a result, NiPcP achieves a maximum Faradaic efficiency of 99.7% and an NH3 yield rate of 14.2 g h⁻1 gcat⁻1, maintaining over 80% efficiency across a broad potential window (from −0.5 to −0.9 V vs. RHE) and wide nitrate concentration range (from 10.0 mmol L⁻1 to 2.0 mol L⁻1). It is the first noble metal-free Ni-based catalyst that exhibits such high FE in such a broad potential window and wide nitrate concentration range simultaneously. This work offers an effective molecular design strategy for developing metal–organic electrocatalysts toward sustainable ammonia synthesis and nitrate pollution remediation.
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DESALINATION
·
2026
·
IF 9.9
Luheng Jing,Siping Ding,Tinglue Zhang,Yang Tong,Tonghui Zhang,Zheyi Meng,Xuefen Wang
Traditional hydrophobic membranes are susceptible to membrane fouling and wetting of membrane pores, limiting the application of membrane distillation (MD) technology in water recovery under increasingly complex water conditions. To address these challenges, we designed a structural integrated hydrophilic-omniphobic Janus membrane via synchronous fluorination/reverse interfacial polymerization (SF/R-IP) based on roughening modified polyvinylidene fluoride (PVDF) nanofibrous membrane. During the SF/R-IP process, not only piperazine (PIP) from the upper aqueous phase solution reacted with trimethylchloroform (TMC) from the lower organic phase solution to form polyamide layer (PA) through IP reaction, the modified PVDF substrate would also be fluorinated synchronously by 1H,1H,2H,2H-perfluorotriethoxysilane (PFDTES) in organic phase. As a consequence, a novel Janus membrane with an ultrathin hydrophilic PA surface layer partially inter-embedded onto an omniphobic substrate was featured, and this special inter-embedding adhesion endowed the Janus membrane excellent structural integrity. The optimized Janus membrane combined the anti-wetting performance of an omniphobic membrane with the oil contamination resistance of the hydrophilic layer and the high permeability of nanofibrous substrate, demonstrating considerable vapor flux (31.1 kg m −2 h −1 ) and complete salt rejection (99.99%) during a long-term (80 h) DCMD experiments using surfactant sodium dodecyl sulfate (SDS)-stabilized oil-in-water (O/W) saline emulsion as the feed solution, and could fully recover optimal flux and continue stable operation after flushing. This study would provide a new strategy in designing high-performance MD membranes and enable robust applications of MD facing the challenges of membrane fouling and wetting.
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