TOXICOLOGICAL SCIENCES
·
2016
·Vol. 153
·期 2
·303-315
·
IF 3.88
Fu Juanli,Shi Qiong,Song Xiufang,Liu Zixuan,Wang Yawen,Wang Yuxin,Song Erqun,Song Yang
Tetrachlorobenzoquinone (TCBQ) is a confirmed active metabolite of a well-known environmental pollutant pentachlorophenol (PCP). Unfortunately, there is insufficient knowledge present available on TCBQ’s toxicity. Our previous studies indicated that TCBQ induces inflammatory response in vivo and in vitro; however, its exact mechanism needs further investigation. Toll-like receptors (TLRs) play a crucial role in conveying of inflammatory signaling, whilst high-mobility group box 1 (HMGB1) functions as a transcription-enhancing nuclear protein that regulates inflammation. Indeed, this study demonstrated that TCBQ induces the secretion/translocation of HMGB1, which in turn activates its receptors, TLR family gene (especially TLR4) and receptor for advanced glycation end-products (RAGE) expressions. Consistently, the binding affinity of HMGB1 with its receptors also increased. In the case of HMGB1 or TLR4 deficiency, there were decreases in TCBQ-induced neuroinflammatory cytokine production and neuropathological changes, eg, neuronal loss, astrocyte and macrophage cells activation. Moreover, we found the mobilization of TLR4 into lipid rafts occurs in response to TCBQ exposure, lipid rafts disruptors weakened this effect, suggested lipid rafts play an essential role for TLR4-mediated signal transduction and target inflammatory cytokines expressions. In summary, our current findings revealed a previously unknown mechanism of TCBQ-induced neurological inflammation related to HMGB1-TLR4 signaling.
研究领域:
毒理学
·
神经科学
·
免疫学
·
环境健康
✓ 已验证
DOI
PubMed
高影响因子
CHEMOSPHERE
·
2024
·
IF 8.1
Meiyao Han,Shiyue Huang,Xiaoxiao Zhang,Ke Zhang
Chlorine, serving as the mainstream disinfectant, can react with dissolved organic matter (DOM) to form undeserved disinfection by-products (DBPs). Free available chlorine (FAC) concentration is crucial to ensure effective disinfection while minimizing the formation of toxic DBPs. In this study, we propose a convenient method using sodium sulfite (Na 2 SO 3 ) to reduce oxidized chlorine in FAC. The molar concentration of reduced chloride ion (Cl − ) was quantified directly by ion chromatography to reflect FAC concentration. Compared with common FAC detection techniques including DPD colorimetry, iodometry, and UV methods, this novel reduction method exhibits a lower detection limit and is more resistant to interference. Common water matrices, such as DOM and anions did not affect the method accuracy (< 3.6%). Furthermore, carbonaceous DBPs (C-DBPs) like regulated trihalomethanes and halogenacetic acids, unregulated aromatic chlorophenols, did not interfere with the determination of FAC by using this reduction method. This lack of interference can be attributed to the low redox potential of Na 2 SO 3 , which does not readily react with these C-DBPs. However, nitrogenated DBPs (N-DBPs) like dichloroacetonitrile displayed slight interference (the effect of common dichloroacetonitrile concentration in water on FAC was less than 0.0007 μM). This suggests that this method is well-suited for determining FAC in chlorination processes where the C-DBPs predominated. Overall, the reduction method enables precise determination of FAC and proves valuable in assessing residual chlorine levels in both laboratory and real disinfected water samples dominated by C-DBPs.
研究领域:
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2011
·
IF 2.594
Shumin Li,Youwei Yao
Zinc barbiturate [Zn(H 2 L) 2 ·2H 2 O, abbreviated as ZnL 2 ] was synthesized by a precipitation method in aqueous solution, and investigated as a co-stabilizer with calcium stearate (CaSt 2 ) for rigid poly(vinyl chloride) (PVC) by the discoloration test and the dehydrochlorination test at 180 °C. ZnL 2 exhibits high stabilizing effect with excellent initial colour of PVC films. In comparison with the synergistic effect of CaSt 2 /ZnSt 2 stabilizers, the CaSt 2 /ZnL 2 stabilizers in mass ratios ranging from 0.3/1.2 to 0.6/0.9 exhibit better synergistic effect. Moreover, PVC films stabilized by CaSt 2 /ZnL 2 show better initial colour with the addition of dibenzoyl methane as an auxiliary stabilizer . The mechanism of stabilizing action of ZnL 2 is also proposed. ZnL 2 may replace the labile chlorine atoms to interrupt the formation of conjugated double bonds in PVC chains, and act as the absorber of hydrogen chloride to restrain the self-catalytic dehydrochlorination.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2018
·
IF 2.441
Xuran Wang,Ming Gao,Jiajia Gao,Xuedong Wang,Meiping Ma,Huili Wang
Herein, we established an ionic liquid (IL)-based liquid-solid transformation microextraction (IL-LTME) combined with HPLC-UV detection for the simultaneous determination of triclosan (TCS) and its methylated product, methyltriclosan (MTCS), in human fluids. The IL-LTME method was based on an in situ metathesis between hydrophilic IL and ion-exchange salt to form a solid hydrophobic IL. According to the above principle, a hydrophilic IL, [C 12 MIM]Br, was selected as the extractant, and NH 4 PF 6 as ion-exchange salt. The prominent advantages of the newly developed method are: (1) the in-situ reaction between the extractant [C 12 MIM]Br and ion-exchange salt NH 4 PF 6 changed the IL from hydrophilic to hydrophobic that avoiding the stick of ionic liquid on the tube wall; (2) bubbling with NH 3 greatly increased the contact area between IL-extractant and analytes resulting in improved extraction recovery; and (3) solidification of the [C 12 MIM] PF 6 provided a good separation and avoided the use of specialized equipment. A series of main parameters were optimized by single-factor screening and central composite design as follows: 0.9 mL of NaOH, 2.0 min of second ultrasonically time, 10 min of centrifugation time, 21 mg of extractant [C 12 MIM]PF 6 , 2.4 min of ultrasonic time, 65 mg of NH 4 PF 6 and 13.8 min of cooling time. Under the optimized conditions, the limits of detection for TCS and MTCS were 0.126–0.161 μg L −1 in plasma samples, and 0.211–0.254 μg L −1 in urine samples, respectively. The extraction recoveries for TCS and MTCS were in the range of 94.1–103.8%. The intra-day and inter-day precisions were 1.00–4.74% and 1.02–5.21%, respectively. In general, the IL-LTME method is environment-friendly, time-saving, economical, high efficient and robust with low detection limits and high recoveries. Thus, the newly developed method has excellent prospects for sample pretreatment and analysis of trace TCS and MTCS in blood and urine samples.
研究领域:
分析化学
·
环境科学
·
医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
WASTE MANAGEMENT
·
2018
·
IF 4.723
Ming-Xiu Zhan,Long-Jie Ji,Yu-Feng Ma,Wang-Ruochen Chen,Sheng-Yong Lu
Catalytic oxidation is regarded an effective technique to control the emissions of chlorinated benzenes (CBzs) and polychlorinated dibenzo- p -dioxins and dibenzofurans (PCDD/Fs) from waste incinerators . Among the numerous factors affecting the degradation efficiency of CBzs and PCDD/Fs, limited attention has been paid to the impact of hydrochloric acid (HCl) present in the flue gas . This study investigates how HCl affects the catalytic degradation of 1,2-dichlorbenzene (1,2-DCBz) at different reaction times and temperature regimes. The results showed that the removal efficiency of 1,2-DCBz, which was achieved by the V 2 O 5 /WO 3 -TiO 2 (VWTi) catalyst, decreased the largest by 10% in the presence of HCl. Furthermore, it was found that the increasing concentration of water vapor hindered the degradation efficiency of 1,2-DCBz. No relationship between the process temperature and the destruction efficiency of PCDD/Fs was observed in the presence of HCl. Potential increasing of the removal efficiency of 1,2-DCBz was confirmed by adding different amount of activated carbon (AC) in the presence of HCl.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 25
·14400-14406
·
IF 3.049
Rong-xiang Zhao,Xiu-ping Li,Chun-feng Mao,Liangpei Hou,Xiaohan Gao
N,N-Dimethylformamide hydrochloric acid/XMCln ([HDMF]Cl/XMCln, M = Zn or Fe, n = 2 or 3) was synthesized by stirring the mixture of [HDMF]Cl and metal chloride. [HDMF]Cl-based DES was characterized by FT-IR spectroscopy, ESI-MS and 1H-NMR spectroscopy. The oxidative desulfurization activity was investigated using [HDMF]Cl/0.2FeCl3 and [HDMF]Cl/ZnCl2 as the extractant and catalyst, and hydrogen peroxide (H2O2) as the oxidant. The desulfurization rate can reach up to 98.08% and 99.2% for DBT using [HDMF]Cl/0.2FeCl3 and [HDMF]Cl/ZnCl2, respectively. After recycling for 7 times, the removal rate of DBT still can reach more than 97%.
研究领域:
化学工程
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Analytical Methods
·
2019
·Vol. 12
·期 8
·1871-1885
·
IF 2.413
Xu Lijun,Miao Xiaohuan,Yang Zhaoguang,Li Haipu,Qiu Bo
Solid-phase extraction (SPE) was combined with dispersive liquid-liquid microextraction based on solidification of floating organic droplet (DLLME-SFO) as a pretreatment technique for the simultaneous analysis of 11 organochlorine pesticides (OCPs) and 5 polychlorinated biphenyls (PCBs) in fish tissue. Gas chromatography with electron capture detector was used for the identification and quantification of these compounds. In the newly developed method, the acetonitrile extractant of the fish sample was cleaned up by commercialized SPE cartridges packed with acid alumina, and then mixed with water, sodium-chloride, and n-pentadecane for the purpose of target analyte enrichment via DLLME-SFO process. Effect of the parameters including SPE packing material, amount and chemical nature of extraction solvent, water volume, and salt concentration on the signal responses were investigated, and the recoveries of this method ranged between 70.1% and 112.3% at three spiked levels under the optimized conditions. The calibration curves were found to be linear in the range of 1.56–312.5 μg L −1 , and the limits of detection ranged from 0.372 to 1.12 μg kg −1 . Comparing the other reported pretreatment method, the presented one was sensitive, time-saving, and environmentally friendly.
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF SOLUTION CHEMISTRY
·
2017
·Vol. 46
·期 9
·1871-1902
·
IF 1.342
Li Dongdong,Gao Dandan,Zeng Dewen,Li Wu
The solid solution–aqueous solution (SSAS) equilibria in the KCl + RbCl + H 2 O system were redetermined at 298.15 K. The experimental data for (K,Rb)Cl were consistent with the formation of a continuous solid solution without miscibility gaps. The Schreinemakers’ wet residues method and an XRD quantitative analysis technique based on the Vegard approach were applied to determine the chemical composition of the solid solution phase of (K,Rb)Cl. The compositions of (K,Rb)Cl derived from the Vegard approach are in accordance with those from the wet residues method. The thermodynamic properties of mixing of the (K,Rb)Cl solid solution were theoretically predicted using atomistic simulations. From these simulations, a regular solution behavior is recognized that is consistent with the knowledge of the thermodynamic properties of mixing of (K,Rb)Cl obtained from SSAS equilibrium studies, but the predicted regular solution model parameter A
0 is significantly larger than that regressed from the SSAS equilibrium data. Finally, a thermodynamic model was developed for representing the SSAS equilibria and element partitioning in the KCl + RbCl + H 2 O system as a function of temperature that can be used for predicting the SSAS equilibria in the studied system over the temperature range 273.15–373.15 K.
研究领域:
化学
·
材料科学
·
物理化学
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2018
·
IF 3.927
Huiming Xiang,Yisheng Shao,Naiyun Gao,Xian Lu,Na An,Chaoqun Tan,Zhaofang Zheng
The degradation of diuron by chlorination and UV/chlorine process and the formation of disinfection by-products (DBPs) was investigated in this study. The degradation of diuron followed the pseudo first-order kinetics model. In UV/chlorine process, hydroxyl radical were proved to provide more contribution in the oxidation. The degradation kinetics increased with the increasing of chlorine dosage and the decreasing of natural organic matter (NOM) dosage. However, the degradation pathways were defined using high performance liquid chromatography coupled with a TSQ Quantum quadrupole mass spectrometer (HPLC-ESI/MS). The formation of DBPs after chlorination and chloramination was defined using gas chromatography with elect ion capture detector (GC-ECD) and gas chromatography–mass spectrometer (GC–MS). Several kinds of DBPs including chloroform (TCM), 1,1-dichloroacetone (1,1-DCP), 1,1,1-trichloroacetone (1,1,1-TCP), trichloronitromethane (TCNM), dichloroacetamide (DCAcAm) and trichloroacetamide (TCAcAm) was identified in this study.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2014
·Vol. 132
·期 10
·
IF 1.64
Hao Li,Ping Yu,Haigang Li,Yunbai Luo
Membrane-based separation technology is one of the most active separation technologies being employed in water treatment. Polyamides (PA) are widely used membrane materials because they exhibit excellent performance, such as high flux with high salt rejection, and enhanced stability against wide range of pH and temperature. Unfortunately, PA membranes exhibit extremely poor resistance to chlorine leading to increased operation costs and decreased membrane lifetime. In this study, we find new ways for prolonging membrane lifetime and reducing the operating costs by investigating the chlorination and modification of PA membranes. Varying concentrations of hypochlorite were used to chlorinate a commercial reverse osmosis membrane (BW-30, DOW). The results showed that short-time exposure to high concentrations of hypochlorite could cause more serious problems to membranes than long-time exposure to low concentrations under the similar total exposure. The performance of the chlorinated membranes was recovered to some extent after treatment with NaOH solution (pH 10), indicating that the alkali treatment could initiate the reversible regeneration of chlorinated membranes. Furthermore, an industrial grade epoxy resin was used to modify the membranes to enhance the chlorine resistance via the reaction between the amide nitrogen and epoxy bond. The successful modifications were confirmed by attenuated total reflectance Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, scanning electron microscopy, and atomic force microscopy. Moreover, the chlorination tests showed that the modifications performed in these experiments enhanced the chlorine resistance of the membranes, especially for the membranes exposed to low concentration of chlorine. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 41584.
研究领域:
材料科学
·
环境工程
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ENERGY & FUELS
·
2018
·
IF 3.024
Yang Chen,Shuhua Zhang,Xiuxiu Han,Xu Zhang,Mengting Yi,Siyuan Yang,Dayang Yu,Weijun Liu
The catalytic effects of CuAl layered double hydroxide (CuAl-LDH) on dechlorination and carbonization of polyvinyl chloride (PVC) during pyrolysis were investigated. The thermal degradation and combustion behaviors were researched via thermogravimetric analysis (TGA) and cone calorimetry (CONE). The released gases were evaluated in detail by thermogravimetric analysis coupled with Fourier transform infrared spectrometry (TGA-FTIR). Subsequently, elemental analysis and scanning electron microscopy-energy dispersive spectrometry (SEM-EDS) were employed to fully characterize the solid residues. The results of TGA and CONE showed that the addition of CuAl-LDH brought about the PVC degradation earlier and the char residues increase significantly. Moreover, the results of TGA-FTIR, elemental analysis, SEM-EDS, and Raman analysis revealed that the existence of CuAl-LDH accelerated the dehydrochlorination and promoted the char formation of PVC. CuAl-LDH maybe a potential catalyst applied to treat PVC waste into carbon materials to realize material and chemical recycling, which possess tremendous environmental and economic benefits.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Catalysts
·
2018
·Vol. 8
·期 3
·116
·
IF 3.465
Meng Ye,Li Chen,Xiaolong Liu,Wenqing Xu,Tingyu Zhu,Guanyi Chen
A series of Ru-based mono and bimetallic materials were prepared and evaluated in the catalytic oxidation of chlorobenzene. Among the different Ru-based catalysts, 1Ru/TiO2(P25) was the most active catalyst and contributed the lowest complete oxidation temperature, suggesting that commercial P25 TiO2was the best support for Ru catalysts. After ceria oxides were introduced into the Ru catalytic system, the catalytic activity of 1Ru-5Ce/TiO2(Rutile) dramatically improved and that of P25 supported catalysts was decreased. Comparing the chlorobenzene consumption rates for 1Ru/TiO2and 1Ru-5Ce/TiO2at 280 °C, it could be concluded that monometallic Ru catalytic system was appropriate for P25 support, and the Ru-Ce bimetallic catalytic system was suitable for the rutile TiO2support. At 280 °C, for 1Ru-5Ce/TiO2(Rutile) and 1Ru-5Ce/TiO2(P25), the chlorobenzene conversion was stabilized at approximately 91% and 86%, respectively. According to the physicochemical properties of the catalysts as characterized by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM), and Hydrogen temperature programmed reduction (H2-TPR), it can be concluded that (a) electrophilic Oadsspecies play an important role in VOCs oxidation; (b) abundant RuO2nanoparticles on the surface of 1Ru-5Ce/TiO2(Rutile) result in higher catalytic activity and stability; and (c) dispersion is not the major factor for the catalytic activity, rather the unique structure greatly facilitated the catalytic activity and stability.Keywords:chlorinated volatile organic compounds;chlorobenzene;catalytic oxidation;ruthenium;bimetallic catalysts
研究领域:
环境科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）