International Journal of Electrochemical Science
·
2023
·
IF 1.5
Hong-Wei Lv,Quan-Fu Li,Hui-Ling Peng
Sodium tetrafluorocuprate (Na 2 CuF 4 ) has been synthesized by the precipitation method. Then, Na 2 CuF 4 was applied to glucose electrocatalysis for the first time, and modified bare Au electrode to obtain Na 2 CuF 4 /Au. Na 2 CuF 4 /Au has strong anti-interference, extremely broad linear range of glucose detection, and great stability through stored for a long time at room temperature. A simple method was used to prepare Na 2 CuF 4 with different morphologies, and the effects of different morphologies for the glucose sensing performance were studied. The optimal experimental parameters of glucose sensing were obtained through parameter optimization, which leads to enhanced glucose sensing performance. The selected Na 2 CuF 4 was composed of large crystals and smaller crystals. The larger crystals sizes of selected Na 2 CuF 4 are in the range from 5 μm to 6 μm, and the smaller are in the range from 230 nm to 300 nm, the two are mixed together. The Na 2 CuF 4 /Au electrode showed high sensitivity and very wide linear range (the first 0.01-0.15 mM, the second 0.15-19.15 mM, the third 19.15-63.15 mM). The Na 2 CuF 4 /Au shows good accuracy, reproducibility and stability, as well as excellent selectivity. The properties of Na 2 CuF 4 indicate that it has a wide application prospect in the field of glucose electrocatalysis as a new glucose sensitive material.
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Surfaces and Interfaces
·
2023
·
IF 6.2
Shengchen Ke,Linling Qin,Ruoxi Zhang,Weijian Zhu,Wenxiang Lu,Lu Ma,Shaolong Wu,Xiaofeng Li
It is of great importance to develop a non-invasive and portable glucose sensor to address challenges and obstacles brought by invasive glucose sensors, such as negative physical and psychological impacts to patients during the fingertip blood collection, limited environment of use for enzyme-based electrodes, and cumbersome active-driven integrated devices. Photoelectrochemical (PEC) sensors have great potential in this regard. In this work, self-driven and enzyme-free sweat glucose PEC sensing is realized by constructing TiO 2 hierarchical nanotubes modified by CuO nanoparticles (CuO@TiO 2 HNT). A sensitivity of 138.9 μA mM −1 cm −2 in the low concentration range (< 200 μM) and a detection limit of 0.7 μM (Signal/Noise=3) are achieved by the as-prepared CuO@TiO 2 HNT photoelectrode at relatively zero bias. The testing results for sweat glucose detection before and after meal consumption are consistent with those from commercial glucometers. The CuO@TiO 2 HNT photoelectrode works well at absolutely zero bias and in a wide temperature range (e.g., 0–60 °C). The extraordinary sensing performance can be mainly attributed to the following two factors: (1) the TiO 2 hierarchical nanotubes have an excellent light-capturing property and large specific surface area, and (2) the CuO nanoparticles substantially facilitate surface-carrier transfer for the glucose oxidation reaction. This work provides an enzyme-free sensing photoelectrode for self-driven sweat glucose detection and an alternative route to portable and noninvasive sensing of glucose.
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FOOD CHEMISTRY
·
2023
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IF 8.8
Wei Jia,Xin Wang
The potential mechanisms about the health risks of endogenous 3-MCPD remain elusive. Here, we researched the influences of 3-MCPD on the metabolic landscape of digested goat infant formulas via integrative UHPLC-Q-Orbitrap HRMS-MS/MS-based peptidomics and metabolomics (%RSDs ≤ 7.35 %, LOQ 2.99–58.77 μg kg −1 ). Digested goat infant formulas under 3-MCPD-interference caused metabolic perturbation by down-regulating levels of peptides VGINYWLAHK (5.98–0.72 mg kg −1 ) and HLMCLSWQ (3.25–0.72 mg kg −1 ) pertained to health-promoting bioactive components, and accelerated the down-regulation of non-essential amino acids (AAs, l -tyrosine 0.88–0.39 mg kg −1 , glutamic acid 8.83–0.88 μg kg −1 , and d -aspartic acid 2.93–0.43 μg kg −1 ), semi-essential AA ( l -arginine 13.06–8.12 μg kg −1 ) and essential AAs ( l -phenylalanine 0.49–0.05 mg kg −1 ) that provide nutritional value. Peptidomics and metabolomics interactions elucidated that 3-MCPD altered the stability of α-lactalbumin and d -aspartate oxidase in a dose-dependent manner, and affected the flavor perception of goat infant formulas, leading to a decline of nutritional value of goat infant formulas.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 31
·14726-14732
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IF 3.3
Lingting Huang,Yuqing Ren,Zhen Yang,Ruijin Zeng,Dianping Tang
Based on the electro-oxidation mode, electrochemical sensors provide an appealing evaluation tool for uric acid (UA) detection. However, improvements in the field of high-performance electrocatalysts remain necessary to enable wide-range and ultrasensitive detection of UA in this way. In recent years, the research and development of thermally treated metal (M) and nitrogen (N) co-doped carbon (M–N–C) catalysts, along with the usage of metal–organic framework materials as precursors, has substantially increased the performance of non-precious metal oxygen reduction catalysts, rendering them a potential species of the active substance. In this work, we synthesized cobalt metal-embedded nitrogen-doped carbon frameworks (Co–CN) through a host–guest synthetic strategy. An electrochemical sensing system was constructed for the accurate detection of UA molecules utilizing the excellent UA electrooxidation performance of Co–CN. The electro-oxidation reaction exhibits double electron/double proton transfer, and a response current signal can be obtained using differential pulse voltammetry (DPV), establishing a correlation between the measured UA concentration and the strength of the DPV current. The target UA concentration and DPV current density exhibited a dose-dependent relationship with a dynamic range of 2–120 μM and a limit of detection of 0.55 μM. During measurement, this sensing approach revealed good accuracy, high specificity, and adequate storage stability. It is worth noting that this detection system introduces a fresh approach for the development of sensitive, portable, and reasonably priced human metabolite analysis in wearable health monitoring devices.
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MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Fang Wang,Fengna Shi,Jingfang Li,Naipin Chen,Cheng Chen,Ziqi Xu,Jiajun Wang
It is extremely important to simultaneously detection different biomarkers in various biological systems. Hereby, we have developed an original flexible nonenzymatic glucose and uric acid sensor using carbon cloth loaded with copper microspheres (Cu MSs) and ZnO nanoparticles decorated single-walled carbon nanotubes (Cu MSs/ZnO@CNTs/CC). Firstly, ZnO@CNTs was synthesized via sol–gel method, and then Cu MSs were uniformly electrodeposited on ZnO@CNTs/CC substrate rapidly. Morphological and compositional characteristics were examined to confirm the successful decoration of Cu microspheres and ZnO nanoparticles. Importantly, the nanocomposite electrode displayed remarkable electrocatalytic activity for glucose and UA, including wide linear detection range, low detection limit, outstanding sensitivity, respectively. Moreover, the nanostructure biosensor exhibited fast response time (0.1 s) and favorable long-term stability, which are attributed to synergistic catalytic effects: (a) the large specific surface area of CNTs offered abundant sites for the decoration of ZnO nanoparticles, and (b) the rough nanosheets assembled Cu microspheres could expose plentiful active sites. Finally, in practical serum samples, the sensor also exhibits considerably favorable precision and accuracy. As such, the novel flexible Cu MSs/ZnO@CNTs/CC sensor developed with economical and efficient preparation method provided a new easy and sensitive platform for glucose and UA determination in real application.
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ACS Applied Nano Materials
·
2023
·
IF 5.9
Jingwen Feng,Jinjuan Gao,Wen Yang,Yaru Li,Jian Shi,Cong Liu,Mingshun Jiang,Shouzhen Jiang
Two-dimensional (2D) metal–organic frameworks (MOFs) have promising applications in surface plasmon resonance (SPR) sensing for their intriguing exciton migration and visible light-near infrared absorption properties. In this study, an effective biosensing structure comprising 2D Cu-TCPP MOF nanosheet-capsulated Au film was developed, such that lower molecular-weight dopamine with small changes of refractive index can be identified on the fiber-optic platform. The large areas of ultrathin 2D Cu-TCPP MOF nanosheets were well prepared, the experimental results indicated that the sensitivity (48%) and figure of merit (18%) were increased notably compared with the bare Au film. Moreover, the finite element method was adopted to numerically analyze and verify the excellent charge-transfer ability of MOF nanosheets and the bidirectional gain properties between MOF nanosheets and Au films. Furthermore, the sensitivity [1.24 nm/log(M)] and selectivity of the dopamine were significantly enhanced with a low limit of detection of 1.50 × 10–13 M and linear response with a wide range of concentrations from 5 × 10–12 M to 5 × 10–7 M through ssDNA surface modification and conformation amplification. As revealed by the above-mentioned results, the Cu-TCPP/Au/SMF biosensor can serve as a promising nanoplatform for clinical diagnosis and medical assessment.
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MEASUREMENT
·
2023
·
IF 5.6
Wenjing Wang,Yumin He,Lei Deng,Hui Wang,Xiaoying Liu,Qing-wen Gui,Zhong Cao,Zemeng Feng,Benhai Xiong,Yulong Yin
L-Lysine (L-Lys) quantification in serum using a novel and highly selective amperometric biosensor has been reported. In this study, an efficient, enzyme-free, and simple anti-fouling biosensor was developed based on a self-screened peptide aptamer. A glassy carbon electrode (GCE) was used to construct anti-fouling interfaces by modifying its surface with polyaniline (PANI) polymer. The peptide aptamer, Cys-Pro-Pro-Pro-Pro-Arg-Glu-Asn-Ile-Gln-Arg-Leu-Thr, was then immobilized onto this electrode via an electroactive cysteine linker and its potential in the determination of L-Lys was examined. Under optimised experimental conditions, the peptide-modified electrodes exhibited excellent anti-fouling and electrochemical sensing. The biosensor was effective in resisting biofouling in a wide range of serum samples and amino acid solutions, and its linear range for L-Lys detection ranged from 1 nM to 10 mM, with a comparatively lower detection limit (0.3 nM; S/N = 3). The anti-fouling biosensor could detect L-Lys in real serum samples, and this approach of designing peptide aptamers based low-fouling biosensors can easily be extended to the development of a bio-sensing platform system for a variety of other metabolites.
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Li Yang,He Wang,Abu Musa Abdullah,Chuizhou Meng,Xue Chen,Anqi Feng,Huanyu Cheng
Wearable electrochemical sensors provide means to detect molecular-level information from the biochemical markers in biofluids for physiological health evaluation. However, a high-density array is often required for multiplexed detection of multiple markers in complex biofluids, which is challenging with low-cost fabrication methods. This work reports the low-cost direct laser writing of porous graphene foam as a flexible electrochemical sensor to detect biomarkers and electrolytes in sweat. The resulting electrochemical sensor exhibits high sensitivity and low limit of detection for various biomarkers (e.g., the sensitivity of 6.49/6.87/0.94/0.16 μA μM–1 cm–2 and detection limit of 0.28/0.26/1.43/11.3 μM to uric acid/dopamine/tyrosine/ascorbic acid) in sweat. The results from this work open up opportunities for noninvasive continuous monitoring of gout, hydration status, and drug intake/overdose.
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Microorganisms
·
2023
·Vol. 11
·期 8
·1989
·
IF 4.5
Xiaoyu Cao,Jingyuan Cai,Yu Zhang,Chao Liu,Meijie Song,Qianqian Xu,Yang Liu,Hai Yan
High serum uric acid levels, known as hyperuricemia (HUA), are associated with an increased risk of developing gout, chronic kidney disease, cardiovascular disease, diabetes, and other metabolic syndromes. In this study, a promising bacterial strain capable of biodegrading uric acid (UA) was successfully isolated fromBaijiucellar mud using UA as the sole carbon and energy source. The bacterial strain was identified asBacillus paramycoides-YC02 through 16S rDNA sequence analysis. Under optimal culture conditions at an initial pH of 7.0 and 38 °C, YC02 completely biodegraded an initial UA concentration of 500 mg/L within 48 h. Furthermore, cell-free extracts of YC02 were found to catalyze and remove UA. These results demonstrate the strong biodegradation ability of YC02 toward UA. To gain further insight into the mechanisms underlying UA biodegradation by YC02, the draft genome of YC02 was sequenced using Illumina HiSeq. Subsequent analysis revealed the presence of gene1779 and gene2008, which encode for riboflavin kinase, flavin mononucleotide adenylyl transferase, and flavin adenine dinucleotide (FAD)-dependent urate hydroxylase. This annotation was based on GO or the KEEG database. These enzymes play a crucial role in the metabolism pathway, converting vitamin B2to FAD and subsequently converting UA to 5-hydroxyisourate (HIU) with the assistance of FAD. Notably, HIU undergoes a slow non-enzymatic breakdown into 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) and (S)-allantoin. The findings of this study provide valuable insights into the metabolism pathway of UA biodegradation byB. paramycoides-YC02 and offer a potential avenue for the development of bacterioactive drugs against HUA and gout.Keywords:uric acid;Bacillus paramycoides-YC02;biodegradation;genomic analysis
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OPTICS EXPRESS
·
2023
·Vol. 31
·期 16
·25662-25679
·
IF 3.8
Qin Tan,Shengnan Wu,Shengnan Wu,Shengnan Wu,Zhenchao Liu,Xiaolu Chen,Sailing He,Sailing He,Sailing He
Disturbance of surrounding temperature inevitably affects the accuracy of fiber biosensors. To that end, we propose a compact label-free optofluidic sensor based on a polished hollow core Bragg fiber (HCBF) that can simultaneously measure the cortisol concentration and surrounding temperature in real-time. The sensor is comprised of fusion splicing single mode fiber (SMF), multimode fiber (MMF) and HCBF. HCBF is side polished to remove part of the cladding that the suspended inner surface of the fiber can contact the external environment. After the incident light passes through the MMF from the SMF, it enters the hollow area, high refractive index (RI) layers, respectively, where the anti-resonant reflecting optical waveguide (ARROW) guiding mechanism and Mach-Zehnder interferometer (MZI) are simultaneously excited. Taking advantage of the high RI layers of HCBF, compared to the fiber with uniform cladding, the light can be more confined in the cladding and more sensitive to inner surface medium. The inner surface of sensor is immobilized with cortisol aptamer for the sake of achieving high sensitivity and specific sensing of cortisol with the limit of detection (LOD) to be 4.303 pM. The proposed sensor has a compact structure, enables temperature compensation, and can be fabricated at low cost making it highly suitable for in-situ monitoring and high-precision sensing of cortisol and other biological analytes.
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Panpan Hao,Rufeng Zhu,Yang Tao,Wei Jiang,Xue Liu,Yan Tan,Yuedan Wang,Dong Wang
Novel enhancement-mode organic electrochemical transistors (OECTs) have been prepared by poly(3, 4-ethylenedioxythiophene)-poly(styrenesulfonate) de-doped polyethylenimine on the multi-walled carbon nanotube-modified viscose yarn. The fabricated devices exhibit low power consumption with a high transconductance of 6.7 mS, rapid response time < 2 s, and excellent cyclic stability. In addition, the device has washing durability and bending and long-term stability suitable for wearable applications. Biosensors based on enhancement-mode OECTs for the selective detection of adrenaline and uric acid (UA) are developed by using molecularly imprinted polymer (MIP)-functionalized gate electrodes. The detection limits of adrenaline and UA analysis are as low as 1 pM, with the linear ranges of 0.5 pM to 10 μM and 1 pM to 1 mM, respectively. Moreover, the sensor based on enhancement-mode transistors can efficiently amplify the current signals according to the modulation of the gate voltage. The MIP-modified biosensor has high selectivity in the presence of interferents and desirable reproducibility. Additionally, due to the wearable nature of the developed biosensor, this sensing tool has the capability of being integrated with fabrics. Therefore, it has successfully been applied in textiles for the determination of adrenaline and UA in artificial urine samples. The excellent recoveries and rsds are 90.22–109.05% and 3.97–6.94%, respectively. Ultimately, these sensitive, low-power, wearable, and dual-analyte sensors help to develop non-laboratory tools for early disease diagnosis and clinical research.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2022
·
IF 6.371
Senyang Song,Xiaoyan Ma,Wenyue Li,Boyuan Zhang,Bo Shao,Xiaoyu Chang,Xiaoju Liu
With the development of power supplies for wearable devices , electrode materials with dual functions have received extensive attention. Herein, we report a strategy of preparing stylophora coral-like Ni/Co bimetal metal organic framework (MOF) with furan-based derivatives as ligands through the simple solvothermal method, which can be utilized as a dual-function electrode material to build supercapacitors and non-enzymatic glucose sensing. It can be found that the high molecular stacking properties of the rigid furan ring skeleton combined with the unique stylophora coral-like morphology can greatly improve the charge transfer efficiency of the electrode reaction process, and the structure of the bimetallic node can effectively adjust the three-dimensional electronic structure, making high capacitive performance during charge storage. The specific capacitance of the furan-based bimetallic MOF material is as high as 531 C g −1 at a current density of 1 A g −1 with a high capacitance retention rate of 83.4% after 5000 cycles. In addition, the glucose sensing performance is analyzed and an outstanding sensitivity value of 366 µA mM −1 cm −2 is achieved with a low limit of detection (2 μM). The as-synthesized furan-based bimetallic MOF material is a promising candidate for electrochemical supercapacitors and efficient glucose detection.
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